Gene Symbol: Calu
Alias: 9530075H20Rik, calumenin, crocalbin
Yabe D, Nakamura T, Kanazawa N, Tashiro K, Honjo T. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. J Biol Chem. 1997;272:18232-9 pubmed
We have identified and characterized a cDNA encoding a novel Ca2+-binding protein named calumenin from mouse heart by the signal sequence trap method...
Sahoo S, Kim T, Kang G, Lee J, Eom S, Kim D. Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum. J Biol Chem. 2009;284:31109-21 pubmed publisher
b>Calumenin is a multiple EF-hand Ca(2+)-binding protein localized in the sarcoplasmic reticulum (SR) with C-terminal SR retention signal HDEF. Recently, we showed evidence that calumenin interacts with SERCA2 in rat cardiac SR (Sahoo, S...
Gogstad G, Hagen I, Korsmo R, Solum N. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981;670:150-62 pubmed
..The dominant three represented the main granule glycoprotein, glycoprotein IIb and glycoprotein IIIa, respectively. More glycoproteins seem to be present in the alpha-granules than was previously recognized. ..
Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. Genomics. 1998;49:331-3 pubmed
Lee Y, Park C, Hahn Y, Park J, Lee J, Yun J, et al
. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000;472:230-4 pubmed
..In addition, we identified an antisense transcript of Copg2, Copg2AS, which overlaps 3'-UTRs of Copg2 and Peg1/Mest. The Copg2AS transcript is maternally imprinted in embryos, neonates, and adult tissues. ..
Nakamura T, Yabe D, Kanazawa N, Tashiro K, Sasayama S, Honjo T. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. Genomics. 1998;54:89-98 pubmed
..FKBP23 mRNA is expressed most strongly in heart, lung, and testis, beginning at day 8.5 of embryonic development. The FKBP23 gene was mapped to mouse chromosome 2. ..
Jung D, Kim D. Characterization of isoforms and genomic organization of mouse calumenin. Gene. 2004;327:185-94 pubmed
b>Calumenin is a multiple EF-hand protein located in endo/sarcoplasmic reticulum of mammalian heart and other tissues [J. Biol. Chem. 272 (1997) 18232; Genomics 49 (1998) 331; Biochim. Biophys. Acta 1386 (1998) 121]...
Vasiljevic M, Heisler F, Hausrat T, Fehr S, Milenkovic I, Kneussel M, et al
. Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain. Neuroscience. 2012;202:29-41 pubmed publisher
b>Calumenin is a Ca(2+)-binding protein that belongs to the CREC superfamily. It contains six EF-hand domains that exhibit a low affinity for Ca(2+) as well as an endoplasmic reticulum retention signal...
Wang Q, Shen B, Chen L, Zheng P, Feng H, Hao Q, et al
. Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Oncogene. 2015;34:1006-18 pubmed publisher
Extracellular proteins are vital for cell activities, such as cell migration. Calumenin is highly conserved among eukaryotes, but its functions are largely unclear...