Gene Symbol: Calcb
Description: calcitonin-related polypeptide, beta
Alias: CGRP2, Calc2, calcitonin gene-related peptide 2, CGRP-II, beta-type CGRP, calcitonin gene-related peptide II
Andrieu D, Meziane H, Marly F, Angelats C, Fernandez P, Muscatelli F. Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 2006;6:56 pubmed
..Finally we also exclude an anti-proliferative role of Necdin in developing sensory neurons. Overall, our data show clearly that, in early development of the nervous system, Necdin is an anti-apoptotic or survival factor. ..
Tsujikawa K, Yayama K, Hayashi T, Matsushita H, Yamaguchi T, Shigeno T, et al
. Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice. Proc Natl Acad Sci U S A. 2007;104:16702-7 pubmed
..These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells. ..
Rezaeian A, Isokane T, Nishibori M, Chiba M, Hiraiwa N, Yoshizawa M, et al
. alphaCGRP and betaCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites. Brain Dev. 2009;31:682-93 pubmed publisher
..These findings together indicate that alphaCGRP and betaCGRP have their own roles in the ontogenic process. ..
Salbaum J, Kruger C, Zhang X, Delahaye N, Pavlinkova G, Burk D, et al
. Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy. Diabetologia. 2011;54:1909-20 pubmed publisher
Sample S, Heaton C, Behan M, Bleedorn J, Racette M, Hao Z, et al
. Role of calcitonin gene-related peptide in functional adaptation of the skeleton. PLoS ONE. 2014;9:e113959 pubmed publisher
..This suggests that release of CGRP from sensory peptidergic fibers in periosteum and bone has a functional role in load-induced bone formation. ..
Thomas P, Nasonkin I, Zhang H, Gagel R, Cote G. Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes. DNA Seq. 2001;12:131-5 pubmed
..The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function. ..
Young H, Turner K, Bergner A. The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gut. Cell Tissue Res. 2005;320:1-9 pubmed
..5). Thus, for enteric neurons, exit from the cell cycle appears to occur after the expression of pan-neuronal proteins but prior to the expression of markers of terminally differentiated neurons. ..
Ringer C, Weihe E, Schütz B. Pre-symptomatic alterations in subcellular betaCGRP distribution in motor neurons precede astrogliosis in ALS mice. Neurobiol Dis. 2009;35:286-95 pubmed publisher