Calb2

Summary

Gene Symbol: Calb2
Description: calbindin 2
Alias: calretinin
Species: mouse

Top Publications

  1. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
  2. ncbi The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9005-10. 2003
  3. ncbi Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway
    Helen B Treloar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 482:201-16. 2005
  4. ncbi A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
  5. ncbi BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
  6. ncbi Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy
    M Liu
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:865-70. 2000
  7. ncbi Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice
    Moritz D Brandt
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 24:603-13. 2003
  8. ncbi Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
    D Hartmann
    Anatomisches Institut der CAU Kiel, Otto Hahn Platz 8, D 24 118, Kiel, Germany
    Curr Biol 9:719-27. 1999
  9. ncbi p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:4259-71. 2001
  10. ncbi Distribution of frequenin in the mouse inner ear during development, comparison with other calcium-binding proteins and synaptophysin
    C Sage
    INSERM U 432, Universite de Montpellier II, Montpellier, France
    Hear Res 150:70-82. 2000

Research Grants

  1. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    Gordon Fishell; Fiscal Year: 2003
  2. Sonic Hedgehog Signaling in the Mammalian Telencephalon
    Gordon Fishell; Fiscal Year: 2007
  3. Developmental Mechanisms of the Chromodomain Gene Chd7
    Donna M Martin; Fiscal Year: 2011
  4. Cell Fate Determination in the Cerebellum
    Gordon Fishell; Fiscal Year: 2007
  5. Analysis of Notch Signaling in Telencephalic Development
    Gordon Fishell; Fiscal Year: 2006
  6. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
  7. Pitx2 Function in Developing Mouse Brain Neurons
    Donna Martin; Fiscal Year: 2007
  8. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
  9. Pitx2 Function in Developing Mouse Brain Neurons
    Donna Martin; Fiscal Year: 2009
  10. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
    ..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
  2. ncbi The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9005-10. 2003
    ..These results provide genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain...
  3. ncbi Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway
    Helen B Treloar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 482:201-16. 2005
    ..express other known markers of PGCs including tyrosine hydroxylase, glutamic acid decarboxylase, calbindin, or calretinin, and only partially overlapped with the subpopulation of PGCs that express parvalbumin...
  4. ncbi A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..We show that calretinin+, calbindin+, and dopaminergic (TH+) periglomerular OB interneurons correspond to distinct subtypes of GABAergic ..
  5. ncbi BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
  6. ncbi Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy
    M Liu
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:865-70. 2000
    ..Furthermore, failure to express BETA2/NeuroD leads to a stereotyped pattern of pathological excitability of the adult central nervous system...
  7. ncbi Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice
    Moritz D Brandt
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 24:603-13. 2003
    ..granule cell development during adult hippocampal neurogenesis is characterized by the transient expression of calretinin (CR)...
  8. ncbi Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
    D Hartmann
    Anatomisches Institut der CAU Kiel, Otto Hahn Platz 8, D 24 118, Kiel, Germany
    Curr Biol 9:719-27. 1999
    ..Physiologically, the presenilins are involved in the Notch and Wnt-beta-catenin signaling pathways...
  9. ncbi p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:4259-71. 2001
    ....
  10. ncbi Distribution of frequenin in the mouse inner ear during development, comparison with other calcium-binding proteins and synaptophysin
    C Sage
    INSERM U 432, Universite de Montpellier II, Montpellier, France
    Hear Res 150:70-82. 2000
    ..The distribution of frequenin was compared with those of other calcium-binding proteins (calbindin, calretinin, parvalbumin) and synaptophysin...
  11. ncbi Math5 is required for both early retinal neuron differentiation and cell cycle progression
    Tien T Le
    Division of Developmental Biology, Children s Hospital Research Foundation, Departments of Pediatrics and Ophthalmology University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 7007, USA
    Dev Biol 295:764-78. 2006
    ..Thus, Math5 orchestrates neurogenesis in multiple ways, regulating both intrinsic and extrinsic processes...
  12. ncbi The Gsh2 homeodomain gene controls multiple aspects of telencephalic development
    J G Corbin
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 127:5007-20. 2000
    ..Taken together, our data support a model in which Gsh2, in response to sonic hedgehog signaling, plays a crucial role in multiple aspects of telencephalic development...
  13. ncbi Midline radial glia translocation and corpus callosum formation require FGF signaling
    KAREN MULLER SMITH
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 9:787-97. 2006
    ..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells...
  14. ncbi Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
    Rachael Brooker
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:1277-86. 2006
    ..Our findings confirm that Notch signalling in the ear has distinct prosensory and lateral-inhibitory functions, for which different ligands are primarily responsible...
  15. ncbi The neuronal basic helix-loop-helix transcription factor NSCL-1 is dispensable for normal neuronal development
    Markus Krüger
    Institute of Physiological Chemistry, University of Halle Wittenberg, 06097 Halle, Germany
    Mol Cell Biol 22:792-800. 2002
    ..Our results argue against a simple functional redundancy within the NSCL gene family...
  16. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  17. ncbi The adhesion molecule TAG-1 is required for proper migration of the superficial migratory stream in the medulla but not of cortical interneurons
    Myrto Denaxa
    University of Crete Medical School, Heraklion 71110, Crete, Greece
    Dev Biol 288:87-99. 2005
    ..Therefore, TAG-1 function is required for the survival of the neurons of some precerebellar nuclei, while it is not required for cortical interneuron migration in vivo...
  18. ncbi Multiple origins of Cajal-Retzius cells at the borders of the developing pallium
    Franck Bielle
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Nat Neurosci 8:1002-12. 2005
    ..Our data also strongly suggest that distinct Cajal-Retzius subtypes exist and that their presence in different territories of the developing cortex might contribute to region-specific properties...
  19. ncbi Differential expression of calretinin and metabotropic glutamate receptor mGluR1alpha defines subsets of unipolar brush cells in mouse cerebellum
    Maria Grazia Nunzi
    Institute for Neuroscience, Northwestern University, Chicago, Illinois 60611, USA
    J Comp Neurol 451:189-99. 2002
    ..the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive for the calcium binding protein calretinin (CR) in both the somatodendritic and axonal compartment...
  20. ncbi Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
    Mikio Hoshino
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuron 47:201-13. 2005
    ..Our results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum...
  21. ncbi The glial sling is a migratory population of developing neurons
    Tianzhi Shu
    The University of Maryland, Baltimore, School of Medicine, Department of Anatomy and Neurobiology, and the Program in Neuroscience, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Development 130:2929-37. 2003
    ..These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance...
  22. ncbi Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons
    Mary Wines-Samuelson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 277:332-46. 2005
    ..These findings show a cell-autonomous role for PS1 in cortical lamination and radial glial development, and a non-cell-autonomous role for PS1 in CR neuron survival...
  23. ncbi Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina
    C Ciolofan
    Department of Physiology, Faculty of Medicine, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba, Canada R3E 3J7
    Neuroscience 140:433-51. 2006
    ....
  24. ncbi Math5 is required for retinal ganglion cell and optic nerve formation
    N L Brown
    Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Development 128:2497-508. 2001
    ..A small number of nascent RGCs are detected during embryogenesis, but these fail to develop further, suggesting that committed RGCs may also require Math5 function...
  25. ncbi Dll3 is expressed in developing hair cells in the mammalian cochlea
    Byron H Hartman
    Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 236:2875-83. 2007
    ..Thus Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2...
  26. ncbi Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract
    Y Sato
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    J Neurosci 18:7800-10. 1998
    ..Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are "guidepost cells" for mitral cell axons...
  27. ncbi Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
    A K Lewis
    Department of Neuroscience, Genentech, Inc, South, San Francisco, CA 94080, USA
    Mech Dev 78:159-63. 1998
    ..Notch2, Notch3, Notch4, and Delta1 are excluded from the inner ear epithelia. These data support the hypothesis that Notch signaling is involved in hair cell differentiation during inner ear morphogenesis...
  28. ncbi An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
    A Bulfone
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Neuron 21:1273-82. 1998
    ..These observations suggest that the establishment of a topographic map is not dependent upon cues provided by, or synapse formation with, the major neuronal cell types in the olfactory bulb...
  29. ncbi Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling
    Rita De Gasperi
    Research and Development James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Dev Dyn 237:2405-14. 2008
    ..Unlike reeler mice the preplate splits in Psen1-/- brain. Thus cortical development in Psen1-/- mice fails only after splitting of the preplate and is not due to an intrinsic failure of reelin signaling...
  30. ncbi Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation
    Elena Colombo
    Stem Cell Research Department, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 27:4786-98. 2007
    ..pallidus and striatum were greatly reduced in the mutants, causing a periventricular accumulation of NPY+ or calretinin+ neurons in the MGE...
  31. ncbi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
  32. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
  33. ncbi Developmental expression of calretinin-immunoreactivity in the thalamic eminence of the fetal mouse
    L C Abbott
    Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A and M University, College Station 77843 4458, USA
    Int J Dev Neurosci 17:331-45. 1999
    An investigation of the developmental expression of calretinin immunoreactivity and mRNA expression was carried out in the developing mouse diencephalon...
  34. ncbi Development of calretinin immunoreactivity in the mouse inner ear
    C J Dechesne
    Laboratoire de Neurophysiologie Sensorielle, Unité INSERM 254, Montpellier, France
    J Comp Neurol 346:517-29. 1994
    b>Calretinin is a calcium-binding protein of the EF-hand family. It has been previously identified in particular cell types of adult guinea pig, rat, and chinchilla inner ear...
  35. ncbi Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes
    Petros Liodis
    Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 27:3078-89. 2007
    ..markers that have been used to classify cortical interneurons are the calcium-binding proteins parvalbumin and calretinin and the neuropeptide somatostatin, which in rodents identify mostly nonoverlapping interneuron subpopulations...
  36. ncbi Prox1 expression patterns in the developing and adult murine brain
    Alfonso Lavado
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 236:518-24. 2007
    ..In adulthood, Prox1 expression remains only in the hippocampus and cerebellum. These complex patterns of expression suggest that Prox1 activity is differentially required during brain development and adulthood...
  37. ncbi Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
    J Galceran
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, CA 94143, USA
    Development 127:469-82. 2000
    ..Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus...
  38. ncbi Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  39. ncbi The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons
    Yasser Elshatory
    Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:3291-7. 2008
    ..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function...
  40. ncbi A developmental switch in the response of DRG neurons to ETS transcription factor signaling
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Switzerland
    PLoS Biol 3:e159. 2005
    ..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation...
  41. ncbi Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
    Victor Borrell
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Neurosci 9:1284-93. 2006
    ..Thus, the meningeal membranes are fundamental in the development of Cajal-Retzius cells and, hence, in the normal development of the cerebral cortex...
  42. ncbi The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons
    Ronald R Waclaw
    Division of Developmental Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Neuron 49:503-16. 2006
    ..give rise to olfactory bulb interneurons at embryonic and postnatal time points and remains expressed in the calretinin-expressing and GABAergic/nondopaminergic interneurons of the glomerular layer...
  43. ncbi Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex
    Sonja Rakic
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Cereb Cortex 16:i35-45. 2006
    ..splitting, we used Nissl staining, carbocyanine dye tracing, cell birthdating, and immunohistochemistry for calretinin (CalR) in p35 and Cdk5 knockout mice...
  44. ncbi Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Cell 125:127-42. 2006
    ..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain...
  45. ncbi A role of MAP1B in Reelin-dependent neuronal migration
    Christian Gonzalez-Billault
    Centro de Biologia Molecular, Universidad Autonoma de Madrid CSIC, Madrid 28049, Spain
    Cereb Cortex 15:1134-45. 2005
    ..Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration...
  46. ncbi Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin
    Silvia Pagliardini
    Department of Physiology, Centre of Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Am J Pathol 167:175-91. 2005
    ....
  47. ncbi SOX5 controls the sequential generation of distinct corticofugal neuron subtypes
    Tina Lai
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neuron 57:232-47. 2008
    ..These data indicate that SOX5 controls the timing of critical fate decisions during corticofugal neuron production and thus subtype-specific differentiation and neocortical neuron diversity...
  48. ncbi FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
  49. ncbi Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse
    S Alcantara
    Department of Animal and Plant Cell Biology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7779-99. 1998
    ..and cerebral cortex, where it was restricted to subsets of GABAergic interneurons that co-expressed calbindin, calretinin, neuropeptide Y, and somatostatin...
  50. ncbi Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye
    Chikako Harada
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Dev Biol 290:57-65. 2006
    ..These results suggest the different mechanism of RGC number control between mouse and chick retina...
  51. ncbi Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina
    Keely M Bumsted-O'Brien
    Department of Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenst 46, 60218 Frankfurt, Germany
    J Comp Neurol 505:58-72. 2007
    ..About 50% of the mouse Meis2+ AM cell population expresses the calcium-binding protein calretinin, and some Meis2+ AM cells show characteristics of Type II CD-15+ cells...
  52. ncbi OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections
    Masato Uemura
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Nat Neurosci 10:1151-9. 2007
    ..The inability of the striatum to extend axons is also observed in vitro. These results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections...
  53. ncbi Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene
    D Acampora
    International Institute of Genetics and Biophysics, Consiglio Nationale delle Ricerche CNR, 80125 Naples, Italy
    Genes Dev 13:2787-800. 1999
    ....
  54. ncbi The role of Pax6 in restricting cell migration between developing cortex and basal ganglia
    P Chapouton
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, Germany
    Development 126:5569-79. 1999
    ..Cortical cells, however, remain confined to the cortex in the Pax6 mutant. Thus, dorsal and ventral cells are restricted to their respective territories by distinct mechanisms...
  55. ncbi Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  56. ncbi Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract
    Hannah Thompson
    Divisions of Visual Science and Molecular Genetics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Dev Biol 296:476-84. 2006
    ..This demonstrates that Slits play an important role in directing the guidance of post-crossing RGC axons within the optic tracts but are not required for target innervation...
  57. ncbi Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo
    Sara Paina
    Dulbecco Telethon Institute c o Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    J Neurosci 31:2675-87. 2011
    ..Finally, we show that the Dlx-mutant environment is unfavorable for GABA differentiation, in vivo and in vitro. We conclude that Dlx genes favor interneuron differentiation also in a non-cell-autonomous fashion, via expression of Wnt5a...
  58. ncbi The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 61:42-56. 2009
    ..Thus, APC is an essential regulator of radial glial polarity and is critical for the construction of cerebral cortex in mammals...
  59. ncbi Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Eur J Neurosci 21:658-68. 2005
    ..In the Lbx1 mutants Satb2 expression is greatly reduced. We suggest that Satb2 may regulate differentiation of subsets of neurons at the level of higher order chromatin structure via binding to MARs...
  60. ncbi Dicer is required for the transition from early to late progenitor state in the developing mouse retina
    Sean A Georgi
    Neurobiology and Behavior Program, Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 30:4048-61. 2010
    ..We conclude that Dicer is necessary for the developmental change in competence of the retinal progenitor cells...
  61. ncbi Coordinated regulation of gene expression by Brn3a in developing sensory ganglia
    S Raisa Eng
    Department of Psychiatry, University of California, San Diego, and the VA San Diego Healthcare System, La Jolla, CA 92093 0603, USA
    Development 131:3859-70. 2004
    ....
  62. ncbi Organization of the embryonic and early postnatal murine hippocampus. I. Immunocytochemical characterization of neuronal populations in the subplate and marginal zone
    E Soriano
    Unit of Cell Biology, Faculty of Biology, University of Barcelona, Spain
    J Comp Neurol 342:571-95. 1994
    ..Some cells in the later stratum displayed MAP2-, gamma-aminobutyric acid (GABA)- and calretinin immunoreactivities. From E15 onwards, the hippocampal and dentate plates became visible...
  63. ncbi The roof plate regulates cerebellar cell-type specification and proliferation
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 319 Chicago, IL 60637, USA
    Development 133:2793-804. 2006
    ..Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning...
  64. ncbi Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1
    A Littlewood Evans
    Friedrich Miescher Institute, Basel, Switzerland
    Nat Genet 24:424-8. 2000
    ..Mutations affecting matrix molecules cause inherited forms of inner ear disease and integrins may mediate some effects of matrix molecules in the ear; thus, mutations in integrin genes may lead to inner-ear diseases as well...
  65. ncbi The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult-generated neurons in the dentate gyrus
    Woon Ryoung Kim
    Department of Anatomy, Brain Korea 21, Korea University College of Medicine, Anam Dong, Seoul, Korea
    Eur J Neurosci 29:1408-21. 2009
    ..These results suggest that the elimination of excess DG neurons via Bax-dependent PCD in the adult brain is required for the normal organization and function of the hippocampus...
  66. ncbi Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus
    Kate D Meyer
    Human Molecular Genetics Program, Department of Pediatrics, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, P O Box 211, Chicago, IL 60614, USA
    Gene Expr Patterns 8:494-501. 2008
    ..Our results are the first report of a detailed immunohistochemical analysis of the ontogeny of Disc1 expression within the hippocampus...
  67. ncbi Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis
    A Hirschberg
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Cell Biol 30:764-80. 2010
    ..These results suggest that Sema4D-plexin-B2 interactions regulate mechanisms underlying cell specification, differentiation, and migration during corticogenesis...
  68. ncbi Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:9184-95. 2006
    ..Our findings support a model of cerebellar neurogenesis, in which glutamatergic and GABAergic neurons are produced from separate progenitor pools located mainly in the rhombic lip and the cerebellar ventricular zone, respectively...
  69. ncbi From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development
    Toshiko R Matsugami
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Proc Natl Acad Sci U S A 103:12161-6. 2006
    ....
  70. ncbi Math1: an essential gene for the generation of inner ear hair cells
    N A Bermingham
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 284:1837-41. 1999
    ..Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells...
  71. ncbi Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo
    Suhua Deng
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 27:6333-47. 2007
    ..These genetic and functional analyses reveal a key requirement for Plexin-B2, but not Plexin-B1, in patterning of the vertebrate nervous system in vivo...
  72. ncbi Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development
    M Albert Basson
    Department of Anatomy and Program in Developmental Biology, University of California San Francisco, CA 94158, USA
    Development 135:889-98. 2008
    ..We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development...
  73. ncbi Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice
    Maria Carmen Piñon
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX13QX, United Kingdom
    J Neurosci 28:8724-34. 2008
    ..Our findings indicate that Pax6 expression gradients in cortical progenitors do not directly impart thalamocortical or corticofugal areal identity...
  74. ncbi Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
    Nina Solberg
    Section for Cellular and Genetic Therapy, Institute of Microbiology, Rikshospitalet, Oslo, Norway
    Dev Dyn 237:1799-811. 2008
    ..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages...
  75. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  76. ncbi Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin
    Catherine Creppe
    GIGA Signal Transduction, University of Liege, C H U Sart Tilman, 4000 Liege, Belgium
    Cell 136:551-64. 2009
    ..Our results uncover alpha-tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons...
  77. ncbi The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse
    Nora Emöke Szabó
    Department of Genes and Behavior, Max Planck Institute of Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 29:2453-66. 2009
    ..In this way, the individual thalamic nuclei show differential dependence on Shh, Gbx2, or both for their differentiation. Additionally, Gbx2 is required for the survival of thalamic neurons...
  78. ncbi The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain
    Guoxin Ying
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Cell Biol 29:3045-61. 2009
    ..Specifically, in Celsr3 knockout mice, calretinin-positive interneurons are reduced in the developing neocortex, accumulated in the corticostriatal boundary, and ..
  79. ncbi Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin
    S N Schiffmann
    Brain Research Unit CP601, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    Proc Natl Acad Sci U S A 96:5257-62. 1999
    ..Here, we show that mice deficient in calretinin (Cr-/-) are impaired in tests of motor coordination...
  80. ncbi Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6
    T Vitalis
    Department of Biomedical Sciences, Medical School, Edinburgh EH8 9AG, Scotland
    J Neurosci 20:6501-16. 2000
    ..This may be responsible for both the altered pathway of catecholaminergic fibers and the ectopic location of catecholaminergic neurons in this region...
  81. ncbi Layer positioning of late-born cortical interneurons is dependent on Reelin but not p35 signaling
    Vicki Hammond
    Howard Florey Institute, The University of Melbourne, Parkville 3010, Victoria, Australia
    J Neurosci 26:1646-55. 2006
    ..Whereas the early-born interneurons appear to be associated with projection neuron layering, late-born interneurons rely on Reelin signaling for their correct lamination...
  82. ncbi Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration
    Hiroyuki Koizumi
    Neurogenetics Laboratory, Department of Neurosciences, University of California, San Diego, La Jolla, California 93093, USA
    Neuron 49:55-66. 2006
    ..Surprisingly, RNAi-mediated knockdown of either gene results in similar migration defects. These results indicate the Dcx microtubule-associated protein family is required for proper neuronal migration and axonal wiring...
  83. ncbi Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding
    Kathie M Bishop
    Molecular Neurobiology Lab, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 457:345-60. 2003
    ..The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development...
  84. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..This reduction preferentially affects calretinin(+) (bipolar cells) and somatostatin(+) subtypes (for example, bitufted cells), whereas parvalbumin(+) ..
  85. ncbi BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
    Fernando Aguado
    Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
    Development 130:1267-80. 2003
    ..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
  86. ncbi Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359630, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    Brain Res Dev Brain Res 141:39-53. 2003
    ..factors characteristic of pallial neurons (Tbr1 and Emx2), contained high levels of glutamate, were usually calretinin(+), and were born early in corticogenesis, on embryonic days (E)10.5 and E11.5...
  87. ncbi Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
    ..Herein, we propose a model whereby early-born RGCs are Dlx1 and Dlx2 independent, but Dlx function is necessary for terminal differentiation of late-born RGC progenitors...
  88. ncbi The Tlx gene regulates the timing of neurogenesis in the cortex
    Kristine Roy
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:8333-45. 2004
    ..These studies indicate that tlx is an essential intrinsic regulator in the decision to proliferate or differentiate in the developing forebrain...
  89. ncbi The transcription factor Bhlhb4 is required for rod bipolar cell maturation
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 43:779-93. 2004
    ..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
  90. ncbi Inactivation of calcium-binding protein genes induces 160 Hz oscillations in the cerebellar cortex of alert mice
    Guy Cheron
    Laboratory of Electrophysiology, Université Mons Hainaut, 7000 Mons, Belgium
    J Neurosci 24:434-41. 2004
    ..b>Calretinin and calbindin are two calcium-binding proteins involved in the shaping of intraneuronal Ca2+ fluxes...
  91. ncbi The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord
    Z F Chen
    Division of Biology 216 76 and, Howard Hughes Medical Institute, California Institute of Technology, 91125, Pasadena, CA, USA
    Neuron 31:59-73. 2001
    ..Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord...
  92. ncbi Ephrin signalling controls brain size by regulating apoptosis of neural progenitors
    Vanessa Depaepe
    Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire IRIBHM, University of Brussels, Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    Nature 435:1244-50. 2005
    ..Together, these results identify ephrin/Eph signalling as a physiological trigger for apoptosis that can alter brain size and shape by regulating the number of neural progenitors...
  93. ncbi Expression of olig2 in retinal progenitor cells
    Kazuaki Nakamura
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Neuroreport 17:345-9. 2006
    ..These results suggest that olig2 is involved in the maintenance of the undifferentiated state of retinal progenitor cells...
  94. ncbi Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    J Neurosci 20:7384-93. 2000
    ..Our results demonstrate a novel and prominent role for TRAF6 in the regional control of PCD within the developing CNS...
  95. ncbi Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression
    Yunhua Chang
    Biologie Moléculaire du Stress, Centre National de la Recherche Scientifique CNRS UMR8541, Ecole Normale Superieure, Paris, France
    Genes Dev 20:836-47. 2006
    ..In conclusion, HSF2 affects cellular populations that assist in radial migration and directly regulates the expression of p35, a crucial actor of radial neuronal migration...
  96. ncbi A role for Pax6 in the normal development of dorsal thalamus and its cortical connections
    T Pratt
    Department of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 127:5167-78. 2000
    ..Our results suggest that normal thalamocortical development requires the actions of Pax6 within the dorsal thalamus itself...
  97. ncbi Development of calretinin-immunoreactive unipolar brush-like cells and an afferent pathway to the embryonic and early postnatal mouse cerebellum
    L C Abbott
    Department of Veterinary Biosciences, University of Illinois 61801, USA
    Anat Embryol (Berl) 191:541-59. 1995
    In the developing mouse hindbrain, immunoreactivity for calretinin, a calcium-binding protein, was first observed at embryonic day 10, and was localized to neuronal cell bodies in the reticular formation...
  98. ncbi Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin
    V Bouilleret
    INSERM U 398, Faculte de Medecine, 11 rue Humann, 67085, Strasbourg, France
    Neuroscience 97:47-58. 2000
    The functional role of the calcium-binding proteins parvalbumin, calretinin, and calbindin D-28k for epileptogenesis and long-term seizure-related alterations of the hippocampal formation was assessed in single- and double-knockout mice, ..
  99. ncbi Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  100. ncbi The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1
    Hye Yeong Ha
    Department of Neuroscience, Neuroscience Research Center and Medical Research Institute, Ewha Womans University School of Medicine, Seoul 110 783, Korea
    Dev Biol 277:184-99. 2005
    ..The JSAP1 null mutation impaired the normal distribution of the Ca+2 regulating protein, calretinin, but not the synaptic vesicle marker, SNAP-25, along the axons of the thalamocortical tract...
  101. ncbi Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins
    Takaaki Kuwajima
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5383-92. 2006
    ..These results suggest that paternally expressed necdin facilitates the differentiation and specification of GABAergic neurons in cooperation with Dlx homeodomain proteins...

Research Grants53

  1. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    Gordon Fishell; Fiscal Year: 2003
    ....
  2. Sonic Hedgehog Signaling in the Mammalian Telencephalon
    Gordon Fishell; Fiscal Year: 2007
    ..Together this proposal will provide a comprehensive examination of Shh signaling during telencephalic development. ..
  3. Developmental Mechanisms of the Chromodomain Gene Chd7
    Donna M Martin; Fiscal Year: 2011
    ..Results of experiments described in this proposal will improve our understanding of genetic and epigenetic factors regulating basic chromatin biology, and their impact on development. ..
  4. Cell Fate Determination in the Cerebellum
    Gordon Fishell; Fiscal Year: 2007
    ..Our studies will reveal the mechanisms by which these populations are generated and thus provide the first step towards finding a cure to these disorders. ..
  5. Analysis of Notch Signaling in Telencephalic Development
    Gordon Fishell; Fiscal Year: 2006
    ....
  6. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  7. Pitx2 Function in Developing Mouse Brain Neurons
    Donna Martin; Fiscal Year: 2007
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  8. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  9. Pitx2 Function in Developing Mouse Brain Neurons
    Donna Martin; Fiscal Year: 2009
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  10. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  11. Cell Fate Determination in the Cerebellum
    GORDON J FISHELL; Fiscal Year: 2010
    ..Our studies will reveal the mechanisms by which these populations are generated and thus provide the first step towards finding a cure to these disorders. ..
  12. Pitx2 Function in Developing Mouse Brain Neurons
    Donna M Martin; Fiscal Year: 2010
    ..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..
  13. Regional and Genetic Diversity of Cortical Interneurons
    GORDON J FISHELL; Fiscal Year: 2010
    ..Moreover, through the genetic profiling of these cells we expect to be able to directly link the function of these cells to specific genetically inherited disorders in human patients. ..
  14. Developmental Mechanisms of the Chromodomain Gene Chd7
    Donna M Martin; Fiscal Year: 2010
    ..Results of experiments described in this proposal will improve our understanding of genetic and epigenetic factors regulating basic chromatin biology, and their impact on development. ..
  15. Regional and Genetic Diversity of Cortical Interneurons
    Gordon Fishell; Fiscal Year: 2009
    ..This proposal will therefore provide the first comprehensive analysis of the developmental origins of cortical interneuron diversity. ..
  16. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2002
    ..Together the sets of experiments described in this proposal will examine the establishment of the subdivisions of forebrain and their significance to the determination of regional cell identity. ..
  17. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 1999
    ..The position, morphology and gene expression within clones resulting from control versus ectopic expression viral vector infections will allow us to evaluated the function of these genes during neural development. ..
  18. Role of Pitx2 in the Mammalian Central Nervous System
    Donna Martin; Fiscal Year: 2005
    ..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
  19. BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENT
    DEBRA BRAMBLETT; Fiscal Year: 2003
    ..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..