Cadps2

Summary

Gene Symbol: Cadps2
Description: Ca2+-dependent activator protein for secretion 2
Alias: A230044C21Rik, Caps-2, Caps2, Cpd2, calcium-dependent secretion activator 2, cerebellum postnatal development associated protein 2
Species: mouse
Products:     Cadps2

Top Publications

  1. Speidel D, Bruederle C, Enk C, Voets T, Varoqueaux F, Reim K, et al. CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron. 2005;46:75-88 pubmed
    ..We conclude that CAPS1 is required for an essential step in the uptake or storage of catecholamines in LDCVs. ..
  2. Sadakata T, Furuichi T. Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. Neurosci Lett. 2006;405:217-22 pubmed
    By fluorescent differential display, we identified six transcripts (CAPS2/Cadps2, Cdh22, b1402, c1502, d1401, and d1501) that showed the differential expression patterns during the postnatal development of the mouse cerebellum...
  3. Jockusch W, Speidel D, Sigler A, S rensen J, Varoqueaux F, Rhee J, et al. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell. 2007;131:796-808 pubmed publisher
    ..Our findings demonstrate that CAPS proteins generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2+) triggered release of transmitters...
  4. Sadakata T, Kakegawa W, Mizoguchi A, Washida M, Katoh Semba R, Shutoh F, et al. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. J Neurosci. 2007;27:2472-82 pubmed
    Ca2+-dependent activator protein for secretion 2 (CAPS2/CADPS2) is a secretory granule-associated protein that is abundant at the parallel fiber terminals of granule cells in the mouse cerebellum and is involved in the release of ..
  5. Sadakata T, Washida M, Furuichi T. Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. BMC Neurosci. 2007;8:25 pubmed
    Ca2+-dependent activator protein 2 (CAPS2/CADPS2) is a secretory vesicle-associated protein involved in the release of neurotrophin...
  6. Shinoda Y, Sadakata T, Nakao K, Katoh Semba R, Kinameri E, Furuya A, et al. Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. Proc Natl Acad Sci U S A. 2011;108:373-8 pubmed publisher
    Calcium-dependent activator protein for secretion 2 (CAPS2) is a dense-core vesicle-associated protein that is involved in the secretion of BDNF...
  7. Cisternas F, Vincent J, Scherer S, Ray P. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. Genomics. 2003;81:279-91 pubmed
    ..In this paper we describe the full-length cloning and characterization of human CADPS and CADPS2, two new homologs of the mouse Cadps protein involved in large dense-core vesicle (LDCV)-regulated exocytosis...
  8. Sadakata T, Shinoda Y, Oka M, Sekine Y, Sato Y, Saruta C, et al. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. Proc Natl Acad Sci U S A. 2012;109:21104-9 pubmed publisher
    Ca(2)(+)-dependent activator protein for secretion 2 (CAPS2 or CADPS2) potently promotes the release of brain-derived neurotrophic factor (BDNF)...
  9. Sadakata T, Furuichi T. Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility. Cerebellum. 2009;8:312-22 pubmed publisher
    ..Using the CDT-DB, Ca(2+)-dependent activator protein for secretion 2 (CAPS2 or CADPS2) was identified as a developmentally regulated gene that is predominantly expressed in cerebellar granule cells (..

More Information

Publications32

  1. Liu Y, Schirra C, Stevens D, Matti U, Speidel D, Hof D, et al. CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. J Neurosci. 2008;28:5594-601 pubmed publisher
    ..We conclude that CAPS is required for the adequate refilling and/or maintenance of a rapidly releasable granule pool. ..
  2. Sadakata T, Washida M, Iwayama Y, Shoji S, Sato Y, Ohkura T, et al. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest. 2007;117:931-43 pubmed
    ..Ca(2+)-dependent activator protein for secretion 2 (CADPS2; also known as CAPS2) mediates the exocytosis of dense-core vesicles, and the human CADPS2 is located within the ..
  3. Sadakata T, Washida M, Morita N, Furuichi T. Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice. J Histochem Cytochem. 2007;55:301-11 pubmed
    ..CAPS1/CADPS1 and CAPS2/CADPS2 have been identified in mammals...
  4. Sadakata T, Itakura M, Kozaki S, Sekine Y, Takahashi M, Furuichi T. Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. J Comp Neurol. 2006;495:735-53 pubmed
    The Ca(2+)-dependent activator protein for secretion (CAPS/Cadps) family consists of two members, CAPS1 and CAPS2, and plays an important role in secretory granule exocytosis...
  5. Sadakata T, Mizoguchi A, Sato Y, Katoh Semba R, Fukuda M, Mikoshiba K, et al. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci. 2004;24:43-52 pubmed
    ..cerebellum, which turned out to be a paralog of CAPS (Ca2+-dependent activator protein for secretion), and named CAPS2. CAPS2 is enriched on vesicular structures of presynaptic parallel fiber terminals of granule cells connecting ..
  6. Speidel D, Varoqueaux F, Enk C, Nojiri M, Grishanin R, Martin T, et al. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. J Biol Chem. 2003;278:52802-9 pubmed
    ..study, we report the identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2. The structure of CAPS2 and its function in LDCV exocytosis from PC12 cells are very similar to those of CAPS1...
  7. Vogl C, Cooper B, Neef J, Wojcik S, Reim K, Reisinger E, et al. Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. J Cell Sci. 2015;128:638-44 pubmed publisher
    ..We conclude that IHCs use an unconventional priming machinery that involves otoferlin. ..
  8. Crawley J. Translational animal models of autism and neurodevelopmental disorders. Dialogues Clin Neurosci. 2012;14:293-305 pubmed
    ..The field is now poised to employ the most robust phenotypes in the most replicable mouse models for preclinical screening of novel therapeutics. ..
  9. Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 2012;279:384-94 pubmed publisher
    The Ca(2+) -dependent activator protein for secretion (CAPS) family consists of two members (CAPS1 and CAPS2) and regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion ..
  10. Hamatake M, Miyazaki N, Sudo K, Matsuda M, Sadakata T, Furuya A, et al. Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats. J Biol Chem. 2011;286:21478-87 pubmed publisher
    ..In the latter mice, no diurnal variation in BDNF levels was observed. These results indicate that regular rhythms of BDNF and NT-3 are essential for correct cortical network formation in juvenile rodents. ..
  11. Sadakata T, Furuichi T. Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes. Neurosci Res. 2010;67:197-202 pubmed publisher
    Ca(2+)-dependent activator protein for secretion 2 (CAPS2 or CADPS2) regulates dense-core vesicle (DCV) exocytosis...
  12. Burgalossi A, Jung S, Meyer G, Jockusch W, Jahn O, Taschenberger H, et al. SNARE protein recycling by ?SNAP and ?SNAP supports synaptic vesicle priming. Neuron. 2010;68:473-87 pubmed publisher
    ..Our analysis of ?- and ?SNAP deletion mutant neurons shows that the two NSF cofactors support synaptic vesicle priming by determining the availability of free SNARE components, particularly during phases of high synaptic activity. ..
  13. Liu Y, Schirra C, Edelmann L, Matti U, Rhee J, Hof D, et al. Two distinct secretory vesicle-priming steps in adrenal chromaffin cells. J Cell Biol. 2010;190:1067-77 pubmed publisher
    ..Either CAPS1 or CAPS2 can rescue secretion in cells lacking both CAPS isoforms...
  14. Eran A, Graham K, Vatalaro K, McCarthy J, Collins C, Peters H, et al. Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". J Clin Invest. 2009;119:679-80; author reply 680-1 pubmed publisher
  15. Speidel D, Salehi A, Obermueller S, Lundquist I, Brose N, Renstrom E, et al. CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Cell Metab. 2008;7:57-67 pubmed publisher
    CAPS1 and CAPS2 regulate dense-core vesicle release of transmitters and hormones in neuroendocrine cells, but their precise roles in the secretory process remain enigmatic...
  16. Dubois S, Waldmann T, Müller J. Survival adjustment of mature dendritic cells by IL-15. Proc Natl Acad Sci U S A. 2005;102:8662-7 pubmed
    ..These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8+/CD44(hi) memory phenotype T cells. ..
  17. Sadakata T, Shinoda Y, Oka M, Sekine Y, Furuichi T. Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene. FEBS Lett. 2013;587:54-9 pubmed publisher
    Ca²?-dependent activator protein for secretion 2 (CAPS2 or CADPS2) facilitates secretion and trafficking of dense-core vesicles...
  18. Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh Semba R, Sekine Y, et al. Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. PLoS ONE. 2014;9:e99524 pubmed publisher
    Ca2+-dependent activator protein for secretion 2 (CAPS2) is a protein that is essential for enhanced release of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from cerebellar granule cells...
  19. Imig C, Min S, Krinner S, Arancillo M, Rosenmund C, Südhof T, et al. The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Neuron. 2014;84:416-31 pubmed publisher
  20. Farina M, van de Bospoort R, He E, Persoon C, van Weering J, Broeke J, et al. CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. elife. 2015;4: pubmed publisher
    ..These data indicate that CAPS-1 promotes fusion competence of immobile (tethered) DCVs in presynaptic terminals and that CAPS-1 localization to DCVs is probably not essential for this role. ..
  21. Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Kang G, et al. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. J Exp Med. 2016;213:433-49 pubmed publisher
    ..We identified 17 regulators of HSPC repopulation: Arhgef5, Armcx1, Cadps2, Crispld1, Emcn, Foxa3, Fstl1, Glis2, Gprasp2, Gpr56, Myct1, Nbea, P2ry14, Smarca2, Sox4, Stat4, and Zfp251...
  22. Sadakata T, Shinoda Y, Ishizaki Y, Furuichi T. Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways. Neurosci Lett. 2017;639:88-93 pubmed publisher
    In the mouse cerebellum, Ca2+-dependent activator protein for secretion 2 (CADPS2, CAPS2) is involved in regulated secretion from dense-core vesicles (DCVs), which contain neuropeptides including brain-derived neurotrophic ..
  23. Walter A, Müller R, Tawfik B, Wierda K, Pinheiro P, Nadler A, et al. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis. elife. 2017;6: pubmed publisher
    ..Thus, optical uncaging of signaling lipids can uncover their rapid effects on cellular processes and identify lipid effectors. ..