Gene Symbol: Cacng7
Description: calcium channel, voltage-dependent, gamma subunit 7
Alias: voltage-dependent calcium channel gamma-7 subunit, TARP gamma-7, neuronal voltage-gated calcium channel gamma-7 subunit, transmembrane AMPAR regulatory protein gamma-7
Kato A, Zhou W, Milstein A, Knierman M, Siuda E, Dotzlaf J, et al
. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. J Neurosci. 2007;27:4969-77 pubmed
..These studies define gamma-7 as a new member of the TARP family that can differentially influence AMPA receptors in cerebellar neurons. ..
Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, et al
. TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum. Eur J Neurosci. 2010;31:2204-20 pubmed publisher
..Therefore, gamma-2 and gamma-7 cooperatively promote synaptic expression of cerebellar AMPA receptors, and the latter also promotes glial expression. ..
Yamazaki M, Le Pichon C, Jackson A, Cerpas M, Sakimura K, Scearce Levie K, et al
. Relative contribution of TARPs Î³-2 and Î³-7 to cerebellar excitatory synaptic transmission and motor behavior. Proc Natl Acad Sci U S A. 2015;112:E371-9 pubmed publisher
..Thus, Î³-7 is capable of supporting a component of excitatory transmission in PCs, sufficient to maintain essentially normal motor behavior, in the absence of Î³-2. ..
Burgess D, Gefrides L, Foreman P, Noebels J. A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics. 2001;71:339-50 pubmed
..In this study, we describe a cluster of three novel gamma subunit genes, CACNG6, CACNG7, and CACNG8, located in a tandem array on 19q13.4...
Chu P, Robertson H, Best P. Calcium channel gamma subunits provide insights into the evolution of this gene family. Gene. 2001;280:37-48 pubmed
Kato A, Gill M, Ho M, Yu H, Tu Y, Siuda E, et al
. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 2010;68:1082-96 pubmed publisher
..Thus, Î³-8 and CNIH-2 functionally interact with common hippocampal AMPA receptor complexes to modulate synergistically kinetics and pharmacology. ..
Moss F, Viard P, Davies A, Bertaso F, Page K, Graham A, et al
. The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression. EMBO J. 2002;21:1514-23 pubmed
..Unlike the genes of other potential gamma subunits identified by their homology to the stargazin gene, CACNG7 is a five-, and not four-exon gene whose mRNA encodes a protein we have designated gamma(7)...
Studniarczyk D, Coombs I, Cull Candy S, Farrant M. TARP Î³-7 selectively enhances synaptic expression of calcium-permeable AMPARs. Nat Neurosci. 2013;16:1266-74 pubmed publisher
..Our results also establish that TARPed synaptic receptors in granule cells require both Î³-2 and Î³-7 and reveal an unexpected basis for the loss of AMPAR-mediated transmission in stargazer mice. ..