Genomes and Genes
Gene Symbol: Cacnb4
Description: calcium channel, voltage-dependent, beta 4 subunit
Alias: 3110038O15Rik, Cchb4, lethargic, CAB4, calcium channel voltage-dependent subunit beta 4, voltage-dependent L-type calcium channel subunit beta-4
- Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cellsPrakash Subramanyam
Department of Physiology and Medical Physics, Division of Physiology, Medical University Innsbruck, Innsbruck, Austria
Channels (Austin) 3:343-55. 2009..The activity-dependent shuttling of beta(4b) into and out of the nucleus indicates a specific role of this beta subunit in neurons, in communicating the activity of calcium channels to the nucleus...
- Glial contribution to seizure: carbonic anhydrase activity in epileptic mammalian brainD Guillaume
Laboratory of Biochemistry, University of Liege, Belgium
Epilepsia 32:10-5. 1991..The hypothesis of an adaptive glial mechanism, relating to the age-dependent decrease of seizure susceptibility in DBA/2 mice, is postulated...
- Neuroanatomical substrates for paroxysmal dyskinesia in lethargic miceRajiv Devanagondi
Department of Neurology, Meyer Room 6 181, 600 North Wolfe Street, Johns Hopkins Hospital, Baltimore, MD 21287, and University of Tennessee, Memphis 38163, USA
Neurobiol Dis 27:249-57. 2007..In the current studies, the anatomical basis for paroxysmal dyskinesias in lethargic mice was determined via histochemical methods sensitive to changes in regional brain activity followed by ..
- The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1)Lihua Y Marmorstein
Department of Ophthalmology and Vision Science, University of Arizona, Tucson 85711, USA
J Gen Physiol 127:577-89. 2006..Nimodipine diminished the LP, leading us to survey VDCC beta-subunit mutant mice. Lethargic mice, which harbor a loss of function mutation in the beta4 subunit of VDCCs, exhibited a significant shift in ..
- Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functionsAbdallah Badou
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Science 307:117-21. 2005..Although Cav1 channels of lymphocytes retain their voltage dependency, T cell receptor stimulation dramatically increases channel opening, providing a new mechanism for calcium entry in lymphocytes...
- Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layerSherry L Ball
Research Service, Cleveland VA Medical Center, Cleveland, Ohio, USA
Invest Ophthalmol Vis Sci 43:1595-603. 2002..The purpose of this study was to dentify which of the four beta subunits of VDCCs participates in the formation of this channel at the photoreceptor synapse and to determine how its absence affects visual processing...
- Pharmacological profiles of generalized absence seizures in lethargic, stargazer and gamma-hydroxybutyrate-treated model miceM Aizawa
Department of Pharmacology, College of Pharmacy, Nihon University, Chiba, Japan
Neurosci Res 29:17-25. 1997..of generalized absence seizures in three mouse models: two mutant strains with spontaneous absence seizures, lethargic and stargazer, and ddY mice (GHB model) in which absence seizures were induced by administering gamma-..
- Ataxic mouse mutants and molecular mechanisms of absence epilepsyC F Fletcher
MGL, ABL BRP, NCI Frederick Cancer Research and Development Center, Frederick, MD, USA
Hum Mol Genet 8:1907-12. 1999..Then, from the new wave of genetic and functional studies of these mutants we discuss their prospects for yielding insight into the molecular mechanisms of epilepsy...
- Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalamiS J Caddick
Department of Neurology, Medical College of Virginia, Richmond, Virginia 23298, USA
J Neurophysiol 81:2066-74. 1999Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami...
- Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouseD L Burgess
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 88:385-92. 1997..We used a positional candidate approach to determine that the ataxia and seizures in the lethargic (lh) mouse arise from mutation of the beta-subunit gene Cchb4 on mouse chromosome 2...
- beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brainD L Burgess
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Neurosci 13:293-311. 1999..The mouse mutant lethargic (lh) exhibits severe neurological defects due to a mutation that deletes the alpha1 subunit interaction domain ..
- Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsyAbir Tadmouri
Unité INSERM U, Grenoble Institute of Neuroscience, Universite Joseph Fourier, La Tronche, France
EMBO J 31:3730-44. 2012..Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription...
- Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brainClotilde Ferrándiz-Huertas
Dept Ciencias Médicas, Instituto de Investigación en Discapacidades Neurológicas IDINE, Facultad de Medicina, Universidad Castilla La Mancha, Albacete, Spain
J Neurochem 122:1095-107. 2012..These results shed new light on the developmental regulation and subcellular localization of Ca(v) β subunits, and their possible role in pre- and post-synaptic transmission...
- Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channelManabu Murakami
Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
J Mol Neurosci 21:13-21. 2003..Furthermore, mRNA of these beta-subunits is strongly expressed in dorsal root ganglion neurons, which have many voltage-dependent calcium channels...
- Paroxysmal dyskinesias in the lethargic mouse mutantZubair Khan
Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosci 22:8193-200. 2002b>Lethargic mutant mice carry a mutation in the CCHB4 gene, which encodes the beta4 subunit of voltage-regulated calcium channels...
- Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1George D Leikauf
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
Am J Respir Crit Care Med 183:1499-509. 2011..Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies...
- Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neuronsB Schlick
Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria
Neuroscience 167:786-98. 2010..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity...
- Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neuronsYi Zhang
Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 22:6362-71. 2002..1/alpha1A subunit), lethargic (lh; beta4 subunit), and stargazer (stg; gamma2 subunit) brain slices...
- Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) miceK Ishige
Department of Pharmacology, College of Pharmacy, Nihon University, Funabashi, Japan
Neurosci Lett 262:53-6. 1999..AMP responsive element (CRE)- and activator protein 1 (AP-1) DNA-binding activities in various brain regions of lethargic (lh/lh) mice, a genetic model of absence seizures...
- Identification of epilepsy genes in human and mouseM H Meisler
Department of Human Genetics, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
Annu Rev Genet 35:567-88. 2001..The development of pharmaceuticals directed towards specific epilepsy genotypes can be anticipated, and the introduction of patient mutations into the mouse genome will provide models for testing these targeted therapies...
- Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosomeS Wakana
Central Institute for Experimental Animals, Kawasaki, Japan
Brain Res 857:286-90. 2000..Since epilepsy is assumed to be a disease syndrome which is probably manifested by abnormal expression of multifocal genes, determination of the role of each chromosomal locus in the provocation of seizure activity is important...
- Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutationsJ Qian
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 20:163-70. 2000..release at hippocampal Schaffer collateral synapses in both tottering (tg, alpha(1A) subunit) and lethargic (lh, beta(4) subunit) mutant mice...
- Critical role for the beta regulatory subunits of Cav channels in T lymphocyte functionAbdallah Badou
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 103:15529-34. 2006..These observations suggest that the Cav channels expressed by T cells have adopted novel regulation/gating mechanisms...
- Regional expression of L-type calcium channel subunits during cardiac developmentLourdes Acosta
Department of Experimental Biology, University of Jaen, Jaen, Spain
Dev Dyn 230:131-6. 2004..These findings suggest that beta subunits might play a major role in conferring calcium handling heterogeneity within the developing embryonic myocardium, while alpha1C subunits might contribute just transiently...
- Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant miceInseon Song
Center for Calcium and Learning, Korea Institute of Science and Technology, Cheongryang, Seoul, 136 791, Korea
J Neurosci 24:5249-57. 2004..e., lethargic (beta4(lh/lh)), tottering (alpha1A(tg/tg)), or stargazer (gamma2(stg/stg))...
- Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neuronsGerald J Obermair
Department of Physiology and Medical Physics, Innsbruck Medical University, Austria
J Biol Chem 285:5776-91. 2010....
- Enhanced tonic GABAA inhibition in typical absence epilepsyDavid W Cope
School of Biosciences, Cardiff University, Cardiff, UK
Nat Med 15:1392-8. 2009..These results identify an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy...
- Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4Stephanie Kuhn
Institute of Physiology II and Department of Otorhinolaryngology, Molecular Neurobiology, University of Tubingen, Tübingen Hearing Research Centre, Tubingen, Germany
Channels (Austin) 3:366-76. 2009..These results indicate that neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties...
- Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heartSabine Link
Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat des Saarlandes, 66421 Homburg, Germany
J Biol Chem 284:30129-37. 2009....
- NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowthVsevolod Bodrikov
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
J Cell Biol 182:1185-200. 2008..Thus, we reveal a novel function for a cell adhesion molecule in coordination of cell behavior with intracellular phosphatase activity...
- Gene expression in cortical interneuron precursors is prescient of their mature functionRenata Batista-Brito
Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University Medical Center, 522 First Avenue, New York, NY 10016, USA
Cereb Cortex 18:2306-17. 2008..Moreover, our work has revealed that many of the genes expressed in cortical interneuron precursors have been independently linked to neurological disorders in both mice and humans...
- Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junctionSimon Kaja
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
Brain Res 1143:92-101. 2007..Ducky, lethargic and stargazer are mutant mice that lack functional alpha(2)delta-2, beta(4) and gamma(2) accessory Ca(v) channel ..
- The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motifXingfu Xu
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 286:9677-87. 2011..An NMR-based two-site docking model of β4c in complex with dimerized CSD is presented. Possible roles for the interaction are discussed...
- Single gene defects in mice: the role of voltage-dependent calcium channels in absence modelsD L Burgess
Department of Neurology, Baylor College of Medicine, Houston, TX 77303, USA
Epilepsy Res 36:111-22. 1999..The tottering (tg) locus encodes the calcium channel alpha1 subunit gene Cacna1a, lethargic (lh) encodes the beta subunit gene Cacnb4, and stargazer (stg) encodes the gamma subunit gene Cacng2...
- Mutations of calcium channel beta subunit genes in miceD Freise
Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg, Germany
Biol Chem 380:897-902. 1999..Here we summarize the phenotype of mice deficient in the beta1 subunit, the beta3 subunit or the beta4 subunit, respectively...
- Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouseC A Kozak
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Room 329, Bethesda, Maryland 20892 0460, USA
Mamm Genome 7:787-8. 1996
- The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced productsR Berger
Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Isreal
Genome Res 6:361-70. 1996..These findings suggest that there may be more human transcripts than currently recognized. The possible involvement of the new growing family of Tmpo proteins in nuclear architecture and cell cycle control is discussed...
- Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsyF H Lin
Department of Medicine Neurology, Duke University, Durham, NC
Brain Res 608:101-6. 1993This study begins to explore possible mechanisms underlying the role of GABAB receptors in absence seizures in lethargic (lh/lh) mice...
- GABAB receptor-mediated effects in synaptosomes of lethargic (lh/lh) miceF H Lin
Department of Medicine Neurology, Duke University, Durham, North Carolina, USA
J Neurochem 65:2087-95. 1995..we have shown a significant increase in number of GABAB receptor binding sites in neocortex and thalamus of lethargic (lh/lh) mice, a mutant strain exhibiting absence seizures...
- Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole modelsD A Hosford
Department of Medicine Neurology, Duke University, Duke University Medical Center, Durham, North Carolina, USA
J Pharmacol Exp Ther 274:1399-403. 1995..In this study we measured the antiabsence effects of SCH 50911 in three animal models: the lethargic (lh/lh) mutant mouse, which has spontaneous absence seizures; and two rat models in which absence seizures were ..
- Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunitsH Chin
Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 28:592-5. 1995..The alpha 1, beta 2, and beta 4 subunit genes, termed Cchna1, Cchb2, and Cchb4, are located at different sites on proximal Chr 2, while the beta 3 subunit gene Cchb3 maps to Chr 15 near Wnt1...
- Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse modelD A Hosford
Department of Medicine Neurology, Duke University, Durham, North Carolina, USA
J Neurosci 15:7367-76. 1995In previous work we have shown that GABAB receptors are required for expression of absence seizures in the lethargic (lh/lh) mouse model; that lh/lh mice have increased numbers of GABAB binding sites compared to nonepileptic littermates (..
- Chronological studies of peripheral motor nerve conduction in "lethargic" miceJ M Herring
Electromyogr Clin Neurophysiol 21:121-34. 1981
- Histo-pathologic observations of the nervous and lymphoid tissues of "lethargic" mutant miceH C Dung
Tex Rep Biol Med 30:23-39. 1972
- The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) miceD A Hosford
Department of Medicine, Duke University, Durham, NC
Science 257:398-401. 1992b>Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures...
- The role of GABAB mechanisms in animal models of absence seizuresS J Caddick
Division of Neurology, Duke University Medical Center, Durham, NC, USA
Mol Neurobiol 13:23-32. 1996..The current evidence and interpretations of this work are presented here...
- Deficiency in the thymus-dependent immunity in "lethargic" mutant miceH C Dung
Transplantation 23:39-43. 1977T cell function of "lethargic" mutant mice which exhibit spontaneous thymic involution was evaluated by skin transplantation and graft-versus-host reaction tests...
- Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 geneS O Castillo
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1766, USA
Genomics 41:250-7. 1997..These data help to explain the different response characteristics of two closely related early response genes, Nurr1 and Nur77...
- Mouse models of spike-wave epilepsyJ Barclay
Department of Paediatrics, The Rayne Institute, University College London Medical School, England, UK
Epilepsia 40:17-22. 1999..The lethargic mouse has been shown to be due to mutations in the gene encoding another calcium channel subunit, beta4...
- Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh miceF Lin
Departments of Medicine Neurology and Neurobiology, Duke University and Veterans Administration Medical Centers, Durham, NC 27705, USA
Brain Res Mol Brain Res 71:131-5. 1999..In this study, we examined the relationship between Cacnb4 and GABA(B) receptor mRNA expression in brains from Cacnb4lh homozygotes and (+/+) controls...
- Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizuresF H Lin
Departments of Medicine Neurology and Neurobiology, Epilepsy Research Laboratory, Duke University and Veterans Administration Medical Centers, Bldg 16, Rm 38, 508 Fulton St, Durham, NC, 27705, USA
Brain Res Mol Brain Res 71:127-30. 1999..These data suggest that GABA-synthesis is maintained or increased in NRT neurons in the Cacnb4lh mouse model...
- Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expressionF Lin
Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27705, USA
Brain Res Mol Brain Res 71:1-10. 1999The mutated gene in the lethargic (Cacnb4lh) mouse model of absence seizures encodes the beta4 subunit of voltage-gated calcium channels (VGCCs), leading to decreased mRNA expression of a beta4 subunit that is truncated and cannot bind ..
- Seizure disorders in mutant mice: relevance to human epilepsiesR S Puranam
Department of Medicine Neurology, Box 3676, Duke University Medical Center, 401 Bryan Research Building, Research Drive, Durham, North Carolina, 27710, USA
Curr Opin Neurobiol 9:281-7. 1999....
- Altered expression and assembly of N-type calcium channel alpha1B and beta subunits in epileptic lethargic (lh/lh) mouseM W McEnery
Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4970, USA
J Biol Chem 273:21435-8. 1998..The focus of this study is the expression and assembly of alpha1B and beta isoforms in the epileptic mouse, lethargic (lh/lh), a mutant anticipated to produce a truncated beta4 subunit (Burgess, D. L., Jones, J. M., Meisler, M. H...
- Divergent expression of alpha1-protease inhibitor genes in mouse and humanJ Tardiff
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Campus Box 347, Boulder, CO 80309, USA
Nucleic Acids Res 26:3794-9. 1998..This difference between the species appears to result from an absence of a functional macrophage-specific promoter in mice...
- Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargicA Escayg
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, 48109 0618, USA
Genomics 50:14-22. 1998The mouse neurological mutant lethargic (lh) is characterized by ataxia, focal myoclonus, and absence epilepsy due to a loss-of-function mutation in the beta4 subunit of the voltage-gated calcium channel...
- Ion channel mutations in mouse models of inherited neurological diseaseM H Meisler
Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
Ann Med 29:569-74. 1997..have been identified by positional cloning of the spontaneous mouse mutants motor endplate disease, tottering, lethargic and weaver...
- Mapping of the human Ca2+ channel beta 4 subunit to 2q22-23 and its expression in developing mouseR Betz
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Mamm Genome 9:310-1. 1998
- A study of the increased serum level of IgG1 in 'lethargic' mice combined with a depressed thymus-dependent lymphoid systemH C Dung
J Immunogenet 4:287-93. 1977In a series of recent studies on 'lethargic' mice, a neurological mutation of the mouse, significant abnormalities were discovered in the thymus and its dependent regions in the lymph nodes and spleen...
- Gene interaction in development and diseaseMiriam H Meisler; Fiscal Year: 2010....
- INSERTIONAL MUTANTS AND DEVELOPMENTMIRIAM MEISLER; Fiscal Year: 2003..The interaction between Scn8a and Scnm1 is a model for gene interactions that modify human susceptibility to inherited neurological disorders. ..
- Gene interaction in development and diseaseMIRIAM MEISLER; Fiscal Year: 2009..We propose to extend this work to related genes and disorders, and to generate better animal models of the human disease in order to understand the pathogenic mechanism and provide an accurate model for testing therapeutic intervention. ..
- Functional Genetics of the Neuronal Sodium Channel Gene SCN8AMiriam H Meisler; Fiscal Year: 2010..This project will characterize the neurological and behavioral effects of specific changes in sodium channel genes, using mouse models of human mutations. ..
- Functional Genetics of the Neuronal Sodium Channel Gene SCN8AMIRIAM MEISLER; Fiscal Year: 2009..This project will characterize the neurological and behavioral effects of specific changes in sodium channel genes, using mouse models of human mutations. ..
- Functional Genetics of the Neuronal Sodium Channel Gene SCN8AMIRIAM MEISLER; Fiscal Year: 2007..This project will characterize the neurological and behavioral effects of specific changes in sodium channel genes, using mouse models of human mutations. ..
- MICHIGAN PREDOCTORAL TRAINING PROGRAM IN GENETICSMIRIAM MEISLER; Fiscal Year: 2007..The GTP is one of the oldest and largest NIH-supported training programs, and continues to be a vital component of graduate education and biomedical research at the University of Michigan. ..
- Gene interaction in development and diseaseMIRIAM MEISLER; Fiscal Year: 2007..Because of the high level of alternative splicing in the nervous system, variation in SCNM1 may be of particular significance for neurological disease. ..
- The neuronal sodium channel gene SCN8AMIRIAM MEISLER; Fiscal Year: 2006..This work will extend our knowledge of the physiological and cellular functions of SCN8A in the CNS and PNS and its role in neurological disease. ..
- INSERTIONAL MUTANTS AND DEVELOPMENT IN TRANSGENIC MICEMIRIAM MEISLER; Fiscal Year: 1999..These projects will contribute to isolation of genes involved in craniofacial development, identification of new genetic disorders, and development of the human and mouse comparative genetic maps. ..
- GENETIC REGULATION OF MOUSE ENZYMESMIRIAM MEISLER; Fiscal Year: 1991..These investigations will contribute to our understanding of the molecular basis of tissue-specific and hormonal regulation of mammalian gene expression...
- INSERTIONAL MUTANTS AND DEVELOPMENT IN TRANSGENIC MICEMIRIAM MEISLER; Fiscal Year: 1993..Insertional mutation in transgenic mice provides a powerful system for the identification and genetic mapping of new functional elements in the mammalian genome, and for molecular characterization of these new genes...
- GENETIC REGULATION OF MOUSE ENZYMESMIRIAM MEISLER; Fiscal Year: 1980..If we can understand how normal enzyme concentration is altered by mutation, the regulatory mechanisms responsible for maintenance of steady-state enzyme levels may be identified. ..
- NEUROMUSCULAR DISEASE GENE ENCODING A NEW SODIUM CHANNELMIRIAM MEISLER; Fiscal Year: 2000..Promoter function will also be assayed in transgenic mice. This work will provide thorough characterization of normal and mutated forms of a novel sodium channel and contribute to the diagnosis and treatment of neuromuscular disease. ..
- Growth Factor Protection in Acute Lung InjuryGEORGE LEIKAUF; Fiscal Year: 2009..The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
- Role of Metalloproteinases in Mucin Overproduction in COPDGEORGE DOUGLAS LEIKAUF; Fiscal Year: 2010....
- Molecular Biology of Calcuim Channel Gamma SubunitsDaniel Burgess; Fiscal Year: 2006....
- Characterization of N-type Ca channels in growth conesMaureen McEnery; Fiscal Year: 2005....