Gene Symbol: Cacnb3
Description: calcium channel, voltage-dependent, beta 3 subunit
Alias: Beta3, CAB3, Ca(v)beta3, Cchb3, voltage-dependent L-type calcium channel subunit beta-3, calcium channel voltage-dependent subunit beta 3
Species: mouse
Products:     Cacnb3

Top Publications

  1. Murakami M, Fleischmann B, De Felipe C, Freichel M, Trost C, Ludwig A, et al. Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem. 2002;277:40342-51 pubmed
    ..The accessory beta3 subunits of calcium channels are preferentially associated with the alpha1B subunit in neurones...
  2. Freise D, Himmerkus N, Schroth G, Trost C, Weissgerber P, Freichel M, et al. Mutations of calcium channel beta subunit genes in mice. Biol Chem. 1999;380:897-902 pubmed
    ..Here we summarize the phenotype of mice deficient in the beta1 subunit, the beta3 subunit or the beta4 subunit, respectively.
  3. Badou A, Jha M, Matza D, Mehal W, Freichel M, Flockerzi V, et al. Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A. 2006;103:15529-34 pubmed
    ..pore-forming Cav1 alpha1 subunits of Cav channels, and we provide genetic evidence for a critical role of the Cav beta3 and Cav beta4 regulatory subunits in T lymphocyte function...
  4. Ohta T, Ohba T, Suzuki T, Watanabe H, Sasano H, Murakami M. Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice. Biochem Biophys Res Commun. 2010;394:464-9 pubmed publisher
    ..The beta3 subunit is expressed in the adrenal gland and participates in forming various calcium channel types...
  5. Murakami M, Ohba T, Takahashi Y, Watanabe H, Miyoshi I, Nakayama S, et al. Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit. J Mol Cell Cardiol. 2006;41:115-25 pubmed
    ..In vitro overlay and immunoprecipitation analyses revealed preferential binding between alpha1C-a and beta2, which is also expressed at a high level in the heart. ..
  6. Murakami M, Ohba T, Xu F, Satoh E, Miyoshi I, Suzuki T, et al. Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit. J Biol Chem. 2008;283:24554-60 pubmed publisher
    ..The accessory beta3 subunit of these channels preferentially forms N-type channels with a pore-forming CaV2.2 subunit...
  7. Jeon D, Song I, Guido W, Kim K, Kim E, Oh U, et al. Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory. J Biol Chem. 2008;283:12093-101 pubmed publisher
    ..Among the four different beta subunits, the beta(3) subunit (Ca(v)beta3) is abundantly expressed in the hippocampus...
  8. Murakami M, Nakagawasai O, Yanai K, Nunoki K, Tan No K, Tadano T, et al. Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit. Brain Res. 2007;1160:102-12 pubmed
    ..In the present study, beta3 subunit-null mice were used to investigate the importance of the beta3 subunit of the voltage-dependent calcium ..
  9. Berggren P, Yang S, Murakami M, Efanov A, Uhles S, Kohler M, et al. Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell. 2004;119:273-84 pubmed
    ..The role of the voltage-gated Ca2+ channel beta3 subunit in the molecular regulation of these [Ca2+]i oscillations has now been clarified by using beta3 subunit-..

More Information


  1. Murakami M, Yamamura H, Suzuki T, Kang M, Ohya S, Murakami A, et al. Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit. J Biol Chem. 2003;278:43261-7 pubmed
    ..Of the four beta subunits reported to date, the beta3 subunit is highly expressed in smooth muscle cells and is thought to consist of L-type calcium channels...
  2. Bodrikov V, Sytnyk V, Leshchyns ka I, den Hertog J, Schachner M. NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. J Cell Biol. 2008;182:1185-200 pubmed publisher
    ..Thus, we reveal a novel function for a cell adhesion molecule in coordination of cell behavior with intracellular phosphatase activity. ..
  3. Link S, Meissner M, Held B, Beck A, Weissgerber P, Freichel M, et al. Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem. 2009;284:30129-37 pubmed publisher
  4. Bernardo J, Magyar C, Sneddon W, Friedman P. Impaired renal calcium absorption in mice lacking calcium channel beta 3 subunits. Can J Physiol Pharmacol. 2009;87:522-30 pubmed publisher
    Transgenic mice lacking calcium channel beta3 subunits (CaVbeta3) were used to determine the involvement of a multimeric calcium channel in mediating stimulated renal calcium absorption...
  5. Jha M, Badou A, Meissner M, McRory J, Freichel M, Flockerzi V, et al. Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. Nat Immunol. 2009;10:1275-82 pubmed publisher
    ..Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of naive CD8(+) T cells...
  6. Serikov V, Bodi I, Koch S, Muth J, Mikala G, Martinov S, et al. Mice with cardiac-specific sequestration of the beta-subunit of the L-type calcium channel. Biochem Biophys Res Commun. 2002;293:1405-11 pubmed
    ..beta isoform was located primarily in the membrane bound fraction of heart protein, whereas the beta1 and beta3 were mostly cytosolic...
  7. Cork R, Namkung Y, Shin H, Mize R. Development of the visual pathway is disrupted in mice with a targeted disruption of the calcium channel beta(3)-subunit gene. J Comp Neurol. 2001;440:177-91 pubmed
  8. De Repentigny Y, Côté P, Pool M, Bernier G, Girard S, Vidal S, et al. Pathological and genetic analysis of the degenerating muscle (dmu) mouse: a new allele of Scn8a. Hum Mol Genet. 2001;10:1819-27 pubmed
    ..Our results suggest that at least a portion of the dmu phenotype is caused by a down-regulation of Scn8a, making dmu a new allele of Scn8a. ..
  9. Hain H, Crabbe J, Bergeson S, Belknap J. Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. J Pharmacol Exp Ther. 2000;293:180-7 pubmed
    ..0015), both associated with clonic seizures on chromosomes 9 (proximal) and 15 (distal). Both QTLs on chromosome 9 were sex-specific, with much larger effects on the phenotype seen in females than in males. ..
  10. Burgess D, Biddlecome G, McDonough S, Diaz M, Zilinski C, Bean B, et al. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999;13:293-311 pubmed
    ..The existence of beta subunit reshuffling demonstrates that molecular plasticity of Ca2+ channel assembly, a normal feature of early brain development, is retained in the mature brain. ..
  11. Etemad S, Obermair G, Bindreither D, Benedetti A, Stanika R, Di Biase V, et al. Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014;34:1446-61 pubmed publisher
  12. Chin H, Kwon O, Jung H, Kim D, Kozak C. Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits. Genomics. 1995;28:592-5 pubmed
    ..termed Cchna1, Cchb2, and Cchb4, are located at different sites on proximal Chr 2, while the beta 3 subunit gene Cchb3 maps to Chr 15 near Wnt1...
  13. Murakami M, Wissenbach U, Flockerzi V. Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products. Eur J Biochem. 1996;236:138-43 pubmed
    The beta3 subunit of high-voltage-gated calcium channels is a peripheral membrane protein that copurifies with neural N-type calcium channels...
  14. Kuhn S, Knirsch M, Ruttiger L, Kasperek S, Winter H, Freichel M, et al. Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4. Channels (Austin). 2009;3:366-76 pubmed
    ..We analyzed Ca(V)beta3 knockout (Ca(V)beta3(-/-)) and Ca(V)beta4 mutant mice (Ca(V)beta4(lh/lh)), which had normal hearing...
  15. Ferrándiz Huertas C, Gil Mínguez M, Lujan R. Regional expression and subcellular localization of the voltage-gated calcium channel ? subunits in the developing mouse brain. J Neurochem. 2012;122:1095-107 pubmed publisher
    ..These results shed new light on the developmental regulation and subcellular localization of Ca(v) ? subunits, and their possible role in pre- and post-synaptic transmission. ..
  16. Shiraiwa T, Kashiwayanagi M, Iijima T, Murakami M. Involvement of the calcium channel beta3 subunit in olfactory signal transduction. Biochem Biophys Res Commun. 2007;355:1019-24 pubmed
    ..Therefore, we investigated olfactory neurotransduction in beta3-deficient mice...
  17. Murakami M, Matsui H, Shiraiwa T, Suzuki T, Sasano H, Takahashi E, et al. Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha1B or beta3 subunits of voltage-dependent Ca2+-channels. Biol Pharm Bull. 2006;29:437-42 pubmed
    ..We investigated the physiological role of the alpha1B and beta3 subunits of the N (neuronal)-type voltage-dependent Ca2+ channel in the neurotransduction in the accessory ..
  18. Ball S, Powers P, Shin H, Morgans C, Peachey N, Gregg R. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci. 2002;43:1595-603 pubmed
    ..The expression of both of these subunits is required for normal maintenance and/or formation of the OPL and synaptic transmission. ..
  19. Schlick B, Flucher B, Obermair G. Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010;167:786-98 pubmed publisher
    ..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity. ..
  20. Jones J, Ranscht B, Berglund E, Gruenheid S, Gros P, Meisler M. Close linkage of three neuronal genes on distal mouse chromosome 15. Mamm Genome. 1996;7:696-7 pubmed
  21. Held B, Tsvilovskyy V, Meissner M, Kaestner L, Ludwig A, Mossmang S, et al. Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse. Cell Calcium. 2007;42:477-87 pubmed
  22. Singh U, Sun T, Looman C, Heuchel R, Elliott R, Freichel M, et al. Expression and function of the gene encoding the voltage-dependent calcium channel beta3-subunit in the mouse placenta. Placenta. 2007;28:412-20 pubmed
    ..There are four genes encoding CACNB subunits and the gene encoding CACNB3 is over expressed in hyperplastic placentas of mouse interspecies hybrids...
  23. Obermair G, Schlick B, Di Biase V, Subramanyam P, Gebhart M, Baumgartner S, et al. Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons. J Biol Chem. 2010;285:5776-91 pubmed publisher
  24. Bros M, Dexheimer N, Ross R, Trojandt S, Höhn Y, Tampe J, et al. Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation. Gene. 2011;472:18-27 pubmed publisher
    ..LCs in response to stimulation, both isoforms of the voltage-dependent Ca²(+) channel (VDCC) regulatory subunit Cacnb3 as well as the DC maturation marker Fscn1 were upregulated most strongly...
  25. Namkung Y, Smith S, Lee S, Skrypnyk N, Kim H, Chin H, et al. Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proc Natl Acad Sci U S A. 1998;95:12010-5 pubmed
    ..We studied the role of the Ca2+ channel beta3 subunit, the major Ca2+ channel beta subunit in neurons, by using a gene-targeting strategy...
  26. Dilger E, Krahe T, Morhardt D, Seabrook T, Shin H, Guido W. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci. 2015;35:3652-62 pubmed publisher
    ..Thus, postsynaptic L-type Ca(2+) activity plays an important role in mediating the refinement of the retinogeniculate pathway. ..