Genomes and Genes
Gene Symbol: Cacnb1
Description: calcium channel, voltage-dependent, beta 1 subunit
Alias: CAB1, Cchb1, Cchlb1, voltage-dependent L-type calcium channel subunit beta-1, calcium channel voltage-dependent subunit beta 1, voltage-dependent calcium channel beta1 subunit
- Woo D, Kurtz I. Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003;15:236-42 pubmed..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control. ..
- Mock B, Krall M, Byrd L, Chin H, Barton C, Charles I, et al. The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. Eur J Immunogenet. 1994;21:231-8 pubmed..This map location is discussed relative to map locations for disease susceptibility loci involved in mediating cutaneous leishmaniasis (ScII) and autoimmune type-I diabetes (Idd4). ..
- Freise D, Himmerkus N, Schroth G, Trost C, Weissgerber P, Freichel M, et al. Mutations of calcium channel beta subunit genes in mice. Biol Chem. 1999;380:897-902 pubmed..Here we summarize the phenotype of mice deficient in the beta1 subunit, the beta3 subunit or the beta4 subunit, respectively. ..
- Pragnell M, Sakamoto J, Jay S, Campbell K. Cloning and tissue-specific expression of the brain calcium channel beta-subunit. FEBS Lett. 1991;291:253-8 pubmed..Hence the encoded brain beta-subunit, which has a primary structure highly similar to its isoform in skeletal muscle, may have a comparable role as an integral regulatory component of a neuronal calcium channel. ..
- Schlick B, Flucher B, Obermair G. Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010;167:786-98 pubmed publisher..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity. ..
- Eltit J, Franzini Armstrong C, Perez C. Amino acid residues 489-503 of dihydropyridine receptor (DHPR) Î²1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor. J Biol Chem. 2014;289:36116-24 pubmed publisher..In addition, our data strongly suggest that the motif Leu(496)-Leu(500)-Trp(503) within the Î²1a C-terminal tail plays a nonessential role in the bidirectional DHPR/RyR1 signaling that supports skeletal-type EC coupling. ..
- Toba Y, Pakiam J, Wray S. Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse. Eur J Neurosci. 2005;22:79-92 pubmed..These results indicate that extracellular calcium is required for initiating GnRH-1 neuronal migration and that these events are partially dependent on N-type VGCC signals. ..
- Murakami M, Miyoshi I, Suzuki T, Sasano H, Iijima T. Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel. J Mol Neurosci. 2003;21:13-21 pubmed..Furthermore, mRNA of these beta-subunits is strongly expressed in dorsal root ganglion neurons, which have many voltage-dependent calcium channels. ..
- Taylor J, Pereyra A, Zhang T, Messi M, Wang Z, Hereñú C, et al. The Cav?1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. J Cell Biol. 2014;205:829-46 pubmed publisher..This work indicates that Cav?1a acts as a Cav-independent regulator of gene expression in MPCs, and is required for their normal expansion during myogenic development. ..
- Ferrándiz Huertas C, Gil Mínguez M, Lujan R. Regional expression and subcellular localization of the voltage-gated calcium channel ? subunits in the developing mouse brain. J Neurochem. 2012;122:1095-107 pubmed publisher..These results shed new light on the developmental regulation and subcellular localization of Ca(v) ? subunits, and their possible role in pre- and post-synaptic transmission. ..
- Karunasekara Y, Rebbeck R, Weaver L, Board P, Dulhunty A, Casarotto M. An ?-helical C-terminal tail segment of the skeletal L-type Ca2+ channel ?1a subunit activates ryanodine receptor type 1 via a hydrophobic surface. FASEB J. 2012;26:5049-59 pubmed publisher..We conclude that specific hydrophobic surface residues in the 35 residue ?(1a) C-terminus bind to RyR1 and increase channel activity in lipid bilayers and thus may support skeletal EC coupling. ..
- Bhattacharya D, Mehle A, Kamp T, Balijepalli R. Intramolecular ex vivo Fluorescence Resonance Energy Transfer (FRET) of Dihydropyridine Receptor (DHPR) Î²1a Subunit Reveals Conformational Change Induced by RYR1 in Mouse Skeletal Myotubes. PLoS ONE. 2015;10:e0131399 pubmed publisher..The present study reveals that the C-terminal of the Î²1a subunit changes conformation in the presence of RyR1 consistent with an interaction between the C-terminal of Î²1a and RyR1 in resting myotubes. ..
- Perez Reyes E, Castellano A, Kim H, Bertrand P, Baggstrom E, Lacerda A, et al. Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. J Biol Chem. 1992;267:1792-7 pubmed..These results indicate that the cardiac L-type Ca2+ channel has a similar subunit structure as in skeletal muscle, and provides evidence for the modulatory role of the beta subunit. ..
- Norris N, Joseph S, Aditya S, Karunasekara Y, Board P, Dulhunty A, et al. Structural and biophysical analyses of the skeletal dihydropyridine receptor ? subunit ?1a reveal critical roles of domain interactions for stability. J Biol Chem. 2017;292:8401-8411 pubmed publisher..These results suggest that intramolecular interactions between the SH3 and guanylate kinase domains play a role in the stability of ?1a while also providing a conduit for allosteric signaling events. ..
- Bodrikov V, Sytnyk V, Leshchyns ka I, den Hertog J, Schachner M. NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. J Cell Biol. 2008;182:1185-200 pubmed publisher..Thus, we reveal a novel function for a cell adhesion molecule in coordination of cell behavior with intracellular phosphatase activity. ..
- Cheng W, Altafaj X, Ronjat M, Coronado R. Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling. Proc Natl Acad Sci U S A. 2005;102:19225-30 pubmed..These findings indicate that EC coupling in skeletal muscle involves the interplay of at least two subunits of the DHPR, namely alpha1S and beta1a, interacting with possibly different domains of RyR1. ..
- Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, et al. Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem. 2002;277:7214-21 pubmed..These results suggest that P-type-specific splice variants may exist but that post-translational processing or modification by uncharacterized interacting proteins is also required for generating the P-type current. ..
- Conklin M, Powers P, Gregg R, Coronado R. Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits. Biophys J. 1999;76:657-69 pubmed..However, excitation-contraction coupling is not essential for Ca2+ spark formation in these cells. ..
- Strube C. Absence of regulation of the T-type calcium current by Cav1.1, beta1a and gamma1 dihydropyridine receptor subunits in skeletal muscle cells. Pflugers Arch. 2008;455:921-7 pubmed..2 is not regulated by beta1 or gamma1 DHPR subunits; (2) T-type and L-type currents have distinct and not interchangeable roles. ..