Gene Symbol: Cacnb1
Description: calcium channel, voltage-dependent, beta 1 subunit
Alias: CAB1, Cchb1, Cchlb1, voltage-dependent L-type calcium channel subunit beta-1, calcium channel voltage-dependent subunit beta 1, voltage-dependent calcium channel beta1 subunit
Species: mouse
Products:     Cacnb1

Top Publications

  1. Serikov V, Bodi I, Koch S, Muth J, Mikala G, Martinov S, et al. Mice with cardiac-specific sequestration of the beta-subunit of the L-type calcium channel. Biochem Biophys Res Commun. 2002;293:1405-11 pubmed
    ..In contrast, beta1 and beta3 in skeletal muscle and brain, the predominant isoforms in these tissues, respectively, are membrane bound. ..
  2. Gregg R, Messing A, Strube C, Beurg M, Moss R, Behan M, et al. Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc Natl Acad Sci U S A. 1996;93:13961-6 pubmed
  3. Burgess D, Biddlecome G, McDonough S, Diaz M, Zilinski C, Bean B, et al. beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol Cell Neurosci. 1999;13:293-311 pubmed
    ..The existence of beta subunit reshuffling demonstrates that molecular plasticity of Ca2+ channel assembly, a normal feature of early brain development, is retained in the mature brain. ..
  4. Ball S, Powers P, Shin H, Morgans C, Peachey N, Gregg R. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci. 2002;43:1595-603 pubmed
    ..The expression of both of these subunits is required for normal maintenance and/or formation of the OPL and synaptic transmission. ..
  5. Leuranguer V, Papadopoulos S, Beam K. Organization of calcium channel beta1a subunits in triad junctions in skeletal muscle. J Biol Chem. 2006;281:3521-7 pubmed
    ..Thus, DHPRs in tetrads may be arranged such that the N and C termini of adjacent beta1a subunits are located >10 nm from one another. ..
  6. Chen F, Liu Y, Sugiura Y, Allen P, Gregg R, Lin W. Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci. 2011;14:570-7 pubmed publisher
    ..Targeted deletion of the ?1 subunit of DHPR (Cacnb1) in mice led to muscle pre-patterning defects, aberrant innervation and precocious maturation of the NMJ...
  7. Ruth P, Röhrkasten A, Biel M, Bosse E, Regulla S, Meyer H, et al. Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle. Science. 1989;245:1115-8 pubmed
    ..The protein contains sites that might be expected to be preferentially phosphorylated by protein kinase C and guanosine 3',5'-monophosphate-dependent protein kinase. A messenger RNA for this protein appears to be expressed in brain. ..
  8. Crawshaw L, Wallace H, Christensen R, Crabbe J. Influence of ethanol on thermoregulation: mapping quantitative trait loci. Physiol Genomics. 2001;7:159-69 pubmed
    ..To our knowledge, this is the first report of QTLs that underlie changes in regulation as well as the disruption of a physiological regulatory system. ..
  9. Marmorstein L, Wu J, McLaughlin P, Yocom J, Karl M, Neussert R, et al. The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1). J Gen Physiol. 2006;127:577-89 pubmed
    ..Furthermore, we suggest that the loss of vision associated with BMD is not caused by the same pathologic process as the diminished LP, but rather is caused by as yet unidentified effects of best-1 on other cellular processes. ..

More Information


  1. Woo D, Kurtz I. Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003;15:236-42 pubmed
    ..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control. ..
  2. Mock B, Krall M, Byrd L, Chin H, Barton C, Charles I, et al. The inducible form of nitric oxide synthase (NOS2) isolated from murine macrophages maps near the nude mutation on mouse chromosome 11. Eur J Immunogenet. 1994;21:231-8 pubmed
    ..This map location is discussed relative to map locations for disease susceptibility loci involved in mediating cutaneous leishmaniasis (ScII) and autoimmune type-I diabetes (Idd4). ..
  3. Freise D, Himmerkus N, Schroth G, Trost C, Weissgerber P, Freichel M, et al. Mutations of calcium channel beta subunit genes in mice. Biol Chem. 1999;380:897-902 pubmed
    ..Here we summarize the phenotype of mice deficient in the beta1 subunit, the beta3 subunit or the beta4 subunit, respectively. ..
  4. Obermair G, Schlick B, Di Biase V, Subramanyam P, Gebhart M, Baumgartner S, et al. Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons. J Biol Chem. 2010;285:5776-91 pubmed publisher
  5. Pragnell M, Sakamoto J, Jay S, Campbell K. Cloning and tissue-specific expression of the brain calcium channel beta-subunit. FEBS Lett. 1991;291:253-8 pubmed
    ..Hence the encoded brain beta-subunit, which has a primary structure highly similar to its isoform in skeletal muscle, may have a comparable role as an integral regulatory component of a neuronal calcium channel. ..
  6. Schlick B, Flucher B, Obermair G. Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010;167:786-98 pubmed publisher
    ..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity. ..
  7. Eltit J, Franzini Armstrong C, Perez C. Amino acid residues 489-503 of dihydropyridine receptor (DHPR) β1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor. J Biol Chem. 2014;289:36116-24 pubmed publisher
    ..In addition, our data strongly suggest that the motif Leu(496)-Leu(500)-Trp(503) within the β1a C-terminal tail plays a nonessential role in the bidirectional DHPR/RyR1 signaling that supports skeletal-type EC coupling. ..
  8. Zhang T, Taylor J, Jiang Y, Pereyra A, Messi M, Wang Z, et al. Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle. Exp Cell Res. 2015;336:276-86 pubmed publisher
  9. Toba Y, Pakiam J, Wray S. Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse. Eur J Neurosci. 2005;22:79-92 pubmed
    ..These results indicate that extracellular calcium is required for initiating GnRH-1 neuronal migration and that these events are partially dependent on N-type VGCC signals. ..
  10. Murakami M, Miyoshi I, Suzuki T, Sasano H, Iijima T. Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel. J Mol Neurosci. 2003;21:13-21 pubmed
    ..Furthermore, mRNA of these beta-subunits is strongly expressed in dorsal root ganglion neurons, which have many voltage-dependent calcium channels. ..
  11. Taylor J, Pereyra A, Zhang T, Messi M, Wang Z, Hereñú C, et al. The Cav?1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. J Cell Biol. 2014;205:829-46 pubmed publisher
    ..This work indicates that Cav?1a acts as a Cav-independent regulator of gene expression in MPCs, and is required for their normal expansion during myogenic development. ..
  12. Link S, Meissner M, Held B, Beck A, Weissgerber P, Freichel M, et al. Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem. 2009;284:30129-37 pubmed publisher
  13. Ferrándiz Huertas C, Gil Mínguez M, Lujan R. Regional expression and subcellular localization of the voltage-gated calcium channel ? subunits in the developing mouse brain. J Neurochem. 2012;122:1095-107 pubmed publisher
    ..These results shed new light on the developmental regulation and subcellular localization of Ca(v) ? subunits, and their possible role in pre- and post-synaptic transmission. ..
  14. Karunasekara Y, Rebbeck R, Weaver L, Board P, Dulhunty A, Casarotto M. An ?-helical C-terminal tail segment of the skeletal L-type Ca2+ channel ?1a subunit activates ryanodine receptor type 1 via a hydrophobic surface. FASEB J. 2012;26:5049-59 pubmed publisher
    ..We conclude that specific hydrophobic surface residues in the 35 residue ?(1a) C-terminus bind to RyR1 and increase channel activity in lipid bilayers and thus may support skeletal EC coupling. ..
  15. Bhattacharya D, Mehle A, Kamp T, Balijepalli R. Intramolecular ex vivo Fluorescence Resonance Energy Transfer (FRET) of Dihydropyridine Receptor (DHPR) β1a Subunit Reveals Conformational Change Induced by RYR1 in Mouse Skeletal Myotubes. PLoS ONE. 2015;10:e0131399 pubmed publisher
    ..The present study reveals that the C-terminal of the β1a subunit changes conformation in the presence of RyR1 consistent with an interaction between the C-terminal of β1a and RyR1 in resting myotubes. ..
  16. Mahalingam M, Perez C, Fessenden J. Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor ?1S Subunit Reveals Conformational Differences Induced by Binding of the ?1a Subunit. J Biol Chem. 2016;291:13762-70 pubmed publisher
  17. Perez Reyes E, Castellano A, Kim H, Bertrand P, Baggstrom E, Lacerda A, et al. Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. J Biol Chem. 1992;267:1792-7 pubmed
    ..These results indicate that the cardiac L-type Ca2+ channel has a similar subunit structure as in skeletal muscle, and provides evidence for the modulatory role of the beta subunit. ..
  18. Norris N, Joseph S, Aditya S, Karunasekara Y, Board P, Dulhunty A, et al. Structural and biophysical analyses of the skeletal dihydropyridine receptor ? subunit ?1a reveal critical roles of domain interactions for stability. J Biol Chem. 2017;292:8401-8411 pubmed publisher
    ..These results suggest that intramolecular interactions between the SH3 and guanylate kinase domains play a role in the stability of ?1a while also providing a conduit for allosteric signaling events. ..
  19. Etemad S, Obermair G, Bindreither D, Benedetti A, Stanika R, Di Biase V, et al. Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014;34:1446-61 pubmed publisher
  20. Bodrikov V, Sytnyk V, Leshchyns ka I, den Hertog J, Schachner M. NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. J Cell Biol. 2008;182:1185-200 pubmed publisher
    ..Thus, we reveal a novel function for a cell adhesion molecule in coordination of cell behavior with intracellular phosphatase activity. ..
  21. Cheng W, Altafaj X, Ronjat M, Coronado R. Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling. Proc Natl Acad Sci U S A. 2005;102:19225-30 pubmed
    ..These findings indicate that EC coupling in skeletal muscle involves the interplay of at least two subunits of the DHPR, namely alpha1S and beta1a, interacting with possibly different domains of RyR1. ..
  22. Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, et al. Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem. 2002;277:7214-21 pubmed
    ..These results suggest that P-type-specific splice variants may exist but that post-translational processing or modification by uncharacterized interacting proteins is also required for generating the P-type current. ..
  23. Conklin M, Powers P, Gregg R, Coronado R. Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits. Biophys J. 1999;76:657-69 pubmed
    ..However, excitation-contraction coupling is not essential for Ca2+ spark formation in these cells. ..
  24. Strube C. Absence of regulation of the T-type calcium current by Cav1.1, beta1a and gamma1 dihydropyridine receptor subunits in skeletal muscle cells. Pflugers Arch. 2008;455:921-7 pubmed
    ..2 is not regulated by beta1 or gamma1 DHPR subunits; (2) T-type and L-type currents have distinct and not interchangeable roles. ..