Gene Symbol: Cacna2d3
Description: calcium channel, voltage-dependent, alpha2/delta subunit 3
Alias: Cacnad3, alapha2delta3, voltage-dependent calcium channel subunit alpha-2/delta-3, alpha 2 delta-3, voltage-gated calcium channel subunit alpha-2/delta-3
Klugbauer N, Lacinova L, Marais E, Hobom M, Hofmann F. Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999;19:684-91 pubmed
Shibasaki M, Kurokawa K, Ohkuma S. Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization. Neuroscience. 2009;163:731-4 pubmed publisher
Davies A, Kadurin I, Alvarez Laviada A, Douglas L, Nieto Rostro M, Bauer C, et al
. The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A. 2010;107:1654-9 pubmed publisher
..In conclusion, this study redefines our understanding of alpha(2)delta subunits, both in terms of their role in calcium-channel function and other roles in synaptogenesis. ..
Schlick B, Flucher B, Obermair G. Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010;167:786-98 pubmed publisher
..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity. ..
Neely G, Hess A, Costigan M, Keene A, Goulas S, Langeslag M, et al
. A genome-wide Drosophila screen for heat nociception identifies ?2?3 as an evolutionarily conserved pain gene. Cell. 2010;143:628-38 pubmed publisher
..Mice mutant for the stj ortholog CACNA2D3 (?2?3) also exhibit impaired behavioral heat pain sensitivity...
Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels J, et al
. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. elife. 2013;2:e00178 pubmed publisher
..The data reveal a hidden means of dynamic RNA regulation linking electrical activity to splicing and protein output, and of mediating homeostatic excitation/inhibition balance in neurons.DOI:http://dx.doi.org/10.7554/eLife.00178.001. ..
Hoerder Suabedissen A, Oeschger F, Krishnan M, Belgard T, Wang W, Lee S, et al
. Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Proc Natl Acad Sci U S A. 2013;110:3555-60 pubmed publisher
..Our report emphasizes the importance of the study of transient features of the developing brain to better understand neurodevelopmental disorders. ..
Etemad S, Obermair G, Bindreither D, Benedetti A, Stanika R, Di Biase V, et al
. Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014;34:1446-61 pubmed publisher
Haller M, Mo Q, Imamoto A, Lamb D. Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A. 2017;114:4981-4986 pubmed publisher