Gene Symbol: Cacna2d3
Description: calcium channel, voltage-dependent, alpha2/delta subunit 3
Alias: Cacnad3, alapha2delta3, voltage-dependent calcium channel subunit alpha-2/delta-3, alpha 2 delta-3, voltage-gated calcium channel subunit alpha-2/delta-3
Species: mouse
Products:     Cacna2d3

Top Publications

  1. Klugbauer N, Lacinova L, Marais E, Hobom M, Hofmann F. Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999;19:684-91 pubmed
  2. Shibasaki M, Kurokawa K, Ohkuma S. Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization. Neuroscience. 2009;163:731-4 pubmed publisher
  3. Davies A, Kadurin I, Alvarez Laviada A, Douglas L, Nieto Rostro M, Bauer C, et al. The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci U S A. 2010;107:1654-9 pubmed publisher
    ..In conclusion, this study redefines our understanding of alpha(2)delta subunits, both in terms of their role in calcium-channel function and other roles in synaptogenesis. ..
  4. Schlick B, Flucher B, Obermair G. Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010;167:786-98 pubmed publisher
    ..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity. ..
  5. Neely G, Hess A, Costigan M, Keene A, Goulas S, Langeslag M, et al. A genome-wide Drosophila screen for heat nociception identifies ?2?3 as an evolutionarily conserved pain gene. Cell. 2010;143:628-38 pubmed publisher
    ..Mice mutant for the stj ortholog CACNA2D3 (?2?3) also exhibit impaired behavioral heat pain sensitivity...
  6. Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels J, et al. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. elife. 2013;2:e00178 pubmed publisher
    ..The data reveal a hidden means of dynamic RNA regulation linking electrical activity to splicing and protein output, and of mediating homeostatic excitation/inhibition balance in neurons.DOI: ..
  7. Hoerder Suabedissen A, Oeschger F, Krishnan M, Belgard T, Wang W, Lee S, et al. Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia. Proc Natl Acad Sci U S A. 2013;110:3555-60 pubmed publisher
    ..Our report emphasizes the importance of the study of transient features of the developing brain to better understand neurodevelopmental disorders. ..
  8. Etemad S, Obermair G, Bindreither D, Benedetti A, Stanika R, Di Biase V, et al. Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014;34:1446-61 pubmed publisher
  9. Haller M, Mo Q, Imamoto A, Lamb D. Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A. 2017;114:4981-4986 pubmed publisher
    ..2. ..

More Information


  1. Pirone A, Kurt S, Zuccotti A, Ruttiger L, Pilz P, Brown D, et al. ?2?3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J Neurosci. 2014;34:434-45 pubmed publisher
    ..Together, our results identify a novel role for the ?2?3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders. ..
  2. Nishihara H, Kobayashi N, Kimura Yoshida C, Yan K, Bormuth O, Ding Q, et al. Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. PLoS Genet. 2016;12:e1006380 pubmed publisher
    ..The present study provides a new perspective suggesting that a huge variety of TEs, in combination, could have accelerated the diversity of cis-regulatory elements involved in morphological evolution. ..