Gene Symbol: Cacna1i
Description: calcium channel, voltage-dependent, alpha 1I subunit
Alias: Ca(V)3.3, voltage-dependent T-type calcium channel subunit alpha-1I, low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I), low-voltage-activated calcium channel alpha13.3
Species: mouse
Products:     Cacna1i

Top Publications

  1. Cribbs L, Martin B, Schroder E, Keller B, Delisle B, Satin J. Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart. Circ Res. 2001;88:403-7 pubmed
    ..We demonstrate that 100 micromol/L Ni(2+) partially blocked alpha1G currents under physiological external Ca(2+). We conclude that alpha1G T-type Ca(2+) channels are functional in midgestational fetal myocardium. ..
  2. Shin J, Martinez Salgado C, Heppenstall P, Lewin G. A T-type calcium channel required for normal function of a mammalian mechanoreceptor. Nat Neurosci. 2003;6:724-30 pubmed
    ..This is the first evidence that a calcium channel is required for normal function of a vertebrate mechanoreceptor. ..
  3. Lee J, Shin H. T-type calcium channels and thalamocortical rhythms in sleep: a perspective from studies of T-type calcium channel knockout mice. CNS Neurol Disord Drug Targets. 2007;6:63-9 pubmed
    ..These findings support the idea that alpha1(G) T-type calcium channels contribute to sleep waves as well as to behavioral state of sleep. ..
  4. Lee S, Lee J, Latchoumane C, Lee B, Oh S, Saud Z, et al. Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice. Proc Natl Acad Sci U S A. 2014;111:11828-33 pubmed publisher
    ..These results call into question the role of burst firing in TRN neurons in the genesis of SWDs, calling for a rethinking of the mechanism for absence seizure induction. ..
  5. Liu D, Lu J, Zhao Q, Hu C, Mei Y. Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels. Sci Rep. 2016;6:28653 pubmed publisher
  6. Yunker A, Sharp A, Sundarraj S, Ranganathan V, Copeland T, McEnery M. Immunological characterization of T-type voltage-dependent calcium channel CaV3.1 (alpha 1G) and CaV3.3 (alpha 1I) isoforms reveal differences in their localization, expression, and neural development. Neuroscience. 2003;117:321-35 pubmed
    ..Taken together, these data provide an anatomical and biochemical basis for interpreting LVA heterogeneity and offer evidence of developmental regulation of LVA isoform expression. ..
  7. Porter G, Makuck R, Rivkees S. Intracellular calcium plays an essential role in cardiac development. Dev Dyn. 2003;227:280-90 pubmed
    ..These data demonstrate that proper intracellular calcium signaling is essential for normal cardiac looping, gene expression, and organ development. ..
  8. Moruzzi A, Abedini N, Hansen M, Olson J, Bosma M. Differential expression of membrane conductances underlies spontaneous event initiation by rostral midline neurons in the embryonic mouse hindbrain. J Physiol. 2009;587:5081-93 pubmed publisher
    ..This demonstrates that expression of specific conductances contributes to the ability to drive spontaneous activity in a developing network. ..
  9. Lin S, Tzeng B, Lee K, Smith R, Campbell K, Chen C. Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014;111:E1990-8 pubmed publisher
    ..Our findings define a previously unidentified mechanism that Ca(2+) influx via the Cav3.2 T-type Ca(2+) channel regulates Sox9 expression through the calcineurin/NFAT signaling pathway during tracheal chondrogenesis. ..

More Information


  1. Basson M, Zeng B, Downey C, Sirivelu M, Tepe J. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β. Mol Oncol. 2015;9:513-26 pubmed publisher
    ..Targeting this pathway may inhibit proliferation in large unresectable tumors. ..
  2. Berthier C, Monteil A, Lory P, Strube C. Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice. J Physiol. 2002;539:681-91 pubmed
  3. Astori S, Wimmer R, Prosser H, Corti C, Corsi M, Liaudet N, et al. The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus. Proc Natl Acad Sci U S A. 2011;108:13823-8 pubmed publisher
    ..Together, these data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development. ..
  4. Astori S, Lüthi A. Synaptic plasticity at intrathalamic connections via CaV3.3 T-type Ca2+ channels and GluN2B-containing NMDA receptors. J Neurosci. 2013;33:624-30 pubmed publisher
    ..Notably, oscillatory burst discharge of reticular neurons is typical for sleep-related rhythms, suggesting that sleep contributes to strengthening intrathalamic circuits. ..