Genomes and Genes
Gene Symbol: Cacna1g
Description: calcium channel, voltage-dependent, T type, alpha 1G subunit
Alias: Cav3.1d, [a]1G, a1G, alpha-1G, mKIAA1123, voltage-dependent T-type calcium channel subunit alpha-1G
- Niwa N, Yasui K, Opthof T, Takemura H, Shimizu A, Horiba M, et al. Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period. Am J Physiol Heart Circ Physiol. 2004;286:H2257-63 pubmed..2 mRNA. These results indicate that Ca(v)3.2 underlies the functional T-type Ca2+ channels in the embryonic murine heart, and there is a subtype switching of transcripts from Ca(v)3.2 to Ca(v)3.1 in the perinatal period. ..
- Monteil A, Chemin J, Bourinet E, Mennessier G, Lory P, Nargeot J. Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels. J Biol Chem. 2000;275:6090-100 pubmed..The partial intron/exon structure of the corresponding gene CACNA1G was defined and several alpha(1G) isoforms were identified, especially two isoforms that exhibit a distinct III-..
- Oguri A, Tanaka T, Iida H, Meguro K, Takano H, Oonuma H, et al. Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytes. Am J Physiol Cell Physiol. 2010;298:C1414-23 pubmed publisher..1 T-type Ca(2+) channel encoded by alpha(1G) subtype is the dominant Ca(V) in mouse preadipocytes and may play a role in regulating preadipocyte proliferation, a key step in adipose tissue development. ..
- Wisniewska M, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W, et al. LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J Neurosci. 2010;30:4957-69 pubmed publisher..Cav3.1 is the predominant T-type channel subunit in the thalamus, and we hypothesized that the Cacna1g gene encoding Cav3.1 is a target of the LEF1/beta-catenin complex...
- Berthier C, Monteil A, Lory P, Strube C. Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice. J Physiol. 2002;539:681-91 pubmed
- Li Y, Wang F, Zhang X, Qi Z, Tang M, Szeto C, et al. ?-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A. PLoS ONE. 2012;7:e39965 pubmed publisher..1)) in cardiomyocytes(,) which is mediated by the cAMP/PKA pathway. The upregulation of I(Ca-T(3.1)) by the ?-adrenergic system could play important roles in cellular functions involving Cav3.1. ..
- Le Quang K, Naud P, Qi X, Duval F, Shi Y, Gillis M, et al. Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice. Cardiovasc Res. 2011;91:420-8 pubmed publisher..1 expression leads to impaired cardiac function and enhanced arrhythmia vulnerability post-MI, whereas Cav3.2 elimination has no effect. ..
- Mizuta E, Shirai M, Arakawa K, Hidaka K, Miake J, Ninomiya H, et al. Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice. Biomed Res. 2010;31:301-5 pubmed..Thus, Cav3.2 may contribute to the development of the outflow tract from the secondary heart field in the embryonic heart, whereas Cav3.1 may be involved in the development of the cardiac conduction-system together with Cav3.2. ..
- Kim D, Song I, Keum S, Lee T, Jeong M, Kim S, et al. Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron. 2001;31:35-45 pubmed..Thus, the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway. ..
- Deleuze C, David F, Béhuret S, Sadoc G, Shin H, Uebele V, et al. T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex. J Neurosci. 2012;32:12228-36 pubmed publisher..Our results establish a novel mechanism for the integration of sensory information by thalamocortical neurons and point to an unexpected role for T-channels in the early stage of information processing. ..
- Na H, Choi S, Kim J, Park J, Shin H. Attenuated neuropathic pain in Cav3.1 null mice. Mol Cells. 2008;25:242-6 pubmed
- Goonasekera S, Hammer K, Auger Messier M, Bodi I, Chen X, Zhang H, et al. Decreased cardiac L-type Ca²? channel activity induces hypertrophy and heart failure in mice. J Clin Invest. 2012;122:280-90 pubmed publisher..This state results in calcineurin/nuclear factor of activated T cells signaling that promotes hypertrophy and disease. ..
- Aanhaanen W, Boukens B, Sizarov A, Wakker V, de Gier de Vries C, van Ginneken A, et al. Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J Clin Invest. 2011;121:534-44 pubmed publisher..Our results suggest that malformation of the annulus fibrosus and preexcitation arise from the disturbed development of the atrioventricular myocardium. ..
- Tyser R, Miranda A, Chen C, Davidson S, Srinivas S, Riley P. Calcium handling precedes cardiac differentiation to initiate the first heartbeat. elife. 2016;5: pubmed publisher..NCX1 blockade impacted on CaMKII signalling to down-regulate cardiac gene expression, leading to impaired differentiation and failed crescent maturation. ..
- Seol M, Kuner T. Ionotropic glutamate receptor GluA4 and T-type calcium channel Cav 3.1 subunits control key aspects of synaptic transmission at the mouse L5B-POm giant synapse. Eur J Neurosci. 2015;42:3033-44 pubmed publisher..1 expression is essential to establish the driver function of L5B-POm synapses at hyperpolarized membrane potentials. ..
- Karmazinova M, Beyl S, Stary Weinzinger A, Suwattanasophon C, Klugbauer N, Hering S, et al. Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating. Pflugers Arch. 2010;460:1015-28 pubmed publisher..1 gating. We hypothesize that cysteines in the large extracellular loop of Ca(V)3.1 form bridges within the loop and/or neighboring channel segments that are essential for channel gating. ..
- Howitt L, Kuo I, Ellis A, Chaston D, Shin H, Hansen P, et al. Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles. Cardiovasc Res. 2013;98:449-57 pubmed publisher..Our data provide evidence for a novel causal link between nitric oxide deficit, oxidative stress, and T-type calcium channel function. ..
- González Ramírez R, Martínez Hernández E, Sandoval A, Felix R. Transcription factor Sp1 regulates T-type Ca(2+) channel CaV 3.1 gene expression. J Cell Physiol. 2014;229:551-60 pubmed publisher..In mammals, there are three distinct T-channel genes (CACNA1G, CACNA1H, and CACNA1I) encoding proteins (CaV 3.1-CaV 3...
- Le Quang K, Benito B, Naud P, Qi X, Shi Y, Tardif J, et al. T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice. Circ Arrhythm Electrophysiol. 2013;6:799-808 pubmed publisher..Loss of T-type Ca(2+) channels worsens bradycardia-related mortality, increases bradycardia-associated adverse remodeling, and enhances the risk of malignant ventricular tachyarrhythmias complicating AVB. ..
- Choy L, Yeo J, Tse V, Chan S, Tse G. Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models. Int J Cardiol Heart Vasc. 2016;12:1-10 pubmed..Mouse models can serve as useful systems in which to explore how protein defects contribute to arrhythmias and direct future therapy. ..
- Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed publisher..Our data identify a new fast calcium signaling pathway in Purkinje cell dendritic spines triggered by short burst of parallel fiber inputs and mediated by T-type calcium channels and mGluR1s. ..
- Wu S, Jian M, Xu Y, Zhou C, Al Mehdi A, Liedtke W, et al. Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. Am J Physiol Lung Cell Mol Physiol. 2009;297:L650-7 pubmed publisher..We conclude that in alveolar septal capillaries Ca(2+) entry through alpha(1G) and TRPV4 channels differentially and specifically regulates the transition of endothelial procoagulant phenotype and barrier integrity, respectively. ..
- Ernst W, Noebels J. Expanded alternative splice isoform profiling of the mouse Cav3.1/alpha1G T-type calcium channel. BMC Mol Biol. 2009;10:53 pubmed publisher..Transcript scanning of the human CACNA1G gene has revealed the presence of 11 regions within the coding sequence subjected to alternative splicing, some ..
- Calhoun J, Hawkins N, Zachwieja N, Kearney J. Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome. Epilepsia. 2017;58:e111-e115 pubmed publisher..We previously identified Cacna1g, encoding the Cav3...
- Kasten M, Rudy B, Anderson M. Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels. J Physiol. 2007;584:565-82 pubmed
- Son W, Han C, Lee J, Jung K, Lee H, Choo Y. Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice. Dev Growth Differ. 2002;44:181-90 pubmed..On E15, signals were detected throughout all organs of the embryo. These findings indicate that the expression of alpha1H T-type Ca2+ channels is spatio-temporally regulated during spermatogenesis and organogenesis. ..
- Kurejova M, Lacinová L. Effect of protein tyrosine kinase inhibitors on the current through the Ca(V)3.1 channel. Arch Biochem Biophys. 2006;446:20-7 pubmed..This mechanism does not involve a PTK-dependent pathway. The alteration of the channel kinetics by genistein suggests an interaction with the voltage sensor of the channel together with the channel pore occlusion. ..
- Choi S, Yu E, Hwang E, LlinÃ¡s R. Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain. Proc Natl Acad Sci U S A. 2016;113:2270-5 pubmed publisher..1 knockout mice. Our results suggest that the presence of CaV3.1 channels is a key element in the pathophysiology of trigeminal neuropathic pain. ..
- Chevalier M, Gilbert G, Roux E, Lory P, Marthan R, Savineau J, et al. T-type calcium channels are involved in hypoxic pulmonary hypertension. Cardiovasc Res. 2014;103:597-606 pubmed publisher..The present study demonstrates that T-VGCCs contribute to intrapulmonary vascular reactivity and is implicated in the development of hypoxic PH. Specific blockers of T-VGCCs may thus prove useful for the therapeutic management of PH. ..
- Wang H, Zhang X, Xue L, Xing J, Jouvin M, Putney J, et al. Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles. Immunity. 2016;44:782-94 pubmed publisher..1-deficient T cells. These data provide evidence for T-type channels in immune cells and their potential role in shaping the autoimmune response. ..
- Ly R, Bouvier G, Schonewille M, Arabo A, Rondi Reig L, Léna C, et al. T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning. Proc Natl Acad Sci U S A. 2013;110:20302-7 pubmed publisher..These data identify a role of low-voltage activated calcium channels in synaptic plasticity and establish a role for CaV3.1 channels in cerebellar learning. ..
- Wang F, Gao H, Kubo H, Fan X, Zhang H, Berretta R, et al. T-type Ca²? channels regulate the exit of cardiac myocytes from the cell cycle after birth. J Mol Cell Cardiol. 2013;62:122-30 pubmed publisher..These results suggest that TTCCs are involved in the regulation of myocyte size and the exit of myocytes from the cell cycle during the first week after birth. ..
- Leslie E, Liu J, Klaassen C, Waalkes M. Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake. Mol Pharmacol. 2006;69:629-39 pubmed..Consistent with this was an intermediate expression of Cacnalpha(1G) in the CdR-rev cell line. These data suggest that decreased expression of Cacnalpha(1G) protects cells from Cd(2+) exposure by limiting Cd(2+) uptake. ..
- Wang L, Yin J, Nickles H, Ranke H, Tabuchi A, Hoffmann J, et al. Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. J Clin Invest. 2012;122:4218-30 pubmed publisher..Based on these data, we propose that HPV originates at the alveolocapillary level, from which the hypoxic signal is propagated as endothelial membrane depolarization to upstream arterioles in a Cx40-dependent manner. ..
- Tzeng B, Chen Y, Huang C, Lin S, Lee K, Chen C. The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res. 2012;96:533-42 pubmed publisher..Ca(v)3.1 is required for VSMC proliferation during neointimal formation, and blocking of Ca(v)3.1 may be beneficial for preventing restenosis. ..
- Nie L, Zhu J, Gratton M, Liao A, Mu K, Nonner W, et al. Molecular identity and functional properties of a novel T-type Ca2+ channel cloned from the sensory epithelia of the mouse inner ear. J Neurophysiol. 2008;100:2287-99 pubmed publisher..The differential expression of the channel during development and the pharmacology of the inner ear Cav3.1 channel may have contributed to the difficulties associated with identification of the non-Cav1.3 currents. ..
- Chen W, Liu I, Chang Y, Chen Y, Chen C, Yen C, et al. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci. 2010;30:10360-8 pubmed publisher..Our findings suggest that Ca(v)3.2 T-channel-dependent activation of ERK in PVA is required for the development of acid-induced chronic mechanical hyperalgesia. ..
- Björling K, Morita H, Olsen M, Prodan A, Hansen P, Lory P, et al. Myogenic tone is impaired at low arterial pressure in mice deficient in the low-voltage-activated CaV 3.1 T-type Ca(2+) channel. Acta Physiol (Oxf). 2013;207:709-20 pubmed publisher..Finally, we caution against using NNC 55-0396 as a specific T-type channel blocker in native cells expressing high-voltage-activated Ca(2+) channels. ..
- Nakamura T, Jeromin A, Mikoshiba K, Wakabayashi S. Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011;109:512-23 pubmed publisher..NCS-1 is an important regulator of immature heart function and hypertrophy, and it functions in part by promoting IP(3)R function, followed by CaMKII-dependent signal activation. ..
- Lee J, Song K, Lee K, Hong J, Lee H, Chae S, et al. Sleep spindles are generated in the absence of T-type calcium channel-mediated low-threshold burst firing of thalamocortical neurons. Proc Natl Acad Sci U S A. 2013;110:20266-71 pubmed publisher..Our findings call into question the essential role of low-threshold burst firings in TC neurons and suggest that tonic firing is important for the generation and propagation of spindle oscillations in the TC circuit. ..
- Choi S, Yu E, Kim D, Urbano F, Makarenko V, Shin H, et al. Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q- and T-type calcium channels: a study in mutant mice. J Physiol. 2010;588:3031-43 pubmed publisher..These findings were supported by results from a mathematical IO neuronal model that incorporated T and P/Q channel kinetics. ..
- Anderson M, Mochizuki T, Xie J, Fischler W, Manger J, Talley E, et al. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A. 2005;102:1743-8 pubmed..1 was deleted from cortical pyramidal neurons. These findings support the hypothesis that thalamic T-type Ca2+ channels are required to block transmission of arousal signals through the thalamus and to stabilize sleep. ..
- Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N. Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice. J Biol Chem. 2003;278:40837-41 pubmed..2 (-/-) cardiomyocytes. In summary, our results imply that calcium channel expression is dynamically regulated during heart development and that the Cav1.3 channel may substitute for Cav1.2 during early embryogenesis. ..
- Porter G, Makuck R, Rivkees S. Intracellular calcium plays an essential role in cardiac development. Dev Dyn. 2003;227:280-90 pubmed..These data demonstrate that proper intracellular calcium signaling is essential for normal cardiac looping, gene expression, and organ development. ..
- Lin S, Tzeng B, Lee K, Smith R, Campbell K, Chen C. Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014;111:E1990-8 pubmed publisher..Our findings define a previously unidentified mechanism that Ca(2+) influx via the Cav3.2 T-type Ca(2+) channel regulates Sox9 expression through the calcineurin/NFAT signaling pathway during tracheal chondrogenesis. ..
- Markandeya Y, Fahey J, Pluteanu F, Cribbs L, Balijepalli R. Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels. J Biol Chem. 2011;286:2433-44 pubmed publisher..Our findings on functional modulation of the Ca(v)3.2 channels by Cav-3 is important for understanding the compartmentalized regulation of Ca(2+) signaling during normal and pathological processes. ..
- Ha S, Lee M, Kurahashi M, Wei L, Jorgensen B, Park C, et al. Transcriptome analysis of PDGFRÎ±+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRÎ±+ cell hyperplasia. PLoS ONE. 2017;12:e0182265 pubmed publisher..We demonstrated that the low voltage-dependent T-type Ca2+ channel Cacna1g gene was particularly expressed in PDGFRÎ±+ cells in the intestinal serosal layer in mice...
- Gilbert G, Courtois A, Dubois M, Cussac L, Ducret T, Lory P, et al. T-type voltage gated calcium channels are involved in endothelium-dependent relaxation of mice pulmonary artery. Biochem Pharmacol. 2017;138:61-72 pubmed publisher..The present study thus demonstrates that T-VGCCs, mainly Cav3.1 channel, contribute to intrapulmonary vascular reactivity in mice by controlling endothelial [Ca2+]i and ACh-mediated relaxation. ..
- Bayazitov I, Westmoreland J, Zakharenko S. Forward suppression in the auditory cortex is caused by the Ca(v)3.1 calcium channel-mediated switch from bursting to tonic firing at thalamocortical projections. J Neurosci. 2013;33:18940-50 pubmed publisher..These data suggest that Ca(v)3.1-dependent synaptic depression at TC projections contributes to mechanisms of forward suppression in the ACx. ..
- Park C, Kim J, Yoon B, Choi E, Lee C, Shin H. T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray. Proc Natl Acad Sci U S A. 2010;107:14857-62 pubmed publisher..These results indicate that alpha1G T-type channels are critical for the opioidergic descending analgesia system in the PAG. ..
- Uebele V, Gotter A, Nuss C, Kraus R, Doran S, Garson S, et al. Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice. J Clin Invest. 2009;119:1659-67 pubmed publisher..Together, these studies reveal what we believe to be a previously unknown role for T-type calcium channels in the regulation of sleep and weight maintenance and suggest the potential for a novel therapeutic approach to treating obesity. ..
- Thuesen A, Andersen H, Cardel M, Toft A, Walter S, Marcussen N, et al. Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo. Am J Physiol Renal Physiol. 2014;307:F445-52 pubmed publisher..1 channels in vivo contribute to renal vascular resistance. It is suggested that endothelial and nerve localization of Cav3.2 and Cav3.1, respectively, may account for the observed effects. ..
- Calhoun J, Hawkins N, Zachwieja N, Kearney J. Cacna1g is a genetic modifier of epilepsy caused by mutation of voltage-gated sodium channel Scn2a. Epilepsia. 2016;57:e103-7 pubmed publisher..Genetic mapping and RNA-Seq analysis identified Cacna1g as a candidate modifier gene at the Moe1 locus, which influences Scn2a(Q54) phenotype severity...
- Gangadharan G, Shin J, Kim S, Kim A, Paydar A, Kim D, et al. Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm. Proc Natl Acad Sci U S A. 2016;113:6550-5 pubmed publisher..These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca(2+) channels in the medial septal GABAergic projection neurons in this behavior. ..
- Perez Reyes E, Cribbs L, Daud A, Lacerda A, Barclay J, Williamson M, et al. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature. 1998;391:896-900 pubmed..Based on the channel's distinctive voltage dependence, slow deactivation kinetics, and 7.5-pS single-channel conductance, we conclude that this channel is a low-voltage-activated T-type calcium channel. ..
- Park Y, Park H, Lee C, Choi S, Jo S, Choi H, et al. Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive. Proc Natl Acad Sci U S A. 2010;107:10731-6 pubmed publisher..Thus, Ca(V)3.1 is a molecular pacemaker substrate for intrinsic neuronal oscillations of inferior olive neurons, and the potentiation of this mechanism can be considered as a pathological cause of essential tremor. ..
- Petrenko A, Tsujita M, Kohno T, Sakimura K, Baba H. Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology. 2007;106:1177-85 pubmed..However, the timely induction of anesthesia/hypnosis by volatile anesthetic agents and some intravenous anesthetic agents may require the normal functioning of these channel subunits. ..
- Kim J, Kim Y, Nakajima R, Shin A, Jeong M, Park A, et al. Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus. Neuron. 2017;95:1181-1196.e8 pubmed publisher..Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities. VIDEO ABSTRACT. ..