C5ar1

Summary

Gene Symbol: C5ar1
Description: complement component 5a receptor 1
Alias: C5aR, C5r1, Cd88, D7Msu1, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5a ligand, C5a-R, complement component 5, receptor 1
Species: mouse
Products:     C5ar1

Top Publications

  1. Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade M, et al. C5L2, a nonsignaling C5A binding protein. Biochemistry. 2003;42:9406-15 pubmed
    ..Unlike the previously described C5aR, C5L2 is obligately uncoupled from heterotrimeric G proteins, in part by virtue of an amino acid alteration in the ..
  2. Kim A, Dimitriou I, Holland M, Mastellos D, Mueller Y, Altman J, et al. Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses. J Immunol. 2004;173:2524-9 pubmed
    ..We examined the CD8(+) T cell response in influenza type A virus-infected mice treated with a peptide antagonist to C5aR to test the potential role of complement components in CD8(+) T cell responses...
  3. Hawlisch H, Belkaid Y, Baelder R, Hildeman D, Gerard C, Köhl J. C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity. 2005;22:415-26 pubmed
    ..Our findings identify the negative impact of C5a on IL-12 family cytokines as an important mechanism for regulating Th1 polarization in response to innate and adaptive immune network activation. ..
  4. Hollmann T, Mueller Ortiz S, Braun M, Wetsel R. Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol. 2008;45:1907-15 pubmed
    ..C5a mediates potent, proinflammatory activities by binding to the C5a receptor (C5aR, CD88)...
  5. Sun L, Guo R, Gao H, Sarma J, Zetoune F, Ward P. Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells. FASEB J. 2009;23:3808-18 pubmed publisher
    ..leukocytes (PMNs)] in the alveolar compartment, these changes being complement (C5a) and C5a receptor (C5aR) dependent...
  6. Gerard C, Bao L, Orozco O, Pearson M, Kunz D, Gerard N. Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992;149:2600-6 pubmed
    ..Additionally, these data provide a reagent for immunologic and molecular genetic studies on the role of C5a receptors in inflammatory models. ..
  7. Looney M, Su X, Van Ziffle J, Lowell C, Matthay M. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006;116:1615-23 pubmed
    ..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors. ..
  8. Riedemann N, Guo R, Neff T, Laudes I, Keller K, Sarma V, et al. Increased C5a receptor expression in sepsis. J Clin Invest. 2002;110:101-8 pubmed
    ..Little is known about the role of the C5a receptor (C5aR) and its presence in different organs during sepsis...
  9. Kumar V, Ali S, Konrad S, Zwirner J, Verbeek J, Schmidt R, et al. Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. J Clin Invest. 2006;116:512-20 pubmed
    ..In contrast, up until now, no specific contribution of C5a and its receptor, C5aR, was recognized in diseases of antibody-dependent type II autoimmunity...

More Information

Publications81

  1. Patel S, Berghout J, Lovegrove F, Ayi K, Conroy A, Serghides L, et al. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med. 2008;205:1133-43 pubmed publisher
    ..D2 mice were susceptible. Antibody blockade of C5a or C5a receptor (C5aR) rescued susceptible mice from CM...
  2. Rittirsch D, Flierl M, Nadeau B, Day D, Huber Lang M, Mackay C, et al. Functional roles for C5a receptors in sepsis. Nat Med. 2008;14:551-7 pubmed publisher
    The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77), especially of C5l2, which was originally termed a 'default receptor', remains a controversial topic...
  3. Konrad S, Ali S, Wiege K, Syed S, Engling L, Piekorz R, et al. Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation. J Biol Chem. 2008;283:33296-303 pubmed publisher
    Fcgamma receptors (FcgammaR) and the C5a receptor (C5aR) are key effectors of the acute inflammatory response to IgG immune complexes (IC)...
  4. Zhang X, Lewkowich I, Köhl G, Clark J, Wills Karp M, Köhl J. A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol. 2009;182:5123-30 pubmed publisher
    ..C5a receptor (C5aR)-targeting of C3aR-deficient mice during allergen sensitization not only reversed the protective effect but ..
  5. Fang C, Zhang X, Miwa T, Song W. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood. 2009;114:1005-15 pubmed publisher
    ..Collectively, these data establish a link between complement/TLR interaction and Th17-cell differentiation and provide new insight into the mechanism of action of complement in autoimmunity. ..
  6. Shagdarsuren E, Bidzhekov K, Mause S, Simsekyilmaz S, Polakowski T, Hawlisch H, et al. C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice. Circulation. 2010;122:1026-36 pubmed publisher
    ..In the present study, we examined the contribution of the C5a receptor (C5aR) to neointima formation in apolipoprotein E-deficient mice employing a C5aR antagonist (C5aRA) and a C5aR-blocking ..
  7. Bao L, Wang Y, Haas M, Quigg R. Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. Kidney Int. 2011;80:524-34 pubmed publisher
    ..Thus, blockade of C3a receptor signaling is a possible treatment to reduce renal inflammation and preserve renal function associated with complement activation. ..
  8. Pavlovski D, Thundyil J, Monk P, Wetsel R, Taylor S, Woodruff T. Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. FASEB J. 2012;26:3680-90 pubmed publisher
    ..mouse cortical neurons constitutively express C5, the precursor of C5a, and express the classical receptor for C5a, CD88. With cell ischemia caused by 12 h glucose deprivation, or oxygen-glucose deprivation (OGD), neurons demonstrated ..
  9. Nakayama Y, Kim S, Kim E, Lambris J, Sandor M, Suresh M. C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection. J Immunol. 2009;183:2921-31 pubmed publisher
    ..These studies have furthered our understanding of C3-mediated regulation of T cell immunity to intracellular pathogens. ..
  10. Peng Q, Li K, Wang N, Li Q, Asgari E, Lu B, et al. Dendritic cell function in allostimulation is modulated by C5aR signaling. J Immunol. 2009;183:6058-68 pubmed publisher
    ..this study, the direct modulation of dendritic cell (DC) activation and its function in T cell stimulation by C5a-C5aR interaction and the involved signaling pathways were investigated...
  11. Schreiber A, Xiao H, Jennette J, Schneider W, Luft F, Kettritz R. C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis. J Am Soc Nephrol. 2009;20:289-98 pubmed publisher
    ..tested the hypothesis that the anaphylatoxin C5a is pivotal to disease induction via the neutrophil C5a receptor (C5aR). Supernatants from ANCA-activated neutrophils activated the complement cascade in normal serum, producing C5a...
  12. Manthey H, Thomas A, Shiels I, Zernecke A, Woodruff T, Rolfe B, et al. Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. FASEB J. 2011;25:2447-55 pubmed publisher
    The complement C5a receptor, CD88, is present on many of the cells found within human atherosclerotic plaques, but little is known about the role of C5a in atherogenesis...
  13. Liu J, Lin F, Strainic M, An F, Miller R, Altuntas C, et al. IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol. 2008;180:5882-9 pubmed
    ..autoimmune encephalomyelitis depends on interactions of locally produced C3a/C5a with APC and T cell C3aR/C5aR. In the absence of the cell surface C3/C5 convertase inhibitor decay-accelerating factor (DAF), but not the ..
  14. Höpken U, Lu B, Gerard N, Gerard C. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature. 1996;383:86-9 pubmed
    ..We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung. ..
  15. Clynes R, Maizes J, Guinamard R, Ono M, Takai T, Ravetch J. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med. 1999;189:179-85 pubmed
    ..Exploiting the FcgammaRII inhibitory pathway could thus provide a new therapeutic approach for modulating antibody-triggered inflammation. ..
  16. Köhl J, Baelder R, Lewkowich I, Pandey M, Hawlisch H, Wang L, et al. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest. 2006;116:783-96 pubmed
    ..Here we report that local pharmacological targeting of the C5a receptor (C5aR) prior to initial allergen sensitization in murine models of inhalation tolerance or allergic asthma resulted in ..
  17. Markiewski M, DeAngelis R, Strey C, Foukas P, Gerard C, Gerard N, et al. The regulation of liver cell survival by complement. J Immunol. 2009;182:5412-8 pubmed publisher
    ..In conclusion, this study documents functions of complement proteins as prosurvival factors that, through their interactions with cytokines, inhibit apoptotic signaling in proliferating cells of epithelial origin. ..
  18. Höpken U, Lu B, Gerard N, Gerard C. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med. 1997;186:749-56 pubmed
    We recently demonstrated that gene-targeted disruption of the C5a anaphylatoxin receptor prevented lung injury in immune complex-mediated inflammation...
  19. Welch T, Frenzke M, Witte D, Davis A. C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. Clin Exp Immunol. 2002;130:43-8 pubmed
    ..In addition to wild-type C57/B6 mice, animals in which the C5a receptor had been deleted (C5aR KO) were used. Animals were killed after 3 or 6 weeks, and kidneys harvested...
  20. Bozic C, Lu B, Höpken U, Gerard C, Gerard N. Neurogenic amplification of immune complex inflammation. Science. 1996;273:1722-5 pubmed
    ..the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil ..
  21. Li R, Coulthard L, Wu M, Taylor S, Woodruff T. C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB J. 2013;27:855-64 pubmed publisher
    ..complement cascade, and has been previously thought to act only through a single, G-protein-coupled, C5a receptor (C5aR; also termed CD88)...
  22. Lalli P, Strainic M, Yang M, Lin F, Medof M, Heeger P. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood. 2008;112:1759-66 pubmed publisher
    ..These effects were traced to locally produced C5a, which through binding to T cell-expressed C5aR, enhanced expression of Bcl-2 and prevented Fas up-regulation...
  23. Skokowa J, Ali S, Felda O, Kumar V, Konrad S, Shushakova N, et al. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol. 2005;174:3041-50 pubmed
    ..Blockade of C5aR completely reversed such changes...
  24. Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris J, et al. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. 2007;110:228-36 pubmed
    ..effect of complement on TLR-induced cytokine production in vivo was mediated by the anaphylatoxin receptors C5aR and C3aR...
  25. Strainic M, Liu J, Huang D, An F, Lalli P, Muqim N, et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity. 2008;28:425-35 pubmed publisher
    ..that locally produced C5a and C3a anaphylatoxins interacting with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signaling are integrally involved in T ..
  26. Mehlhop E, Diamond M. Protective immune responses against West Nile virus are primed by distinct complement activation pathways. J Exp Med. 2006;203:1371-81 pubmed
    ..Our results suggest that individual pathways of complement activation control WNV infection by priming adaptive immune responses through distinct mechanisms. ..
  27. Vieyra M, Leisman S, Raedler H, Kwan W, Yang M, Strainic M, et al. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am J Pathol. 2011;179:766-74 pubmed publisher
    ..CD8(+) T cells lacking C3a receptor (C3aR) and C5a receptor (C5aR) proliferate weakly to allogeneic DCs despite CD4 help, indicating that CD4-cell help is mediated, in part, through ..
  28. Drouin S, Kildsgaard J, Haviland J, Zabner J, Jia H, McCray P, et al. Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J Immunol. 2001;166:2025-32 pubmed
    ..C3a and C5a mediate these effects by binding to their specific receptors, C3aR and C5aR, respectively...
  29. Mueller Ortiz S, Wang D, Morales J, Li L, Chang J, Wetsel R. Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock. J Immunol. 2009;182:6533-9 pubmed publisher
    ..This hypersensitivity was completely resolved in CPN1(-/-)/C5aR(-/-) but not in CPN1(-/-)/C3aR(-/-) mice. Moreover, CPN1(-/-) mice given C5a i.v...
  30. Heyl K, Karsten C, Slevogt H. Galectin-3 binds highly galactosylated IgG1 and is crucial for the IgG1 complex mediated inhibition of C5aReceptor induced immune responses. Biochem Biophys Res Commun. 2016;479:86-90 pubmed publisher
    ..this sense it has been shown that highly galactosylated but not agalactosylated IgG1 immune complexes (ICs) inhibit C5aR-mediated pro-inflammatory immune responses via the assembly of Fc?RIIB-Dectin-1 receptor complexes...
  31. Johswich K, Martin M, Bleich A, Kracht M, Dittrich Breiholz O, Gessner J, et al. Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1812-23 pubmed publisher
    ..and chronic dextran sulfate-induced colitis were used to further elucidate the impact of C5a and its receptor (C5aR) on disease development...
  32. Xu D, Zaets S, Chen R, Lu Q, Rajan H, Yang X, et al. Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs. Shock. 2009;31:493-9 pubmed publisher
    ..To further understand the role of C5a receptor (C5aR) pathway in ischemia/reperfusion (I/R) injury, and to evaluate the potential of antagonizing C5aR to protect from I/..
  33. Oikonomopoulou K, DeAngelis R, Chen H, Diamandis E, Hollenberg M, Ricklin D, et al. Induction of complement C3a receptor responses by kallikrein-related peptidase 14. J Immunol. 2013;191:3858-66 pubmed publisher
  34. Shubitowski D, Wills Karp M, Ewart S. The complement factor 5a receptor gene maps to murine chromosome 7. Cytogenet Genome Res. 2002;97:133-5 pubmed
    ..We had an interest in C5a and its receptor, C5r1, because we previously identified C5a as a positional candidate gene for the quantitative trait locus Abhr2, which ..
  35. Bogestål Y, Barnum S, Smith P, Mattisson V, Pekny M, Pekna M. Signaling through C5aR is not involved in basal neurogenesis. J Neurosci Res. 2007;85:2892-7 pubmed
    ..In the present study, we assessed basal neurogenesis in mice lacking C5a receptor (C5aR(-/-)) and mice expressing C3a and C5a, respectively in the CNS under the control of glial fibrillary acidic protein ..
  36. Sakuma M, Morooka T, Wang Y, Shi C, Croce K, Gao H, et al. The intrinsic complement regulator decay-accelerating factor modulates the biological response to vascular injury. Arterioscler Thromb Vasc Biol. 2010;30:1196-202 pubmed publisher
    ..Targeting the C3a and C5a receptors may be useful for the prevention of neointimal hyperplasia. ..
  37. Veninga H, Hoek R, de Vos A, de Bruin A, An F, van der Poll T, et al. A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. PLoS ONE. 2011;6:e24431 pubmed publisher
    ..Collectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense. ..
  38. Redecha P, Tilley R, Tencati M, Salmon J, Kirchhofer D, Mackman N, et al. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood. 2007;110:2423-31 pubmed
    ..The identification of TF as an important mediator of C5a-induced oxidative burst in neutrophils in aPL-induced fetal injury provides a new target for therapy to prevent pregnancy loss in the antiphospholipid syndrome. ..
  39. Nomaru H, Sakumi K, Katogi A, Ohnishi Y, Kajitani K, Tsuchimoto D, et al. Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia. 2014;62:1284-98 pubmed publisher
    ..Of these genes, we focused on C5ar1 and C5ar2, which encode receptors for complement C5a...
  40. Grumelli S, Lu B, Peterson L, Maeno T, Gerard C. CD46 protects against chronic obstructive pulmonary disease. PLoS ONE. 2011;6:e18785 pubmed publisher
  41. Phieler J, Chung K, Chatzigeorgiou A, Klotzsche von Ameln A, Garcia Martin R, Sprott D, et al. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol. 2013;191:4367-74 pubmed publisher
    ..The complement anaphylatoxin C5a receptor (C5aR) has been implicated in inflammatory processes and as regulator of macrophage activation and polarization...
  42. Heimbach L, Li Z, Berkowitz P, Zhao M, Li N, Rubenstein D, et al. The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid. J Biol Chem. 2011;286:15003-9 pubmed publisher
    ..We found that mice deficient in MCs or the C5a receptor (C5aR) injected with pathogenic anti-BP180 IgG failed to develop subepidermal blisters and exhibited a drastic reduction ..
  43. Lee H, Wu W, Wysoczynski M, Liu R, Zuba Surma E, Kucia M, et al. Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes. Leukemia. 2009;23:2052-62 pubmed publisher
    ..Therefore, in this study, we focused on the mobilization-enhancing role of C5a. We found that C5a receptor (C5aR) is not expressed on the surface of HSPCs, and that C5a-mediated promobilization effects are mediated by ..
  44. Alexander J, Chaves L, Chang A, Quigg R. The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int. 2012;82:961-8 pubmed publisher
    ..The exaggerated humoral immune response in CFH(-/-) mice was normalized in CFH(-/-)C5aR(-/-) double knockout mice, highlighting the C5aR dependence...
  45. McDonald C, Cahill L, Ho K, Yang J, Kim H, Silver K, et al. Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway. PLoS Pathog. 2015;11:e1005140 pubmed publisher
    ..levels, to test the hypothesis that in utero exposure to malaria alters neurodevelopment through a C5a-C5aR dependent pathway...
  46. Atefi G, Zetoune F, Herron T, JALIFE J, Bosmann M, Al Aref R, et al. Complement dependency of cardiomyocyte release of mediators during sepsis. FASEB J. 2011;25:2500-8 pubmed publisher
    ..Cardiomyocytes from septic mice (C57Bl/6) showed increased mRNA for TNFR1, IL-6 (gp80), and C5aR at 6 h after sepsis...
  47. Ramos T, Wohler J, Barnum S. Deletion of both the C3a and C5a receptors fails to protect against experimental autoimmune encephalomyelitis. Neurosci Lett. 2009;467:234-6 pubmed publisher
    ..We performed EAE in C3aR/C5aR double knockout mice (C3aR/C5aR(-/-)) and observed delayed onset of disease but no attenuation of disease severity ..
  48. Sun D, Zhang M, Liu G, Wu H, Zhu X, Zhou H, et al. Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling. Infect Immun. 2016;84:216-29 pubmed publisher
    ..Neutrophils were directly seen to chase C. neoformans cells and then rapidly internalize them. Complement C5a-C5aR signaling guided neutrophils to migrate to the yeast cells, resulting in optimal phagocytosis and subsequent ..
  49. Lajoie S, Lewkowich I, Suzuki Y, Clark J, Sproles A, Dienger K, et al. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol. 2010;11:928-35 pubmed publisher
    ..production of anaphylatoxins, as mouse strains deficient in complement factor 5 (C5) or the complement receptor C5aR mounted robust IL-17A responses, whereas mice deficient in C3aR had fewer IL-17-producing helper T cells (T(H)17 ..
  50. Chehoud C, Rafail S, Tyldsley A, Seykora J, Lambris J, Grice E. Complement modulates the cutaneous microbiome and inflammatory milieu. Proc Natl Acad Sci U S A. 2013;110:15061-6 pubmed publisher
    ..Inhibiting signaling of the complement component C5a receptor (C5aR) altered the composition and diversity of the skin microbiota as revealed by deep sequencing of the bacterial 16S ..
  51. van der Touw W, Cravedi P, Kwan W, Paz Artal E, Merad M, Heeger P. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol. 2013;190:5921-5 pubmed publisher
    ..Building upon our previous observations that T cell-expressed receptors for C3a (C3aR) and C5a (C5aR) drive Th1 maturation, we tested the impact of C3aR/C5aR signaling on induction and stability of alloreactive iTreg...
  52. Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, et al. Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. PLoS ONE. 2017;12:e0179512 pubmed publisher
    The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts...
  53. Nozaki M, Raisler B, Sakurai E, Sarma J, Barnum S, Lambris J, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A. 2006;103:2328-33 pubmed
    ..Collectively, these findings establish a mechanistic basis for the clinical observation that drusen predispose to CNV, revealing a role for immunological phenomena in angiogenesis and providing therapeutic targets for AMD...
  54. Kelly M, McNagny K, Williams D, Van Rooijen N, Maxwell L, Gwozd C, et al. The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1. Am J Respir Cell Mol Biol. 2008;38:227-38 pubmed
    ..Depletion of alveolar macrophages did not affect the response to zymosan. Neither complement, macrophages, nor TLR2, TLR4, MyD88, and/or dectin-1 receptors were involved in the pulmonary in vivo inflammatory response to zymosan. ..
  55. Brennan F, Gordon R, Lao H, Biggins P, Taylor S, Franklin R, et al. The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury. J Neurosci. 2015;35:6517-31 pubmed publisher
    ..b>C5ar(-/-) mice, which lack the signaling receptor for C5a, displayed signs of improved locomotor recovery and reduced ..
  56. Soruri A, Kim S, Kiafard Z, Zwirner J. Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody. Immunol Lett. 2003;88:47-52 pubmed
    ..Expression of its receptor C5aR (CD88) has been detected on cells of myeloid origin such as granulocytes and monocytes/macrophages...
  57. Bode J, Dutow P, Sommer K, Janik K, Glage S, Tummler B, et al. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS ONE. 2012;7:e50327 pubmed publisher
    ..This study demonstrates for the first time a strong and complex influence of complement effector functions, downstream of C3 and upstream of C5, on the outcome of an infection with intracellular bacteria, such as C. psittaci. ..
  58. Banda N, Hyatt S, Antonioli A, White J, Glogowska M, Takahashi K, et al. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J Immunol. 2012;188:1469-78 pubmed publisher
    ..Clinical disease activity in C3aR(-/-), C5aR(-/-), and C6-deficient (C6-def) mice was decreased by 52, 94, and 65%, respectively, as compared with wild-type ..
  59. Denny K, Coulthard L, Jeanes A, Lisgo S, Simmons D, Callaway L, et al. C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. J Immunol. 2013;190:3493-9 pubmed publisher
    ..C5aR was also found to be expressed in the neuroepithelium of early human embryos. Ablation of the C5ar1 gene or the administration of a specific C5aR peptide antagonist to folic acid-deficient pregnant mice resulted in ..
  60. Hsu W, Yang F, Lin C, Hsieh S, Chen N. C5L2 is required for C5a-triggered receptor internalization and ERK signaling. Cell Signal. 2014;26:1409-19 pubmed publisher
    ..Here we show that, like the canonical C5a receptor C5aR, C5L2 plays a pro-inflammatory role in a murine model of acute experimental colitis...
  61. Binstadt B, Patel P, Alencar H, Nigrovic P, Lee D, Mahmood U, et al. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol. 2006;7:284-92 pubmed
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders. ..
  62. Corrales L, Ajona D, Rafail S, Lasarte J, Riezu Boj J, Lambris J, et al. Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression. J Immunol. 2012;189:4674-83 pubmed publisher
    ..In conclusion, lung cancer cells have the capacity to generate C5a, a molecule that creates a favorable tumor microenvironment for lung cancer progression. ..
  63. Ramos T, Darley M, Hu X, Billker O, Rayner J, Ahras M, et al. Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria. J Immunol. 2011;186:6657-60 pubmed publisher
    ..Surprisingly, we observed that C5aR(-/-) mice were fully susceptible to disease, indicating that C5a is not required for ECM...
  64. Gorelik A, Sapir T, Haffner Krausz R, Olender T, Woodruff T, Reiner O. Developmental activities of the complement pathway in migrating neurons. Nat Commun. 2017;8:15096 pubmed publisher
    ..Pharmacological activation of the downstream receptors rescue Masp2 and C3 knockdown as well as C3 knockout. Therefore, we propose that the complement pathway is functionally important in migrating neurons of the developing cortex. ..
  65. Sadik C, Kim N, Iwakura Y, Luster A. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc?R signaling. Proc Natl Acad Sci U S A. 2012;109:E3177-85 pubmed publisher
    ..Previous investigations showed that this model of autoantibody-induced arthritis requires the C5a receptor C5aR and Fc?Rs, but the simultaneous necessity for both pathways was not understood...
  66. Surace L, Lysenko V, Fontana A, Cecconi V, Janssen H, Bicvic A, et al. Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response. Immunity. 2015;42:767-77 pubmed publisher
    ..Overall, our findings indicate that anaphylatoxins are key players in radiotherapy-induced tumor-specific immunity and the ensuing clinical responses. ..
  67. Schmitz V, Almeida L, Svensjo E, Monteiro A, Köhl J, Scharfstein J. C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection. J Immunol. 2014;193:3613-23 pubmed publisher
    ..In this study, we show that pharmacological targeting of the C5a receptor (C5aR) or the bradykinin B2 receptor (B2R) inhibited plasma leakage in hamster cheek pouch topically exposed to tissue ..
  68. Tong H, Lambert G, Li Y, Thurman J, Stahl G, Douthitt K, et al. Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. PLoS ONE. 2014;9:e95160 pubmed publisher
    ..In contrast, mice deficient in the complement C5a receptor (C5aR) demonstrated enhanced bacterial clearance and reduced severity of OM...
  69. Zheng X, Zhang X, Feng B, Sun H, Suzuki M, Ichim T, et al. Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury. Am J Pathol. 2008;173:973-80 pubmed publisher
    ..Here, we report a novel therapy for kidney I/R injury through silencing of the C5a receptor (C5aR) gene using siRNA. Mice were injected with 50 microg of C5aR siRNA 2 days before induction of ischemia...
  70. Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner K, Otterbein L, et al. Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling. Biochem Biophys Res Commun. 2014;449:94-9 pubmed publisher
    ..Among them, the complement receptor 5a (C5aR) plays an integral role in the development of inflammatory disorders...
  71. Khor K, Moore T, Shiels I, Greer R, Arumugam T, Mills P. A Potential Link between the C5a Receptor 1 and the β1-Adrenoreceptor in the Mouse Heart. PLoS ONE. 2016;11:e0146022 pubmed publisher
    ..We investigated the role of the complement 5a receptor 1 (C5aR1/CD88) in the cardiac response to inflammation or atenolol, and the effect of C5aR1 deletion in control of baseline ..
  72. Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos R, et al. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma. Immunology. 2004;113:234-45 pubmed