C3ar1

Summary

Gene Symbol: C3ar1
Description: complement component 3a receptor 1
Alias: AZ3B, C3AR, HNFAG09, C3a anaphylatoxin chemotactic receptor, C3a-R, anaphylatoxin C3a receptor
Species: mouse
Products:     C3ar1

Top Publications

  1. Schadt E, Lamb J, Yang X, Zhu J, Edwards S, GuhaThakurta D, et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet. 2005;37:710-7 pubmed
    ..We also demonstrate the utility of this approach by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity. ..
  2. Fang C, Zhang X, Miwa T, Song W. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood. 2009;114:1005-15 pubmed publisher
    ..Collectively, these data establish a link between complement/TLR interaction and Th17-cell differentiation and provide new insight into the mechanism of action of complement in autoimmunity. ..
  3. Drouin S, Corry D, Hollman T, Kildsgaard J, Wetsel R. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J Immunol. 2002;169:5926-33 pubmed
    ..we assessed the role of the complement anaphylatoxin C3a in a mouse model of pulmonary allergy by challenging C3aR-deficient mice intranasally with a mixed Ag preparation of Aspergillus fumigatus cell culture filtrate and OVA...
  4. Strainic M, Shevach E, An F, Lin F, Medof M. Absence of signaling into CD4? cells via C3aR and C5aR enables autoinductive TGF-?1 signaling and induction of Foxp3? regulatory T cells. Nat Immunol. 2013;14:162-71 pubmed publisher
    Signaling through the G protein-coupled receptors for the complement fragments C3a and C5a (C3aR and C5aR, respectively) by dendritic cells and CD4(+) cells provides costimulatory and survival signals to effector T cells...
  5. Peng Q, Li K, Anderson K, Farrar C, Lu B, Smith R, et al. Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood. 2008;111:2452-61 pubmed
    ..To clarify the mechanism for enhancement of the immune response, we have explored the role of C3a receptor (C3aR)-ligand interaction on murine bone marrow dendritic cells (DCs)...
  6. Liu J, Lin F, Strainic M, An F, Miller R, Altuntas C, et al. IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol. 2008;180:5882-9 pubmed
    ..experimental autoimmune encephalomyelitis depends on interactions of locally produced C3a/C5a with APC and T cell C3aR/C5aR...
  7. Mizutani N, Nabe T, Yoshino S. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J Immunol. 2009;183:4039-46 pubmed publisher
    ..The mechanism leading to the development of these symptoms may correlate with the recruitment of neutrophils and/or the production of IL-1beta induced by C3a. ..
  8. Kwan W, Hashimoto D, Paz Artal E, Ostrow K, Greter M, Raedler H, et al. Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest. 2012;122:2234-8 pubmed publisher
    ..T cells deficient in C3a receptor (C3aR) and/or C5a receptor (C5aR) responded weakly in allogeneic hosts and exhibited limited ability to induce GvHD...
  9. Drouin S, Kildsgaard J, Haviland J, Zabner J, Jia H, McCray P, et al. Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J Immunol. 2001;166:2025-32 pubmed
    ..C3a and C5a mediate these effects by binding to their specific receptors, C3aR and C5aR, respectively...

More Information

Publications81

  1. Zhang X, Lewkowich I, Köhl G, Clark J, Wills Karp M, Köhl J. A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol. 2009;182:5123-30 pubmed publisher
    ..In this study, we show that C3a receptor (C3aR)-deficient mice are protected from the development of Th2 immunity in a model of house dust mite-induced asthma...
  2. Ratajczak J, Reca R, Kucia M, Majka M, Allendorf D, Baran J, et al. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood. 2004;103:2071-8 pubmed
    ..induced with granulocyte colony-stimulating factor (G-CSF) in both C3-deficient (C3-/-) and C3a receptor-deficient (C3aR-/-) mice as well as in wild-type (wt) mice in the presence or absence of a C3aR antagonist, SB 290157...
  3. Kildsgaard J, Hollmann T, Matthews K, Bian K, Murad F, Wetsel R. Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J Immunol. 2000;165:5406-9 pubmed
    The complement anaphylatoxin C3a, on binding the C3aR, mediates numerous proinflammatory activities. In addition, recent in vitro studies with C3a have implicated C3aR as a possible anti-inflammatory receptor...
  4. Humbles A, Lu B, Nilsson C, Lilly C, Israel E, Fujiwara Y, et al. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature. 2000;406:998-1001 pubmed
    ..We propose that, in addition to acquired immune responses, the innate immune system and complement (C3a in particular) are involved in the pathogenesis of asthma. ..
  5. Vieyra M, Leisman S, Raedler H, Kwan W, Yang M, Strainic M, et al. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am J Pathol. 2011;179:766-74 pubmed publisher
    ..CD8(+) T cells lacking C3a receptor (C3aR) and C5a receptor (C5aR) proliferate weakly to allogeneic DCs despite CD4 help, indicating that CD4-cell help is ..
  6. Lajoie S, Lewkowich I, Suzuki Y, Clark J, Sproles A, Dienger K, et al. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol. 2010;11:928-35 pubmed publisher
    ..complement factor 5 (C5) or the complement receptor C5aR mounted robust IL-17A responses, whereas mice deficient in C3aR had fewer IL-17-producing helper T cells (T(H)17 cells) and less AHR after allergen challenge...
  7. Strainic M, Liu J, Huang D, An F, Lalli P, Muqim N, et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity. 2008;28:425-35 pubmed publisher
    ..locally produced C5a and C3a anaphylatoxins interacting with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signaling are integrally involved in T cell ..
  8. Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris J, et al. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. 2007;110:228-36 pubmed
    ..of complement on TLR-induced cytokine production in vivo was mediated by the anaphylatoxin receptors C5aR and C3aR. Additionally, changes in lipopolysaccharide (LPS)-induced cytokine production in DAF-deficient mice correlated ..
  9. Mueller Ortiz S, Wang D, Morales J, Li L, Chang J, Wetsel R. Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock. J Immunol. 2009;182:6533-9 pubmed publisher
    ..This hypersensitivity was completely resolved in CPN1(-/-)/C5aR(-/-) but not in CPN1(-/-)/C3aR(-/-) mice. Moreover, CPN1(-/-) mice given C5a i.v., but not C3a, experienced 100% mortality...
  10. Niebuhr M, Baumer W, Kietzmann M, Wichmann K, Heratizadeh A, Werfel T. Participation of complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis. Exp Dermatol. 2012;21:52-6 pubmed publisher
    The complement system has emerged as a bridge between innate and adaptive immune responses. An involvement of C3aR has been described during skin inflammation...
  11. Wysoczynski M, Reca R, Lee H, Wu W, Ratajczak J, Ratajczak M. Defective engraftment of C3aR-/- hematopoietic stem progenitor cells shows a novel role of the C3a-C3aR axis in bone marrow homing. Leukemia. 2009;23:1455-61 pubmed publisher
    ..We also showed that this homing-promoting effect is not C3a receptor (C3aR) dependent...
  12. Markiewski M, DeAngelis R, Strey C, Foukas P, Gerard C, Gerard N, et al. The regulation of liver cell survival by complement. J Immunol. 2009;182:5412-8 pubmed publisher
    ..In conclusion, this study documents functions of complement proteins as prosurvival factors that, through their interactions with cytokines, inhibit apoptotic signaling in proliferating cells of epithelial origin. ..
  13. Zhang L, Bell B, Yu M, Chan C, Peachey N, Fung J, et al. Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis. J Leukoc Biol. 2016;99:447-54 pubmed publisher
  14. Boos L, Campbell I, Ames R, Wetsel R, Barnum S. Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis. J Immunol. 2004;173:4708-14 pubmed
    The C3aR is expressed throughout the CNS and is increased in expression on glial cells during CNS inflammation...
  15. Quell K, Karsten C, Kordowski A, Almeida L, Briukhovetska D, Wiese A, et al. Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse. J Immunol. 2017;199:688-706 pubmed publisher
    C3a exerts multiple biologic functions through activation of its cognate C3a receptor. C3-/- and C3aR-/- mice have been instrumental in defining important roles of the C3a/C3aR axis in the regulation of acute and ..
  16. Yang X, Peterson L, Thieringer R, Deignan J, Wang X, Zhu J, et al. Identification and validation of genes affecting aortic lesions in mice. J Clin Invest. 2010;120:2414-22 pubmed publisher
    ..mice, and we experimentally validated one of these candidate causal genes, complement component 3a receptor 1 (C3ar1), using a knockout mouse model...
  17. Mizutani N, Goshima H, Nabe T, Yoshino S. Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice. J Immunol. 2012;188:5694-705 pubmed publisher
    ..The mechanisms leading to the IgE-mediated late-phase asthmatic response and AHR are closely associated with neutrophilic inflammation through the production of IL-17 induced by C3a. ..
  18. Kwan W, van der Touw W, Paz Artal E, Li M, Heeger P. Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells. J Exp Med. 2013;210:257-68 pubmed publisher
    ..Previous findings linking signals transmitted through T cell-expressed C5a receptor (C5aR) and C3a receptor (C3aR) to activation, differentiation, and expansion of conventional CD4(+)CD25(-) T cells (T conv cells), raised the ..
  19. Hsu M, Ember J, Wang M, Prossnitz E, Hugli T, Ye R. Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene. Immunogenetics. 1997;47:64-72 pubmed
    The mouse anaphylatoxin C3a receptor (mC3aR) gene was isolated using a human C3aR cDNA probe. The genomic fragment contains an open reading frame of 1431 base pairs that encodes a peptide of 477 amino acids...
  20. Lim H, Kim Y, Drouin S, Mueller Ortiz S, Yun K, Morschl E, et al. Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice. PLoS ONE. 2012;7:e52666 pubmed publisher
    ..Here, we show that mice deficient in C3a receptor (C3aR) exhibited (i) higher percentages of endogenous IL-17-producing CD4(+) T cells in the lungs, (ii) higher amounts of ..
  21. Miwa T, Sato S, Gullipalli D, Nangaku M, Song W. Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice. J Immunol. 2013;190:3552-9 pubmed publisher
    ..we used this model to dissect the pathway(s) by which complement is activated in renal IRI and to evaluate whether C3aR- or C5aR-mediated inflammation or the membrane attack complex was pathogenic...
  22. Barnum S, Ames R, Maycox P, Hadingham S, Meakin J, Harrison D, et al. Expression of the complement C3a and C5a receptors after permanent focal ischemia: An alternative interpretation. Glia. 2002;38:169-73 pubmed
    ..C5a receptor expression was dramatically elevated within 3 h after middle cerebral artery occlusion, while C3aR expression was reduced to 25% of control animals...
  23. Bao L, Osawe I, Haas M, Quigg R. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol. 2005;175:1947-55 pubmed
    Signaling of the C3a anaphylatoxin through its G protein-coupled receptor, C3aR, is relevant in a variety of inflammatory diseases, but its role in lupus nephritis is undefined...
  24. Laudisi F, Spreafico R, Evrard M, Hughes T, Mandriani B, Kandasamy M, et al. Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1? release. J Immunol. 2013;191:1006-10 pubmed publisher
    ..These findings provide insight into the molecular processes underlying complement-mediated inflammation and highlight the possibility of targeting IL-1? to control complement-induced disease and pathological inflammation. ..
  25. Guglietta S, Chiavelli A, Zagato E, Krieg C, Gandini S, Ravenda P, et al. Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis. Nat Commun. 2016;7:11037 pubmed publisher
    ..This study provides a mechanistic explanation for the tumour-promoting effects of hypercoagulation, which could be used as a new biomarker or as a therapeutic target. ..
  26. Pinto A, RAMOS H, Wu X, Aggarwal S, Shrestha B, Gorman M, et al. Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. PLoS Pathog. 2014;10:e1004086 pubmed publisher
    ..Collectively, our findings establish the dominant role of type I IFN signaling in myeloid cells in restricting virus infection and controlling pathological inflammation and tissue injury. ..
  27. Verschoor A, Neuenhahn M, Navarini A, Graef P, Plaumann A, Seidlmeier A, et al. A platelet-mediated system for shuttling blood-borne bacteria to CD8?+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol. 2011;12:1194-201 pubmed publisher
    ..Other gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria. ..
  28. Tu Z, Bu H, Dennis J, Lin F. Efficient osteoclast differentiation requires local complement activation. Blood. 2010;116:4456-63 pubmed publisher
    ..Abrogating C3aR/C5aR activity either genetically or pharmaceutically suppressed OC generation, while stimulating WT or C3(-/-) BM ..
  29. Yang X, Deignan J, Qi H, Zhu J, Qian S, Zhong J, et al. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 2009;41:415-23 pubmed publisher
    ..Integration of gene expression in the design and analysis of traditional F(2) intercross studies allows high-confidence prediction of causal genes and identification of pathways and networks involved. ..
  30. Sun S, Zhao G, Liu C, Wu X, Guo Y, Yu H, et al. Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection. Am J Respir Cell Mol Biol. 2013;49:221-30 pubmed publisher
    ..MBL)-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR and C5aR...
  31. Langer H, Chung K, Orlova V, Choi E, Kaul S, Kruhlak M, et al. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood. 2010;116:4395-403 pubmed publisher
    ..Consistently, macrophage depletion in vivo reversed the increased neovascularization associated with C3- or C5aR deficiency. Taken together, complement and in particular the C5a-C5aR axes are potent inhibitors of angiogenesis. ..
  32. Nabizadeh J, Manthey H, Steyn F, Chen W, Widiapradja A, Md Akhir F, et al. The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses. J Immunol. 2016;196:4783-92 pubmed publisher
    ..We used a murine model of melanoma (B16-F0) to identify a hitherto unknown role for C3a-C3aR signaling in promoting tumor growth...
  33. Kumar L, Lu B, Gerard C, Geha R. C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. J Allergy Clin Immunol. 2013;132:746-748.e3 pubmed publisher
  34. Markiewski M, Mastellos D, Tudoran R, DeAngelis R, Strey C, Franchini S, et al. C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury. J Immunol. 2004;173:747-54 pubmed
  35. Oikonomopoulou K, DeAngelis R, Chen H, Diamandis E, Hollenberg M, Ricklin D, et al. Induction of complement C3a receptor responses by kallikrein-related peptidase 14. J Immunol. 2013;191:3858-66 pubmed publisher
  36. Read R, Vogt S, Barnum S. The complement anaphylatoxin receptors are not required for the development of experimental autoimmune uveitis. J Neuroimmunol. 2013;264:127-9 pubmed publisher
    ..disease in wild type and complement anaphylatoxin receptor-deficient mice (C3a receptor(-/-), C5a receptor(-/-) and C3aR(-/-)/C5aR(-/-)) and evaluated the eyes three weeks post-induction...
  37. Wang X, Werneck M, WILSON B, Kim H, Kluk M, Thom C, et al. TCR-dependent transformation of mature memory phenotype T cells in mice. J Clin Invest. 2011;121:3834-45 pubmed publisher
    ..Our findings further suggest that agents that impinge upon TCR signaling may represent an effective therapeutic modality for this class of lethal human cancers. ..
  38. de Valle E, Grigoriadis G, O Reilly L, Willis S, Maxwell M, Corcoran L, et al. NF?B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016;213:621-41 pubmed publisher
    ..Collectively, our findings identify a previously unrecognized role for NF?B1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells. ..
  39. Tornetta M, Foley J, Sarau H, Ames R. The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression. J Immunol. 1997;158:5277-82 pubmed
    The anaphylatoxin C3a receptor (C3aR) is unique among the family of G protein-coupled receptors in possessing an unusually large predicted second extracellular loop...
  40. Melendi G, Hoffman S, Karron R, Irusta P, Laham F, Humbles A, et al. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. J Virol. 2007;81:991-9 pubmed
    ..b>C3aR expression in bronchial epithelial and smooth muscle cells in the lungs of C5-deficient mice was enhanced compared ..
  41. Surace L, Lysenko V, Fontana A, Cecconi V, Janssen H, Bicvic A, et al. Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response. Immunity. 2015;42:767-77 pubmed publisher
    ..Overall, our findings indicate that anaphylatoxins are key players in radiotherapy-induced tumor-specific immunity and the ensuing clinical responses. ..
  42. Na M, Jarneborn A, Ali A, Welin A, Magnusson M, Stokowska A, et al. Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice. Infect Immun. 2016;84:930-939 pubmed publisher
    ..the complement component 3 (C3(-/-)), complement factor B (fB(-/-)), and receptor for C3-derived anaphylatoxin C3a (C3aR(-/-)) and wild-type (WT) control mice were intravenously or intra-articularly inoculated with S...
  43. Mueller Ortiz S, Morales J, Wetsel R. The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis. J Immunol. 2014;193:1278-89 pubmed publisher
    ..In a model of systemic L. monocytogenes infection, we show that mice lacking the receptor for C3a (C3aR(-/-)) are significantly more sensitive to infection compared with wild-type mice, as demonstrated by decreased ..
  44. Hollmann T, Haviland D, Kildsgaard J, Watts K, Wetsel R. Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene. Mol Immunol. 1998;35:137-48 pubmed
    The complement C3a anaphylatoxin receptor (C3aR) is a seven-transmembrane G-protein coupled chemoattractant receptor that on binding the C3a peptide ligand mediates numerous cellular responses, including histamine release from mast cells...
  45. Wenderfer S, Wang H, Ke B, Wetsel R, Braun M. C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse. Mol Immunol. 2009;46:1397-404 pubmed publisher
    ..anaphylatoxin C3a is a product of complement activation with immunomodulatory properties, and the receptor for C3a (C3aR) is not only expressed by granulocytes and antigen presenting cell populations, but it is also strongly up-..
  46. Gorelik A, Sapir T, Haffner Krausz R, Olender T, Woodruff T, Reiner O. Developmental activities of the complement pathway in migrating neurons. Nat Commun. 2017;8:15096 pubmed publisher
    ..Pharmacological activation of the downstream receptors rescue Masp2 and C3 knockdown as well as C3 knockout. Therefore, we propose that the complement pathway is functionally important in migrating neurons of the developing cortex. ..
  47. Ramos T, Darley M, Hu X, Billker O, Rayner J, Ahras M, et al. Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria. J Immunol. 2011;186:6657-60 pubmed publisher
    ..b>C3aR(-/-) and C3aR(-/-) × C5aR(-/-) mice were equally susceptible to ECM as were wild-type mice, indicating that ..
  48. Lian H, Litvinchuk A, Chiang A, Aithmitti N, Jankowsky J, Zheng H. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. J Neurosci. 2016;36:577-89 pubmed publisher
    ..factor kappa B (NF-κB), leading to the release of complement C3, which acts on the neuronal C3a receptor (C3aR) to influence dendritic morphology and cognitive function...
  49. Mueller Ortiz S, Hollmann T, Haviland D, Wetsel R. Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia. Am J Physiol Lung Cell Mol Physiol. 2006;291:L157-65 pubmed
    ..C3a mediates numerous biological functions on binding its receptor (C3aR), which is present on both myeloid and nonmyeloid cells...
  50. Napier B, Brubaker S, Sweeney T, Monette P, Rothmeier G, Gertsvolf N, et al. Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity. J Exp Med. 2016;213:2365-2382 pubmed
    ..of caspase-11 orthologues, caspase-4 and -5, in primary human macrophages during inflammation and that c3aR1 and caspase-5 transcripts are highly expressed in patients with severe sepsis; thus, suggesting that these ..
  51. Wu M, Brennan F, Lynch J, Mantovani S, Phipps S, Wetsel R, et al. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc Natl Acad Sci U S A. 2013;110:9439-44 pubmed publisher
    C3a is a key complement activation fragment, yet its neutrophil-expressed receptor (C3aR) still has no clearly defined role...
  52. Broders Bondon F, Paul Gilloteaux P, Gazquez E, Heysch J, Piel M, Mayor R, et al. Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin. Dev Biol. 2016;414:85-99 pubmed publisher
    ..control and N-cadherin mutant gut explants cultured on fibronectin (FN) and micropatterned FN-stripes with C3a or C3aR antagonist, and studied cell migration behavior with the use of triangulation analysis to quantify cell dispersion...
  53. Lawson P, Reid K. A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000;12:231-40 pubmed
    ..These results provide new insights into the evolution of this group of proteins. ..
  54. Zhang C, Li Y, Wang C, Wu Y, Cui W, Miwa T, et al. Complement 5a receptor mediates angiotensin II-induced cardiac inflammation and remodeling. Arterioscler Thromb Vasc Biol. 2014;34:1240-8 pubmed publisher
    ..Therapeutic inhibition of complement may protect patients from hypertension-related heart injury. ..
  55. Jacob A, Bao L, Brorson J, Quigg R, Alexander J. C3aR inhibition reduces neurodegeneration in experimental lupus. Lupus. 2010;19:73-82 pubmed publisher
    ..the role of C3a/C3a receptor (R) signaling in brains of the lupus model, MRL/lpr mice, by treating the mice with C3aR antagonist (a) from 13 to 19 weeks of age. C3aR mRNA (0.2 +/- 0.027 versus 0.56 +/- 0.19) and protein (0.16 +/- 0...
  56. Ren W, Liu Y, Wang X, Piao C, Ma Y, Qiu S, et al. The Complement C3a-C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression. J Immunol. 2018;200:1829-1838 pubmed publisher
    ..These findings indicated activation of classical and alternative complement pathways. Further, expression of C3aR was obviously increased in smooth muscle cells of human and mouse dissected aortas, and knockout of C3aR notably ..
  57. Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, et al. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest. 2004;114:399-407 pubmed
    ..C3a binds to a seven-transmembrane G protein-coupled receptor, C3aR. We used C3aR(-/-) mice to examine the role of C3a in a mouse model of allergic inflammation induced by ..
  58. Li K, Anderson K, Peng Q, Noble A, Lu B, Kelly A, et al. Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. Blood. 2008;112:5084-94 pubmed publisher
    ..Here we present evidence that engagement of C3a receptor (C3aR) on the surface of dendritic cells (DCs) leads to alterations in the level of intracellular cyclic adenosine ..
  59. Roy R, Paes H, Nanjappa S, Sorkness R, Gasper D, Sterkel A, et al. Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation. MBio. 2013;4: pubmed publisher
    ..C3(-/-) and C3aR(-/-) mice were protected from chitin-dependent sensitization to Aspergillus and had reduced lung eosinophilia and ..
  60. Busche M, Stahl G. Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury. Ger Med Sci. 2010;8: pubmed publisher
  61. Qing X, Koo G, Salmon J. Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-?1 in Gr-1+ myeloid cells. Eur J Immunol. 2012;42:1723-34 pubmed publisher
    ..Thus, complement activation indirectly regulates cDC-NK-cell activation in response to inflammatory stimuli such as TLR3 by promoting TGF-?1 production in Gr-1(+) myeloid cells at steady state. ..
  62. Wang W, Irani R, Zhang Y, Ramin S, Blackwell S, Tao L, et al. Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia. Hypertension. 2012;60:712-21 pubmed publisher
    ..These studies are the first to link angiotensin II type 1 receptor agonistic autoantibody with complement activation and to provide important new opportunities for therapeutic intervention in PE. ..
  63. Hannedouche S, Beck V, Leighton Davies J, Beibel M, Roma G, Oakeley E, et al. Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. J Biol Chem. 2013;288:27434-43 pubmed publisher
    ..using a series of defined receptor antagonists and siRNAs led to the identification of complement C3a receptor-1 (C3AR1) as a target for TLQP-21 in rodents...
  64. Yu M, Zou W, Peachey N, McIntyre T, Liu J. A novel role of complement in retinal degeneration. Invest Ophthalmol Vis Sci. 2012;53:7684-92 pubmed publisher
    ..examined mice lacking the main complement component C3 and the receptors for complement activation fragments C3a (C3aR) and/or C5a (C5aR)...
  65. Hillian A, McMullen M, Sebastian B, Roychowdhury S, Rowchowdhury S, Kashyap S, et al. Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis. J Biol Chem. 2013;288:22565-75 pubmed publisher
    ..Together, these studies reveal an important role for C1q in the classical pathway of complement activation in the development of high fat diet-induced insulin resistance. ..
  66. Dick J, Gan P, Kitching A, Holdsworth S. The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis. PLoS ONE. 2018;13:e0190655 pubmed publisher
    ..the C5a receptor is important in this disease, the role of the anaphylatoxin C3a signalling via the C3a receptor (C3aR) is not known...
  67. Ramos T, Wohler J, Barnum S. Deletion of both the C3a and C5a receptors fails to protect against experimental autoimmune encephalomyelitis. Neurosci Lett. 2009;467:234-6 pubmed publisher
    ..We performed EAE in C3aR/C5aR double knockout mice (C3aR/C5aR(-/-)) and observed delayed onset of disease but no attenuation of disease ..
  68. Nozaki M, Raisler B, Sakurai E, Sarma J, Barnum S, Lambris J, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A. 2006;103:2328-33 pubmed
    ..Collectively, these findings establish a mechanistic basis for the clinical observation that drusen predispose to CNV, revealing a role for immunological phenomena in angiogenesis and providing therapeutic targets for AMD...
  69. Kerepesi L, Hess J, Nolan T, Schad G, Abraham D. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol. 2006;176:4315-22 pubmed
    ..Larval survival in naive C3(-/-) mice was increased as compared with survival in wild-type mice, whereas C3aR(-/-) and wild-type mice had equivalent levels of larval killing...
  70. Hollmann T, Mueller Ortiz S, Braun M, Wetsel R. Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol. 2008;45:1907-15 pubmed
    ..Moreover, they provide additional in vivo evidence that C3a and C5a have divergent biological functions in Gram-negative bacteremia and shock. ..
  71. Banda N, Hyatt S, Antonioli A, White J, Glogowska M, Takahashi K, et al. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J Immunol. 2012;188:1469-78 pubmed publisher
    ..Clinical disease activity in C3aR(-/-), C5aR(-/-), and C6-deficient (C6-def) mice was decreased by 52, 94, and 65%, respectively, as compared with ..
  72. van der Touw W, Cravedi P, Kwan W, Paz Artal E, Merad M, Heeger P. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol. 2013;190:5921-5 pubmed publisher
    ..Building upon our previous observations that T cell-expressed receptors for C3a (C3aR) and C5a (C5aR) drive Th1 maturation, we tested the impact of C3aR/C5aR signaling on induction and stability of ..