Gene Symbol: C1qtnf12
Description: C1q and tumor necrosis factor related 12
Alias: 1110035L05Rik, C1qdc2, CTRP12, Fam132a, alipolin, adipolin, C1q domain containing 2, adipose-derived insulin-sensitizing factor, complement C1q tumor necrosis factor-related protein 12, family with sequence similarity 132, member A, protein FAM132A
Species: mouse
Products:     C1qtnf12

Top Publications

  1. Wei Z, Peterson J, Lei X, Cebotaru L, Wolfgang M, Baldeviano G, et al. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem. 2012;287:10301-15 pubmed publisher
    ..Here, we describe CTRP12, a novel adipokine with anti-diabetic actions...
  2. Wei Z, Lei X, Seldin M, Wong G. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem. 2012;287:35804-14 pubmed publisher
    ..We recently described C1q/TNF-related protein-12 (CTRP12), a novel insulin-sensitizing adipokine that regulates glucose metabolism in liver and adipose tissue...
  3. Bell Anderson K, Funnell A, Williams H, Mat Jusoh H, Scully T, Lim W, et al. Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2). Diabetes. 2013;62:2728-37 pubmed publisher
    ..We found that mRNA expression of Fam132a, which encodes a newly identified insulin-sensitizing adipokine, adipolin, is significantly upregulated in the absence of KLF3...
  4. Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, et al. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. J Biol Chem. 2011;286:34552-8 pubmed publisher
    ..as an insulin-sensitizing adipokine that is abundantly expressed by fat tissues and designate this adipokine as adipolin (adipose-derived insulin-sensitizing factor)...
  5. Enomoto T, Shibata R, Ohashi K, Kambara T, Kataoka Y, Uemura Y, et al. Regulation of adipolin/CTRP12 cleavage by obesity. Biochem Biophys Res Commun. 2012;428:155-9 pubmed publisher
    ..Obesity is highly associated with the development of insulin resistance and type 2 diabetes. Recently we found that adipolin/CRTP12 is an adipocytokine that exerts beneficial actions on glucose metabolism...
  6. Tan S, Little H, Lei X, Li S, Rodriguez S, Wong G. Partial deficiency of CTRP12 alters hepatic lipid metabolism. Physiol Genomics. 2016;48:936-949 pubmed publisher
    ..heterozygous mouse model, we show that the loss of a single copy of the Ctrp12 gene (also known as Fam132a and adipolin) affects whole body lipid metabolism...
  7. Pan X, Karner C, Carroll T. Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells. Development. 2017;144:4173-4182 pubmed publisher
  8. Karner C, Das A, Ma Z, Self M, Chen C, Lum L, et al. Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development. 2011;138:1247-57 pubmed publisher
    ..These findings provide novel insights into the molecular mechanisms that regulate progenitor cell differentiation during normal and pathological conditions. ..
  9. Conde J, Scotece M, Lopez V, Gomez R, Lago F, Pino J, et al. Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line. Ann Rheum Dis. 2013;72:140-2 pubmed publisher

More Information


  1. Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, et al. Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 15. PLoS ONE. 2013;8:e83183 pubmed publisher
    ..We identified adipolin/CTRP12 as an insulin-sensitizing and anti-inflammatory adipokine...