Bsn

Summary

Gene Symbol: Bsn
Description: bassoon
Alias: presynaptic cytomatrix protein, protein bassoon
Species: mouse

Top Publications

  1. ncbi Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling
    Thomas Frank
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen Medical Center, 37099 Gottingen, Germany
    Neuron 68:724-38. 2010
  2. ncbi Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons
    Bradley N Buran
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 30:7587-97. 2010
  3. ncbi Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
    Shizue Ohsawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:13366-71. 2010
  4. ncbi Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
  5. ncbi Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
    Konark Mukherjee
    Department of Molecular and Cellular Physiology, Stanford University, CA 94304, USA
    Proc Natl Acad Sci U S A 107:6504-9. 2010
  6. ncbi Hair cell synaptic ribbons are essential for synchronous auditory signalling
    Darina Khimich
    Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Goettingen, 37099 Goettingen, Germany
    Nature 434:889-94. 2005
  7. ncbi The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina
    Oliver Dick
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    Neuron 37:775-86. 2003
  8. ncbi Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
    Wilko D Altrock
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 37:787-800. 2003
  9. ncbi Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses
    Dana Specht
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:505-15. 2009
  10. ncbi The amino-terminal domain of glutamate receptor delta2 triggers presynaptic differentiation
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 377:1315-9. 2008

Scientific Experts

  • Frank Angenstein
  • Bradley N Buran
  • Stacy L Donovan
  • Stefan Hallermann
  • Susanne Tom Dieck
  • Johann Helmut Brandstätter
  • Dana Specht
  • Eckart D Gundelfinger
  • Takeshi Uemura
  • Hanna Regus-Leidig
  • Anna Fejtova
  • Darina Khimich
  • Jae Yeol Joo
  • Jie Chen
  • Wilko D Altrock
  • Shizue Ohsawa
  • Konark Mukherjee
  • Thomas Frank
  • Frederic Lanore
  • Masayoshi Mishina
  • Veronica Ghiglieri
  • Shun Hamada
  • Shigeru Sato
  • Ariadna Laguna
  • Sonoko Hasegawa
  • Silke Haverkamp
  • Alexander Egner
  • Tobias Moser
  • Karin Richter
  • Detlef Balschun
  • Keith Vosseller
  • Eckart Dieter Gundelfinger
  • Kerstin Reim
  • Josef Ammermüller
  • Johann H Brandstätter
  • Christian Rosenmund
  • Thomas Dresbach
  • Oliver Dick
  • Shernaz X Bamji
  • Abdeljalil Jellali
  • Masahiko Watanabe
  • Tomoyuki Yoshida
  • Sung Jin Lee
  • Sara E Billings
  • Hiroshi Nishimune
  • Misato Yasumura
  • Hiroki Yoshida
  • Tatsushi Igaki
  • Benjamin Harke
  • M Kneussel
  • Christophe Mulle
  • Amy Lee
  • Christophe Blanchet
  • Eckart Gundelfinger
  • Keisuke Kuida
  • Nicola Strenzke
  • M Charles Liberman
  • Keith E Bryan
  • Stefan H Gerber
  • Thomas C Sudhof
  • Paulo Pinheiro
  • Anna Fetjova
  • Angela Ho
  • Masayuki Miura
  • Mark A Rutherford
  • Hyung Bae Kwon
  • Pablo E Castillo
  • Xinran Liu
  • Tina Pangrsic
  • Andreas Neef
  • Dietmar Riedel
  • Xiaofei Yang
  • Uwe Wolfrum
  • Monica Di Luca
  • Martine Ammassari-Teule
  • Giorgio Bernardi
  • Peter Dearden
  • Giovambattista De Sarro
  • Carmelo Sgobio
  • Federica Polli
  • Vincent Paille
  • Paolo Calabresi
  • Marion Maw
  • Vincenza Bagetta
  • Ilaria Barone
  • Paul Turner
  • Wilko Altrock
  • Fabrizio Gardoni
  • Frank Koentgen
  • Shu Biao Wu

Detail Information

Publications31

  1. ncbi Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling
    Thomas Frank
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen Medical Center, 37099 Gottingen, Germany
    Neuron 68:724-38. 2010
    ..structure and function of hair cell ribbon synapses following genetic disruption of the presynaptic scaffold protein Bassoon. Mutant synapses--mostly lacking the ribbon--showed a reduction in membrane-proximal vesicles, with ..
  2. ncbi Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons
    Bradley N Buran
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 30:7587-97. 2010
    ....
  3. ncbi Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
    Shizue Ohsawa
    Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:13366-71. 2010
    ..Our findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development...
  4. ncbi Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
    ..These data indicate that Bassoon is a strong candidate to be involved in cytomatrix organization at the site of neurotransmitter release...
  5. ncbi Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
    Konark Mukherjee
    Department of Molecular and Cellular Physiology, Stanford University, CA 94304, USA
    Proc Natl Acad Sci U S A 107:6504-9. 2010
    ..Thus, we propose that piccolo and bassoon play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release...
  6. ncbi Hair cell synaptic ribbons are essential for synchronous auditory signalling
    Darina Khimich
    Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Goettingen, 37099 Goettingen, Germany
    Nature 434:889-94. 2005
    ..Here we show that anchoring of IHC ribbons is impaired in mouse mutants for the presynaptic scaffolding protein Bassoon. The lack of active-zone-anchored synaptic ribbons reduced the presynaptic readily releasable vesicle pool, ..
  7. ncbi The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina
    Oliver Dick
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    Neuron 37:775-86. 2003
    ..We have investigated the role of the presynaptic cytomatrix protein Bassoon, a major component of the photoreceptor ribbon, in a mouse retina deficient of functional ..
  8. ncbi Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
    Wilko D Altrock
    Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
    Neuron 37:787-800. 2003
    Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion...
  9. ncbi Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses
    Dana Specht
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 50:505-15. 2009
    ..L-type VDCCalpha1 subtype expression in wild-type and mutant mice was examined, to investigate the underlying pathologic mechanism...
  10. ncbi The amino-terminal domain of glutamate receptor delta2 triggers presynaptic differentiation
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 377:1315-9. 2008
    ..These results suggest that GluRdelta2 triggers presynaptic differentiation by direct interaction with presynaptic components through the NTD...
  11. ncbi The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development
    Ariadna Laguna
    Center for Genomic Regulation, UPF, 08003 Barcelona, Spain
    Dev Cell 15:841-53. 2008
    ..Our data suggest a model in which dysregulation of the apoptotic response in differentiating neurons participates in the neuropathology of diseases that display DYRK1A gene-dosage imbalance effects, such as Down's syndrome...
  12. ncbi Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice
    Veronica Ghiglieri
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Rome, Italy
    Eur J Neurosci 29:1979-93. 2009
    ..As the absence of functional scaffolding protein Bassoon in mutant mice is associated with the development of pronounced spontaneous seizures, we utilized this new ..
  13. ncbi Absence of functional active zone protein Bassoon affects assembly and transport of ribbon precursors during early steps of photoreceptor synaptogenesis
    Hanna Regus-Leidig
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Staudtstr 5, 91058 Erlangen, Germany
    Eur J Cell Biol 89:468-75. 2010
    ..component of the precursor spheres and a key player in attaching the ribbon to the active zone is the presynaptic cytomatrix protein Bassoon...
  14. ncbi Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones
    Jie Chen
    Department of Anatomy and Cell Biology and Kansas Intellectual and Developmental Disabilities Research Center, University of Kansas Medical School, Kansas City, Kansas 66160, USA
    J Neurosci 31:512-25. 2011
    ..These results suggest that presynaptic VDCCs link the target-derived synapse organizer laminin β2 to active-zone proteins and function as scaffolding proteins to anchor active-zone proteins to the presynaptic membrane...
  15. ncbi Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon
    Frederic Lanore
    Laboratoire Physiologie Cellulaire de la Synapse, CNRS UMR 5091, University of Bordeaux, Bordeaux, France
    J Physiol 588:2133-45. 2010
    ..altered during the first 2 weeks of postnatal development in mutant mice lacking the central region of Bassoon (Bsn(-/-) mice)...
  16. ncbi Bassoon speeds vesicle reloading at a central excitatory synapse
    Stefan Hallermann
    Carl Ludwig Institute of Physiology, Medical Faculty, University of Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany
    Neuron 68:710-23. 2010
    ..Thus, our data show that the cytomatrix protein Bassoon speeds the reloading of vesicles to release sites at a central excitatory synapse.
  17. ncbi Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation
    Shigeru Sato
    Department of Developmental Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka, 565 0874, Japan
    Nat Neurosci 11:923-31. 2008
    ..This may also advance our understanding of the molecular mechanisms underlying the retinal electrophysiological abnormalities observed in muscular dystrophy patients...
  18. ncbi The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
    Sonoko Hasegawa
    KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Mol Cell Neurosci 38:66-79. 2008
    ..Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb...
  19. ncbi Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    D A Persons
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 23:159-65. 1999
    ..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
  20. ncbi The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse
    M Kneussel
    Departments of Neurochemistry and Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenstrasse 46, D 60528 Frankfurt Main, Germany
    Proc Natl Acad Sci U S A 97:8594-9. 2000
    ..Consistent with this idea, a close homolog of GABARAP, p16, has been found to function as a late-acting intra-Golgi transport factor...
  21. ncbi Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina
    Abdeljalil Jellali
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, INSERM EMI 99 18, Universite Louis Pasteur, 1 Place de l Hopital, 67091 Strasbourg Cedex, France
    J Comp Neurol 449:76-87. 2002
    ..VIAAT localization in mouse and human horizontal cells further support the role of inhibitory transmitters in lateral inhibition at the photoreceptor terminals...
  22. ncbi Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion...
  23. ncbi Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex
    Susanne Tom Dieck
    Department of Neuroanatomy, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    J Cell Biol 168:825-36. 2005
    ..In mice deficient for the CAZ protein Bassoon, ribbons are not anchored to the presynaptic membrane but float freely in the cytoplasm...
  24. ncbi Structurally and functionally unique complexins at retinal ribbon synapses
    Kerstin Reim
    Department of Molecular Neurobiology, Max Planck Institute for Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 169:669-80. 2005
    ..The novel CPXs III and IV may contribute to the unique release efficacy of retinal sensory neurons...
  25. ncbi O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry
    Keith Vosseller
    Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
    Mol Cell Proteomics 5:923-34. 2006
    ....
  26. ncbi Manganese-enhanced MRI reveals structural and functional changes in the cortex of Bassoon mutant mice
    Frank Angenstein
    Special Laboratory for Non Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cereb Cortex 17:28-36. 2007
    ..ME-MRI) was used to analyze the brain architecture in mice lacking the functional presynaptic active zone protein Bassoon. Anatomical characterization revealed a significant increase in the total brain volume in Bassoon mutants as ..
  27. ncbi Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  28. ncbi Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study
    Frank Angenstein
    Special Laboratory for Non Invasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany
    Cereb Cortex 18:890-7. 2008
    Mice lacking functional presynaptic active zone protein Bassoon are characterized by an enlarged cerebral cortex and an altered cortical activation pattern...
  29. ncbi Structural and functional remodeling in the retina of a mouse with a photoreceptor synaptopathy: plasticity in the rod and degeneration in the cone system
    Dana Specht
    Department of Biology, Animal Physiology, University of Erlangen Nuremberg, Staudtstrasse 5, 91058 Erlangen, Germany
    Eur J Neurosci 26:2506-15. 2007
    ..In the retinae of mice, mutant for the presynaptic scaffolding protein Bassoon, signal transfer at photoreceptor ribbon synapses is disturbed due to impaired ribbon attachment to the ..
  30. ncbi Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods
    Silke Haverkamp
    Department of Neuroanatomy, Max Planck Institute for Brain Research, 60528 Frankfurt Main, Germany
    J Comp Neurol 507:1087-101. 2008
    ..In contrast, true cone-selective type 1 and 2 OFF cone bipolar cells did not show sprouting in the Bassoon mouse mutant...
  31. ncbi Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons
    Jae Yeol Joo
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 406:627-32. 2011
    ..These results suggest that Cbln subtypes exert synaptogenic activities in cortical neurons by differentially interacting with NRXN variants containing S4...