Bsg

Summary

Gene Symbol: Bsg
Description: basigin
Alias: AI115436, AI325119, CD147, EMMPRIN, HT-7, basigin, 5A11/Basigin, HT7 antigen, basic immunoglobulin superfamily, gp 42, membrane glycoprotein gp42, neurothelin
Species: mouse
Products:     Bsg

Top Publications

  1. Ochrietor J, Moroz T, van Ekeris L, Clamp M, Jefferson S, deCarvalho A, et al. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest Ophthalmol Vis Sci. 2003;44:4086-96 pubmed
    5A11/Basigin has recently been identified as a critical glycoprotein for full maturity and function of the mouse retina. However, the biological function of 5A11/Basigin has yet to be determined...
  2. Igakura T, Kadomatsu K, Kaname T, Muramatsu H, Fan Q, Miyauchi T, et al. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev Biol. 1998;194:152-65 pubmed
    b>Basigin is a highly glycosylated transmembrane protein with two immunoglobulin-like domains. We generated mutant mice lacking the basigin gene (Bsg) by gene targeting. Bsg (-/-) embryos developed normally during preimplantation stages...
  3. Fan Q, Yuasa S, Kuno N, Senda T, Kobayashi M, Muramatsu T, et al. Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Neurosci Res. 1998;30:53-63 pubmed
    Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Chicken Bsg (HT7/neurothelin/ 5A11) is expressed in neuroblasts, but disappears from neurons after a specific stage of cytodifferentiation, and ..
  4. Miyauchi T, Masuzawa Y, Muramatsu T. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J Biochem. 1991;110:770-4 pubmed
    ..in the transmembrane and cytoplasmic domains was conserved not only in human and mouse basigin but also in HT7 antigen. The conserved structure may be required for interaction with a membranous protein...
  5. Agrawal S, Silva C, Tourtellotte W, Yong V. EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci. 2011;31:669-77 pubmed publisher
    Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the Ig superfamily, with various physiological roles including the induction of matrix metalloproteinases (MMPs), leukocyte activation, and tumor progression...
  6. Miyauchi T, Kanekura T, Yamaoka A, Ozawa M, Miyazawa S, Muramatsu T. Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class II antigen. J Biochem. 1990;107:316-23 pubmed
    ..F9 embryonal carcinoma cells, resulting in detection of a cDNA clone specifying a new glycoprotein termed "basigin." The glycoprotein has been suggested to be a transmembrane one, and was found to be a new member of the ..
  7. Altruda F, Cervella P, Gaeta M, Daniele A, Giancotti F, Tarone G, et al. Cloning of cDNA for a novel mouse membrane glycoprotein (gp42): shared identity to histocompatibility antigens, immunoglobulins and neural-cell adhesion molecules. Gene. 1989;85:445-51 pubmed
    ..Some of these conserved residues are also present in immunoglobulins (Ig) and in the neural-cell adhesion molecule, thus indicating that gp42 is a new member of the Ig superfamily. ..
  8. Philp N, Ochrietor J, Rudoy C, Muramatsu T, Linser P. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci. 2003;44:1305-11 pubmed
    ..Recently, it was reported that targeting of MCT1 and -4 to the plasma membrane requires association with 5A11/basigin (CD147)...
  9. Toyama Y, Maekawa M, Kadomatsu K, Miyauchi T, Muramatsu T, Yuasa S. Histological characterization of defective spermatogenesis in mice lacking the basigin gene. Anat Histol Embryol. 1999;28:205-13 pubmed
    b>Basigin is a transmembrane protein belonging to the immunoglobulin superfamily...

More Information

Publications85

  1. Miyauchi T, Jimma F, Igakura T, Yu S, Ozawa M, Muramatsu T. Structure of the mouse basigin gene, a unique member of the immunoglobulin superfamily. J Biochem. 1995;118:717-24 pubmed
    b>Basigin is a membrane glycoprotein belonging to the immunoglobulin superfamily. The mouse basigin gene was isolated from a genomic DNA library of the BALB/c mouse, and the structure of the gene and its flanking region (11...
  2. Xu J, Xu H, Zhang Q, Song F, Jiang J, Yang X, et al. HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res. 2007;5:605-14 pubmed
    b>CD147 molecule is reported to be correlated with the malignancy of some cancers; however, it remains unclear whether it is involved in the progression of hepatocellular carcinoma (HCC)...
  3. Igakura T, Kadomatsu K, Taguchi O, Muramatsu H, Kaname T, Miyauchi T, et al. Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier. Biochem Biophys Res Commun. 1996;224:33-6 pubmed
    ..Although histochemical studies on the localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved in the function of the blood-brain barrier, basigin knockout mice ..
  4. Renno T, Wilson A, Dunkel C, Coste I, Maisnier Patin K, Benoit de Coignac A, et al. A role for CD147 in thymic development. J Immunol. 2002;168:4946-50 pubmed
    ..In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning...
  5. Hori K, Katayama N, Kachi S, Kondo M, Kadomatsu K, Usukura J, et al. Retinal dysfunction in basigin deficiency. Invest Ophthalmol Vis Sci. 2000;41:3128-33 pubmed
    To examine the retina of basigin (Bsg) knockout mice by electrophysiological and histologic methods and thereby to determine the possible function of Bsg in phototransduction and retinal development...
  6. Chen S, Kadomatsu K, Kondo M, Toyama Y, Toshimori K, Ueno S, et al. Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147. Biochem Biophys Res Commun. 2004;324:147-53 pubmed
    ..Here we employed a breeding strategy to compare three lines of mice deficient in the basigin (Bsg)/CD147 gene. The first line was F2 from F1 hybrid offspring of the 129/SV chimera and C57BL/6J...
  7. Naruhashi K, Kadomatsu K, Igakura T, Fan Q, Kuno N, Muramatsu H, et al. Abnormalities of sensory and memory functions in mice lacking Bsg gene. Biochem Biophys Res Commun. 1997;236:733-7 pubmed
    b>Basigin is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. We used mutant mice lacking the basigin gene (Bsg) to investigate its involvement in learning and memory...
  8. Muramatsu T, Miyauchi T. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol Histopathol. 2003;18:981-7 pubmed publisher
    ..Bsg is also called CD147 and EMMPRIN, and the symbol for the human basigin gene is BSG. BSG is located in chromosome 19 band p13. 3...
  9. Kuno N, Kadomatsu K, Fan Q, Hagihara M, Senda T, Mizutani S, et al. Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. FEBS Lett. 1998;425:191-4 pubmed
    b>Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Bsg knock-out mice exhibit infertility of both sexes...
  10. Chen Y, Gou X, Kong D, Wang X, Wang J, Chen Z, et al. EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Oncotarget. 2015;6:32575-85 pubmed publisher
    b>EMMPRIN, a cell adhesion molecule highly expressed in a variety of tumors, is associated with poor prognosis in cancer patients...
  11. Zhu W, Khachi S, Hao Q, Shen F, Young W, Yang G, et al. Upregulation of EMMPRIN after permanent focal cerebral ischemia. Neurochem Int. 2008;52:1086-91 pubmed publisher
    ..The extracellular MMP inducer (EMMPRIN) is a 58-kDa cell surface glycoprotein, which has been known to play a key regulatory role for MMP activities...
  12. Kapfhamer D, Burmeister M. Genetic map of the region around grizzled (gr) and mocha (mh) on mouse chromosome 10, homologous to human 19p13.3. Genomics. 1994;23:635-42 pubmed
    ..One recombination event for each of the flanking markers Basigin (Bsg) and D10Mit22 was identified...
  13. Finch N, Linser P, Ochrietor J. Hydrophobic interactions stabilize the basigin-MCT1 complex. Protein J. 2009;28:362-8 pubmed publisher
    Previous reports demonstrated that monocarboxylate transporter-1 (MCT1) interacts with Basigin. It was hypothesized that the two proteins interact via the transmembrane domain of Basigin, specifically through the glutamate residue within ..
  14. Oishi H, Miyazaki T, Mizuki S, Kamogawa J, Lu L, Tsubaki T, et al. Accelerating effect of an MRL gene locus on the severity and onset of arthropathy in DBA/1 mice. Arthritis Rheum. 2005;52:959-66 pubmed
    ..Arthropathy in DBA/1 mice is under the control of an allelic combination of gene loci, one of which is common to the locus for sialadenitis in MRL/MpJ-lpr/lpr mice. ..
  15. Reddy V, Prabhu S, Mummidi S, Valente A, Venkatesan B, Shanmugam P, et al. Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation. Am J Physiol Heart Circ Physiol. 2010;299:H1242-54 pubmed publisher
    IL-18 and the extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) stimulate the expression of proinflammatory cytokines and MMPs and are elevated in myocardial hypertrophy, remodeling, and failure...
  16. Zhang X, Ding S, Gao Y, Liang Y, Foda H. [Expression of various matrix metalloproteinases in mice with hyperoxia-induced acute lung injury]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006;18:449-51 pubmed
    To investigate the role of matrix metalloproteinases (MMPs) and extracellular matrix metalloproteinase inducer (EMMPRIN) in the pathogenesis of acute lung injury induced by hyperoxia...
  17. Chen L, Belton R, Nowak R. Basigin-mediated gene expression changes in mouse uterine stromal cells during implantation. Endocrinology. 2009;150:966-76 pubmed publisher
    ..The membrane glycoprotein basigin (CD147/EMMPRIN), a known inducer of MMPs, is necessary for normal implantation in the mouse...
  18. Serikawa T, Montagutelli X, Simon Chazottes D, Guenet J. Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping. Mamm Genome. 1992;3:65-72 pubmed
    ..From these experiments we conclude that, under precisely standardized PCR conditions, the DNA molecules amplified with these arbitrarily designed primers are useful and reliable markers for genetic mapping in both mouse and rat. ..
  19. Lu M, Wu J, He F, Wang X, Li C, Chen Z, et al. Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma. J Mol Histol. 2015;46:79-91 pubmed publisher
    Overexpression of CD147/basigin in hepatic cells promotes the progression of hepatocellular carcinoma (HCC). Whether CD147 also expressed in liver non-parenchymal cells and associated with HCC development was unknown...
  20. Miranda P, Allaire A, Sosnik J, Visconti P. Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod. 2009;80:897-904 pubmed publisher
    ..In this study, a subset of these proteins (TEX101, basigin, hexokinase 1, facilitated glucose transporter 3, IZUMO, and SPAM1) and other molecules known to be enriched in ..
  21. Simon Chazottes D, Matsubara S, Miyauchi T, Muramatsu T, Guenet J. Chromosomal localization of two cell surface-associated molecules of potential importance in development: midkine (Mdk) and basigin (Bsg). Mamm Genome. 1992;2:269-71 pubmed
  22. Jia L, Wang S, Zhou H, Cao J, Hu Y, Zhang J. Caveolin-1 up-regulates CD147 glycosylation and the invasive capability of murine hepatocarcinoma cell lines. Int J Biochem Cell Biol. 2006;38:1584-93 pubmed
    b>CD147 which is a regulator of matrix metalloproteinase (MMP) production on the surface of many malignant tumor cells, shows a highly specific association with caveolin-1 (Cav-1)...
  23. Fan J, Wang S, Yu S, He J, Zheng W, Zhang J. N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147. Glycoconj J. 2012;29:323-34 pubmed publisher
    ..Furthermore, we found that the regulated GnT-IVa converts the heterogeneous N-glycosylated forms of CD147 in Hepa1-6 and Hca-F cells, and significantly changed the antennary oligosaccharide structures on CD147...
  24. Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, et al. CD147/basigin limits lupus nephritis and Th17 cell differentiation in mice by inhibiting the interleukin-6/STAT-3 pathway. Arthritis Rheumatol. 2015;67:2185-95 pubmed publisher
    ..Recently, we demonstrated that plasma levels of CD147/basigin (Bsg) in patients with lupus nephritis (LN) were closely associated with disease activity...
  25. Ke X, Fei F, Chen Y, Xu L, Zhang Z, Huang Q, et al. Hypoxia upregulates CD147 through a combined effect of HIF-1? and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors. Carcinogenesis. 2012;33:1598-607 pubmed publisher
    ..In this study, we investigated the functional role of CD147, a transmembrane glycoprotein highly overexpressed on the surface of tumor cells, in hypoxic microenvironment ..
  26. Li H, Ju D, Zhang D, Li H, Kong L, Guo Y, et al. Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis. Sci Rep. 2015;5:16552 pubmed publisher
    ..We hypothesized a positive feedback signaling loop of TGF-β1-CD147 promoting liver fibrogenesis by activation of HSCs...
  27. Shi L, Li L, Wang D, Li S, Chen Z, An Z. Spatiotemporal expression of caveolin-1 and EMMPRIN during mouse tooth development. J Mol Histol. 2016;47:337-44 pubmed publisher
    ..into the caveolae and regulating their activity, including extracellular matrix metalloproteinase inducer (EMMPRIN)...
  28. Jansen S, Pantaleon M, Kaye P. Characterization and regulation of monocarboxylate cotransporters Slc16a7 and Slc16a3 in preimplantation mouse embryos. Biol Reprod. 2008;79:84-92 pubmed publisher
  29. Seizer P, Ochmann C, Schonberger T, Zach S, Rose M, Borst O, et al. Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. Arterioscler Thromb Vasc Biol. 2011;31:1377-86 pubmed publisher
    ..The extracellular matrix metalloproteinase inducer EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) may be involved in both processes...
  30. Kanekura T, Miyauchi T, Tashiro M, Muramatsu T. Basigin, a new member of the immunoglobulin superfamily: genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences. Cell Struct Funct. 1991;16:23-30 pubmed
    b>Basigin is a new member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and major histocompatibility complex class II antigen beta-chain...
  31. Khaddam M, Huet E, Vallee B, Bensidhoum M, Le Denmat D, Filatova A, et al. EMMPRIN/CD147 deficiency disturbs ameloblast-odontoblast cross-talk and delays enamel mineralization. Bone. 2014;66:256-66 pubmed publisher
    ..b>EMMPRIN/CD147 is an Extracellular Matrix MetalloPRoteinase (MMP) INducer that mediates epithelial-mesenchymal ..
  32. Huet E, Vallee B, Delbe J, Mourah S, Prulière Escabasse V, Tremouilleres M, et al. EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease. Am J Pathol. 2011;179:1278-86 pubmed publisher
    ..We show that extracellular matrix metalloproteinase inducer (EMMPRIN; also termed CD147), an inducer of MMP expression, participates in the pathogenesis of dry eye through MMP-..
  33. Chang H, Ni H, Ma X, Xu L, Kadomatsu K, Muramatsu T, et al. Basigin expression and regulation in mouse ovary during the sexual maturation and development of corpus luteum. Mol Reprod Dev. 2004;68:135-41 pubmed
    b>Basigin is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. Basigin-deficient male mice are azoospermic. The majority of basigin null embryos die around the time of implantation...
  34. Unger C, Seulberger H, Breier G, Albrecht U, Achen M, Risau W. Expression of the HT7 gene in blood-brain barrier. Adv Exp Med Biol. 1993;331:211-5 pubmed
  35. Voigt H, Houben R, Schrama D, Hofmann U, Vetter Kauczok C, Becker J. Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma. Tumour Biol. 2007;28:229-37 pubmed
    It was conclusively demonstrated that the cell surface glycoprotein CD147 on tumor cells mediates induction of matrix metalloproteinases (MMPs) by stromal cells in humans. However, for murine models such evidence remains elusive...
  36. Nishioku T, Terasawa M, Baba M, Yamauchi A, Kataoka Y. CD147 promotes the formation of functional osteoclasts through NFATc1 signalling. Biochem Biophys Res Commun. 2016;473:620-4 pubmed publisher
    b>CD147, a membrane glycoprotein of the immunoglobulin superfamily, is highly upregulated during dynamic cellular events including tissue remodelling. Elevated CD147 expression is present in the joint of rheumatoid arthritis patients...
  37. Huet E, Gabison E, Vallee B, Mougenot N, Linguet G, Riou B, et al. Deletion of extracellular matrix metalloproteinase inducer/CD147 induces altered cardiac extracellular matrix remodeling in aging mice. J Physiol Pharmacol. 2015;66:355-66 pubmed
    Extracellular matrix metalloproteinase inducer (EMMPRIN), known for its ability to induce matrix metalloproteinase (MMP) expression, was proposed to play a role in the adverse cardiac extracellular matrix remodeling...
  38. Wang C, Yao H, Chen L, Jia J, Wang L, Dai J, et al. CD147 induces angiogenesis through a vascular endothelial growth factor and hypoxia-inducible transcription factor 1?-mediated pathway in rheumatoid arthritis. Arthritis Rheum. 2012;64:1818-27 pubmed publisher
    ..Our objective was to study the role of CD147 in angiogenesis and determine whether the strategy in which CD147 is suppressed might be useful in reducing ..
  39. Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, et al. Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Circ Res. 2014;115:738-50 pubmed publisher
    ..However, the role of extracellular CyPA and its receptor Basigin (Bsg, encoded by Bsg) in the pathogenesis of pulmonary hypertension (PH) remains to be elucidated...
  40. Seizer P, Ungern Sternberg S, Schönberger T, Borst O, Münzer P, Schmidt E, et al. Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2015;35:655-63 pubmed publisher
    ..Targeting extracellular CyPA via a specific inhibitor may be a promising strategy for platelet inhibition without affecting critical functions of intracellular CyPA. ..
  41. Geng J, Tang J, Yang X, Chen R, Zhang Y, Zhang K, et al. Targeting CD147 for T to NK Lineage Reprogramming and Tumor Therapy. EBioMedicine. 2017;20:98-108 pubmed publisher
    b>CD147 is highly expressed on the surface of numerous tumor cells to promote invasion and metastasis. Targeting these cells with CD147-specific antibodies has been validated as an effective approach for lung and liver cancer therapy...
  42. Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, et al. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J Am Soc Nephrol. 2009;20:1565-76 pubmed publisher
    E-selectin and its ligands are essential for extravasation of leukocytes in inflammation. Here, we report that basigin (Bsg)/CD147 is a ligand for E-selectin that promotes renal inflammation in ischemia/reperfusion...
  43. Nakai M, Chen L, Nowak R. Tissue distribution of basigin and monocarboxylate transporter 1 in the adult male mouse: a study using the wild-type and basigin gene knockout mice. Anat Rec A Discov Mol Cell Evol Biol. 2006;288:527-35 pubmed
    b>Basigin (Bsg) is a transmembrane protein that is responsible for targeting of monocarboxylate transporters (MCTs) to the cell membrane...
  44. Jia L, Wei W, Cao J, Xu H, Miao X, Zhang J. Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells. Ann Hematol. 2009;88:753-60 pubmed publisher
    Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member glycoprotein enriched on the surface of many malignant tumor cells, promotes tumor progression and confers resistance to some chemotherapeutic ..
  45. Xie M, Jiao T, Chen Y, Xu C, Li J, Jiang X, et al. EMMPRIN (basigin/CD147) is involved in the morphogenesis of tooth germ in mouse molars. Histochem Cell Biol. 2010;133:585-94 pubmed publisher
    The pattern of gene expression for extracellular matrix metalloproteinase inducer (EMMPRIN) was revealed in the tooth germ of mouse mandibular molars using quantitative real-time PCR...
  46. Wang C, Fok K, Cai Z, Chen H, Chan H. CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways. Oncotarget. 2017;8:3132-3143 pubmed publisher
    b>CD147 null mutant male mice are infertile with arrested spermatogenesis and increased apoptotic germ cells. Our previous studies have shown that CD147 prevents apoptosis in mouse spermatocytes but not spermatogonia...
  47. Kapfhamer D, Sweet H, Sufalko D, Warren S, Johnson K, Burmeister M. The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3. Genomics. 1996;35:533-8 pubmed
    ..3 nor for spinocerebellar ataxia II (SCA2) on 12q22-q24. The closely linked markers presented here will facilitate positional cloning of the ji gene. ..
  48. Saxena D, Oh oka T, Kadomatsu K, Muramatsu T, Toshimori K. Behaviour of a sperm surface transmembrane glycoprotein basigin during epididymal maturation and its role in fertilization in mice. Reproduction. 2002;123:435-44 pubmed
    b>Basigin (bsg) is a transmembrane glycoprotein belonging to an immunoglobulin superfamily and is localized on the surface of the sperm tail...
  49. Clamp M, Ochrietor J, Moroz T, Linser P. Developmental analyses of 5A11/Basigin, 5A11/Basigin-2 and their putative binding partner MCT1 in the mouse eye. Exp Eye Res. 2004;78:777-89 pubmed
    Recent reports by this laboratory and others have demonstrated an association between 5A11/Basigin, a member of the immunoglobulin gene superfamily, and monocarboxylate transporter-1 (MCT1), a lactose transporter...
  50. Huang Y, Jiang J, Dou K, Chen Z. HAb18G/CD147 enhances the secretion of matrix metalloproteinases (MMP) via cGMP/NO-sensitive capacitative calcium entry (CCE) and accordingly attenuates adhesion ability of fibroblasts. Eur J Cell Biol. 2005;84:59-73 pubmed
    The present study examined the effect of hepatoma-associated antigen HAb18G (homologous to CD147) expression on the NO/cGMP-regulated Ca2+ mobilization to induce matrix metalloproteinases (MMP) production and attenuate adhesion ability ..
  51. Bi J, Li Y, Sun F, Saalbach A, Klein C, Miller D, et al. Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cells. Dev Biol. 2013;380:145-56 pubmed publisher
    b>Basigin (BSG) is a multifunctional glycoprotein that plays an important role in male reproduction since male knockout (KO) mice are sterile...
  52. Pons M, Cousins S, Alcazar O, Striker G, Marin Castano M. Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degener. Am J Pathol. 2011;178:2665-81 pubmed publisher
    ..RPE-derived matrix metalloproteinase (MMP)-2, MMP-14, and basigin (BSG) are major enzymes involved in the maintenance of ECM turnover...
  53. Cheng Y, Li X, Kamholz J, Burns F. Organization of the mouse GP42/Basigin gene: a member of the Ig superfamily. Biochim Biophys Acta. 1994;1217:307-11 pubmed
    We have mapped and sequenced the GP42/Basigin gene isolated from a Balb/C mouse genomic library. The genomic organization and upstream, putative regulatory, regions of this gene have not been previously reported...
  54. Seizer P, Schonberger T, Schött M, Lang M, Langer H, Bigalke B, et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis. 2010;209:51-7 pubmed publisher
    ..Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/..
  55. Fan Q, Kadomatsu K, Uchimura K, Muramatsu T. Embigin/basigin subgroup of the immunoglobulin superfamily: different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers. Dev Growth Differ. 1998;40:277-86 pubmed
    Embigin and basigin are highly glycosylated transmembrane glycoproteins with two immunoglobulin domains and form a subgroup in the immunoglobulin superfamily...
  56. Tarin C, Lavin B, Gomez M, Saura M, Diez Juan A, Zaragoza C. The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric oxide in myocardial ischemia/reperfusion. Free Radic Biol Med. 2011;51:387-95 pubmed publisher
    ..and was associated with significantly increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and EMMPRIN-associated MMPs...
  57. Maekawa F, Minehira K, Kadomatsu K, Pellerin L. Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins. J Neurochem. 2008;107:789-98 pubmed publisher
    ..b>Basigin, a chaperone protein for specific monocarboxylate transporters (MCTs), represents a putatively important ..
  58. Hanna S, Kirk P, Holt O, Puklavec M, Brown M, Barclay A. A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically. BMC Biochem. 2003;4:17 pubmed
    b>CD147 is a broadly distributed integral membrane glycoprotein with two Ig-like domains implicated in a wide range of functions...
  59. Schuster V, Lu R, Kanai N, Bao Y, Rosenberg S, Prie D, et al. Cloning of the rabbit homologue of mouse 'basigin' and rat 'OX-47': kidney cell type-specific expression, and regulation in collecting duct cells. Biochim Biophys Acta. 1996;1311:13-9 pubmed
    ..with high homology to mouse 'gp42' or 'basigin', human 'M6' or 'EMMPRIN', rat 'OX-47' or 'CE-9', and avian 'neurothelin', 'HT7', or '5A11'...
  60. Schulz C, von Brühl M, Barocke V, Cullen P, Mayer K, Okrojek R, et al. EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall. J Thromb Haemost. 2011;9:1007-19 pubmed publisher
    ..To investigate the role of the extracellular matrix metalloproteinase inducer (EMMPRIN) in platelet-monocyte interactions...
  61. Guyot R, Magre S, Leduque P, le Magueresse Battistoni B. Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development. Dev Dyn. 2003;227:357-66 pubmed
    ..Experiments are now under way to determine to what extent TIMP-1 is a morphogenic gene involved in seminiferous cord formation and development. ..
  62. Xie M, Xing G, Hou L, Bao J, Chen Y, Jiao T, et al. Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars. J Mol Histol. 2015;46:21-32 pubmed publisher
    Our previous research has shown that the extracellular matrix metalloproteinase inducer (EMMPRIN) is expressed during and may function in the early development of tooth germs...
  63. Chen H, Fok K, Yu S, Jiang J, Chen Z, Gui Y, et al. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Mol Hum Reprod. 2011;17:405-14 pubmed publisher
    ..Matrix metalloproteinases (MMPs) are essential in regulating Sertoli cell TJ in the testis. CD147 is known to stimulate the production of MMPs in tumor metastasis and its knockout mice are infertile...
  64. Yao H, Teng Y, Sun Q, Xu J, Chen Y, Hou N, et al. Important functional roles of basigin in thymocyte development and T cell activation. Int J Biol Sci. 2013;10:43-52 pubmed publisher
    b>Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown...
  65. Jia L, Cao J, Wei W, Wang S, Zuo Y, Zhang J. CD147 depletion down-regulates matrix metalloproteinase-11, vascular endothelial growth factor-A expression and the lymphatic metastasis potential of murine hepatocarcinoma Hca-F cells. Int J Biochem Cell Biol. 2007;39:2135-42 pubmed
    Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147), which is a plasma membrane glycoprotein enriched on the surface of many malignant tumors promotes adhesion, invasion and metastasis of tumor cells...
  66. Agrawal S, Silva C, Wang J, Tong J, Yong V. A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis. J Neuroinflammation. 2012;9:64 pubmed publisher
    Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs)...
  67. Liu H, Yang L, Guo R, Zhu G, Shi Y, Wang X, et al. Functional blockage of EMMPRIN ameliorates atherosclerosis in apolipoprotein E-deficient mice. Int J Cardiol. 2013;168:3248-53 pubmed publisher
    Extracellular matrix metalloproteinase inducer (EMMPRIN), a 58-kDa cell surface glycoprotein, has been identified as a key receptor for transmitting cellular signals mediating metalloproteinase activities, as well as inflammation and ..
  68. Wang H, Zhuo Y, Hu X, Shen W, Zhang Y, Chu T. CD147 deficiency blocks IL-8 secretion and inhibits lung cancer-induced osteoclastogenesis. Biochem Biophys Res Commun. 2015;458:268-73 pubmed publisher
    ..RNA interference was used to silence CD147 expression in A549 human lung cancer cells...
  69. Xiao L, Chang H, Ding N, Ni H, Kadomatsu K, Yang Z. Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period. Mol Reprod Dev. 2002;63:47-54 pubmed
    b>Basigin, a transmembrane glycoprotein belonging to the immunoglobulin superfamily, has been shown to be essential for fertilization and implantation...
  70. Chen C, Maekawa M, Yamatoya K, Nozaki M, Ito C, Iwanaga T, et al. Interaction between basigin and monocarboxylate transporter 2 in the mouse testes and spermatozoa. Asian J Androl. 2016;18:600-6 pubmed publisher
    b>Basigin is a member of the immunoglobulin superfamily and plays various important roles in biological events including spermatogenesis...
  71. Dai L, Guinea M, Slomiany M, Bratoeva M, Grass G, Tolliver L, et al. CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol. 2013;182:577-85 pubmed publisher
    CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a member of the Ig superfamily, is widespread in normal tissues, but highly up-regulated in many types of malignant cancer cells...
  72. Fu T, Lin C, Tang P. Steroid hormone-regulated let-7b mediates cell proliferation and basigin expression in the mouse endometrium. J Reprod Dev. 2011;57:627-35 pubmed
    ..After transfection of let-7b into mouse stromal cells isolated from day 7 of pregnancy, the expression of Basigin (Bsg), a matrix metalloproteinase (MMP) inducer, was suppressed, as well as that of MMP-9...
  73. Venkatesan B, Valente A, Prabhu S, Shanmugam P, Delafontaine P, Chandrasekar B. EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling. J Mol Cell Cardiol. 2010;49:655-63 pubmed publisher
    The transmembrane glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN), and the pleiotropic proinflammatory cytokine interleukin (IL)-18, play critical roles in myocardial remodeling, by inducing matrix degrading ..
  74. Chen H, Fok K, Jiang X, Jiang J, Chen Z, Gui Y, et al. CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia. Hum Reprod. 2012;27:1568-76 pubmed publisher
    ..Previous study has demonstrated that CD147 knockout mice are infertile with arrested germ cells...
  75. Moreno V, Gonzalo P, Gómez Escudero J, Pollán A, Acin Perez R, Breckenridge M, et al. An EMMPRIN-?-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci. 2014;127:3768-81 pubmed publisher
    ..We identify the Ig superfamily member EMMPRIN (also known as basigin) as a coordinator of forces at endothelial junctions...
  76. Hérubel F, El Mouatassim S, Guérin P, Frydman R, Menezo Y. Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Zygote. 2002;10:175-81 pubmed
    ..Human and mouse genetic expression of MCT members 1, 2, 3, 4 and basigin, a chaperone protein of MCT1 and MCT4, was qualitatively analysed using the reverse transcription nested ..