Brd4

Summary

Gene Symbol: Brd4
Description: bromodomain containing 4
Alias: Brd5, HUNK1, MCAP, WI-11513, bromodomain-containing protein 4, bromodomain-containing 5, fsh-like protein, mitotic chromosome-associated protein
Species: mouse
Products:     Brd4

Top Publications

  1. Dey A, Ellenberg J, Farina A, Coleman A, Maruyama T, Sciortino S, et al. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. Mol Cell Biol. 2000;20:6537-49 pubmed
    We describe a novel nuclear factor called mitotic chromosome-associated protein (MCAP), which belongs to the poorly understood BET subgroup of the bromodomain superfamily...
  2. Devaiah B, Lewis B, Cherman N, Hewitt M, Albrecht B, Robey P, et al. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A. 2012;109:6927-32 pubmed publisher
    The bromodomain protein, BRD4, has been identified recently as a therapeutic target in acute myeloid leukemia, multiple myeloma, Burkitt's lymphoma, NUT midline carcinoma, colon cancer, and inflammatory disease; its loss is a prognostic ..
  3. Lin Y, Umehara T, Inoue M, Saito K, Kigawa T, Jang M, et al. Solution structure of the extraterminal domain of the bromodomain-containing protein BRD4. Protein Sci. 2008;17:2174-9 pubmed publisher
    b>BRD4, which is a member of the BET (bromodomains and extraterminal) protein family, interacts preferentially with acetylated chromatin and possesses multiple cellular functions in meiosis, embryonic development, the cell cycle, and ..
  4. Yang Z, He N, Zhou Q. Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression. Mol Cell Biol. 2008;28:967-76 pubmed
    b>Brd4, a bromodomain protein capable of interacting with acetylated histones, is implicated in transmitting epigenetic memory through mitosis...
  5. Huang B, Yang X, Zhou M, Ozato K, Chen L. Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol. 2009;29:1375-87 pubmed publisher
    ..In this study, we demonstrate that bromodomains of Brd4 bind to acetylated lysine-310...
  6. Zhang G, Liu R, Zhong Y, Plotnikov A, Zhang W, Zeng L, et al. Down-regulation of NF-?B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012;287:28840-51 pubmed publisher
    ..of NF-?B transcriptional activity by small molecule blocking NF-?B binding to the transcriptional cofactor BRD4, which is required for the assembly of the productive transcriptional complex comprising positive transcription ..
  7. You J, Croyle J, Nishimura A, Ozato K, Howley P. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell. 2004;117:349-60 pubmed
    ..We have identified the bromodomain protein Brd4 as a major cellular interacting partner of the bovine papillomavirus E2...
  8. Patel M, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, et al. BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes. Mol Cell Biol. 2013;33:2497-507 pubmed publisher
    ..We investigated this question in interferon (IFN)-stimulated transcription, focusing on BRD4, a BET family protein that interacts with P-TEFb...
  9. McPhillips M, Oliveira J, Spindler J, Mitra R, McBride A. Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses. J Virol. 2006;80:9530-43 pubmed
    Bromodomain protein 4 (Brd4) has been identified as the cellular binding target through which the E2 protein of bovine papillomavirus type 1 links the viral genome to mitotic chromosomes...

More Information

Publications65

  1. Houzelstein D, Bullock S, Lynch D, Grigorieva E, Wilson V, Beddington R. Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol Cell Biol. 2002;22:3794-802 pubmed
    In a gene trap screen we recovered a mouse mutant line in which an insertion generated a null allele of the Brd4 gene...
  2. Wu S, Chiang C. The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation. J Biol Chem. 2007;282:13141-5 pubmed
    b>Brd4 is a double bromodomain-containing protein that binds preferentially to acetylated chromatin...
  3. Zuber J, Shi J, Wang E, Rappaport A, Herrmann H, Sison E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478:524-8 pubmed publisher
    ..chromatin regulators in a genetically defined AML mouse model, we identify the protein bromodomain-containing 4 (Brd4) as being critically required for disease maintenance...
  4. Mochizuki K, Nishiyama A, Jang M, Dey A, Ghosh A, Tamura T, et al. The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. J Biol Chem. 2008;283:9040-8 pubmed publisher
    b>Brd4 is a bromodomain protein that binds to acetylated chromatin. It regulates cell growth, although the underlying mechanism has remained elusive...
  5. Vollmuth F, Blankenfeldt W, Geyer M. Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution. J Biol Chem. 2009;284:36547-56 pubmed publisher
    b>Brd4 is a member of the bromodomains and extra terminal domain (BET) family of proteins that recognize acetylated chromatin structures through their bromodomains and act as transcriptional activators...
  6. Di Micco R, Fontanals Cirera B, Low V, Ntziachristos P, Yuen S, Lovell C, et al. Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes. Cell Rep. 2014;9:234-47 pubmed publisher
    ..Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-..
  7. Dey A, Nishiyama A, Karpova T, McNally J, Ozato K. Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription. Mol Biol Cell. 2009;20:4899-909 pubmed publisher
    ..The nature of mitotic gene marking, however, has been obscure. Brd4 is a double bromodomain protein that localizes to chromosomes during mitosis and is implicated in holding mitotic ..
  8. Itzen F, Greifenberg A, B sken C, Geyer M. Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation. Nucleic Acids Res. 2014;42:7577-90 pubmed publisher
    The bromodomain protein Brd4 regulates the transcription of signal-inducible genes. This is achieved by recruiting the positive transcription elongation factor P-TEFb to promoters by its P-TEFb interaction domain (PID)...
  9. Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A. 2003;100:8758-63 pubmed
    ..b>Brd4 is a member of the BET family that carries two bromodomains...
  10. Cheung K, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, et al. Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol Cell. 2017;65:1068-1080.e5 pubmed publisher
    ..In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (Th17) cell ..
  11. Maruyama T, Farina A, Dey A, Cheong J, Bermudez V, Tamura T, et al. A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. Mol Cell Biol. 2002;22:6509-20 pubmed
    b>Brd4 belongs to the BET family of nuclear proteins that carry two bromodomains implicated in the interaction with chromatin. Expression of Brd4 correlates with cell growth and is induced during early G(1) upon mitogenic stimuli...
  12. Bandukwala H, Gagnon J, Togher S, Greenbaum J, Lamperti E, Parr N, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012;109:14532-7 pubmed publisher
    ..Our study demonstrates that inhibiting the functions of BET-family proteins during early T-cell differentiation causes long-lasting suppression of the proinflammatory functions of Th1 cells. ..
  13. Horne G, Stewart H, Dickson J, Knapp S, Ramsahoye B, Chevassut T. Nanog requires BRD4 to maintain murine embryonic stem cell pluripotency and is suppressed by bromodomain inhibitor JQ1 together with Lefty1. Stem Cells Dev. 2015;24:879-91 pubmed publisher
    ..We show that the effects of JQ1 are recapitulated by knockdown of the BET family member BRD4 implicating this protein in Nanog regulation...
  14. Alsarraj J, Walker R, Webster J, Geiger T, Crawford N, Simpson R, et al. Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion. Cancer Res. 2011;71:3121-31 pubmed publisher
    The bromodomain-containing chromatin-modifying factor BRD4 is an inherited susceptibility gene for breast cancer progression and metastasis, but its functionality in these settings has yet to be explored...
  15. Wu X, Qi J, Bradner J, Xiao G, Chen L. Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor ?B (NF-?B) signaling. J Biol Chem. 2013;288:36094-105 pubmed publisher
    ..Acetylation of the RelA subunit of NF-?B and the subsequent recruitment of bromodomain-containing factor Brd4 are important for the expression of NF-?B target genes in response to various stimuli...
  16. Brown J, Lin C, Duan Q, Griffin G, Federation A, Paranal R, et al. NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell. 2014;56:219-231 pubmed publisher
    ..BET bromodomain inhibition abrogates super enhancer-mediated inflammatory transcription, atherogenic endothelial responses, and atherosclerosis in vivo. ..
  17. Ray S, Zhao Y, Jamaluddin M, Edeh C, Lee C, Brasier A. Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. Cell Signal. 2014;26:1445-55 pubmed publisher
    ..ectopically expressed ubi-STAT3-FP, we observed enhanced complex formation with bromodomain-containing protein 4 (BRD4), a component of the activated positive transcriptional elongation factor (P-TEFb) complex...
  18. Williams C, Fernández Alonso R, Wang J, Toth R, Gray N, Findlay G. Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity. Cell Rep. 2016;16:1820-8 pubmed publisher
    ..Using compound selectivity engineering and CRISPR/Cas9 genome editing, we reveal distinct functions for Erk5 and Brd4 in pluripotency regulation...
  19. Bao Y, Wu X, Chen J, Hu X, Zeng F, Cheng J, et al. Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of I?B?. Proc Natl Acad Sci U S A. 2017;114:E3993-E4001 pubmed publisher
    Bromodomain-containing factor Brd4 has emerged as an important transcriptional regulator of NF-?B-dependent inflammatory gene expression...
  20. Gao F, Yang Y, Wang Z, Gao X, Zheng B. BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-κB activation. Cell Immunol. 2015;294:1-8 pubmed publisher
    ..Here we demonstrate a new role of bromodomain and extraterminal domain (BET) protein BRD4 in GC B cell development...
  21. Korb E, Herre M, Zucker Scharff I, Gresack J, Allis C, Darnell R. Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell. 2017;170:1209-1223.e20 pubmed publisher
    ..To determine if targeting epigenetic factors could reverse phenotypes associated with the disorder, we focused on Brd4, a BET protein and chromatin reader targeted by FMRP...
  22. Patel A, Liao C, Chen Z, Liu C, Wang Y, Le L. BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Cell Rep. 2014;6:81-92 pubmed publisher
    ..Strikingly, in MPNSTs we found upregulation of a chromatin regulator, Brd4, and show that BRD4 inhibition profoundly suppresses both growth and tumorigenesis...
  23. Tang Y, Gholamin S, Schubert S, Willardson M, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014;20:732-40 pubmed publisher
    ..We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and ..
  24. Bhagwat A, Roe J, Mok B, Hohmann A, Shi J, Vakoc C. BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Rep. 2016;15:519-530 pubmed publisher
    The bromodomain and extraterminal (BET) protein BRD4 can physically interact with the Mediator complex, but the relevance of this association to the therapeutic effects of BET inhibitors in cancer is unclear...
  25. Proserpio V, Fittipaldi R, Ryall J, Sartorelli V, Caretti G. The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 2013;27:1299-312 pubmed publisher
    ..SMYD3 targets the myostatin and c-Met genes and participates in the recruitment of the bromodomain protein BRD4 to their regulatory regions through protein-protein interaction...
  26. Wienerroither S, Rauch I, Rosebrock F, Jamieson A, Bradner J, Muhar M, et al. Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins. Mol Cell Biol. 2014;34:415-27 pubmed publisher
    ..bacterial pathogen Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter and that a profound reduction of Nos2 expression occurred in the presence of the BET inhibitor ..
  27. Yamada A, Honma K, Mochizuki K, Goda T. BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver. Metabolism. 2016;65:1478-88 pubmed publisher
    ..We examined whether (+)-JQ1, an inhibitor of the binding between the BRD4 and acetylated histones, inhibited the expressions of fructose-inducible genes, histone acetylation and BRD4 ..
  28. Gilan O, Lam E, Becher I, Lugo D, Cannizzaro E, Joberty G, et al. Functional interdependence of BRD4 and DOT1L in MLL leukemia. Nat Struct Mol Biol. 2016;23:673-81 pubmed publisher
    Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containing protein 4 (BRD4) are currently being evaluated in clinical trials...
  29. Lin A, Wang S, Nguyen T, Shire K, Frappier L. The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4. J Virol. 2008;82:12009-19 pubmed publisher
    ..We have tested the ability of four host proteins (Brd2, Brd4, DEK, and MeCP2) implicated in the segregation of papillomavirus and Kaposi's sarcoma-associated herpesvirus to ..
  30. Kanno T, Kanno Y, LeRoy G, Campos E, Sun H, Brooks S, et al. BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Nat Struct Mol Biol. 2014;21:1047-57 pubmed publisher
    ..the epigenetic interactions between acetylated histones and the bromodomains of the BET family proteins, including BRD4, and they potently inhibit growth of malignant cells by targeting cancer-promoting genes...
  31. Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, et al. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012;26:2477-82 pubmed publisher
    ..kinase inhibitor (CDKI) gene, in PGCs is selectively activated by P-TEFb and its recruiting molecule, Brd4, when the amount of active P-TEFb is increased due to reduction of the 7SK snRNP, and PGCs consequently undergo ..
  32. Bryant J, Donahue G, Wang X, Meyer Ficca M, Luense L, Weller A, et al. Characterization of BRD4 during mammalian postmeiotic sperm development. Mol Cell Biol. 2015;35:1433-48 pubmed publisher
    ..Immunofluorescence of spermatogenic cells revealed BRD4 in a ring around the nuclei of spermatids containing hyperacetylated histones...
  33. Lee J, Park Y, Park S, Jang Y, Waring N, Dey A, et al. Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. Nat Commun. 2017;8:2217 pubmed publisher
    The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell differentiation and animal development remains largely unclear...
  34. Wang S, Pike A, Lee S, Strong M, Connelly C, Greider C. BRD4 inhibitors block telomere elongation. Nucleic Acids Res. 2017;45:8403-8410 pubmed publisher
    ..Using an unbiased shRNA screen targeting known kinases, we identified bromodomain-containing protein 4 (BRD4) as a telomere length regulator...
  35. Ding N, Hah N, Yu R, Sherman M, Benner C, Leblanc M, et al. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A. 2015;112:15713-8 pubmed publisher
    ..We report here that JQ1, a small molecule inhibitor of bromodomain-containing protein 4 (BRD4), a member of bromodomain and extraterminal (BET) proteins, abrogate cytokine-induced activation of HSCs...
  36. Roe J, Mercan F, Rivera K, Pappin D, Vakoc C. BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia. Mol Cell. 2015;58:1028-39 pubmed publisher
    The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well understood...
  37. Stanlie A, Yousif A, Akiyama H, Honjo T, Begum N. Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining. Mol Cell. 2014;55:97-110 pubmed publisher
    ..Here, we show that the acetylated histone reader Brd4 is critical for nonhomologous end-joining (NHEJ) repair of AID- and I-SceI-induced DNA breaks...
  38. Zou Z, Huang B, Wu X, Zhang H, Qi J, Bradner J, et al. Brd4 maintains constitutively active NF-?B in cancer cells by binding to acetylated RelA. Oncogene. 2014;33:2395-404 pubmed publisher
    ..Bromodomain-containing factor Brd4 has been shown to bind to acetylated lysine-310 (AcLys310) and to regulate the transcriptional activity of NF-?B, ..
  39. Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, et al. Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells. Proc Natl Acad Sci U S A. 2015;112:E4448-57 pubmed publisher
    ..We explored Aire's collaboration with the bromodomain-containing protein, Brd4, uncovering an astonishing correspondence between those genes induced by Aire and those inhibited by a small-..
  40. Banu Y, Matsuda M, Yoshihara M, Kondo M, Sutou S, Matsukuma S. Golgi matrix protein gene, Golga3/Mea2, rearranged and re-expressed in pachytene spermatocytes restores spermatogenesis in the mouse. Mol Reprod Dev. 2002;61:288-301 pubmed
    ..Golga3/Mea2, and DeltaMea2 in homozygotes, in a certain excessive amount may be important for survival of pachytene spermatocytes in the mouse. ..
  41. Nagashima T, Maruyama T, Furuya M, Kajitani T, Uchida H, Masuda H, et al. Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis. Mol Hum Reprod. 2007;13:141-8 pubmed
    ..Only some chromosomal proteins, such as bromodomain containing protein 4 (BRD4), have a potential to associate with mitotic chromosomes in a histone acetylation-dependent ..
  42. Hellert J, Weidner Glunde M, Krausze J, Richter U, Adler H, Fedorov R, et al. A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. PLoS Pathog. 2013;9:e1003640 pubmed publisher
    ..nuclear microdomains, termed 'LANA speckles', which also contain cellular chromatin proteins, including BRD2 and BRD4, members of the BRD/BET family of chromatin modulators...
  43. Malik N, Vollmer S, Nanda S, López Pelaéz M, Prescott A, Gray N, et al. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. Biochem J. 2015;468:363-72 pubmed publisher
    ..2, but without affecting the nuclear translocation of IRF5. We found that the BET family member BRD4 (bromodomain-containing protein 4) was associated with the IFNB promoter and that this interaction was enhanced by ..
  44. Tian B, Zhao Y, Sun H, Zhang Y, Yang J, Brasier A. BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1183-L1201 pubmed publisher
    ..Phospho-Ser276 RelA binds to the BRD4/CDK9 transcriptional elongation complex, activating the paused RNA Pol II by phosphorylation on Ser2 in its carboxy-..
  45. Crawford N, Alsarraj J, Lukes L, Walker R, Officewala J, Yang H, et al. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci U S A. 2008;105:6380-5 pubmed publisher
    ..The bromodomain protein Brd4 physically interacts with and modulates the enzymatic activity of Sipa1...
  46. Liu W, Stein P, Cheng X, Yang W, Shao N, Morrisey E, et al. BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos. Cell Death Differ. 2014;21:1950-60 pubmed publisher
    Bromodomain-containing protein 4 (BRD4) is an important epigenetic reader implicated in the pathogenesis of a number of different cancers and other diseases...
  47. Bolden J, Tasdemir N, Dow L, van Es J, Wilkinson J, Zhao Z, et al. Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell Rep. 2014;8:1919-1929 pubmed publisher
    ..Using an inducible and reversible transgenic RNAi mouse model, we show that strong suppression of the BET protein Brd4 in adult animals has dramatic effects in multiple tissues...
  48. Tang X, Peng R, Phillips J, Deguzman J, Ren Y, Apparsundaram S, et al. Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis. Am J Pathol. 2013;183:470-9 pubmed publisher
    ..release observed in LFs from patients with rapidly progressing IPF are attenuated by pharmacologic inhibition of Brd4. These changes are accompanied by enhanced histone H4 lysine5 acetylation and association of Brd4 with genes ..
  49. Devaiah B, Case Borden C, Gegonne A, Hsu C, Chen Q, Meerzaman D, et al. BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin. Nat Struct Mol Biol. 2016;23:540-8 pubmed publisher
    Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers...
  50. Devaiah B, Gegonne A, Singer D. Bromodomain 4: a cellular Swiss army knife. J Leukoc Biol. 2016;100:679-686 pubmed
    Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that plays a pivotal role in cancer and inflammatory diseases...
  51. Di Stefano B, Collombet S, Jakobsen J, Wierer M, Sardina J, Lackner A, et al. C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4. Nat Cell Biol. 2016;18:371-81 pubmed publisher
    ..that C/EBPα post-transcriptionally increases the abundance of several hundred proteins, including Lsd1, Hdac1, Brd4, Med1 and Cdk9, components of chromatin-modifying complexes present at super-enhancers...
  52. Nishiyama A, Dey A, Miyazaki J, Ozato K. Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. Mol Biol Cell. 2006;17:814-23 pubmed
    The mammalian bromodomain protein Brd4 interacts with mitotic chromosomes by binding to acetylated histone H3 and H4 and is thought to play a role in epigenetic memory. Mitotic cells are susceptible to antimicrotubule drugs...
  53. Korb E, Herre M, Zucker Scharff I, Darnell R, Allis C. BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice. Nat Neurosci. 2015;18:1464-73 pubmed publisher
    ..b>Brd4 is a member of the bromodomain and extra-terminal domain (BET) protein family, which binds acetylated histones and ..
  54. Wu T, Pinto H, Kamikawa Y, Donohoe M. The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression. Stem Cell Reports. 2015;4:390-403 pubmed publisher
    ..Here we show that BRD4, a member of the BET protein subfamily, interacts with OCT4...
  55. Resch K, Korthaus D, Wedemeyer N, Lengeling A, Ronsiek M, Thiel C, et al. Homology between human chromosome 2p13.3 and the wobbler critical region on mouse chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs. Mamm Genome. 1998;9:893-8 pubmed
  56. Gonzales Cope M, Sidoli S, Bhanu N, Won K, Garcia B. Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells. BMC Genomics. 2016;17:95 pubmed publisher
    ..More importantly, we found a global decrease of multiply acetylated histone H4 peptides. Brd4 targets acetylated H4 with a strong affinity to multiply modified H4 acetylation sites...