Brca1

Summary

Gene Symbol: Brca1
Description: breast cancer 1, early onset
Alias: breast cancer type 1 susceptibility protein homolog, RING-type E3 ubiquitin transferase BRCA1, breast cancer associated 1
Species: mouse
Products:     Brca1

Top Publications

  1. Ludwig T, Fisher P, Ganesan S, Efstratiadis A. Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev. 2001;15:1188-93 pubmed
    We generated mouse mutants carrying in the Brca1 locus a modification (Brca1(tr)) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or ..
  2. Arlt M, Xu B, Durkin S, Casper A, Kastan M, Glover T. BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol Cell Biol. 2004;24:6701-9 pubmed
    ..F. Arlt, and T. W. Glover, Cell 111:779-789, 2002). Here we demonstrate that mouse and human cells deficient for BRCA1, due to mutation or knockdown by RNA interference, also have elevated fragile-site expression...
  3. Cressman V, Backlund D, Hicks E, Gowen L, Godfrey V, Koller B. Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth Differ. 1999;10:1-10 pubmed
    The inheritance of a mutant copy of the BRCA1 gene greatly increases a woman's lifetime risk for ovarian and breast cancer...
  4. Smart C, Wronski A, French J, Edwards S, Asselin Labat M, Waddell N, et al. Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit. Oncogene. 2011;30:1597-607 pubmed publisher
    Disruption of the breast cancer susceptibility gene Brca1 results in defective lobular-alveolar development in the mammary gland and a predisposition to breast tumourigenesis in humans and in mice...
  5. Turner J, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli G, et al. BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol. 2004;14:2135-42 pubmed
    ..onset of MSCI and that this localization is disrupted in mice with a mutant form of the tumor suppressor protein BRCA1. In the mutant pachytene cells, ATR is usually present at nonsex chromosomal sites, where it colocalizes with ..
  6. Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen H, Deng C, et al. Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol. 2005;15:561-5 pubmed
    Women with germline mutations in BRCA1 have a 40% risk of developing ovarian cancer by age 70 and are also predisposed to cancers of the fallopian tubes...
  7. Ludwig T, Chapman D, Papaioannou V, Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997;11:1226-41 pubmed
    Mutations of the human BRCA1 and BRCA2 genes encoding tumor suppressors have been implicated in inherited predisposition to breast and other cancers...
  8. Jaspers J, Kersbergen A, Boon U, Sol W, Van Deemter L, Zander S, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013;3:68-81 pubmed publisher
    Inhibition of PARP is a promising therapeutic strategy for homologous recombination-deficient tumors, such as BRCA1-associated cancers...
  9. Deng C, Xu X. Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol. 2004;280:185-200 pubmed
    Germline mutations of the breast tumor suppressor gene BRCA1 predispose women to breast and ovarian cancers...

More Information

Publications78

  1. Stark J, Pierce A, Oh J, Pastink A, Jasin M. Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol. 2004;24:9305-16 pubmed
    ..repair components affected both SSA and HDR, but in opposite directions: SSA and HDR were reduced by mutation of Brca1, which, like Brca2, predisposes to breast cancer, whereas SSA and HDR were increased by Ku70 mutation, which ..
  2. Cao L, Xu X, Cao L, Wang R, Coumoul X, Kim S, et al. Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach. Carcinogenesis. 2007;28:1401-7 pubmed
    ..We have shown previously that mice, which are homozygous for full-length breast cancer-associated gene-1 (Brca1) deletion and heterozygous for a p53-null mutation (Brca1(Delta11/Delta11)p53(+/-)), display premature aging and ..
  3. Hall J, Lee M, Newman B, Morrow J, Anderson L, Huey B, et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science. 1990;250:1684-9 pubmed
    ..Likelihood ratios in favor of linkage heterogeneity among families ranged between 2000:1 and greater than 10(6):1 on the basis of multipoint analysis of four loci in the region. ..
  4. Cao L, Li W, Kim S, Brodie S, Deng C. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev. 2003;17:201-13 pubmed
    ..Here we provide evidence to support this theory by showing that the absence of the Brca1 full-length isoform causes senescence in mutant embryos and cultured cells as well as aging and tumorigenesis in ..
  5. Liu X, Holstege H, van der Gulden H, Treur Mulder M, Zevenhoven J, Velds A, et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007;104:12111-6 pubmed
    Women carrying germ-line mutations in BRCA1 are strongly predisposed to developing breast cancers with characteristic features also observed in sporadic basal-like breast cancers...
  6. Shukla V, Coumoul X, Cao L, Wang R, Xiao C, Xu X, et al. Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res. 2006;66:7151-7 pubmed
    The breast cancer-associated gene-1 (BRCA1) plays many important functions in multiple biological processes/pathways...
  7. Suzuki A, de la Pompa J, Hakem R, Elia A, Yoshida R, Mo R, et al. Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997;11:1242-52 pubmed
    ..Thus, Brca2(10-11) mutants are similar in phenotype to Brca1(5-6) mutants but less severely affected...
  8. Evers B, Jonkers J. Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene. 2006;25:5885-97 pubmed
    Germline mutations in BRCA1 and BRCA2 are responsible for a large proportion of hereditary breast and ovarian cancers...
  9. Zhu Q, Pao G, Huynh A, Suh H, Tonnu N, Nederlof P, et al. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature. 2011;477:179-84 pubmed publisher
    Mutations in the tumour suppressor gene BRCA1 lead to breast and/or ovarian cancer. Here we show that loss of Brca1 in mice results in transcriptional de-repression of the tandemly repeated satellite DNA...
  10. Shakya R, Reid L, Reczek C, Cole F, Egli D, Lin C, et al. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science. 2011;334:525-8 pubmed publisher
    Germline mutations of the breast cancer 1 (BRCA1) gene are a major cause of familial breast and ovarian cancer...
  11. Wojtasz L, Cloutier J, Baumann M, Daniel K, Varga J, Fu J, et al. Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 2012;26:958-73 pubmed publisher
    ..Thus, we provide convincing evidence for the existence of a distinct asynapsis surveillance mechanism that safeguards the ploidy of the mammalian germline. ..
  12. Szabova L, Yin C, Bupp S, Guerin T, Schlomer J, Householder D, et al. Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer. Cancer Res. 2012;72:4141-53 pubmed publisher
    ..subset of human SEOC harbors a combination of germline and somatic mutations as well as epigenetic dysfunction for BRCA1/2...
  13. Deeb K, Michalowska A, Yoon C, Krummey S, Hoenerhoff M, Kavanaugh C, et al. Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res. 2007;67:8065-80 pubmed
    ..Rather, it is uniquely activated primarily in tumors with aberrant p53, Rb, or BRCA1 expression but not in tumors initiated through the overexpression of myc, ras, her2/neu, or polyoma middle T ..
  14. Liu S, Ginestier C, Charafe Jauffret E, Foco H, Kleer C, Merajver S, et al. BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci U S A. 2008;105:1680-5 pubmed publisher
    Although it is well established that women with germ-line mutations in the BRCA1 gene have a greatly increased lifetime incidence of breast and ovarian cancer, the molecular mechanisms responsible for this tissue-specific carcinogenesis ..
  15. Bunting S, Callén E, Kozak M, Kim J, Wong N, López Contreras A, et al. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Mol Cell. 2012;46:125-35 pubmed publisher
    b>Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development...
  16. Callen E, Di Virgilio M, Kruhlak M, Nieto Soler M, Wong N, Chen H, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013;153:1266-80 pubmed publisher
    ..During S phase, BRCA1 antagonizes 53BP1 to promote HR...
  17. Gowen L, Johnson B, Latour A, Sulik K, Koller B. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996;12:191-4 pubmed
    The breast and ovarian cancer susceptibility gene, BRCA1, has been cloned and shown to encode a zinc-finger protein of unknown function...
  18. Venkitaraman A. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002;108:171-82 pubmed
    Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers...
  19. McPherson J, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, et al. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes Dev. 2004;18:1144-53 pubmed
    Disruption of Brca1 results in cellular demise or tumorigenesis depending on cellular context. Inactivation of p53 contributes to Brca1-associated tumor susceptibility...
  20. Rottenberg S, Nygren A, Pajic M, van Leeuwen F, van der Heijden I, van de Wetering K, et al. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A. 2007;104:12117-22 pubmed
    We have studied in vivo responses of "spontaneous" Brca1- and p53-deficient mammary tumors arising in conditional mouse mutants to treatment with doxorubicin, docetaxel, or cisplatin...
  21. Molyneux G, Geyer F, Magnay F, McCarthy A, Kendrick H, Natrajan R, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell. 2010;7:403-17 pubmed publisher
    Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like phenotype. It has been suggested that this results from an origin in basal breast epithelial stem cells...
  22. Hakem R, de la Pompa J, Elia A, Potter J, Mak T. Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet. 1997;16:298-302 pubmed
    Mutations in the mouse Brca1 gene cause lethality at different embryonic stages. We have shown that Brca1 mutant embryos, in which the fifth and sixth exons of Brca1 are deleted die before E7.5 and show decreased cellular proliferation...
  23. Liu C, Flesken Nikitin A, Li S, Zeng Y, Lee W. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 1996;10:1835-43 pubmed
    b>BRCA1 is proposed to be a tumor suppressor gene...
  24. Fukuda T, Pratto F, Schimenti J, Turner J, Camerini Otero R, Hoog C. Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS Genet. 2012;8:e1002485 pubmed publisher
    ..HORMAD1, HORMAD2, and SMC3 are dramatically reduced in the absence of initiation of meiotic recombination, whereas BRCA1 and SYCP3 are required for normal levels of phosphorylation of HORMAD1 and HORMAD2, but not of SMC3...
  25. Cao L, Xu X, Bunting S, Liu J, Wang R, Cao L, et al. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell. 2009;35:534-41 pubmed publisher
    ..with constitutively increased DNA damage due to the absence of the full-length form of the tumor suppressor Brca1 (Brca1(Delta 11/Delta 11)), we show that deletion of p53 binding protein 1 (53BP1) selectivity abrogates ..
  26. Marquis S, Rajan J, Wynshaw Boris A, Xu J, Yin G, Abel K, et al. The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995;11:17-26 pubmed
    We have examined the developmental expression of the murine breast and ovarian cancer susceptibility gene, Brca1, to investigate its role in the control of cell growth and differentiation...
  27. Xu X, Weaver Z, Linke S, Li C, Gotay J, Wang X, et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999;3:389-95 pubmed
    Germline mutations of the Brca1 tumor suppressor gene predispose women to breast and ovarian cancers...
  28. Xu X, Wagner K, Larson D, Weaver Z, Li C, Ried T, et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet. 1999;22:37-43 pubmed
    Cre-mediated excision of exon 11 of the breast-tumour suppressor gene Brca1 in mouse mammary epithelial cells causes increased apoptosis and abnormal ductal development...
  29. Xing D, Orsulic S. A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res. 2006;66:8949-53 pubmed
    Little is known about the mechanisms that underlie Brca1-associated ovarian tumorigenesis, mainly due to the lack of an appropriate experimental model...
  30. Deng C. Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice. Mutat Res. 2001;477:183-9 pubmed
    Germline mutations in Brca1 are responsible for most cases of familial breast and ovarian cancers, but somatic mutations in the gene are rarely detected in sporadic tumors...
  31. Deng C, Scott F. Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation. Oncogene. 2000;19:1059-64 pubmed
    Germline mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers...
  32. Kim S, Cao L, Li C, Xu X, Huber L, Chodosh L, et al. Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Mol Cell Biol. 2004;24:9498-507 pubmed
    The tumor suppressor BRCA1 contains multiple functional domains that interact with many proteins. After DNA damage, BRCA1 is phosphorylated by CHK2 at serine 988, followed by a change in its intracellular location...
  33. Henderson B. Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking. Bioessays. 2005;27:884-93 pubmed
    The subcellular location and function of many proteins are regulated by nuclear-cytoplasmic shuttling. BRCA1 and BARD1 provide an interesting model system for understanding the influence of protein dimerization on nuclear transport and ..
  34. Deng C. Tumor formation in Brca1 conditional mutant mice. Environ Mol Mutagen. 2002;39:171-7 pubmed
    b>BRCA1 is the first breast cancer-associated gene, whose mutation predisposes women to breast and ovarian cancers...
  35. Zhong Q, Chen C, Chen P, Lee W. BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem. 2002;277:28641-7 pubmed
    b>BRCA1 is critical for the maintenance of genomic stability, in part through its interaction with the Rad50.Mre11...
  36. Deng C. Roles of BRCA1 in centrosome duplication. Oncogene. 2002;21:6222-7 pubmed
    ..Recent studies indicate that breast cancer suppressor gene 1 (BRCA1) plays an important role in regulating centrosome duplication...
  37. Magnard C, Bachelier R, Vincent A, Jaquinod M, Kieffer S, Lenoir G, et al. BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. Oncogene. 2002;21:6729-39 pubmed
    Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 is a 220-kDa protein that contains a tandem of two BRCA1 C-Terminal (BRCT) domains...
  38. Deng C, Brodie S. Roles of BRCA1 and its interacting proteins. Bioessays. 2000;22:728-37 pubmed
    Germline mutations of BRCA1 predispose women to breast and ovarian cancers...
  39. Brodie S, Xu X, Qiao W, Li W, Cao L, Deng C. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene. 2001;20:7514-23 pubmed
    Germline mutations in the tumor suppressor gene BRCA1 predispose women to breast cancer, however somatic mutations in the gene are rarely detected in sporadic cancers...
  40. Clark Knowles K, Garson K, Jonkers J, Vanderhyden B. Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes. Exp Cell Res. 2007;313:133-45 pubmed
    ..Germline mutations in the BRCA1 tumor suppressor gene result in a significantly increased risk of developing EOC and a large proportion of ..
  41. Bunting S, Callén E, Wong N, Chen H, Polato F, Gunn A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 2010;141:243-54 pubmed publisher
    ..by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations...
  42. Li W, Xiao C, Vonderhaar B, Deng C. A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. Oncogene. 2007;26:7204-12 pubmed
    Estrogen and its receptor alpha (ERalpha) have been implicated in the tissue-specific tumorigenesis associated with BRCA1 mutations...
  43. Miki Y, Swensen J, Shattuck Eidens D, Futreal P, Harshman K, Tavtigian S, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994;266:66-71 pubmed
    A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods...
  44. Blackshear P, Goldsworthy S, Foley J, McAllister K, Bennett L, Collins N, et al. Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene. 1998;16:61-8 pubmed
    The mouse homologues of the breast cancer susceptibility genes, Brca1 and Brca2, are expressed in a cell cycle-dependent fashion in vitro and appear to be regulated by similar or overlapping pathways...
  45. Lorick K, Jensen J, Fang S, Ong A, Hatakeyama S, Weissman A. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci U S A. 1999;96:11364-9 pubmed
    ..Several otherwise-unrelated RING finger proteins, including BRCA1, Siah-1, TRC8, NF-X1, kf-1, and Praja1, were assessed for their ability to facilitate E2-dependent ubiquitination...
  46. Chandler J, Hohenstein P, Swing D, Tessarollo L, Sharan S. Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice. Genesis. 2001;29:72-7 pubmed
    Half of all familial breast cancers are due to mutation in the BRCA1 gene. However, despite its importance, attempts to model BRCA1-induced disease in the mouse have been disappointing...
  47. Gonzalez M, Li X, Toy K, DuPrie M, Ventura A, Banerjee M, et al. Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1. Oncogene. 2009;28:843-53 pubmed publisher
    ..EZH2 knockdown upregulated BRCA1 protein...
  48. Kogo H, Tsutsumi M, Inagaki H, Ohye T, Kiyonari H, Kurahashi H. HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Genes Cells. 2012;17:897-912 pubmed publisher
    ..Our results thus show a HORMAD2-dependent quality control mechanism that recognizes unsynapsis and recruits ATR activity during mammalian meiosis. ..
  49. Kitagawa R, Bakkenist C, McKinnon P, Kastan M. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004;18:1423-38 pubmed
    ..Here, we show that NBS1 and BRCA1 are required for the recruitment of previously activated ATM to the sites of DNA breaks after ionizing irradiation,..
  50. Ganesan S, Silver D, Greenberg R, Avni D, Drapkin R, Miron A, et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 2002;111:393-405 pubmed
    b>BRCA1, a breast and ovarian tumor suppressor, colocalizes with markers of the inactive X chromosome (Xi) on Xi in female somatic cells and associates with XIST RNA, as detected by chromatin immunoprecipitation...
  51. Herschkowitz J, Simin K, Weigman V, Mikaelian I, Usary J, Hu Z, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8:R76 pubmed
    ..of several models displayed characteristics of human basal-like breast tumors, including two models with induced Brca1 deficiencies...
  52. Shen S, Weaver Z, Xu X, Li C, Weinstein M, Chen L, et al. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998;17:3115-24 pubmed
    ..Moreover, mouse embryos deficient for Brca1 have been shown to die during early embryogenesis due to a proliferation defect...
  53. Mahadevaiah S, Bourc his D, de Rooij D, Bestor T, Turner J, Burgoyne P. Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol. 2008;182:263-76 pubmed publisher
    ..We suggest that MSUC-related proteins, including the MSUC initiator BRCA1, are sequestered at unrepaired DSBs...
  54. Lane T, Deng C, Elson A, Lyu M, Kozak C, Leder P. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 1995;9:2712-22 pubmed
    We have isolated genomic and cDNA clones of Brca1, a mouse homolog of the recently cloned breast cancer-associated gene, BRCA1...
  55. Berton T, Matsumoto T, Page A, Conti C, Deng C, Jorcano J, et al. Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. Oncogene. 2003;22:5415-26 pubmed
    The BRCA1 tumor-suppressor protein has been implicated in the regulation of transcription, DNA repair, proliferation, and apoptosis...
  56. Wang R, Yu H, Deng C. A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A. 2004;101:17108-13 pubmed
    b>BRCA1-associated breast cancer exhibits significantly higher levels of chromosomal abnormalities than sporadic breast cancers. However, the molecular mechanisms regarding the roles of BRCA1 in maintaining genome integrity remain elusive...
  57. Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell. 2012;22:106-16 pubmed publisher
    Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions ascribed to them cannot fully explain all of their cellular roles...
  58. Kang H, Hong Y, Kim H, Rodriguez O, Nath R, Tilli E, et al. Detoxification: a novel function of BRCA1 in tumor suppression?. Toxicol Sci. 2011;122:26-37 pubmed publisher
    Our studies found that BRCA1 levels negatively correlate with DNA adducts induced by Benzo(a)pyrene (BaP)...
  59. Chen J, Silver D, Walpita D, Cantor S, Gazdar A, Tomlinson G, et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998;2:317-28 pubmed
    b>BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51...
  60. Celeste A, Fernandez Capetillo O, Kruhlak M, Pilch D, Staudt D, Lee A, et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol. 2003;5:675-9 pubmed
    ..Despite their initial recruitment to DSBs, numerous factors, including Nbs1, 53BP1 and Brca1, subsequently fail to form IRIF...
  61. Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, et al. Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat Cell Biol. 2011;13:599-610 pubmed publisher
  62. Xu X, Qiao W, Linke S, Cao L, Li W, Furth P, et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001;28:266-71 pubmed
    ..and approximately half of these are associated with germline mutations of the breast tumor suppressor gene BRCA1 (refs. 1,2)...
  63. Bernard Gallon D, De Latour M, Sylvain V, Vissac C, Aunoble B, Chassagne J, et al. Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int J Oncol. 2001;18:271-80 pubmed
    We have analyzed by immunohistochemistry Brca1 and Brca2 protein expression in mouse during embryonic development, in adult tissues, and during postnatal mammary gland development...
  64. Deng C. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 2006;34:1416-26 pubmed
    Germline mutations of the breast cancer associated gene 1 (BRCA1) predispose women to breast and ovarian cancers...
  65. Hakem R, de la Pompa J, Sirard C, Mo R, Woo M, Hakem A, et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996;85:1009-23 pubmed
    Mutations of the BRCA1 gone in humans are associated with predisposition to breast and ovarian cancers. We show here that Brca1+/- mice are normal and fertile and lack tumors by age eleven months...
  66. Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie S, et al. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene. 2002;21:5097-107 pubmed
    b>BRCA1 mutation carriers have an increased susceptibility to breast and ovarian cancer. Excision of exon 11 of Brca1 in the mouse, using a conditional knockout (Cre-loxP) approach, results in mammary tumor formation after long latency...
  67. Clark Knowles K, Senterman M, Collins O, Vanderhyden B. Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas. PLoS ONE. 2009;4:e8534 pubmed publisher
    ..Germline mutations in the BRCA1 tumor suppressor gene result in a significantly increased risk of developing EOC and a large proportion of ..
  68. Deng C, Wang R. Roles of BRCA1 in DNA damage repair: a link between development and cancer. Hum Mol Genet. 2003;12 Spec No 1:R113-23 pubmed
    DNA damage causes devastating problems for developing organisms. Recent studies reveal that BRCA1 plays essential roles in homologous recombinational repair, non-homologous end joining, and nucleotide excision repair...
  69. Reid L, Shakya R, Modi A, Lokshin M, Cheng J, Jasin M, et al. E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci U S A. 2008;105:20876-81 pubmed publisher
    Hereditary cases of breast and ovarian cancer are often attributed to germ-line mutations of the BRCA1 tumor suppressor gene...