Gene Symbol: Brap
Description: BRCA1 associated protein
Alias: 3010002G07Rik, BRAP2, IMP, BRCA1-associated protein, RING-type E3 ubiquitin transferase BRAP2, brap, impedes mitogenic signal propagation
Species: mouse
Products:     Brap

Top Publications

  1. Matheny S, Chen C, Kortum R, Razidlo G, Lewis R, White M. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature. 2004;427:256-60 pubmed
    ..Here we report that the Ras effector protein Impedes Mitogenic signal Propagation (IMP) modulates sensitivity of the MAP kinase cascade to stimulus-dependent activation by limiting ..
  2. Czyzyk J, Chen H, Bottomly K, Flavell R. p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells. J Biol Chem. 2008;283:23004-15 pubmed publisher
    ..role of a recently described Ras GTPase effector and repressor of the Raf/MEK/ERK cascade called impedes mitogenic signal propagation (Imp) in limiting the induction of T-cell cytokines...
  3. Chen C, Lewis R, White M. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. J Biol Chem. 2008;283:12789-96 pubmed publisher
    The Ras effector and ubiquitin-protein isopeptide ligase family member IMP acts as a steady-state resistor within the Raf-MEK-ERK kinase module...
  4. Takashima O, Tsuruta F, Kigoshi Y, Nakamura S, Kim J, Katoh M, et al. Brap2 regulates temporal control of NF-?B localization mediated by inflammatory response. PLoS ONE. 2013;8:e58911 pubmed publisher
    ..In this study, we report that BRCA1-associated protein 2 (Brap2) is a novel Nedd8-binding protein that interacts with SCF complex, and is involved in NF-?B translocation ..
  5. Lanctot A, Guo Y, Le Y, Edens B, Nowakowski R, Feng Y. Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017;20:1148-1160 pubmed publisher
    ..Here, we report that proper G1 phase completion in NPCs requires Brap, a Ras-Erk signaling modulator with ubiquitin E3 ligase activity...
  6. Nakajima A, Kataoka K, Hong M, Sakaguchi M, Huh N. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 2003;201:195-201 pubmed
    ..The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1...
  7. Davies R, Wagstaff K, McLaughlin E, Loveland K, Jans D. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. Biochim Biophys Acta. 2013;1833:3436-3444 pubmed publisher
    ..The breast cancer antigen BRCA1-binding protein BRAP2 has been reported as a novel negative regulator of nuclear import of various nuclear localization signal (NLS)-..
  8. Fatima S, Wagstaff K, Loveland K, Jans D. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Sci Rep. 2015;5:9459 pubmed publisher
    Although the negative regulator of nuclear import (NRNI) BRCA1 binding protein 2 (BRAP2) is highly expressed in testis, its role is largely unknown...