Gene Symbol: Brap
Description: BRCA1 associated protein
Alias: 3010002G07Rik, BRAP2, IMP, BRCA1-associated protein, RING-type E3 ubiquitin transferase BRAP2, brap, impedes mitogenic signal propagation
Matheny S, Chen C, Kortum R, Razidlo G, Lewis R, White M. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature. 2004;427:256-60 pubmed
..Here we report that the Ras effector protein Impedes Mitogenic signal Propagation (IMP) modulates sensitivity of the MAP kinase cascade to stimulus-dependent activation by limiting ..
Czyzyk J, Chen H, Bottomly K, Flavell R. p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells. J Biol Chem. 2008;283:23004-15 pubmed publisher
..role of a recently described Ras GTPase effector and repressor of the Raf/MEK/ERK cascade called impedes mitogenic signal propagation (Imp) in limiting the induction of T-cell cytokines...
Chen C, Lewis R, White M. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. J Biol Chem. 2008;283:12789-96 pubmed publisher
The Ras effector and ubiquitin-protein isopeptide ligase family member IMP acts as a steady-state resistor within the Raf-MEK-ERK kinase module...
Takashima O, Tsuruta F, Kigoshi Y, Nakamura S, Kim J, Katoh M, et al
. Brap2 regulates temporal control of NF-?B localization mediated by inflammatory response. PLoS ONE. 2013;8:e58911 pubmed publisher
..In this study, we report that BRCA1-associated protein 2 (Brap2) is a novel Nedd8-binding protein that interacts with SCF complex, and is involved in NF-?B translocation ..
Lanctot A, Guo Y, Le Y, Edens B, Nowakowski R, Feng Y. Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017;20:1148-1160 pubmed publisher
..Here, we report that proper G1 phase completion in NPCs requires Brap, a Ras-Erk signaling modulator with ubiquitin E3 ligase activity...
Nakajima A, Kataoka K, Hong M, Sakaguchi M, Huh N. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 2003;201:195-201 pubmed
..The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1...
Davies R, Wagstaff K, McLaughlin E, Loveland K, Jans D. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. Biochim Biophys Acta. 2013;1833:3436-3444 pubmed publisher
..The breast cancer antigen BRCA1-binding protein BRAP2 has been reported as a novel negative regulator of nuclear import of various nuclear localization signal (NLS)-..
Fatima S, Wagstaff K, Loveland K, Jans D. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Sci Rep. 2015;5:9459 pubmed publisher
Although the negative regulator of nuclear import (NRNI) BRCA1 binding protein 2 (BRAP2) is highly expressed in testis, its role is largely unknown...