brain specific angiogenesis inhibitor 1


Gene Symbol: brain specific angiogenesis inhibitor 1
Description: adhesion G protein-coupled receptor B1
Alias: B830018M07Rik, Bai1, R75078, mKIAA4089, adhesion G protein-coupled receptor B1, brain-specific angiogenesis inhibitor 1
Species: mouse

Top Publications

  1. Koh J, Lee Z, Ahn K, Kim J, Bae C, Kim H, et al. Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. Brain Res Mol Brain Res. 2001;87:223-37 pubmed
    ..The ability of BAP4 to interact with BAI1 was confirmed by pulling-down BAI1 with GST-BAP4 protein and immunoprecipitation study using brain lysate...
  2. Park D, Tosello Trampont A, Elliott M, Lu M, Haney L, Ma Z, et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007;450:430-4 pubmed
    ..Here we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a receptor upstream of ELMO and as a receptor that can bind phosphatidylserine on apoptotic cells...
  3. Sokolowski J, Nobles S, Heffron D, Park D, Ravichandran K, Mandell J. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2011;25:915-21 pubmed publisher
    Brain-specific angiogenesis inhibitor-1 (BAI1) is a transmembrane protein highly expressed in normal brain that has been ascribed two apparently distinct functions: inhibition of angiogenesis and recognition and engulfment of apoptotic ..
  4. D Amours G, Bureau G, Boily M, Cyr M. Differential gene expression profiling in the mouse brain during motor skill learning: focus on the striatum structure. Behav Brain Res. 2011;221:108-17 pubmed publisher
    ..Our study provides the first report of a whole genome analysis of gene expression in mice that have memorized a new complex motor task, and expands our knowledge on striatal gene expression changes associated with motor skill learning. ..
  5. Arac D, Boucard A, Bolliger M, Nguyen J, Soltis S, Sudhof T, et al. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J. 2012;31:1364-78 pubmed publisher
    ..Thus, the GAIN domain embodies a unique, evolutionarily ancient and widespread autoproteolytic fold whose function is likely relevant for GPCR signalling and for multiple human diseases. ..
  6. Stephenson J, Paavola K, Schaefer S, Kaur B, Van Meir E, Hall R. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. J Biol Chem. 2013;288:22248-56 pubmed publisher
    Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties...
  7. Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E, Dalvi P, et al. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013;24:286-94 pubmed publisher
  8. Billings E, Lee C, Owen K, D Souza R, Ravichandran K, Casanova J. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016;9:ra14 pubmed publisher
    ..We previously characterized brain-specific angiogenesis inhibitor 1 (BAI1), a member of the adhesion family of G protein (heterotrimeric guanine nucleotide-binding protein)-coupled ..
  9. Kee H, Ahn K, Choi K, Won Song J, Heo T, Jung S, et al. Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma. FEBS Lett. 2004;569:307-16 pubmed
    ..In situ hybridization analyses of the brain showed the same localization of BAI3 as BAI1 and BAI2, which includes most neurons of cerebral cortex and hippocampus...

More Information


  1. Das S, Owen K, Ly K, Park D, Black S, Wilson J, et al. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011;108:2136-41 pubmed publisher
    ..Brain angiogenesis inhibitor 1 (BAI1) is a receptor that recognizes apoptotic cells through its conserved type I thrombospondin repeats and triggers ..
  2. Ozkan A, Bicer A, Avsar T, Seker A, Toktas Z, Bozkurt S, et al. Temporal expression analysis of angiogenesis-related genes in brain development. Vasc Cell. 2012;4:16 pubmed publisher
    ..b>Bai1 (brain specific angiogenesis inhibitor-1), a recently identified novel anti-angiogenic gene, has been selected for ..
  3. Duman J, Tzeng C, Tu Y, Munjal T, Schwechter B, Ho T, et al. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013;33:6964-78 pubmed publisher
    ..Here, we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a synaptic adhesion GPCR that is required for spinogenesis and synaptogenesis in mice and rats...
  4. Hochreiter Hufford A, Lee C, Kinchen J, Sokolowski J, Arandjelovic S, Call J, et al. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013;497:263-7 pubmed publisher
    ..Here we report an unexpected discovery that the membrane protein BAI1, previously linked to recognition of apoptotic cells by phagocytes, promotes myoblast fusion...
  5. Zhu D, Li C, Swanson A, Villalba R, Guo J, Zhang Z, et al. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015;125:1497-508 pubmed publisher
    ..Here, we demonstrated that mice lacking brain-specific angiogenesis inhibitor 1 (BAI1) have severe deficits in hippocampus-dependent spatial learning and memory that are accompanied by enhanced long-..
  6. Fond A, Lee C, Schulman I, Kiss R, Ravichandran K. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest. 2015;125:2748-58 pubmed publisher
    ..This pathway involves the phagocytic receptor brain-specific angiogenesis inhibitor 1 (BAI1), which recognizes phosphatidylserine on apoptotic cells, and the intracellular signaling intermediates engulfment ..
  7. Lee C, Penberthy K, Wheeler K, Juncadella I, Vandenabeele P, Lysiak J, et al. Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. Immunity. 2016;44:807-20 pubmed publisher
    ..In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated...