Gene Symbol: Bpnt1
Description: bisphosphate 3'-nucleotidase 1
Alias: BPntase, 3'(2'),5'-bisphosphate nucleotidase 1, PAP-inositol 1,4-phosphatase, PIP
Species: mouse
Products:     Bpnt1

Top Publications

  1. Spiegelberg B, Xiong J, Smith J, Gu R, York J. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. J Biol Chem. 1999;274:13619-28 pubmed
    ..Native and recombinant protein harbored intrinsic magnesium-dependent bisphosphate nucleotidase activity (BPntase), which removed the 3'-phosphate from 3'-5' bisphosphate nucleosides and 3'-phosphoadenosine 5'-phosphosulfate ..
  2. Hudson B, Frederick J, Drake L, Megosh L, Irving R, York J. Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. Proc Natl Acad Sci U S A. 2013;110:5040-5 pubmed publisher
    ..Golgi-resident 3'-phosphoadenosine 5'-phosphate (PAP) phosphatase (gPAPP) and Bisphosphate 3'-nucleotidase 1 (Bpnt1)...
  3. Hudson B, York J. Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture. Adv Biol Regul. 2014;54:208-13 pubmed publisher
    ..related 3'-nucleotidases, Golgi-resident PAP phosphatase (gPAPP) and cytoplasmic bisphosphate 3'-nucleotidase 1 (Bpnt1), which hydrolyze PAP to 5'-AMP and whose inactivation results in severe physiological defects...
  4. Hudson B, Hale A, Irving R, Li S, York J. Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. Proc Natl Acad Sci U S A. 2018;115:3000-3005 pubmed publisher
    ..We report that loss of a key enzymatic component of the pathway, bisphosphate 3'-nucleotidase (Bpnt1), in mice, both whole animal and intestine-specific, leads to iron-deficiency anemia...