Gene Symbol: Bpifb1
Description: BPI fold containing family B, member 1
Alias: Lplunc1, BPI fold-containing family B member 1, long palate, lung and nasal epithelium carcinoma associated 1, long palate, lung and nasal epithelium carcinoma-associated protein 1, von Ebner minor salivary gland protein, von Ebner minor salivary protein
Species: mouse
Products:     Bpifb1

Top Publications

  1. LeClair E, Nomellini V, Bahena M, Singleton V, Bingle L, Craven C, et al. Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium. Genomics. 2004;83:658-66 pubmed
    ..By comparing the expression profiles of splunc5, splunc1, and a third related sequence, lplunc1, in mice, we show that these genes are expressed in unique domains along a continuous corridor of oral, lingual, ..
  2. Hou J, Yashiro K, Okazaki Y, Saijoh Y, Hayashizaki Y, Hamada H. Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Dev Dyn. 2004;229:373-9 pubmed
    ..Here, we report on the gene LPlunc1, a member of BPI/PLUNC gene superfamily, which is asymmetrically expressed in the developing mouse node...
  3. Briand F, Thieblemont Q, Andre A, Ouguerram K, Sulpice T. CETP inhibitor torcetrapib promotes reverse cholesterol transport in obese insulin-resistant CETP-ApoB100 transgenic mice. Clin Transl Sci. 2011;4:414-20 pubmed publisher
    ..001). In conclusion, CETP inhibition by torcetrapib improves RCT in CETP-apoB100 mice. These results emphasize the potential of CETP inhibition to prevent cardiovascular diseases. ..
  4. Saund R, Kanai Azuma M, Kanai Y, Kim I, Lucero M, Saijoh Y. Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012;139:2426-35 pubmed publisher
    ..Our findings suggest an essential role of endoderm cells in the signal transfer step from the node to the LPM, possibly using gap junction communication to establish the LR axis of the mouse...
  5. Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott H, et al. Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice. Cell Tissue Res. 2012;350:455-64 pubmed publisher
    ..antibodies to systematically localize two members of this protein family; BPIFA1 (PLUNC/SPLUNC1) and BPIFB1 (LPLUNC1) in adult mice. In general, these proteins exhibit distinct and only partially overlapping localization...
  6. Nashida T, Yoshimura K, Yoshie S, Mizuhashi F, Shimomura Kuroki J. Upregulation of Bpifb1 expression in the parotid glands of non-obese diabetic mice. Oral Dis. 2016;22:46-52 pubmed publisher
    To define the increased mRNA expression of Bpifb1, a member of the bactericidal/permeability-increasing protein family, in parotid acinar cells from non-obese diabetic (NOD) mice, an animal model for Sjögren's syndrome...
  7. Furtado M, Solloway M, Jones V, Costa M, Biben C, Wolstein O, et al. BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev. 2008;22:3037-49 pubmed publisher
    ..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system. ..
  8. Shum A, Alimohammadi M, Tan C, Cheng M, Metzger T, Law C, et al. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013;5:206ra139 pubmed publisher
    ..syndrome type 1 (APS1), and established a strong link between an autoimmune response to the lung-specific protein BPIFB1 (bactericidal/permeability-increasing fold-containing B1) and clinical ILD...
  9. Fuller K, O Connell J, Gordon J, Mauti O, EGGENSCHWILER J. Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Dev Biol. 2014;391:182-95 pubmed publisher
    ..Collectively, these data suggest that Rab23 is an essential component of the mechanism that transmits asymmetric patterning information from the node to the LPM. ..

More Information


  1. Donoghue L, Livraghi Butrico A, McFadden K, Thomas J, Chen G, Grubb B, et al. Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1. Genetics. 2017;207:801-812 pubmed publisher
    ..MUC5B QTL allele effects and subsequent phylogenetic analysis allowed us to narrow the MUC5B QTL and identify Bpifb1 as a candidate gene...