Gene Symbol: Bpifa1
Description: BPI fold containing family A, member 1
Alias: LUNX, NASG, Plunc, SPLUNC1, SPURT, BPI fold-containing family A member 1, palate lung and nasal epithelium clone protein, palate, lung, and nasal epithelium associated, palate, lung, and nasal epithelium clone, palate, lung, and nasal epithelium expressed transcript, protein Plunc
Species: mouse
Products:     Bpifa1

Top Publications

  1. Sung Y, Moon C, Yoo J, Moon C, Pearse D, Pevsner J, et al. Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. J Biol Chem. 2002;277:12762-9 pubmed
    ..We isolated the rat homologue of plunc, a murine gene highly expressed in lung and nasopharyngeal regions, by this method...
  2. LeClair E, Nomellini V, Bahena M, Singleton V, Bingle L, Craven C, et al. Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium. Genomics. 2004;83:658-66 pubmed
    Palate, lung, and nasal epithelium clone (Plunc, now renamed Splunc1) is a small secreted protein expressed in the oropharynx and upper airways of humans, mice, rats, and cows...
  3. Weston W, LeClair E, Trzyna W, McHugh K, Nugent P, Lafferty C, et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem. 1999;274:13698-703 pubmed
    ..Based on these observations, we propose that we have identified a new gene, which we call plunc (for palate, lung, and nasal epithelium clone; GenBankTM accession number U69172).
  4. Chu H, Thaikoottathil J, Rino J, Zhang G, Wu Q, Moss T, et al. Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation. J Immunol. 2007;179:3995-4002 pubmed
    ..Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is a recently described large airway epithelial cell-derived molecule that was predicted to exert host ..
  5. Gally F, Di Y, Smith S, Minor M, Liu Y, Bratton D, et al. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol. 2011;178:2159-67 pubmed publisher
    Short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein is highly expressed in normal airways, but is dramatically decreased in allergic and cigarette smoke exposure settings...
  6. Lukinskiene L, Liu Y, Reynolds S, Steele C, Stripp B, Leikauf G, et al. Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. J Immunol. 2011;187:382-90 pubmed publisher
    ..The bactericidal/permeability-increasing protein family has demonstrated antimicrobial activity in vitro. PLUNC (palate, lung, and nasal epithelium associated) is a 25-kDa secreted protein that shares homology with ..
  7. Thaikoottathil J, Martin R, Di P, Minor M, Case S, Zhang B, et al. SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice. Am J Respir Cell Mol Biol. 2012;47:253-60 pubmed publisher
    Short palate, lung and nasal epithelium clone 1 (SPLUNC1) is enriched in normal airway lining fluid, but is significantly reduced in airway epithelium exposed to a Th2 cytokine milieu...
  8. Bingle C, Bingle L. Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. Biochim Biophys Acta. 2000;1493:363-7 pubmed
    Here we report the cloning and characterization of the human homologue of plunc, a murine gene expressed specifically in the upper airways and nasopharyngeal regions...
  9. LeClair E, Nguyen L, Bingle L, MacGowan A, Singleton V, Ward S, et al. Genomic organization of the mouse plunc gene and expression in the developing airways and thymus. Biochem Biophys Res Commun. 2001;284:792-7 pubmed
    ..A recently identified mouse cDNA, plunc, appears to be confined to the upper airways and nasopharyngeal epithelium, and may prove a useful marker for ..

Scientific Experts

More Information


  1. Liu Y, Di M, Chu H, Liu X, Wang L, Wenzel S, et al. Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice. J Immunol. 2013;191:4259-68 pubmed publisher
    ..On the basis of its homology with BPIs and restricted expression of SPLUNC1 in serous cells of submucosal glands and surface epithelial cells of the upper respiratory tract, SPLUNC1 is ..
  2. Di Y, Tkach A, Yanamala N, Stanley S, Gao S, Shurin M, et al. Dual acute proinflammatory and antifibrotic pulmonary effects of short palate, lung, and nasal epithelium clone-1 after exposure to carbon nanotubes. Am J Respir Cell Mol Biol. 2013;49:759-67 pubmed publisher
    ..The short palate, lung, and nasal epithelium clone-1 (SPLUNC1) protein, a member of the bactericidal/permeability-increasing-fold (BPIF)-containing protein family, is a 25-kD ..
  3. Liu Y, Bartlett J, Di M, Bomberger J, Chan Y, Gakhar L, et al. SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. Am J Pathol. 2013;182:1519-31 pubmed publisher
    ..The short palate, lung, nasal epithelium clone (PLUNC) 1 (SPLUNC1) protein is a member of the bactericidal/permeability-increasing (BPI) fold-containing (BPIF) protein family, ..
  4. Chu H, Gally F, Thaikoottathil J, Janssen Heininger Y, Wu Q, Zhang G, et al. SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling. Respir Res. 2010;11:155 pubmed publisher
    ..We have shown that mouse short palate, lung, and nasal epithelium clone 1 (SPLUNC1) protein was able to inhibit Mp growth...
  5. Britto C, Liu Q, Curran D, Patham B, Dela Cruz C, Cohn L. Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity. Am J Respir Cell Mol Biol. 2013;48:717-24 pubmed publisher
    Short palate, lung, and nasal epithelial clone-1 (SPLUNC1) is a protein abundantly expressed by the respiratory epithelium of the proximal lower respiratory tract, a site of great environmental exposure...
  6. Larsen K, Madsen L, Bendixen C. Porcine SPLUNC1: molecular cloning, characterization and expression analysis. Biochim Biophys Acta. 2005;1727:220-6 pubmed
    b>SPLUNC1, originally named PLUNC for palate, lung and nasal epithelium clone, is a small protein which is secreted from the epithelial cells of the nasal cavity and the upper respiratory tract in humans, mice, rats and cows...
  7. Augustin M, Sedlmeier R, Peters T, Huffstadt U, Kochmann E, Simon D, et al. Efficient and fast targeted production of murine models based on ENU mutagenesis. Mamm Genome. 2005;16:405-13 pubmed
    ..We conclude that ENU-based targeted mutagenesis is a powerful tool for the fast and high-throughput production of murine gene-specific models for biomedical research. ..
  8. Da Lee R, Rhee G, An S, Kim S, Kwack S, Seok J, et al. Differential gene profiles in developing embryo and fetus after in utero exposure to ethanol. J Toxicol Environ Health A. 2004;67:2073-84 pubmed
    ..showed alterations in several gene profiles, including the "palate, lung, and nasal epithelium clone (plunc), "neurofilament, " and "pale ear...
  9. Bartlett J, Meyerholz D, Wohlford Lenane C, Naumann P, Salzman N, McCray P. Increased susceptibility to otitis media in a Splunc1-deficient mouse model. Dis Model Mech. 2015;8:501-8 pubmed publisher
    ..The SPLUNC1 (short palate, lung, nasal epithelial clone 1) protein is a highly abundant secretory product of the mammalian ..
  10. Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott H, et al. Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice. Cell Tissue Res. 2012;350:455-64 pubmed publisher
    ..used species-specific antibodies to systematically localize two members of this protein family; BPIFA1 (PLUNC/SPLUNC1) and BPIFB1 (LPLUNC1) in adult mice...