Gene Symbol: Bpi
Description: bactericidal permeablility increasing protein
Alias: 9230105K17Rik, Bpifd1, bactericidal permeability-increasing protein
Species: mouse
Products:     Bpi

Top Publications

  1. Wittmann I, Schönefeld M, Aichele D, Groer G, Gessner A, Schnare M. Murine bactericidal/permeability-increasing protein inhibits the endotoxic activity of lipopolysaccharide and gram-negative bacteria. J Immunol. 2008;180:7546-52 pubmed
    ..and functional characterization of the mouse homolog of human bactericidal/permeability-increasing protein (BPI)...
  2. Lennartsson A, Pieters K, Vidovic K, Gullberg U. A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow. J Leukoc Biol. 2005;77:369-77 pubmed
    The bactericidal/permeability-increasing protein (BPI), stored in human neutrophil granulocytes, is cytotoxic against Gram-negative bacteria...
  3. Tanaka M, Gombart A, Koeffler H, Shiohara M. Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon. Int J Hematol. 2007;85:304-11 pubmed
    Bactericidal/permeability-increasing protein (BPI) is a 55-kd cationic protein found mainly in neutrophil primary granules. BPI shows cytotoxicity against Gram-negative bacteria...
  4. Li K, Liu Y, Xia X, Wang L, Lu M, Hu Y, et al. Bactericidal/permeability-increasing protein in the reproductive system of male mice may be involved in the sperm-oocyte fusion. Reproduction. 2013;146:135-44 pubmed publisher
    Bactericidal/permeability-increasing protein (BPI) is a 455-residue (?55?kDa) protein found mainly in the primary (azurophilic) granules of human neutrophils...
  5. Eckert M, Wittmann I, Rollinghoff M, Gessner A, Schnare M. Endotoxin-induced expression of murine bactericidal permeability/increasing protein is mediated exclusively by toll/IL-1 receptor domain-containing adaptor inducing IFN-beta-dependent pathways. J Immunol. 2006;176:522-8 pubmed
    ..report the identification and cloning of the mouse homologue of human bactericidal permeability/increasing protein (BPI). Mouse BPI is constitutively expressed in lymphatic organs and tissues as well as in mouse testis...
  6. Wu H, Liu L, Lin M, Liu L, He C, Zheng D, et al. Importance of the residue 190 on bactericidal activity of the bactericidal/permeability-increasing protein 5. Oncotarget. 2016;7:43088-43094 pubmed publisher
    The bactericidal/permeability-increasing protein (BPI) with bactericidal and endotoxin-neutralizing activity is of considerable interest in clinical applications...