Bmpr2

Summary

Gene Symbol: Bmpr2
Description: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Alias: 2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPR-II, BMPRII, BRK-3, Gm20272, bone morphogenetic protein receptor type-2, BMP type II receptor, BMP type-2 receptor, bone morphogenic protein receptor, type II (serine/threonine kinase)
Species: mouse

Top Publications

  1. pmc Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
    Yanli Song
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Circulation 112:553-62. 2005
  2. ncbi Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    H Beppu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Oncogene 27:1063-70. 2008
  3. ncbi Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
    Moira Hagen
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1473-9. 2007
  4. ncbi Generation of a floxed allele of the mouse BMP type II receptor gene
    Hideyuki Beppu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genesis 41:133-7. 2005
  5. ncbi Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:24443-50. 2005
  6. pmc Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
    Tero Pekka Alastalo
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
    J Clin Invest 121:3735-46. 2011
  7. doi Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function
    Victoria J Burton
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, West Sussex, United Kingdom
    Blood 117:333-41. 2011
  8. pmc Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation
    Monika Podkowa
    Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Cell Biol 30:2241-50. 2010
  9. ncbi Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
    Lu Long
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circ Res 98:818-27. 2006
  10. doi Recent advances in BMP receptor signaling
    Christina Sieber
    Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Germany
    Cytokine Growth Factor Rev 20:343-55. 2009

Scientific Experts

  • Paul B Yu
  • Emily A Meyers
  • Kohei Miyazono
  • Laura W Gamer
  • M Talati
  • L Ye
  • Shigeko Torihashi
  • Herman Schreuder
  • H Beppu
  • Fang Xu Jiang
  • A Nadiri
  • Katsuhiko Hayashi
  • Rory E Morty
  • James West
  • Victoria J Burton
  • Tero Pekka Alastalo
  • Vinicio A de Jesus Perez
  • Nicholas W Morrell
  • Petra Knaus
  • Michael W Pickup
  • Lu Long
  • Yuji Tada
  • Philip Owens
  • Yanli Song
  • Jennifer A Johnson
  • David C Budd
  • Alan M Holmes
  • Marlene Rabinovitch
  • Susan Majka
  • Ying Yi Zhang
  • Joseph Loscalzo
  • Moira Hagen
  • Monika Podkowa
  • En Li
  • Julie Harral
  • David M Rodman
  • Vahan B Indjeian
  • Mai Fujimoto
  • Kwon Ho Hong
  • Audrey F Wright
  • Xueping Wu
  • Susu Mao
  • Anna Chytil
  • Agnieszka E Gorska
  • Harold L Moses
  • Sergey V Novitskiy
  • Takashi Nagashima
  • Jana Bagarova
  • Chan Woo Kim
  • Yi Zhou
  • Shan Shan Wang
  • Catarina Osório
  • Christoph E Albers
  • Hongbin Liu
  • Victoria N Parikh
  • Jose Gomez-Arroyo
  • Rachel J Davies
  • Md Talat Nasim
  • Elizabeth M Mushaben
  • Rong Han
  • Christoph Walker
  • Loredana I Ciuclan
  • Kenichi Kashimada
  • Ying Zhang
  • Geun Taek Lee
  • Hirofumi Sawada
  • Margaret R MacLean
  • Ningning Wu
  • Yuto Kamiya
  • Ming Shi
  • Kyle Niessen
  • Manuel Amieva
  • Chaozhe Yang
  • Sho Ohta
  • Hadas Tilleman
  • Raphaela Schwappacher
  • Xudong Yang
  • Christina Sieber
  • Daniel Crona
  • Xiangzhen Sui
  • Richard C Trembath
  • Shahab M Danesh
  • Gerhard Sengle
  • David B Frank
  • Nathalie Lebeurrier
  • Jeffrey W Wertz
  • Meilin Wu
  • Kenneth D Bloch
  • Oliver Eickelberg
  • Charles Durand

Detail Information

Publications92

  1. pmc Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
    Yanli Song
    Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Circulation 112:553-62. 2005
    Bone morphogenetic protein receptor-2 (BMPR2)-heterozygous, mutant (BMPR2(+/-)) mice have a genetic trait similar to that of certain patients with idiopathic pulmonary arterial hypertension (IPAH)...
  2. ncbi Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    H Beppu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Oncogene 27:1063-70. 2008
    ..We observed that conditional inactivation of the BMP type II receptor (BMPRII) in the stroma leads to epithelial hyperplasia throughout the colon with increased epithelial cell ..
  3. ncbi Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
    Moira Hagen
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1473-9. 2007
    ..arterial hypertension (PAH) cases are caused by mutations in the type 2 bone morphogenetic protein receptor (BMPR2)...
  4. ncbi Generation of a floxed allele of the mouse BMP type II receptor gene
    Hideyuki Beppu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genesis 41:133-7. 2005
    ..b>BMP type II receptor (BMPR-II) transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I ..
  5. ncbi Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:24443-50. 2005
    Bone morphogenetic protein (BMP) ligands signal by binding the BMP type II receptor (BMPR2) or the activin type II receptors (ActRIIa and ActRIIb) in conjunction with type I receptors to activate SMADs 1, 5, and 8, as well as members of ..
  6. pmc Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
    Tero Pekka Alastalo
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
    J Clin Invest 121:3735-46. 2011
    Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair pulmonary arterial EC (PAEC) function. This can adversely affect EC survival and promote SMC proliferation...
  7. doi Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function
    Victoria J Burton
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, West Sussex, United Kingdom
    Blood 117:333-41. 2011
    ..We speculate that this may be a key mechanism involved in the initiation of the disease in heritable PAH that results from defects in BMPR-II expression...
  8. pmc Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation
    Monika Podkowa
    Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Cell Biol 30:2241-50. 2010
    ..regulators of microtubule dynamics, and we show that JNKs associate with the carboxy terminus of the BMP receptor, BMPRII. Activation and binding of JNKs to BMPRII is required for BMP7-induced microtubule stabilization and for BMP7-..
  9. ncbi Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice
    Lu Long
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
    Circ Res 98:818-27. 2006
    ..We investigated the pulmonary circulation of mice deficient in BMPR-II (BMPR2(+/-) mice) and show that pulmonary hemodynamics and vascular morphometry of BMPR2(+/-) mice were similar to wild-..
  10. doi Recent advances in BMP receptor signaling
    Christina Sieber
    Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Germany
    Cytokine Growth Factor Rev 20:343-55. 2009
    ..Examples of BMP action during development, but also physiological and pathophysiological conditions in the adult organism are presented...
  11. doi Bone morphogenetic protein receptors and signal transduction
    Kohei Miyazono
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Biochem 147:35-51. 2010
    ..The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signalling pathways...
  12. pmc BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines
    Rachel J Davies
    Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Am J Physiol Lung Cell Mol Physiol 302:L604-15. 2012
    ..on PASMC proliferation was characterized in three different models of BMPR-II dysfunction: 1) HPAH PASMCs, 2) Bmpr2(+/-) mouse PASMCs, and 3) control human PASMCs transfected with BMPR-II small interfering RNA...
  13. pmc Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity
    Raphaela Schwappacher
    Institute for Chemistry Biochemistry, FU Berlin, Berlin, Germany
    EMBO J 28:1537-50. 2009
    ..cGKI, a key mediator of vasodilation and hypertension diseases, interacts with and phosphorylates the BMP type II receptor (BMPRII)...
  14. pmc BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis
    Hideyuki Beppu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    Dev Biol 331:167-75. 2009
    ..To investigate the role of the BMP type II receptor (BMPRII) in heart development, the BMPRII gene was deleted throughout the embryo during gastrulation using ..
  15. pmc Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
    Vinicio A de Jesus Perez
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 184:83-99. 2009
    Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary artery endothelial cell (PAEC) apoptosis and the loss of small vessels seen in idiopathic pulmonary arterial hypertension...
  16. doi Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells
    Jeffrey W Wertz
    Department of Surgery, University of Pittsburgh, BST 3, Room 6058, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 375:557-61. 2008
    Recent studies demonstrate the interaction of BMPRII and caveolin-1 in various cell types. In this study we test the hypothesis that caveolin-1 interacts with and regulates BMPRII-dependent signaling in vascular smooth muscle cells...
  17. pmc Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension
    Kwon Ho Hong
    Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida College of Medicine, Gainesville, USA
    Circulation 118:722-30. 2008
    ..Heterozygous mutations in BMPR2 can be detected in 50% to 70% of patients with familial PAH and 10% to 40% of patients with idiopathic PAH...
  18. pmc Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice
    Yanli Song
    Cardiovascular Division, Dept of Medicine, Brigham and Women s Hosiptal and Harvard Medical School, 77 Ave Louis Pasteur, NRB 630, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 295:H677-90. 2008
    Heterozygous bone morphogenetic protein receptor-II-knockout (BMPR2(+/-)) mice have a similar genetic trait like that in some idiopathic pulmonary arterial hypertension patients...
  19. ncbi Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature
    David B Frank
    Department of Cell and Developmental Biology, Vanderbilt Univ School of Medicine, S3223 Medical Center North, 1161 21 St South, Nashville, TN 37232 2372, USA
    Am J Physiol Lung Cell Mol Physiol 294:L98-109. 2008
    ..arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary vascular responses to chronic ..
  20. ncbi BMP signaling is required for septation of the outflow tract of the mammalian heart
    Emmanuèle C Délot
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Development 130:209-20. 2003
    ..We engineered a knockout mouse that expresses a BMP type II receptor that lacks half of the ligand-binding domain...
  21. ncbi cDNA cloning and genomic organization of the mouse BMP type II receptor
    H Beppu
    Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, Toshima ku, Tokyo
    Biochem Biophys Res Commun 235:499-504. 1997
    ..Knowledge of the structure of the BMPR-II gene is essential for the understanding of the role of bone morphogenetic proteins in the developmental and physiological processes of animals...
  22. doi BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH
    Md Talat Nasim
    Department of Medical and Molecular Genetics, King s College London, London, UK
    Hum Mol Genet 21:2548-58. 2012
    ..Heterozygous mutations in the type II receptor for bone morphogenetic protein (BMPR2) underlie the majority of the inherited and familial forms of PAH...
  23. ncbi Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    James West
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine and Department of Anesthesia, Denver, Colo 80262, USA
    Circ Res 94:1109-14. 2004
    ..The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality ..
  24. ncbi BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    Hideyuki Beppu
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1241-7. 2004
    ..Our results suggest that, in mice, mutation of one copy of the BMPR-II gene causes pulmonary hypertension but impairs the ability of the pulmonary vasculature to remodel in response to prolonged hypoxic breathing...
  25. pmc Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
    Si Tuen Lee-Hoeflich
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    EMBO J 23:4792-801. 2004
    ..we show that LIM kinase 1 (LIMK1), a key downstream effector of Rho GTPases, colocalizes with the BMP receptor, BMPRII, in the tips of neurites and binds to BMPRII...
  26. ncbi Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH
    Yuji Tada
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1556-63. 2007
    ..IPAH) in human patients is associated with mutations in type 2 receptor for the bone morphogenic protein pathway (BMPR2)...
  27. ncbi BMP type II receptor is required for gastrulation and early development of mouse embryos
    H Beppu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
    Dev Biol 221:249-58. 2000
    ..b>BMP type II receptor (BMPR-II) is a type II serine/threonine kinase receptor, which transduces signals for BMPs through ..
  28. doi Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage
    Shan Shan Wang
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China
    FEBS J 280:2644-51. 2013
    ..The type I receptor Bmpr1a and the type II receptors Bmpr2 and Acvr2a mediate the Gdf6 signaling pathway...
  29. pmc Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells
    Chan Woo Kim
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 33:1350-9. 2013
    ..BMP actions are mediated by 2 different types of BMP receptors (BMPRI and BMPRII)...
  30. pmc Constitutively active ALK2 receptor mutants require type II receptor cooperation
    Jana Bagarova
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 33:2413-24. 2013
    ..Signaling via GS domain ALK2 mutants could be restored by the expression of either BMP type II receptor. The contribution of BMP type II receptors was independent of their ligand-binding or kinase function but ..
  31. pmc Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development
    Catarina Osório
    School of Biosciences, Cardiff University, Cardiff CF10 3AT, UK
    Development 140:4751-62. 2013
    ....
  32. doi miR-17 regulates the proliferation and differentiation of the neural precursor cells during mouse corticogenesis
    Susu Mao
    Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University School of Life Sciences, China
    FEBS J 281:1144-58. 2014
    ..Taken together, these findings suggest that miR-17 family members play a pivotal role in regulating cell activity during early development of the mouse cortex...
  33. doi Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
    Xueping Wu
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Life Sci 97:145-54. 2014
    ..We investigated if the expression of BMP4 and its receptors BMPR1a and BMPR2 were activated in post-infarction remodeling and heart failure.
  34. pmc BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation
    Michael W Pickup
    Department of Cancer Biology, USA
    Mol Oncol 9:179-91. 2015
    ..We sought to investigate the requirement for BMPR2 in stromal fibroblasts during mammary tumor formation and metastasis...
  35. doi Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptors
    Mai Fujimoto
    Division of Pathophysiology M F, S O, K O, A M, S T, T M, S K, T K, Research Center for Genomic Medicine, Saitama Medical University, Hidaka shi, Saitama 350 1241, Japan Division of Orthodontics M F, N S, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado shi, Saitama 350 0283, Japan Division of Molecular Signaling and Biochemistry S K, Department of Health Promotion, Kyushu Dental University, Kitakyusyu, Fukuoka 803 8580, Japan
    Mol Endocrinol 29:140-52. 2015
    ..These findings suggest that the mutant ALK2 related to FOP is enhanced by BMP type II receptors via the T203-regulated phosphorylation of ALK2. ..
  36. pmc Oestrogen receptor alpha in pulmonary hypertension
    Audrey F Wright
    College of Medical, Veterinary, and Life Sciences, Research Institute of Cardiovascular and Medical Sciences, University of Glasgow, Room 448, West Medical Building Wolfson Link Building, Glasgow G12 8QQ, UK
    Cardiovasc Res 106:206-16. 2015
    Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH...
  37. pmc Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins
    Vahan B Indjeian
    Howard Hughes Medical Institute Stanford University School of Medicine, Department of Developmental Biology, 279 Campus Drive, Beckman Center B300, Stanford, CA 94305, USA
    Cell 164:45-56. 2016
    ..Both gain and loss of regulatory elements can localize BMP changes to specific anatomical locations, providing a flexible regulatory basis for evolving species-specific changes in skeletal form. ..
  38. pmc A pair of transmembrane receptors essential for the retention and pigmentation of hair
    Rong Han
    Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Genesis 50:783-800. 2012
    ..Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are ..
  39. pmc Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation
    Hongbin Liu
    Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, Louisiana 70112, USA
    J Cell Physiol 227:952-63. 2012
    ..The observed functional redundancy of type II BMP receptors in osteoblasts is novel information about the BMP signaling pathway essential for initiating osteoblast differentiation...
  40. pmc Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators
    Philip Owens
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 109:2814-9. 2012
    ..We sought to determine whether disruption of the BMP receptor 2 (BMPR2) would alter mammary tumor progression in mice that express the Polyoma middle T antigen...
  41. ncbi [Expression of bone morphogenetic protein receptor 2 in myocardialization of cardiac proximal outflow tract septum in connexin 43 knockout embryonic mice]
    Ying Zhang
    Pediatric Heart Center, Children s Hospital of Fudan University, Shanghai 201102, China
    Zhonghua Yi Xue Za Zhi 91:2211-5. 2011
    ..To investigate the mechanism of myocardialization of proximal outflow tract septum and its effect on the conotruncal anomaly in mice...
  42. pmc Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension
    Jennifer A Johnson
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 302:L474-84. 2012
    ..arterial hypertension (PAH) is typically caused by a mutation in bone morphogenic protein receptor type 2 (BMPR2), and mice expressing Bmpr2 mutations develop PAH with features similar to human disease...
  43. pmc Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction
    Yuto Kamiya
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 285:30804-13. 2010
    ..Smad7 thus has an additional mode of interaction with TGF-β family type I receptors not possessed by Smad6, which may play roles in mediating the inhibitory effects unique to Smad7...
  44. pmc A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
    Jose Gomez-Arroyo
    Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA 23298, USA
    Am J Physiol Lung Cell Mol Physiol 302:L977-91. 2012
    ..Anatomical, cellular, and genetic differences distinguish mice and rats, and pharmacogenomics may explain the degree of PH and the particular mode of pulmonary vascular adaptation and also the response of the right ventricle...
  45. pmc ALK1 signaling regulates early postnatal lymphatic vessel development
    Kyle Niessen
    Department of Tumor Biology and Angiogenesis, Division of Research, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Blood 115:1654-61. 2010
    ..Thus, our study reveals a novel aspect of ALK1 signaling in regulating lymphatic development and suggests that targeting ALK1 pathway might provide additional control of lymphangiogenesis in human diseases...
  46. pmc Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice
    Elizabeth M Mushaben
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e32468. 2012
    Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been identified in patients with heritable pulmonary arterial hypertension (PAH); however, disease penetrance is low, suggesting additional ..
  47. doi L51P - A BMP2 variant with osteoinductive activity via inhibition of Noggin
    Christoph E Albers
    Group for Bone Biology and Orthopedic Research, Department of Clinical Research, University of Bern, CH 3010 Bern, Switzerland
    Bone 51:401-6. 2012
    ..The described strategy may help to decrease the amounts of exogenous BMPs currently required to stimulate bone healing...
  48. pmc Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye
    Yi Zhou
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 110:8966-71. 2013
    ..Based on our findings, we propose that Jag1-Notch2 signaling controls CB morphogenesis at least in part by regulating cell proliferation and BMP signaling...
  49. pmc BMPR2 is required for postimplantation uterine function and pregnancy maintenance
    Takashi Nagashima
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 123:2539-50. 2013
    ..In this study, we discovered that bone morphogenetic protein receptor type 2 (BMPR2) is essential for postimplantation physiology and fertility...
  50. pmc MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach
    Victoria N Parikh
    Brigham and Women s Hospital, New Research Building, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Circulation 125:1520-32. 2012
    ..Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies. Owing to their pleiotropic actions, microRNA molecules are potential candidates for coordinated regulation of these disease stimuli...
  51. ncbi SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast
    Katsuhiko Hayashi
    Division of Molecular Biology, Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278 0022, Japan
    Mech Dev 118:99-109. 2002
    ..These results indicate that SMAD1 signaling possesses a critical and non-redundant function in the initial commitment of the germ cell lineage...
  52. ncbi Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells
    Paul B Yu
    Cardiovascular Research Center and Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 283:3877-88. 2008
    ..The association of mutations in the BMP type II receptor (BMPRII) with idiopathic pulmonary arterial hypertension suggests an important role of this receptor in ..
  53. doi Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interaction
    Geun Taek Lee
    Section of Urologic Oncology and the Dean and Betty Gallo Prostate Cancer Center, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street 4560, New Brunswick, NJ 08903, United States
    Mol Immunol 48:1540-7. 2011
    ..the present study, we demonstrate that BMP-6 increases IL-1β expression in macrophages via the receptors ALK3 and BMPRII as well as the downstream signaling protein Smad1...
  54. ncbi Differential expression of BMP receptors in early mouse development
    B A Roelen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Int J Dev Biol 41:541-9. 1997
    ..In postimplantation embryos BMPR-II transcripts were first detected from 6.0 days post coitum. In situ hybridization analysis revealed that BMPR-II mRNA is ubiquitously expressed in the entire embryo at least until midgestation...
  55. pmc Physiologic and molecular consequences of endothelial Bmpr2 mutation
    Susan Majka
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Respir Res 12:84. 2011
    ..Most hereditary PAH is associated with BMPR2 mutations...
  56. pmc Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II
    Victoria J Burton
    Novartis Institutes for BioMedical Research, West Sussex, UK
    Blood 118:4750-8. 2011
    ..Here we demonstrate that, in mice with endothelial-specific loss of BMPR-II expression (L1Cre(+);Bmpr2(f/f)), reduction in barrier function and the resultant pulmonary hypertension observed in vivo are the result of ..
  57. ncbi Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression
    D Zhang
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 18:3314-26. 1998
    ....
  58. ncbi Expression of bone morphogenetic protein receptors in the developing mouse metanephros
    G Martinez
    Department of Anatomy and Cell Biology, Monash University, Clayton, Vic, Australia
    Exp Nephrol 9:372-9. 2001
    ..These patterns of receptor expression suggest that these molecules are important regulators of epithelial-mesenchymal interactions, nephron development and ureteric branching morphogenesis...
  59. ncbi Bmp signaling is required for development of primary lens fiber cells
    Sonya C Faber
    Division of Developmental Biology and Department of Ophthalmology, Children s Hospital Research Foundation, 3333 Burnet Avenue Cincinnati, OH 45229, USA
    Development 129:3727-37. 2002
    ..We conclude that Bmp signaling is required for primary lens fiber cell differentiation and, given the asymmetry of the differentiation inhibition, that distinct differentiation stimuli may be active in different quadrants of the eye...
  60. ncbi Crystal structure of recombinant human growth and differentiation factor 5: evidence for interaction of the type I and type II receptor-binding sites
    Herman Schreuder
    Sanofi Aventis, Industriepark Hoechst, Building G 865, A 65926 Frankfurt, Germany
    Biochem Biophys Res Commun 329:1076-86. 2005
    ....
  61. ncbi Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells
    R Fernández-Lloris
    Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, 08907 L Hospitalet de Llobregat, Spain
    Mol Endocrinol 17:1332-43. 2003
    ..Taken together, these results indicate that SOX6 is an important downstream mediator of BMP-2 signaling in chondrogenesis...
  62. pmc B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling
    Sean Park
    Department of Physiology and Functional Genomics, University of Florida, 1600 SW Archer Rd, Room D533d, Gainesville, FL 32610, USA
    Mol Cell Biol 24:10256-62. 2004
    ..In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling...
  63. ncbi Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation
    Ariadne L Hager-Theodorides
    Department of Biological Sciences, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK
    J Immunol 169:5496-504. 2002
    ..Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation...
  64. ncbi Expression of the dystrophin gene in mouse and rat brain
    D Gorecki
    MRC Molecular Neurobiology Unit, University of Cambridge Medical School, England
    Neuroreport 2:773-6. 1991
    ..We find the gene strongly expressed in the hippocampus and cerebral cortex, areas with an established cognitive function, and also in the Purkinje cells of the cerebellum, an area associated with motor coordination...
  65. ncbi Temporal and spatial expression profiles of BMP receptors and noggin during BMP-2-induced ectopic bone formation
    Yukio Nakamura
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    J Bone Miner Res 18:1854-62. 2003
    ..The results suggest that positive and negative feedback mechanisms modulate ectopic osteogenesis induced by this growth factor...
  66. ncbi Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
    Emily A Morgan
    Shriners Hospital for Children, Portland, OR 97239, USA
    Development 130:3095-109. 2003
    ..Finally, a novel role for Hoxa13 in the vascularization of the glans penis is also identified...
  67. ncbi Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells
    Lin Ye
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Health Park, Cardiff, CF14 4XN, UK
    Int J Oncol 30:521-9. 2007
    ..This may have important implications in the development of bone metastasis in prostate cancer...
  68. pmc Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells
    Charles Durand
    Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:20838-43. 2007
    ..We suggest that Bmp4 plays a relatively late role in the regulation of HSCs as they emerge in the midgestation AGM...
  69. pmc Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice
    Meilin Wu
    Department of Cell and Developmental Biology and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2076-87. 2008
    ..These studies provide in vivo evidence for the importance of Pax3 downregulation during differentiation of multipotent neural crest precursors and cranial development...
  70. ncbi Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Dev Dyn 236:2825-35. 2007
    ..We describe changes in the expression and localization of BMP receptors (Bmpr1a, Bmpr1b, and Bmpr2) and Smad (Smad1, Smad4, Smad5, and Smad8) intracellular signaling proteins during the saccular and ..
  71. pmc A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7
    Gerhard Sengle
    Shriners Hospital for Children, Oregon Health and Science University, OR 97239, USA
    J Mol Biol 381:1025-39. 2008
    ....
  72. ncbi Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium
    P Kemoun
    Department of Oral Biology, Faculty of Odontology, 3 chemin des Maraichers, 31062 Toulouse Cedex, France
    Tissue Cell 39:257-66. 2007
    ..These results suggest that STRO-1 positive DF cells may be target of BMPs secreted by HERS. BMP-3 might be involved in the arrest of this process by inhibiting the signaling provided by cementogenic and osteogenic BMPs...
  73. doi Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin
    Nathalie Lebeurrier
    INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit SP2U, Cyceron, F 14074 France
    J Cell Sci 121:3357-65. 2008
    ..This study demonstrates the existence of an AMH-dependent signalling pathway in the brain leading to an overexpression of the serine-protease inhibitor, neuroserpin, and neuronal survival...
  74. ncbi Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension
    Anna Zakrzewicz
    University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, D 35392 Giessen, Germany
    Circulation 115:2957-68. 2007
    ..Heterozygous mutations in BMPR2, encoding the type II bone morphogenetic protein receptor (BMPRII), were identified in PAH, suggesting that alterations to BMPRII function are involved in disease onset and/or ..
  75. doi Activation of the bone morphogenetic protein receptor by H11kinase/Hsp22 promotes cardiac cell growth and survival
    Xiangzhen Sui
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 104:887-95. 2009
    ..Therefore, potentiation of the BMP receptor by H11K promotes an activation of the PI3K/Akt pathway mediated by TAK1, which dictates the physiological effects of H11K on cardiac cell growth and survival...
  76. doi The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut
    Shigeko Torihashi
    Department of Health Science, Nagoya University Graduate School of Medicine, 1 1 20 Daikouminami, Higashi ku, Nagoya 461 8673, Japan
    Differentiation 77:277-89. 2009
    ..Taken together, BMP signaling was expressed for a short window in the smooth muscle progenitors and the signal, especially BMP2, plays an essential role in smooth muscle differentiation in cooperation with PDGF signaling...
  77. pmc BMP and BMP receptor expression during murine organogenesis
    Shahab M Danesh
    Department of Molecular Biology, NA8 300, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Gene Expr Patterns 9:255-65. 2009
    ..expression profiles of three BMP ligands (Bmp2, Bmp4, Bmp7) and three BMP receptors (Bmpr1a, Bmpr1b, and BmprII), as well as their molecular antagonist (noggin), in the early embryo during the initial steps of murine ..
  78. ncbi Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4
    Yin Xia
    Program in Membrane Biology and the Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Biol Chem 282:18129-40. 2007
    ..cells and mouse pulmonary artery smooth muscle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII), but not activin receptor type IIA (ActRIIA) or ActRIIB, based on changes in BMP signaling by small interfering ..
  79. ncbi Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension
    Rory E Morty
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Aulweg 123 Raum 6 11, D 35392 Giessen, Germany
    Arterioscler Thromb Vasc Biol 27:1072-8. 2007
    Mutations in the bmpr2 gene, encoding the type II bone morphogenetic protein (BMP) receptor, have been identified in patients with pulmonary arterial hypertension (PAH), implicating BMP signaling in PAH...
  80. doi BMPR-II is dispensable for formation of the limb skeleton
    Laura W Gamer
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts
    Genesis 49:719-24. 2011
    ..From these data, we conclude that BMPR-II is not required for endochondral ossification in the limb where loss of BMPR-II may be compensated by BMP utilization of Acvr2a and Acvr2b. genesis, 00:1-6, 2011. © 2011 Wiley-Liss, Inc...
  81. pmc Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion
    Marek Dudas
    Developmental Biology Program, The Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Dev Biol 296:298-314. 2006
    ....
  82. doi Generation of a mouse model with expression of bone morphogenetic protein type II receptor lacking the cytoplasmic domain in osteoblasts
    Chaozhe Yang
    Shihezi Medical College, Shihezi University, Xinjiang, China
    Ann N Y Acad Sci 1192:286-91. 2010
    ..Here we established a mouse model in which a C-terminal truncated BMP type II receptor (BMPRII) is expressed specifically in osteoblasts as a dominant negative form in the BMP/Smad signaling ..
  83. doi Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons
    Hadas Tilleman
    Zlotowski Center for Neuroscience, Department of Morphology, Division of Basic Sciences, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    Mol Cell Neurosci 45:1-11. 2010
    ..In addition, we conclude that the position of the mid-hindbrain organizer determines the size of the LC and propose that Bmp5/7 play an important role in mediating this organizer function...
  84. pmc BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension
    M Talati
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010
    ..PAH) and in particular to heritable PAH (HPAH) with known bone morphogenetic protein type 2 receptor (BMPR2) mutations is not known...
  85. ncbi Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor
    Sylke Hassel
    Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
    J Cell Physiol 206:457-67. 2006
    ..Our data suggest that the complex formation between c-kit and BMPR-II leads to phosphorylation of BMPR-II at Ser757, which modulates BMPR-II-dependent signaling...
  86. doi Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells
    Ningning Wu
    Chongqing Medical University, China
    Acta Biochim Biophys Sin (Shanghai) 42:699-708. 2010
    ..We found that three DN type II TGF-β receptors, DN-BMPRII, DN-ActRII, and DN-ActRIIB, diminished BMP-9-induced alkaline phosphatase (ALP) activity, led to a decrease in BMP-..
  87. pmc BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst
    Sho Ohta
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132 3401, USA
    Dev Biol 347:369-81. 2010
    ....
  88. doi DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina
    Ming Shi
    Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, China
    Dev Biol 348:87-96. 2010
    ..Thus, our findings suggest that DCC is a key regulator for the survival of specific types of neurons during retinal development and that DCC-P3 domain is essential for this developing event...
  89. pmc FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development
    Kenichi Kashimada
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Endocrinology 152:272-80. 2011
    ..Further, Wnt4-knockout mice showed reduced expression of Fst limited to early ovarian development, suggesting a role for WNT4 in the initiation, but not the maintenance, of Fst expression...
  90. pmc BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
    Vinicio A de Jesus Perez
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 192:171-88. 2011
    ..We speculate that, in response to injury, factors that subvert BMP-2-mediated tandem activation of Wnt-βC and Wnt-PCP pathways contribute to obliterative vascular disease in both the systemic and pulmonary circulations...
  91. ncbi Expression patterns of BMPRs in the developing mouse molar
    A Nadiri
    INSERM UMR S595, Faculte de Chirurgie Dentaire, Universite Louis Pasteur, 67085, Strasbourg, France
    Cell Tissue Res 324:33-40. 2006
    ....
  92. ncbi Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Exp Cell Res 308:114-22. 2005
    ..These results demonstrate a convergence of BMP and Ln-1 signaling through P13K and MAP kinase pathways to induce proliferation and colony formation in E15.5 fetal mouse pancreatic cells...