Genomes and Genes
Gene Symbol: Bmpr2
Description: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Alias: 2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPR-II, BMPRII, BRK-3, Gm20272, bone morphogenetic protein receptor type-2, BMP type II receptor, BMP type-2 receptor, bone morphogenic protein receptor, type II (serine/threonine kinase)
- Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant miceYanli Song
Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Circulation 112:553-62. 2005Bone morphogenetic protein receptor-2 (BMPR2)-heterozygous, mutant (BMPR2(+/-)) mice have a genetic trait similar to that of certain patients with idiopathic pulmonary arterial hypertension (IPAH)...
- Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formationH Beppu
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Oncogene 27:1063-70. 2008..We observed that conditional inactivation of the BMP type II receptor (BMPRII) in the stroma leads to epithelial hyperplasia throughout the colon with increased epithelial cell ..
- Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscleMoira Hagen
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 292:L1473-9. 2007..arterial hypertension (PAH) cases are caused by mutations in the type 2 bone morphogenetic protein receptor (BMPR2)...
- Generation of a floxed allele of the mouse BMP type II receptor geneHideyuki Beppu
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Genesis 41:133-7. 2005..b>BMP type II receptor (BMPR-II) transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I ..
- Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cellsPaul B Yu
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Biol Chem 280:24443-50. 2005Bone morphogenetic protein (BMP) ligands signal by binding the BMP type II receptor (BMPR2) or the activin type II receptors (ActRIIa and ActRIIb) in conjunction with type I receptors to activate SMADs 1, 5, and 8, as well as members of ..
- Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survivalTero Pekka Alastalo
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 5162, USA
J Clin Invest 121:3735-46. 2011Reduced bone morphogenetic protein receptor 2 (BMPR2) expression in patients with pulmonary arterial hypertension (PAH) can impair pulmonary arterial EC (PAEC) function. This can adversely affect EC survival and promote SMC proliferation...
- Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier functionVictoria J Burton
Respiratory Disease Area, Novartis Institutes for BioMedical Research, West Sussex, United Kingdom
Blood 117:333-41. 2011..We speculate that this may be a key mechanism involved in the initiation of the disease in heritable PAH that results from defects in BMPR-II expression...
- Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formationMonika Podkowa
Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Mol Cell Biol 30:2241-50. 2010..regulators of microtubule dynamics, and we show that JNKs associate with the carboxy terminus of the BMP receptor, BMPRII. Activation and binding of JNKs to BMPRII is required for BMP7-induced microtubule stabilization and for BMP7-..
- Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient miceLu Long
Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge, United Kingdom
Circ Res 98:818-27. 2006..We investigated the pulmonary circulation of mice deficient in BMPR-II (BMPR2(+/-) mice) and show that pulmonary hemodynamics and vascular morphometry of BMPR2(+/-) mice were similar to wild-..
- Recent advances in BMP receptor signalingChristina Sieber
Institute for Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Germany
Cytokine Growth Factor Rev 20:343-55. 2009..Examples of BMP action during development, but also physiological and pathophysiological conditions in the adult organism are presented...
- Bone morphogenetic protein receptors and signal transductionKohei Miyazono
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
J Biochem 147:35-51. 2010..The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signalling pathways...
- BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokinesRachel J Davies
Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Am J Physiol Lung Cell Mol Physiol 302:L604-15. 2012..on PASMC proliferation was characterized in three different models of BMPR-II dysfunction: 1) HPAH PASMCs, 2) Bmpr2(+/-) mouse PASMCs, and 3) control human PASMCs transfected with BMPR-II small interfering RNA...
- Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activityRaphaela Schwappacher
Institute for Chemistry Biochemistry, FU Berlin, Berlin, Germany
EMBO J 28:1537-50. 2009..cGKI, a key mediator of vasodilation and hypertension diseases, interacts with and phosphorylates the BMP type II receptor (BMPRII)...
- BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesisHideyuki Beppu
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
Dev Biol 331:167-75. 2009..To investigate the role of the BMP type II receptor (BMPRII) in heart development, the BMPRII gene was deleted throughout the embryo during gastrulation using ..
- Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathwaysVinicio A de Jesus Perez
Department of Medicine, Stanford University, Stanford, CA 94305, USA
J Cell Biol 184:83-99. 2009Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary artery endothelial cell (PAEC) apoptosis and the loss of small vessels seen in idiopathic pulmonary arterial hypertension...
- Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cellsJeffrey W Wertz
Department of Surgery, University of Pittsburgh, BST 3, Room 6058, Pittsburgh, PA 15261, USA
Biochem Biophys Res Commun 375:557-61. 2008Recent studies demonstrate the interaction of BMPRII and caveolin-1 in various cell types. In this study we test the hypothesis that caveolin-1 interacts with and regulates BMPRII-dependent signaling in vascular smooth muscle cells...
- Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertensionKwon Ho Hong
Department of Physiology and Functional Genomics, Shands Cancer Center, University of Florida College of Medicine, Gainesville, USA
Circulation 118:722-30. 2008..Heterozygous mutations in BMPR2 can be detected in 50% to 70% of patients with familial PAH and 10% to 40% of patients with idiopathic PAH...
- Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant miceYanli Song
Cardiovascular Division, Dept of Medicine, Brigham and Women s Hosiptal and Harvard Medical School, 77 Ave Louis Pasteur, NRB 630, Boston, MA 02115, USA
Am J Physiol Heart Circ Physiol 295:H677-90. 2008Heterozygous bone morphogenetic protein receptor-II-knockout (BMPR2(+/-)) mice have a similar genetic trait like that in some idiopathic pulmonary arterial hypertension patients...
- Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculatureDavid B Frank
Department of Cell and Developmental Biology, Vanderbilt Univ School of Medicine, S3223 Medical Center North, 1161 21 St South, Nashville, TN 37232 2372, USA
Am J Physiol Lung Cell Mol Physiol 294:L98-109. 2008..arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary vascular responses to chronic ..
- BMP signaling is required for septation of the outflow tract of the mammalian heartEmmanuèle C Délot
Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
Development 130:209-20. 2003..We engineered a knockout mouse that expresses a BMP type II receptor that lacks half of the ligand-binding domain...
- cDNA cloning and genomic organization of the mouse BMP type II receptorH Beppu
Department of Biochemistry, The Cancer Institute, Japanese Foundation for Cancer Research, Toshima ku, Tokyo
Biochem Biophys Res Commun 235:499-504. 1997..Knowledge of the structure of the BMPR-II gene is essential for the understanding of the role of bone morphogenetic proteins in the developmental and physiological processes of animals...
- BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAHMd Talat Nasim
Department of Medical and Molecular Genetics, King s College London, London, UK
Hum Mol Genet 21:2548-58. 2012..Heterozygous mutations in the type II receptor for bone morphogenetic protein (BMPR2) underlie the majority of the inherited and familial forms of PAH...
- Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscleJames West
University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine and Department of Anesthesia, Denver, Colo 80262, USA
Circ Res 94:1109-14. 2004..The type-II receptor (BMPRII) is required for recognition of all BMPs, and targeted deletion of BMPRII in mice results in fetal lethality ..
- BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxiaHideyuki Beppu
Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Am J Physiol Lung Cell Mol Physiol 287:L1241-7. 2004..Our results suggest that, in mice, mutation of one copy of the BMPR-II gene causes pulmonary hypertension but impairs the ability of the pulmonary vasculature to remodel in response to prolonged hypoxic breathing...
- Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesisSi Tuen Lee-Hoeflich
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
EMBO J 23:4792-801. 2004..we show that LIM kinase 1 (LIMK1), a key downstream effector of Rho GTPases, colocalizes with the BMP receptor, BMPRII, in the tips of neurites and binds to BMPRII...
- Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAHYuji Tada
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 292:L1556-63. 2007..IPAH) in human patients is associated with mutations in type 2 receptor for the bone morphogenic protein pathway (BMPR2)...
- BMP type II receptor is required for gastrulation and early development of mouse embryosH Beppu
Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
Dev Biol 221:249-58. 2000..b>BMP type II receptor (BMPR-II) is a type II serine/threonine kinase receptor, which transduces signals for BMPs through ..
- Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineageShan Shan Wang
Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China
FEBS J 280:2644-51. 2013..The type I receptor Bmpr1a and the type II receptors Bmpr2 and Acvr2a mediate the Gdf6 signaling pathway...
- Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cellsChan Woo Kim
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
Arterioscler Thromb Vasc Biol 33:1350-9. 2013..BMP actions are mediated by 2 different types of BMP receptors (BMPRI and BMPRII)...
- Constitutively active ALK2 receptor mutants require type II receptor cooperationJana Bagarova
Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Mol Cell Biol 33:2413-24. 2013..Signaling via GS domain ALK2 mutants could be restored by the expression of either BMP type II receptor. The contribution of BMP type II receptors was independent of their ligand-binding or kinase function but ..
- Growth differentiation factor 5 is a key physiological regulator of dendrite growth during developmentCatarina Osório
School of Biosciences, Cardiff University, Cardiff CF10 3AT, UK
Development 140:4751-62. 2013....
- miR-17 regulates the proliferation and differentiation of the neural precursor cells during mouse corticogenesisSusu Mao
Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University School of Life Sciences, China
FEBS J 281:1144-58. 2014..Taken together, these findings suggest that miR-17 family members play a pivotal role in regulating cell activity during early development of the mouse cortex...
- Expression of bone morphogenetic protein 4 and its receptors in the remodeling heartXueping Wu
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
Life Sci 97:145-54. 2014..We investigated if the expression of BMP4 and its receptors BMPR1a and BMPR2 were activated in post-infarction remodeling and heart failure.
- BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammationMichael W Pickup
Department of Cancer Biology, USA
Mol Oncol 9:179-91. 2015..We sought to investigate the requirement for BMPR2 in stromal fibroblasts during mammary tumor formation and metastasis...
- Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptorsMai Fujimoto
Division of Pathophysiology M F, S O, K O, A M, S T, T M, S K, T K, Research Center for Genomic Medicine, Saitama Medical University, Hidaka shi, Saitama 350 1241, Japan Division of Orthodontics M F, N S, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado shi, Saitama 350 0283, Japan Division of Molecular Signaling and Biochemistry S K, Department of Health Promotion, Kyushu Dental University, Kitakyusyu, Fukuoka 803 8580, Japan
Mol Endocrinol 29:140-52. 2015..These findings suggest that the mutant ALK2 related to FOP is enhanced by BMP type II receptors via the T203-regulated phosphorylation of ALK2. ..
- Oestrogen receptor alpha in pulmonary hypertensionAudrey F Wright
College of Medical, Veterinary, and Life Sciences, Research Institute of Cardiovascular and Medical Sciences, University of Glasgow, Room 448, West Medical Building Wolfson Link Building, Glasgow G12 8QQ, UK
Cardiovasc Res 106:206-16. 2015Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH...
- Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic ProteinsVahan B Indjeian
Howard Hughes Medical Institute Stanford University School of Medicine, Department of Developmental Biology, 279 Campus Drive, Beckman Center B300, Stanford, CA 94305, USA
Cell 164:45-56. 2016..Both gain and loss of regulatory elements can localize BMP changes to specific anatomical locations, providing a flexible regulatory basis for evolving species-specific changes in skeletal form. ..
- A pair of transmembrane receptors essential for the retention and pigmentation of hairRong Han
Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Genesis 50:783-800. 2012..Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are ..
- Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiationHongbin Liu
Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, Louisiana 70112, USA
J Cell Physiol 227:952-63. 2012..The observed functional redundancy of type II BMP receptors in osteoblasts is novel information about the BMP signaling pathway essential for initiating osteoblast differentiation...
- Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediatorsPhilip Owens
Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 109:2814-9. 2012..We sought to determine whether disruption of the BMP receptor 2 (BMPR2) would alter mammary tumor progression in mice that express the Polyoma middle T antigen...
- [Expression of bone morphogenetic protein receptor 2 in myocardialization of cardiac proximal outflow tract septum in connexin 43 knockout embryonic mice]Ying Zhang
Pediatric Heart Center, Children s Hospital of Fudan University, Shanghai 201102, China
Zhonghua Yi Xue Za Zhi 91:2211-5. 2011..To investigate the mechanism of myocardialization of proximal outflow tract septum and its effect on the conotruncal anomaly in mice...
- Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertensionJennifer A Johnson
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 302:L474-84. 2012..arterial hypertension (PAH) is typically caused by a mutation in bone morphogenic protein receptor type 2 (BMPR2), and mice expressing Bmpr2 mutations develop PAH with features similar to human disease...
- Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interactionYuto Kamiya
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 285:30804-13. 2010..Smad7 thus has an additional mode of interaction with TGF-β family type I receptors not possessed by Smad6, which may play roles in mediating the inhibitory effects unique to Smad7...
- A brief overview of mouse models of pulmonary arterial hypertension: problems and prospectsJose Gomez-Arroyo
Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA 23298, USA
Am J Physiol Lung Cell Mol Physiol 302:L977-91. 2012..Anatomical, cellular, and genetic differences distinguish mice and rats, and pharmacogenomics may explain the degree of PH and the particular mode of pulmonary vascular adaptation and also the response of the right ventricle...
- ALK1 signaling regulates early postnatal lymphatic vessel developmentKyle Niessen
Department of Tumor Biology and Angiogenesis, Division of Research, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Blood 115:1654-61. 2010..Thus, our study reveals a novel aspect of ALK1 signaling in regulating lymphatic development and suggests that targeting ALK1 pathway might provide additional control of lymphangiogenesis in human diseases...
- Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type miceElizabeth M Mushaben
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, United States of America
PLoS ONE 7:e32468. 2012Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been identified in patients with heritable pulmonary arterial hypertension (PAH); however, disease penetrance is low, suggesting additional ..
- L51P - A BMP2 variant with osteoinductive activity via inhibition of NogginChristoph E Albers
Group for Bone Biology and Orthopedic Research, Department of Clinical Research, University of Bern, CH 3010 Bern, Switzerland
Bone 51:401-6. 2012..The described strategy may help to decrease the amounts of exogenous BMPs currently required to stimulate bone healing...
- Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eyeYi Zhou
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Proc Natl Acad Sci U S A 110:8966-71. 2013..Based on our findings, we propose that Jag1-Notch2 signaling controls CB morphogenesis at least in part by regulating cell proliferation and BMP signaling...
- BMPR2 is required for postimplantation uterine function and pregnancy maintenanceTakashi Nagashima
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Invest 123:2539-50. 2013..In this study, we discovered that bone morphogenetic protein receptor type 2 (BMPR2) is essential for postimplantation physiology and fertility...
- MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approachVictoria N Parikh
Brigham and Women s Hospital, New Research Building, 77 Ave Louis Pasteur, Boston, MA 02115, USA
Circulation 125:1520-32. 2012..Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies. Owing to their pleiotropic actions, microRNA molecules are potential candidates for coordinated regulation of these disease stimuli...
- SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblastKatsuhiko Hayashi
Division of Molecular Biology, Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278 0022, Japan
Mech Dev 118:99-109. 2002..These results indicate that SMAD1 signaling possesses a critical and non-redundant function in the initial commitment of the germ cell lineage...
- Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cellsPaul B Yu
Cardiovascular Research Center and Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 283:3877-88. 2008..The association of mutations in the BMP type II receptor (BMPRII) with idiopathic pulmonary arterial hypertension suggests an important role of this receptor in ..
- Bone morphogenetic protein 6-induced interleukin-1β expression in macrophages requires PU.1/Smad1 interactionGeun Taek Lee
Section of Urologic Oncology and the Dean and Betty Gallo Prostate Cancer Center, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street 4560, New Brunswick, NJ 08903, United States
Mol Immunol 48:1540-7. 2011..the present study, we demonstrate that BMP-6 increases IL-1β expression in macrophages via the receptors ALK3 and BMPRII as well as the downstream signaling protein Smad1...
- Differential expression of BMP receptors in early mouse developmentB A Roelen
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
Int J Dev Biol 41:541-9. 1997..In postimplantation embryos BMPR-II transcripts were first detected from 6.0 days post coitum. In situ hybridization analysis revealed that BMPR-II mRNA is ubiquitously expressed in the entire embryo at least until midgestation...
- Physiologic and molecular consequences of endothelial Bmpr2 mutationSusan Majka
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA
Respir Res 12:84. 2011..Most hereditary PAH is associated with BMPR2 mutations...
- Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-IIVictoria J Burton
Novartis Institutes for BioMedical Research, West Sussex, UK
Blood 118:4750-8. 2011..Here we demonstrate that, in mice with endothelial-specific loss of BMPR-II expression (L1Cre(+);Bmpr2(f/f)), reduction in barrier function and the resultant pulmonary hypertension observed in vivo are the result of ..
- Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expressionD Zhang
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 18:3314-26. 1998....
- Expression of bone morphogenetic protein receptors in the developing mouse metanephrosG Martinez
Department of Anatomy and Cell Biology, Monash University, Clayton, Vic, Australia
Exp Nephrol 9:372-9. 2001..These patterns of receptor expression suggest that these molecules are important regulators of epithelial-mesenchymal interactions, nephron development and ureteric branching morphogenesis...
- Bmp signaling is required for development of primary lens fiber cellsSonya C Faber
Division of Developmental Biology and Department of Ophthalmology, Children s Hospital Research Foundation, 3333 Burnet Avenue Cincinnati, OH 45229, USA
Development 129:3727-37. 2002..We conclude that Bmp signaling is required for primary lens fiber cell differentiation and, given the asymmetry of the differentiation inhibition, that distinct differentiation stimuli may be active in different quadrants of the eye...
- Crystal structure of recombinant human growth and differentiation factor 5: evidence for interaction of the type I and type II receptor-binding sitesHerman Schreuder
Sanofi Aventis, Industriepark Hoechst, Building G 865, A 65926 Frankfurt, Germany
Biochem Biophys Res Commun 329:1076-86. 2005....
- Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cellsR Fernández-Lloris
Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, 08907 L Hospitalet de Llobregat, Spain
Mol Endocrinol 17:1332-43. 2003..Taken together, these results indicate that SOX6 is an important downstream mediator of BMP-2 signaling in chondrogenesis...
- B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signalingSean Park
Department of Physiology and Functional Genomics, University of Florida, 1600 SW Archer Rd, Room D533d, Gainesville, FL 32610, USA
Mol Cell Biol 24:10256-62. 2004..In view of the genetic evidence that reduced BMP signaling causes posteriorization of the vertebral pattern, we propose that the observed vertebral phenotype in Btg2-null mice is due to attenuated BMP signaling...
- Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiationAriadne L Hager-Theodorides
Department of Biological Sciences, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK
J Immunol 169:5496-504. 2002..Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation...
- Expression of the dystrophin gene in mouse and rat brainD Gorecki
MRC Molecular Neurobiology Unit, University of Cambridge Medical School, England
Neuroreport 2:773-6. 1991..We find the gene strongly expressed in the hippocampus and cerebral cortex, areas with an established cognitive function, and also in the Purkinje cells of the cerebellum, an area associated with motor coordination...
- Temporal and spatial expression profiles of BMP receptors and noggin during BMP-2-induced ectopic bone formationYukio Nakamura
Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan
J Bone Miner Res 18:1854-62. 2003..The results suggest that positive and negative feedback mechanisms modulate ectopic osteogenesis induced by this growth factor...
- Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadiaEmily A Morgan
Shriners Hospital for Children, Portland, OR 97239, USA
Development 130:3095-109. 2003..Finally, a novel role for Hoxa13 in the vascularization of the glans penis is also identified...
- Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cellsLin Ye
Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Health Park, Cardiff, CF14 4XN, UK
Int J Oncol 30:521-9. 2007..This may have important implications in the development of bone metastasis in prostate cancer...
- Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cellsCharles Durand
Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
Proc Natl Acad Sci U S A 104:20838-43. 2007..We suggest that Bmp4 plays a relatively late role in the regulation of HSCs as they emerge in the midgestation AGM...
- Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in miceMeilin Wu
Department of Cell and Developmental Biology and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:2076-87. 2008..These studies provide in vivo evidence for the importance of Pax3 downregulation during differentiation of multipotent neural crest precursors and cranial development...
- Temporal and spatial regulation of bone morphogenetic protein signaling in late lung developmentMiguel A Alejandre-Alcázar
Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
Dev Dyn 236:2825-35. 2007..We describe changes in the expression and localization of BMP receptors (Bmpr1a, Bmpr1b, and Bmpr2) and Smad (Smad1, Smad4, Smad5, and Smad8) intracellular signaling proteins during the saccular and ..
- A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7Gerhard Sengle
Shriners Hospital for Children, Oregon Health and Science University, OR 97239, USA
J Mol Biol 381:1025-39. 2008....
- Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontiumP Kemoun
Department of Oral Biology, Faculty of Odontology, 3 chemin des Maraichers, 31062 Toulouse Cedex, France
Tissue Cell 39:257-66. 2007..These results suggest that STRO-1 positive DF cells may be target of BMPs secreted by HERS. BMP-3 might be involved in the arrest of this process by inhibiting the signaling provided by cementogenic and osteogenic BMPs...
- Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpinNathalie Lebeurrier
INSERM, INSERM U919, Serine Proteases and Pathophysiology of the neurovascular Unit SP2U, Cyceron, F 14074 France
J Cell Sci 121:3357-65. 2008..This study demonstrates the existence of an AMH-dependent signalling pathway in the brain leading to an overexpression of the serine-protease inhibitor, neuroserpin, and neuronal survival...
- Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertensionAnna Zakrzewicz
University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, D 35392 Giessen, Germany
Circulation 115:2957-68. 2007..Heterozygous mutations in BMPR2, encoding the type II bone morphogenetic protein receptor (BMPRII), were identified in PAH, suggesting that alterations to BMPRII function are involved in disease onset and/or ..
- Activation of the bone morphogenetic protein receptor by H11kinase/Hsp22 promotes cardiac cell growth and survivalXiangzhen Sui
Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Circ Res 104:887-95. 2009..Therefore, potentiation of the BMP receptor by H11K promotes an activation of the PI3K/Akt pathway mediated by TAK1, which dictates the physiological effects of H11K on cardiac cell growth and survival...
- The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gutShigeko Torihashi
Department of Health Science, Nagoya University Graduate School of Medicine, 1 1 20 Daikouminami, Higashi ku, Nagoya 461 8673, Japan
Differentiation 77:277-89. 2009..Taken together, BMP signaling was expressed for a short window in the smooth muscle progenitors and the signal, especially BMP2, plays an essential role in smooth muscle differentiation in cooperation with PDGF signaling...
- BMP and BMP receptor expression during murine organogenesisShahab M Danesh
Department of Molecular Biology, NA8 300, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
Gene Expr Patterns 9:255-65. 2009..expression profiles of three BMP ligands (Bmp2, Bmp4, Bmp7) and three BMP receptors (Bmpr1a, Bmpr1b, and BmprII), as well as their molecular antagonist (noggin), in the early embryo during the initial steps of murine ..
- Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4Yin Xia
Program in Membrane Biology and the Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Biol Chem 282:18129-40. 2007..cells and mouse pulmonary artery smooth muscle cells, BMP2 and BMP4 signaling required BMP receptor type II (BMPRII), but not activin receptor type IIA (ActRIIA) or ActRIIB, based on changes in BMP signaling by small interfering ..
- Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertensionRory E Morty
Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Aulweg 123 Raum 6 11, D 35392 Giessen, Germany
Arterioscler Thromb Vasc Biol 27:1072-8. 2007Mutations in the bmpr2 gene, encoding the type II bone morphogenetic protein (BMP) receptor, have been identified in patients with pulmonary arterial hypertension (PAH), implicating BMP signaling in PAH...
- BMPR-II is dispensable for formation of the limb skeletonLaura W Gamer
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts
Genesis 49:719-24. 2011..From these data, we conclude that BMPR-II is not required for endochondral ossification in the limb where loss of BMPR-II may be compensated by BMP utilization of Acvr2a and Acvr2b. genesis, 00:1-6, 2011. © 2011 Wiley-Liss, Inc...
- Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusionMarek Dudas
Developmental Biology Program, The Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
Dev Biol 296:298-314. 2006....
- Generation of a mouse model with expression of bone morphogenetic protein type II receptor lacking the cytoplasmic domain in osteoblastsChaozhe Yang
Shihezi Medical College, Shihezi University, Xinjiang, China
Ann N Y Acad Sci 1192:286-91. 2010..Here we established a mouse model in which a C-terminal truncated BMP type II receptor (BMPRII) is expressed specifically in osteoblasts as a dominant negative form in the BMP/Smad signaling ..
- Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neuronsHadas Tilleman
Zlotowski Center for Neuroscience, Department of Morphology, Division of Basic Sciences, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
Mol Cell Neurosci 45:1-11. 2010..In addition, we conclude that the position of the mid-hindbrain organizer determines the size of the LC and propose that Bmp5/7 play an important role in mediating this organizer function...
- BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertensionM Talati
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010..PAH) and in particular to heritable PAH (HPAH) with known bone morphogenetic protein type 2 receptor (BMPR2) mutations is not known...
- Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptorSylke Hassel
Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
J Cell Physiol 206:457-67. 2006..Our data suggest that the complex formation between c-kit and BMPR-II leads to phosphorylation of BMPR-II at Ser757, which modulates BMPR-II-dependent signaling...
- Identification and analysis of type II TGF-β receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cellsNingning Wu
Chongqing Medical University, China
Acta Biochim Biophys Sin (Shanghai) 42:699-708. 2010..We found that three DN type II TGF-β receptors, DN-BMPRII, DN-ActRII, and DN-ActRIIB, diminished BMP-9-induced alkaline phosphatase (ALP) activity, led to a decrease in BMP-..
- BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocystSho Ohta
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132 3401, USA
Dev Biol 347:369-81. 2010....
- DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retinaMing Shi
Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai, China
Dev Biol 348:87-96. 2010..Thus, our findings suggest that DCC is a key regulator for the survival of specific types of neurons during retinal development and that DCC-P3 domain is essential for this developing event...
- FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian developmentKenichi Kashimada
Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Endocrinology 152:272-80. 2011..Further, Wnt4-knockout mice showed reduced expression of Fst limited to early ovarian development, suggesting a role for WNT4 in the initiation, but not the maintenance, of Fst expression...
- BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathwaysVinicio A de Jesus Perez
Department of Medicine, Stanford University, Stanford, CA 94305, USA
J Cell Biol 192:171-88. 2011..We speculate that, in response to injury, factors that subvert BMP-2-mediated tandem activation of Wnt-βC and Wnt-PCP pathways contribute to obliterative vascular disease in both the systemic and pulmonary circulations...
- Expression patterns of BMPRs in the developing mouse molarA Nadiri
INSERM UMR S595, Faculte de Chirurgie Dentaire, Universite Louis Pasteur, 67085, Strasbourg, France
Cell Tissue Res 324:33-40. 2006....
- Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cellsFang Xu Jiang
Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
Exp Cell Res 308:114-22. 2005..These results demonstrate a convergence of BMP and Ln-1 signaling through P13K and MAP kinase pathways to induce proliferation and colony formation in E15.5 fetal mouse pancreatic cells...