Gene Symbol: Bmpr1a
Description: bone morphogenetic protein receptor, type 1A
Alias: 1110037I22Rik, ALK-3, ALK3, AU045487, BMPR-1A, BMPR-IA, Bmpr, SKR5, bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMP-2/BMP-4 receptor, activin receptor-like kinase 3, serine/threonine-protein kinase receptor R5
Species: mouse
Products:     Bmpr1a

Top Publications

  1. Ming Kwan K, Li A, Wang X, Wurst W, Behringer R. Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis. Genesis. 2004;39:10-25 pubmed
    ..The conditional mutation of Bmpr1a in ventral limb ectoderm and its derivatives (epidermis and hair follicles) resulted in a lack of hair outgrowth ..
  2. Stottmann R, Choi M, Mishina Y, Meyers E, Klingensmith J. BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development. 2004;131:2205-18 pubmed
    ..Mouse has three known BMP2/4 type I receptors, of which Bmpr1a is expressed in the neural tube sufficiently early to be involved in neural crest development from the outset; ..
  3. Dewulf N, Verschueren K, Lonnoy O, Moren A, Grimsby S, Vande Spiegle K, et al. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. Endocrinology. 1995;136:2652-63 pubmed
    ..In addition, the expression of these genes in many soft tissues suggests broader functions for BMPs in embryogenesis. ..
  4. Beppu H, Minowa O, Miyazono K, Kawabata M. cDNA cloning and genomic organization of the mouse BMP type II receptor. Biochem Biophys Res Commun. 1997;235:499-504 pubmed
    The cDNA for the mouse bone morphogenetic protein type II receptor (BMPR-II) was isolated using the human counterpart as a probe and its genomic structure was determined...
  5. Sun J, Chen H, Chen C, Whitsett J, Mishina Y, Bringas P, et al. Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol. 2008;172:571-82 pubmed publisher
    ..We found that BMP type I receptor Alk3 is expressed predominantly in airway epithelial cells during development...
  6. Mishina Y, Hanks M, Miura S, Tallquist M, Behringer R. Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 2002;32:69-72 pubmed
  7. Huang J, Dattilo L, Rajagopal R, Liu Y, Kaartinen V, Mishina Y, et al. FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development. 2009;136:1741-50 pubmed publisher
    ..A second row of eyelashes is a feature of human lymphedema-distichiasis syndrome, which is associated with mutations in FOXC2...
  8. Baur S, Mai J, Dymecki S. Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development. 2000;127:605-19 pubmed
  9. Maloum F, Allaire J, Gagné Sansfaçon J, Roy E, Belleville K, Sarret P, et al. Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. Am J Physiol Gastrointest Liver Physiol. 2011;300:G1065-79 pubmed publisher
    ..the Cre/loxP system, we generated a mouse model with an early deletion during development of BMP receptor 1A (Bmpr1a) exclusively in the foregut endoderm...

More Information


  1. Liu W, Sun X, Braut A, Mishina Y, Behringer R, Mina M, et al. Distinct functions for Bmp signaling in lip and palate fusion in mice. Development. 2005;132:1453-61 pubmed
    ..dissect the function of Bmp signaling in orofacial clefting, we conditionally inactivated the type 1 Bmp receptor Bmpr1a in the facial primordia, using the Nestin cre transgenic line...
  2. Yoon B, Ovchinnikov D, Yoshii I, Mishina Y, Behringer R, Lyons K. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 2005;102:5062-7 pubmed
    ..Whereas mice deficient in type 1 receptors Bmpr1a or Bmpr1b in cartilage are able to form intact cartilaginous elements, double mutants develop a severe generalized ..
  3. Edson M, Nalam R, Clementi C, Franco H, DeMayo F, Lyons K, et al. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol. 2010;24:1251-66 pubmed publisher
    ..transduced by multiple type I and type II TGFbeta family receptors, and of the type I receptors, BMP receptor 1A (BMPR1A) and BMP receptor 1B (BMPR1B) are known to be expressed in rodent granulosa cells...
  4. Furuta Y, Hogan B. BMP4 is essential for lens induction in the mouse embryo. Genes Dev. 1998;12:3764-75 pubmed
    ..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals. ..
  5. Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, et al. Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling. Development. 2009;136:367-72 pubmed publisher
    ..These results indicate the presence of growth factor signal cross-talk involving beta-catenin signaling, which regulates the HF fate. ..
  6. Auclair B, Benoit Y, Rivard N, Mishina Y, Perreault N. Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology. 2007;133:887-96 pubmed
    ..With the use of tissue-specific gene ablation, we generated mice lacking the Bmp receptor type IA (Bmpr1a) exclusively in the intestinal epithelium...
  7. Li L, Lin M, Wang Y, Cserjesi P, Chen Z, Chen Y. BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol. 2011;349:451-61 pubmed publisher
    ..Our results demonstrate an essential role for BmprIa in the mesenchymal component and a limited functional redundancy between BmprIa and BmprIb in a tissue-specific manner during tooth and palate development...
  8. Nomura Kitabayashi A, Phoon C, Kishigami S, Rosenthal J, Yamauchi Y, Abe K, et al. Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest. Am J Physiol Heart Circ Physiol. 2009;297:H1617-28 pubmed publisher
    ..assess hemodynamic function in mouse embryos with P0-Cre transgene mediated neural crest ablation of Bmpr1a (P0 mutants). Similar to previous studies, the neural crest-deleted Bmpr1a P0 mutants died at approximately E12...
  9. Lamm M, Podlasek C, Barnett D, Lee J, Clemens J, Hebner C, et al. Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev Biol. 2001;232:301-14 pubmed
    ..Taken together, our data indicate that BMP4 is a urogenital sinus mesenchymal factor that restricts prostate ductal budding and branching morphogenesis. ..
  10. Namiki M, Akiyama S, Katagiri T, Suzuki A, Ueno N, Yamaji N, et al. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. J Biol Chem. 1997;272:22046-52 pubmed
    ..Two type I receptors (BMPR-IA and BMPR-IB) have been identified for BMP-2...
  11. Winbanks C, Chen J, Qian H, Liu Y, Bernardo B, Beyer C, et al. The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass. J Cell Biol. 2013;203:345-57 pubmed publisher
    ..Our studies highlight a novel role for the BMP signaling pathway in promoting muscle growth and inhibiting muscle wasting, which may have significant implications for the development of therapeutics for neuromuscular disorders. ..
  12. Ishidou Y, Kitajima I, Obama H, Maruyama I, Murata F, Imamura T, et al. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. J Bone Miner Res. 1995;10:1651-9 pubmed
    Type I receptors for bone morphogenetic proteins (BMPs), i.e., BMPR-IA and BMPR-IB, are transmembrane serine/threonine kinases, that bind osteogenic protein-1 (OP-1, also termed BMP-7) and BMP-4...
  13. Kamiya N, Ye L, Kobayashi T, Lucas D, Mochida Y, Yamauchi M, et al. Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res. 2008;23:2007-17 pubmed publisher
    ..b>Bmpr1a conditional knockout mice (cKO) showed increased bone mass primarily in trabecular bone at P21 and 22 wk as ..
  14. Orvis G, Jamin S, Kwan K, Mishina Y, Kaartinen V, Huang S, et al. Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse. Biol Reprod. 2008;78:994-1001 pubmed publisher
    ..gene inactivation with an Amhr2-Cre allele, we have determined that two TGF-beta type I receptors (Acvr1 and Bmpr1a) and all three BMP receptor-Smads (Smad1, Smad5, and Smad8) function redundantly in transducing the anti-Mü..
  15. Wu X, Zhang N, Lee M. Mullerian inhibiting substance recruits ALK3 to regulate Leydig cell differentiation. Endocrinology. 2012;153:4929-37 pubmed
    ..Müllerian duct regression are activin A type II receptor, type I [Acvr1/activin receptor-like kinase 2 (ALK2)], ALK3, and ALK6, but the one recruited by MIS in Leydig cells is unknown...
  16. Suzuki A, Thies R, Yamaji N, Song J, Wozney J, Murakami K, et al. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc Natl Acad Sci U S A. 1994;91:10255-9 pubmed
    ..These findings suggest that endogenous BMP-2 and BMP-4 are involved in the dorsal-ventral specification in the embryo and that ventral fate requires induction rather than resulting from an absence of dorsal specification. ..
  17. He X, Zhang J, Tong W, Tawfik O, Ross J, Scoville D, et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet. 2004;36:1117-21 pubmed
    In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively...
  18. Andl T, Ahn K, Kairo A, Chu E, Wine Lee L, Reddy S, et al. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development. 2004;131:2257-68 pubmed
    ..epithelium of severely affected mutant follicles, indicating that activation of the WNT pathway lies downstream of BMPR1A signaling in postnatal follicles...
  19. Miyazaki Y, Oshima K, Fogo A, Hogan B, Ichikawa I. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest. 2000;105:863-73 pubmed
    ..ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously (Alk3) or exclusively in the WD and ureter epithelium (Alk6)...
  20. Keller S, Nickel J, Zhang J, Sebald W, Mueller T. Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol. 2004;11:481-8 pubmed
    ..Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design. ..
  21. Ahn K, Mishina Y, Hanks M, Behringer R, Crenshaw E. BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development. 2001;128:4449-61 pubmed
    We demonstrate that signaling via the bone morphogenetic protein receptor IA (BMPR-IA) is required to establish two of the three cardinal axes of the limb: the proximal-distal axis and the dorsal-ventral axis...
  22. Mishina Y, Suzuki A, Ueno N, Behringer R. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 1995;9:3027-37 pubmed
    ..b>Bmpr, also known as ALK-3 and Brk-1, encodes a type I transforming growth factor-beta (TGF-beta) family receptor for BMP-..
  23. Danesh S, Villasenor A, Chong D, Soukup C, Cleaver O. BMP and BMP receptor expression during murine organogenesis. Gene Expr Patterns. 2009;9:255-65 pubmed publisher of the developmental expression profiles of three BMP ligands (Bmp2, Bmp4, Bmp7) and three BMP receptors (Bmpr1a, Bmpr1b, and BmprII), as well as their molecular antagonist (noggin), in the early embryo during the initial steps ..
  24. Omori A, Harada M, Ohta S, Villacorte M, Sugimura Y, Shiraishi T, et al. Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development: a mouse model for congenital cystic dilation. Congenit Anom (Kyoto). 2011;51:102-9 pubmed publisher
    ..These results suggest that Bmp signaling contributes to BUG development. Bmp receptor1a (Bmpr1a) is known as the major type 1 signal transducer in some organogeneses...
  25. Ono Y, Calhabeu F, Morgan J, Katagiri T, Amthor H, Zammit P. BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells. Cell Death Differ. 2011;18:222-34 pubmed publisher
    ..Activated satellite cells expressed BMP receptor type 1A (BMPR-1A/Alk-3) and contained phosphorylated Smad proteins, indicating that BMP signalling is operating during ..
  26. Li L, Wang Y, Lin M, Yuan G, Yang G, Zheng Y, et al. Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PLoS ONE. 2013;8:e66107 pubmed publisher
    ..In this study, we took a gain-of-function approach to further address the role of BMPR-IA-mediated signaling in the mesenchymal compartment during tooth and palate development...
  27. Morikawa Y, Zehir A, Maska E, Deng C, Schneider M, Mishina Y, et al. BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development. 2009;136:3575-84 pubmed publisher
    ..To determine if BMP signaling is a cell-autonomous requirement of SNS development, the Alk3 (BMP receptor IA) was deleted in the NC lineage...
  28. Scott G, Ray M, Ward T, McCann K, Peddada S, Jiang F, et al. Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling. Genesis. 2009;47:385-91 pubmed publisher
    ..Here, we report the abnormalities of heterozygous mice for Bmpr1a in glucose metabolism during the course of intraperitoneal glucose tolerance test...
  29. Grishina I, Kim S, Ferrara C, Makarenkova H, Walden P. BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol. 2005;288:334-47 pubmed
    ..Based on our studies, we propose a model that BMP7 inhibits branching morphogenesis in the prostate and limits the number of domains with high Notch1/Hes1 activity. ..
  30. Rountree R, Schoor M, Chen H, Marks M, Harley V, Mishina Y, et al. BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol. 2004;2:e355 pubmed
    ..Mice with null mutations in Bmpr1a are known to die early in embryogenesis with multiple defects...
  31. Seemann P, Schwappacher R, Kjaer K, Krakow D, Lehmann K, Dawson K, et al. Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2. J Clin Invest. 2005;115:2373-81 pubmed
    ..Biosensor interaction analyses revealed loss of binding to BMPR1A and BMPR1B ectodomains for the L441P mutant, whereas the R438L mutant showed normal binding to BMPR1B but ..
  32. Soshnikova N, Zechner D, Huelsken J, Mishina Y, Behringer R, Taketo M, et al. Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev. 2003;17:1963-8 pubmed
    ..Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/beta-catenin and BMP receptor signaling. ..
  33. Kobielak K, Pasolli H, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol. 2003;163:609-23 pubmed
  34. Panchision D, Pickel J, Studer L, Lee S, Turner P, Hazel T, et al. Sequential actions of BMP receptors control neural precursor cell production and fate. Genes Dev. 2001;15:2094-110 pubmed
    ..To determine the mechanisms underlying BMP actions, we analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor cells in vitro and in vivo...
  35. Yoon B, Pogue R, Ovchinnikov D, Yoshii I, Mishina Y, Behringer R, et al. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006;133:4667-78 pubmed
    ..Therefore, we characterized the skeletal phenotypes of mice lacking Bmpr1a in chondrocytes (Bmpr1a(CKO)) and Bmpr1a(CKO);Bmpr1b+/- (Bmpr1a(CKO);1b+/-) in order to test the roles of BMP ..
  36. Hartwig S, Bridgewater D, Di Giovanni V, Cain J, Mishina Y, Rosenblum N. BMP receptor ALK3 controls collecting system development. J Am Soc Nephrol. 2008;19:117-24 pubmed publisher
    ..Members of the bone morphogenetic protein (BMP) family signal through the type I BMP receptor ALK3 to inhibit ureteric bud and collecting duct cell morphogenesis in vitro...
  37. Mishina Y, Starbuck M, Gentile M, Fukuda T, Kasparcova V, Seedor J, et al. Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem. 2004;279:27560-6 pubmed
    ..To investigate the role of BMPs during bone remodeling, we generated a postnatal osteoblast-specific disruption of Bmpr1a that encodes the type IA receptor for BMPs in mice...
  38. Koenig B, Cook J, Wolsing D, Ting J, Tiesman J, Correa P, et al. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol. 1994;14:5961-74 pubmed
    ..We conclude that BRK-1 is a putative BMP type I receptor capable of interacting with a known type II receptor for BMPs. ..
  39. Hens J, Dann P, Zhang J, Harris S, Robinson G, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development. 2007;134:1221-30 pubmed
  40. Belville C, Jamin S, Picard J, Josso N, di Clemente N. Role of type I receptors for anti-Müllerian hormone in the SMAT-1 Sertoli cell line. Oncogene. 2005;24:4984-92 pubmed
    ..type I receptors and small interfering RNA technology, we demonstrate that, in an AMH Sertoli target cell line, ALK3 mediates AMH effects on both Smad1 activation and P450 side-chain cleavage enzyme...
  41. Baek J, Lan Y, Liu H, Maltby K, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011;350:520-31 pubmed publisher
    ..In this report, we show that the Bmpr1a gene, encoding a type I receptor for bone morphogenetic proteins (Bmp), is preferentially expressed in the primary ..
  42. Kua H, Liu H, Leong W, Li L, Jia D, Ma G, et al. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol. 2012;14:727-37 pubmed publisher
    ..These findings identify c-Abl as a regulator of BMP signalling pathways and uncover a role for c-Abl in p16(INK4a) expression and osteoprogenitor expansion. ..
  43. Hager Theodorides A, Outram S, Shah D, Sacedon R, Shrimpton R, Vicente A, et al. Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J Immunol. 2002;169:5496-504 pubmed
    ..BMP2 and BMP4 are produced by the thymic stroma and the requisite BMP receptor molecules (BMPR-1A, BMPR-1B, BMPR-II), and signal transduction molecules (Smad-1, -5, -8, and -4) are expressed by DN thymocytes...
  44. Jamin S, Arango N, Mishina Y, Hanks M, Behringer R. Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Nat Genet. 2002;32:408-10 pubmed
    ..Here we show that targeted disruption of the widely expressed type I bone morphogenetic protein (BMP) receptor Bmpr1a (also known as Alk3) in the mesenchymal cells of the Müllerian ducts leads to retention of oviducts and uteri in ..
  45. Leyton P, Beppu H, Pappas A, Martyn T, Derwall M, Baron D, et al. Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function. PLoS ONE. 2013;8:e76947 pubmed publisher
    ..These findings suggest that the tail domain of Bmpr2 is essential for normal embryogenesis and inhibits Alk2?mediated BMP7 signaling in PaSMCs. ..
  46. Meng Q, Jin C, Chen Y, Chen J, Medvedovic M, Xia Y. Expression of signaling components in embryonic eyelid epithelium. PLoS ONE. 2014;9:e87038 pubmed publisher
    ..Erbb2, Shh, Ptch1 and 2, Smo and Gli2, and Jag1 and Notch1, the IE cells had more abundant expression of Bmp5 and Bmpr1a. In addition, the LE cells had more abundant expression of adenomatosis polyposis coli down-regulated 1 (Apcdd1), ..
  47. Plikus M, Guerrero Juarez C, Ito M, Li Y, Dedhia P, Zheng Y, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017;355:748-752 pubmed publisher
    ..i> Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans. ..
  48. Haraguchi R, Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S, et al. The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential signaling relay for urinary tract morphogenesis. PLoS ONE. 2012;7:e42245 pubmed publisher
    ..These results suggested that Hh-responsive mesenchymal Bmp signaling maintains the population of peri-cloacal mesenchyme cells, which is essential for the development of the ureter and the upper urinary tract. ..
  49. Murali D, Kawaguchi Niida M, Deng C, Furuta Y. Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-? signaling system in the embryonic mouse retina. Invest Ophthalmol Vis Sci. 2011;52:2930-7 pubmed publisher
    ..In addition, genetic requirements for Smad4 in the embryonic retina are evident predominantly in the developmental events regulated by the BMP branch of the TGF-? signaling pathway. ..
  50. Liu R, Ginn S, Lek M, North K, Alexander I, Little D, et al. Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a. BMC Musculoskelet Disord. 2009;10:51 pubmed publisher
    ..Myoblasts and osteoprogenitors grown in osteogenic media rapidly upregulated Bmpr-1a expression...
  51. Rigueur D, Brugger S, Anbarchian T, Kim J, Lee Y, Lyons K. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015;30:733-41 pubmed publisher
    ..BMPs transduce their signals through three type I receptors: BMPR1A, BMPR1B, and ACVR1/ALK2...
  52. Iura A, McNerny E, Zhang Y, Kamiya N, Tantillo M, Lynch M, et al. Mechanical Loading Synergistically Increases Trabecular Bone Volume and Improves Mechanical Properties in the Mouse when BMP Signaling Is Specifically Ablated in Osteoblasts. PLoS ONE. 2015;10:e0141345 pubmed publisher
    ..We previously reported that conditional knockout (cKO) of Bmpr1a, which encodes one of the type 1 receptors for Bone Morphogenetic Proteins (BMPs), in an osteoblast-specific ..
  53. Sahni V, Mukhopadhyay A, Tysseling V, Hebert A, Birch D, McGuire T, et al. BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury. J Neurosci. 2010;30:1839-55 pubmed publisher
    ..We investigated the role of bone morphogenetic protein (BMP) signaling in gliosis after SCI and find that BMPR1a and BMPR1b signaling exerts opposing effects on hypertrophy...
  54. Coucouvanis E, Martin G. BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. Development. 1999;126:535-46 pubmed
    ..Based on these and other data, we propose a model for the role of BMP signaling during peri-implantation stages of mouse embryo development. ..
  55. Zhou X, Wang Y, Ongaro L, Boehm U, Kaartinen V, Mishina Y, et al. Normal gonadotropin production and fertility in gonadotrope-specific Bmpr1a knockout mice. J Endocrinol. 2016;229:331-41 pubmed publisher
    ..BMP2 signals preferentially via the BMP type I receptor, BMPR1A, to stimulate murine Fshb transcription in vitro Here, we used a Cre-lox approach to assess BMPR1A's role in FSH ..
  56. Steinbicker A, Bartnikas T, Lohmeyer L, Leyton P, Mayeur C, Kao S, et al. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011;118:4224-30 pubmed publisher
    ..Two BMP type I receptors, Alk2 (Acvr1) and Alk3 (Bmpr1a), are expressed in murine hepatocytes...
  57. Wang S, Huang H, Chen S, Li X, Zhang W, Tang Q. Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. FEBS J. 2013;280:2644-51 pubmed publisher
    ..The type I receptor Bmpr1a and the type II receptors Bmpr2 and Acvr2a mediate the Gdf6 signaling pathway...
  58. Stroud D, Gaussin V, Burch J, Yu C, Mishina Y, Schneider M, et al. Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation. 2007;116:2535-43 pubmed
    ..A recent study demonstrated that signaling by Alk3, the type 1a receptor for bone morphogenetic proteins, in the myocardium of the AV canal was required for the ..
  59. Leung Y, Kandyba E, Chen Y, Ruffins S, Chuong C, Kobielak K. Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration. Proc Natl Acad Sci U S A. 2014;111:15114-9 pubmed publisher
  60. Jiang F, Mishina Y, Baten A, Morahan G, Harrison L. Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis. Biol Open. 2015;4:1016-23 pubmed publisher
    ..throughput transcriptomic analyses on the islets isolated from mice with a pancreas-specific deletion of the gene, Bmpr1a, encoding the type 1a BMP receptor...
  61. Huang J, Liu Y, Filas B, Gunhaga L, Beebe D. Negative and positive auto-regulation of BMP expression in early eye development. Dev Biol. 2015;407:256-64 pubmed publisher
    ..embryo pre-lens ectoderm explant assay, and also studied transgenic mice, in which the type I BMP receptors, Bmpr1a and Acvr1, are deleted from the prospective lens ectoderm...
  62. Wu X, Robinson C, Fong H, Gimble J. Analysis of the native murine bone morphogenetic protein serine threonine kinase type I receptor (ALK-3). J Cell Physiol. 1996;168:453-61 pubmed
    ..These findings support the current model that BMP interacts with a pre-existing complex consisting of a type I and type II receptor protein. ..