Gene Symbol: Bmp7
Description: bone morphogenetic protein 7
Alias: OP1, bone morphogenetic protein 7, osteogenic protein 1
Species: mouse
Products:     Bmp7

Top Publications

  1. Rizzoti K, Lovell Badge R. SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007;134:3437-48 pubmed
    ..They also give insight into the formation of pharyngeal pouches, of which little is known in vertebrates. Finally, this work introduces two new players in craniofacial development - SOX3 and SOX2. ..
  2. Zhang Q, Shi Y, Wada J, Malakauskas S, Liu M, Ren Y, et al. In vivo delivery of Gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7. PLoS ONE. 2010;5:e11709 pubmed publisher
    ..We conclude that inhibition of Gremlin exerts beneficial effects on the diabetic kidney mainly through maintenance of BMP-7 activity and that Gremlin may serve as a novel therapeutic target in the management of diabetic nephropathy. ..
  3. Sehgal R, Sheibani N, Rhodes S, Belecky Adams T. BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression. Dev Biol. 2009;332:429-43 pubmed publisher
    ..Thus, appropriate expression of Pax2 is essential for astrocyte determination and differentiation. Although BMP7 and SHH have been shown to regulate Pax2 expression, the molecular mechanism by which this regulation occurs is not ..
  4. Vukicevic S, Kopp J, Luyten F, Sampath T. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci U S A. 1996;93:9021-6 pubmed
    ..As osteogenic protein 1 (OP-1/bone morphogenetic protein 7), a member of the TGF-beta superfamily of proteins, is expressed predominantly in the kidney, we ..
  5. Lee K, Mendelsohn M, Jessell T. Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. Genes Dev. 1998;12:3394-407 pubmed
    ..More generally, these results suggest that BMP signaling may have a prominent role in the assignment of neuronal identity within the mammalian CNS. ..
  6. Bulchand S, Grove E, Porter F, Tole S. LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech Dev. 2001;100:165-75 pubmed
    ..The defect in the Lhx2-/- telencephalon appears to be at this step. ..
  7. Ohazama A, Johnson E, Ota M, Choi H, Choi H, Porntaveetus T, et al. Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS ONE. 2008;3:e4092 pubmed publisher
    ..Thus in this context Wise acts as an extracellular signaling molecule linking two signaling pathways. We further show that a downstream mediator of this integration is the Shh signaling pathway. ..
  8. Zouvelou V, Passa O, Segklia K, Tsalavos S, Valenzuela D, Economides A, et al. Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol. 2009;53:597-603 pubmed publisher
    ..b>Bmp7 has been implicated in developmental disorders and in a variety of diseases, but functional studies to elucidate ..
  9. Liu W, Selever J, Wang D, Lu M, Moses K, Schwartz R, et al. Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A. 2004;101:4489-94 pubmed
    ..We also demonstrate a strong genetic interaction between Bmp4 and Bmp7 in OFT development...

More Information


  1. Blank U, Brown A, Adams D, Karolak M, Oxburgh L. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development. 2009;136:3557-66 pubmed publisher
    ..Maintenance of nephron progenitors is absolutely dependent on BMP7 signaling, and Bmp7-null mice exhibit rapid loss of progenitors...
  2. Self M, Lagutin O, Bowling B, Hendrix J, Cai Y, Dressler G, et al. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006;25:5214-28 pubmed
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  3. Carroll T, Park J, Hayashi S, Majumdar A, McMahon A. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005;9:283-92 pubmed
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  4. Boon M, van der Horst G, van der Pluijm G, Tamsma J, Smit J, Rensen P. Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency. Cytokine Growth Factor Rev. 2011;22:221-9 pubmed publisher
    b>Bone morphogenetic protein 7 (BMP7) is a member of the transforming growth factor-? (TGF-?) superfamily of growth factors. In recent years, it has become clear that BMP7 is a very pleiotropic growth factor...
  5. Luo G, Hofmann C, Bronckers A, Sohocki M, Bradley A, Karsenty G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995;9:2808-20 pubmed
    ..In addition, BMP-7-deficient mice have eye defects that appear to originate during lens induction. Finally, BMP-7-deficient mice also have skeletal patterning defects restricted to the rib cage, the skull, and the hindlimbs. ..
  6. Oxburgh L, Dudley A, Godin R, Koonce C, Islam A, Anderson D, et al. BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol. 2005;286:637-46 pubmed
    ..BMP4-deficient embryos display mesodermal patterning defects at early post-implantation stages, whereas loss of BMP7 selectively disrupts kidney and eye morphogenesis...
  7. Kazama I, Mahoney Z, Miner J, Graf D, Economides A, Kreidberg J. Podocyte-derived BMP7 is critical for nephron development. J Am Soc Nephrol. 2008;19:2181-91 pubmed publisher
    ..In the absence of the growth factor bone morphogenic protein 7 (BMP7), kidney development arrests after induction of a small number of nephrons...
  8. Wang Y, Rutherford B, Upholt W, Mina M. Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme. Dev Dyn. 1999;216:320-35 pubmed
    ..Our combined data suggest that BMP-7 is a component of the signaling network mediating epithelial-mesenchymal interactions during the initiation phase of odontogenesis and morphogenesis of the mandibular arch. ..
  9. Zouvelou V, Luder H, Mitsiadis T, Graf D. Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex. J Exp Zool B Mol Dev Evol. 2009;312B:361-74 pubmed publisher
    ..Using a lacZ reporter mouse we mapped the spatiotemporal expression of BMP7 in the developing craniofacial region...
  10. Zakin L, Reversade B, Kuroda H, Lyons K, De Robertis E. Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005;132:2489-99 pubmed
    ..We report that the loss of bone morphogenetic protein 7 (Bmp7) in combination with a half dose or complete loss of twisted gastrulation (Tsg) causes ..
  11. Podkowa M, Zhao X, Chow C, Coffey E, Davis R, Attisano L. Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation. Mol Cell Biol. 2010;30:2241-50 pubmed publisher
    ..Bone morphogenetic proteins (BMPs) play an important role in neuronal differentiation and morphogenesis, and BMP7 in particular induces the formation of dendrites...
  12. Suzuki K, Haraguchi R, Ogata T, Barbieri O, Alegria O, Vieux Rochas M, et al. Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet. 2008;16:36-44 pubmed
    ..We show here that Dlx5, Dlx6, p63 and Bmp7, one of the p63 downstream candidate genes, are all expressed in the developing urethral plate (UP) and that ..
  13. Ueki Y, Reh T. EGF stimulates Müller glial proliferation via a BMP-dependent mechanism. Glia. 2013;61:778-89 pubmed publisher
    ..In dissociated Müller glial culture, treatment with EGF induced the upregulation of Bmp7, and this upregulation was blocked significantly by co-treatment with the BMP inhibitor dorsomorphin, suggesting ..
  14. Nie X. Apoptosis, proliferation and gene expression patterns in mouse developing tongue. Anat Embryol (Berl). 2005;210:125-32 pubmed
    ..localized within the mesenchyme at the early embryonic stage of tongue development (E12 to E13), whereas Bmp3 and Bmp7 were mainly expressed in the epithelium...
  15. Bénazet J, Bischofberger M, Tiecke E, Gonçalves A, Martin J, Zuniga A, et al. A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science. 2009;323:1050-3 pubmed publisher
    ..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways. ..
  16. Morgan E, Nguyen S, Scott V, Stadler H. Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development. 2003;130:3095-109 pubmed the developing mouse genital tubercle, we show that Hoxa13 is essential for normal expression of Fgf8 and Bmp7 in the urethral plate epithelium...
  17. Katagiri T, Boorla S, Frendo J, Hogan B, Karsenty G. Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev Genet. 1998;22:340-8 pubmed
    ..of the combined absence of some Bmp genes expressed in the same areas, we have intercrossed heterozygous Bmp7 mice with Bmp2 +/-, Bmp4 +/-, or Bmp5 +/- animals...
  18. Park J, Ma W, O Brien L, Chung E, Guo J, Cheng J, et al. Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012;23:637-51 pubmed publisher
  19. Wawersik S, Purcell P, Rauchman M, Dudley A, Robertson E, Maas R. BMP7 acts in murine lens placode development. Dev Biol. 1999;207:176-88 pubmed
    Targeted inactivation of the Bmp7 gene in mouse leads to eye defects with late onset and variable penetrance (A. T. Dudley et al., 1995, Genes Dev. 9, 2795-2807; G. Luo et al., 1995, Genes Dev. 9, 2808-2820)...
  20. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001;105:533-45 pubmed
    ..Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate. ..
  21. Tsuji K, Cox K, Gamer L, Graf D, Economides A, Rosen V. Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res. 2010;28:384-9 pubmed publisher
    While the osteoinductive activity of recombinant bone morphogenetic protein 7 (BMP7) is well established, evaluation of the role of endogenous BMP7 in bone formation and fracture healing has been hampered by perinatal lethality in BMP7 ..
  22. Khokha M, Hsu D, Brunet L, Dionne M, Harland R. Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet. 2003;34:303-7 pubmed
    ..Although Bmps and their antagonists have multiple roles in limb development, these experiments show that gremlin is the principal BMP antagonist required for early limb outgrowth and patterning. ..
  23. Hofmann C, Luo G, Balling R, Karsenty G. Analysis of limb patterning in BMP-7-deficient mice. Dev Genet. 1996;19:43-50 pubmed
    ..Taken together, our data suggest that BMP-7 is involved in regulating proliferation and/or epithelial-mesenchymal interactions in the developing limb. ..
  24. Du Y, Xiao Q, Yip H. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest Ophthalmol Vis Sci. 2010;51:3764-73 pubmed publisher
    ..CONCLUSIONS. These results suggest that Id genes are one of the potential targets of BMP signaling in the differentiation of RPCs. ..
  25. Thompson N, Gesina E, Scheinert P, Bucher P, Grapin Botton A. RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol. 2012;32:1189-99 pubmed publisher
    ..In addition, we identify Bmp7, Nr5a2, RhoV, and P2rx1 as new targets of PTF1a in pancreas progenitors.
  26. Furuta Y, Piston D, Hogan B. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 1997;124:2203-12 pubmed
    ..of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7)...
  27. Dudley A, Robertson E. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn. 1997;208:349-62 pubmed
    b>BMP7 is expressed at diverse sites in the developing mouse embryo, including visceral endoderm, notochord, heart, eye, kidney, and bone. A null mutation in BMP7 results in defects largely confined to the developing kidney and eye...
  28. Andl T, Reddy S, Gaddapara T, Millar S. WNT signals are required for the initiation of hair follicle development. Dev Cell. 2002;2:643-53 pubmed
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation. ..
  29. Murashima Suginami A, Takahashi K, Sakata T, Tsukamoto H, Sugai M, Yanagita M, et al. Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun. 2008;369:1012-6 pubmed publisher
    ..Based upon these results, we conclude that enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model. ..
  30. Gkantidis N, Blumer S, Katsaros C, Graf D, Chiquet M. Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo. PLoS ONE. 2012;7:e47762 pubmed publisher
    ..activity at this site was not the consequence of epithelial fold formation, as it was also observed in Bmp7-deficient embryos where shelf elevation is delayed...
  31. Morcillo J, Martinez Morales J, Trousse F, Fermin Y, Sowden J, Bovolenta P. Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development. 2006;133:3179-90 pubmed
    ..We also show that in the absence of Bmp7, fissure formation is not initiated...
  32. Fujimori S, Novak H, Weissenböck M, Jussila M, Gonçalves A, Zeller R, et al. Wnt/?-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol. 2010;348:97-106 pubmed publisher
    ..This provides a mechanism whereby the number of incisors arising from one placode can be varied through local alterations of a mesenchymal signaling circuit involving ?-catenin, Lef1, Tcf1 and Bmp4. ..
  33. Myllärniemi M, Lindholm P, Ryynänen M, KLIMENT C, Salmenkivi K, Keski Oja J, et al. Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. Am J Respir Crit Care Med. 2008;177:321-9 pubmed
    ..Rescue of BMP signaling activity may represent a potential beneficial strategy for treating human pulmonary fibrosis. ..
  34. Zeisberg M, Shah A, Kalluri R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem. 2005;280:8094-100 pubmed
  35. Adams D, Karolak M, Robertson E, Oxburgh L. Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species. Dev Biol. 2007;311:679-90 pubmed
    b>Bmp7 is expressed in numerous tissues throughout development and is required for morphogenesis of the eye, hindlimb and kidney...
  36. Ohkubo Y, Chiang C, Rubenstein J. Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience. 2002;111:1-17 pubmed
  37. Ortega J, Alcantara S. BDNF/MAPK/ERK-induced BMP7 expression in the developing cerebral cortex induces premature radial glia differentiation and impairs neuronal migration. Cereb Cortex. 2010;20:2132-44 pubmed publisher
    ..demonstrate that brain-derived neurotrophic factor (BDNF), one of those local acting factors, induces Bone Morphogenetic Protein 7 (BMP7) expression in embryonic neurons by activating Mitogen-Activated Protein Kinase/Extracellular ..
  38. Bonilla Claudio M, Wang J, Bai Y, Klysik E, Selever J, Martin J. Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development. 2012;139:709-19 pubmed publisher
    ..The complimentary experiment, CNC inactivation of Bmp2, Bmp4 and Bmp7, resulted in complete or partial loss of multiple CNC-derived skeletal elements, revealing a crucial requirement ..
  39. Gonçalves A, Zeller R. Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos. PLoS ONE. 2011;6:e19370 pubmed publisher
    ..Another BMP ligand, BMP7, was shown to control the proliferative expansion of nephrogenic progenitors and its requirement for nephrogenesis ..
  40. Wang S, De Caestecker M, Kopp J, Mitu G, LaPage J, Hirschberg R. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol. 2006;17:2504-12 pubmed
    ..The findings also establish a role for endogenous glomerular BMP-7 as an autocrine regulator of podocyte integrity in vivo. ..
  41. Godin R, Takaesu N, Robertson E, Dudley A. Regulation of BMP7 expression during kidney development. Development. 1998;125:3473-82 pubmed
    ..Analysis of BMP7 expression during kidney development, in conjunction with studies analyzing the effect of recombinant BMP7 on ..
  42. Otani H, Otsuka F, Inagaki K, Takeda M, Miyoshi T, Suzuki J, et al. Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am J Physiol Renal Physiol. 2007;292:F1513-25 pubmed
  43. Naski M, Colvin J, Coffin J, Ornitz D. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development. 1998;125:4977-88 pubmed
  44. Gritli Linde A, Bei M, Maas R, Zhang X, Linde A, McMahon A. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002;129:5323-37 pubmed
    ..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells. ..
  45. Michos O, Panman L, Vintersten K, Beier K, Zeller R, Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development. 2004;131:3401-10 pubmed
    ..As a consequence, the metanephric mesenchyme is eliminated by apoptosis, in the same way as the core mesenchymal cells of the limb bud. ..
  46. Pajni Underwood S, Wilson C, Elder C, Mishina Y, Lewandoski M. BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development. 2007;134:2359-68 pubmed
    ..We conclude that during normal embryogenesis, BMP signaling to the AER indirectly regulates interdigit PCD by regulating AER-FGFs, which act as survival factors for the interdigit mesenchyme. ..
  47. Xu K, Wu X, Shapiro E, Huang H, Zhang L, Hickling D, et al. Bmp7 functions via a polarity mechanism to promote cloacal septation. PLoS ONE. 2012;7:e29372 pubmed publisher
    ..Yet, the cellular mechanisms of cloacal septation remain poorly understood. We previously detected Bone morphogenetic protein 7 (Bmp7) expression in the urorectal mesenchyme (URM), and have shown that loss of Bmp7 function results ..
  48. Solloway M, Robertson E. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development. 1999;126:1753-68 pubmed
    ..Here we describe the coexpression of two members of the 60A subfamily of BMPs, Bmp5 and Bmp7, at a number of different sites in the embryo from gastrulation onwards...
  49. Hägglund A, Dahl L, Carlsson L. Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development. PLoS ONE. 2011;6:e23387 pubmed publisher
    ..Thus, we have defined a distinct progenitor cell population in the forebrain committed to eye development and identified genes linked to Lhx2's function in the expansion and patterning of these progenitor cells. ..
  50. Cai C, Liang X, Shi Y, Chu P, Pfaff S, Chen J, et al. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell. 2003;5:877-89 pubmed
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells. ..
  51. Leung Hagesteijn C, Hu M, Mahendra A, Hartwig S, Klamut H, Rosenblum N, et al. Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol. 2005;25:3648-57 pubmed
    b>Bone morphogenetic protein 7 (BMP7) stimulates renal branching morphogenesis via p38 mitogen-activated protein kinase (p38(MAPK)) and activating transcription factor 2 (ATF-2) (M. C. Hu, D. Wasserman, S. Hartwig, and N. D. Rosenblum, J...
  52. Krizhanovsky V, Ben Arie N. A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech Dev. 2006;123:67-75 pubmed
    ..Moreover, a blocking antibody against BMP7, a morphogenetic protein expressed in the choroid plexus, blocked the inhibitory effect of the choroid plexus, ..
  53. Levi G, Mantero S, Barbieri O, Cantatore D, Paleari L, Beverdam A, et al. Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Mech Dev. 2006;123:3-16 pubmed
    ..At the basis of this effect, our data implicate the Bmp (Bmp7, Bmp4)/Bmp antagonist (Follistatin) signal: in the Dlx5(-/-) palate changes in the expression level of Bmp7 and ..
  54. Wu X, Ferrara C, Shapiro E, Grishina I. Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium. Gene Expr Patterns. 2009;9:224-30 pubmed publisher
    ..Here, we employed the Bmp7(lacZ) strain to perform a detailed analysis of Bmp7 expression and the null phenotype during development of the ..
  55. Jena N, Martín Seisdedos C, McCue P, Croce C. BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res. 1997;230:28-37 pubmed
    ..we screened a genomic library of the above transgenic line with a transgene-specific probe and found that the Bmp7 gene, a member of the TGF beta superfamily, was inactivated by insertional mutagenesis due to transgene integration...
  56. Beites C, Hollenbeck P, Kim J, Lovell Badge R, Lander A, Calof A. Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development. 2009;136:2187-97 pubmed publisher
    ..Loss of Fst leads to elevated activity and increased expression of epithelial Bmp7; the latter effect is consistent with BMP7 positive autoregulation, a phenomenon we demonstrate directly...
  57. Danesh S, Villasenor A, Chong D, Soukup C, Cleaver O. BMP and BMP receptor expression during murine organogenesis. Gene Expr Patterns. 2009;9:255-65 pubmed publisher
    ..Here, we present a detailed study of the developmental expression profiles of three BMP ligands (Bmp2, Bmp4, Bmp7) and three BMP receptors (Bmpr1a, Bmpr1b, and BmprII), as well as their molecular antagonist (noggin), in the early ..
  58. Grishina I, Kim S, Ferrara C, Makarenkova H, Walden P. BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol. 2005;288:334-47 pubmed
    ..Dev. Biol. 232, 301-314). Here, we show that Bone Morphogenetic Protein 7 (BMP7) restricts branching of the prostate epithelium...
  59. Ozkaynak E, Schnegelsberg P, Oppermann H. Murine osteogenic protein (OP-1): high levels of mRNA in kidney. Biochem Biophys Res Commun. 1991;179:116-23 pubmed
    ..Moreover, our data suggest that kidneys may be the main site of OP-1 synthesis, even though it is distant from its physiological site of action, skeletal bone. ..
  60. Helder M, Ozkaynak E, Sampath K, Luyten F, Latin V, Oppermann H, et al. Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. J Histochem Cytochem. 1995;43:1035-44 pubmed
    ..These data suggest that, although OP-1 has been isolated from bone matrix, it may have additional regulatory roles in the morphogenesis and/or function of the kidney, limb bud, tooth, heart, and intestine. ..
  61. Tanaka M, Endo S, Okuda T, Economides A, Valenzuela D, Murphy A, et al. Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int. 2008;73:181-91 pubmed
    ..Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome. ..
  62. Townsend K, Suzuki R, Huang T, Jing E, Schulz T, Lee K, et al. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J. 2012;26:2187-96 pubmed publisher
    ..We have previously demonstrated that BMP7 can regulate brown adipogenesis and energy expenditure...
  63. Li Y, Litingtung Y, Ten Dijke P, Chiang C. Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Dev Dyn. 2007;236:746-54 pubmed
    ..Notably, ablating Bmp7 function in Nog(-/-) embryos rescued EA/TEF and notochord branching defects, establishing a critical role of Noggin-..
  64. Maatouk D, Choi K, Bouldin C, Harfe B. In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol. 2009;327:516-23 pubmed publisher
    ..Our data suggests that AER expression of Bmp2 and Bmp4 is required for digit and dorsal-ventral patterning but surprisingly not for limb outgrowth...
  65. Dudley A, Godin R, Robertson E. Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme. Genes Dev. 1999;13:1601-13 pubmed
    ..Previous studies have shown that a loss of Bmp7 function leads to kidney defects that are a likely result of progressive loss of nephrogenic mesenchyme by ..
  66. Bastida M, Sheth R, Ros M. A BMP-Shh negative-feedback loop restricts Shh expression during limb development. Development. 2009;136:3779-89 pubmed publisher
    ..Our study emphasizes the intricacy of the crosstalk between the major signaling pathways in the posterior limb bud. ..
  67. Ahn K, Mishina Y, Hanks M, Behringer R, Crenshaw E. BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development. 2001;128:4449-61 pubmed
    ..The expression pattern of Bmp4 and Bmp7 suggest that these growth factors play an instructive role in specifying dorsoventral pattern in the limb...
  68. Rebbapragada A, Benchabane H, Wrana J, Celeste A, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol. 2003;23:7230-42 pubmed
    ..While both BMP7 and BMP2 activated transcription from the BMP-responsive I-BRE-Lux reporter and induced adipogenic differentiation, ..
  69. Gregory K, Ono R, Charbonneau N, Kuo C, Keene D, Bachinger H, et al. The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix. J Biol Chem. 2005;280:27970-80 pubmed
    ..In addition, they raise the possibility that prodomains of other TGFbeta-like growth factors interact with fibrillins and/or LTBPs and are also targeted to the extracellular matrix. ..