Birc5

Summary

Gene Symbol: Birc5
Description: baculoviral IAP repeat-containing 5
Alias: AAC-11, Api4, TIAP, survivin40, baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, apoptosis inhibitor survivin, survivin
Species: mouse
Products:     Birc5

Top Publications

  1. Li F, Cheng Q, Ling X, Stablewski A, Tang L, Foster B, et al. Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers. Am J Pathol. 2010;176:1629-38 pubmed publisher
    ..However, because of a lack of appropriate animal models, the role and dynamic expression of survivin during pathophysiology are not well defined...
  2. Jiang Y, Nishimura W, Devor Henneman D, Kusewitt D, Wang H, Holloway M, et al. Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin. Diabetes. 2008;57:2718-27 pubmed publisher
    ..of this study was to determine whether a gene critical for cell division and cell survival in cancer cells, survivin, might also be important for beta-cells...
  3. Song J, So T, Cheng M, Tang X, Croft M. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity. 2005;22:621-31 pubmed
    ..Here, we show that Survivin is controlled in peripheral T cells by OX40 cosignaling via sustained PI3k and PKB activation...
  4. Levkau B, Schäfers M, Wohlschlaeger J, von Wnuck Lipinski K, Keul P, Hermann S, et al. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation. 2008;117:1583-93 pubmed publisher
    b>Survivin inhibits apoptosis and regulates cell division in many organs, but its function in the heart is unknown. We show that cardiac-specific deletion of survivin resulted in premature cardiac death...
  5. Kindt N, Menzebach A, Van de Wouwer M, Betz I, De Vriese A, Conway E. Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J. 2008;22:510-21 pubmed
    ..Using transgenic mice with diminished levels of the inhibitor of apoptosis protein, survivin, we show that survivin is required to protect the kidney from apoptosis, to suppress renal expression of p53, and ..
  6. Kang B, Xia F, Pop R, Dohi T, Socolovsky M, Altieri D. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. J Biol Chem. 2011;286:16758-67 pubmed publisher
    b>Survivin is a multifunctional protein with essential roles in cell division and inhibition of apoptosis, but the molecular underpinnings of its cytoprotective properties are poorly understood...
  7. Wu X, Zhang Q, Wang X, Zhu J, Xu K, Okada H, et al. Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model. PLoS ONE. 2012;7:e41976 pubmed publisher
    ..Mice with beta cell-specific deletion of survivin (RIPCre(+)survivin(fl/fl)) and their control littermates (RIPCre(+)survivin(+/+)) were examined to determine the ..
  8. Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh W, et al. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med. 2004;199:399-410 pubmed
    Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown...
  9. Wang H, Gambosova K, Cooper Z, Holloway M, Kassai A, Izquierdo D, et al. EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic ?-cells. BMC Mol Biol. 2010;11:66 pubmed publisher
    ..b>Survivin, an oncofetal protein with both pro-proliferative and anti-apoptotic properties, is a known transcriptional ..

More Information

Publications81

  1. Jiang Y, de Bruin A, Caldas H, Fangusaro J, Hayes J, Conway E, et al. Essential role for survivin in early brain development. J Neurosci. 2005;25:6962-70 pubmed
    ..To characterize the role of the inhibitor of apoptosis gene, survivin, during neurogenesis, we used the Cre-loxP-system to generate mice lacking survivin in neuronal precursor cells...
  2. Conway E, Zwerts F, Van Eygen V, Devriese A, Nagai N, Luo W, et al. Survivin-dependent angiogenesis in ischemic brain: molecular mechanisms of hypoxia-induced up-regulation. Am J Pathol. 2003;163:935-46 pubmed
    ..b>Survivin, the inhibitor of apoptosis protein, is up-regulated in vitro in vascular endothelial cells by angiogenic factors,..
  3. Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura R, et al. Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood. 2007;109:4742-52 pubmed
    ..cell apoptosis during development by generating mouse embryos lacking the inhibitor of apoptosis protein (IAP) survivin in endothelium...
  4. Li F, Altieri D. The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression. Cancer Res. 1999;59:3143-51 pubmed
    b>Survivin is the first apoptosis inhibitor described to date to be expressed in G2-M in a cell cycle-dependent manner and to directly associate with mitotic spindle microtubules...
  5. Deveraux Q, Reed J. IAP family proteins--suppressors of apoptosis. Genes Dev. 1999;13:239-52 pubmed
  6. Kobayashi K, Hatano M, Otaki M, Ogasawara T, Tokuhisa T. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci U S A. 1999;96:1457-62 pubmed
    ..Herein we describe a newly defined murine IAP, designated Tiap, that proved to be a murine homologue of human survivin based on sequence comparison. TIAP has one baculovirus IAP repeat and lacks a C-terminal RING finger motif...
  7. Conway E, Pollefeyt S, Steiner Mosonyi M, Luo W, Devriese A, Lupu F, et al. Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. Gastroenterology. 2002;123:619-31 pubmed
    b>Survivin is an inhibitor of apoptosis protein (IAP), which also is crucial for mitosis and cell cycle progression. IAPs participate in regulating Fas ligand-induced hepatic apoptosis...
  8. Lens S, Wolthuis R, Klompmaker R, Kauw J, Agami R, Brummelkamp T, et al. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J. 2003;22:2934-47 pubmed
    Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive...
  9. Bradley E, Ruan M, Oursler M. PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival. J Cell Physiol. 2008;217:752-8 pubmed publisher
    ..Functionally, PAK1 promoted osteoclast survival by modulating expression of the IAP family member Survivin. M-CSF therefore functions to promote PAK1 activation as a novel MEK-independent Raf target to control Survivin-..
  10. Chen J, Chen J, Conway E, Harris R. Survivin mediates renal proximal tubule recovery from AKI. J Am Soc Nephrol. 2013;24:2023-33 pubmed publisher
    AKI induces the renoprotective upregulation of survivin expression in kidney epithelial cells, but the underlying mechanisms have not been identified...
  11. Jiang Y, Saavedra H, Holloway M, Leone G, Altura R. Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004;279:40511-20 pubmed
    b>Survivin is a putative oncogene that is aberrantly expressed in cancer cells. It has been hypothesized to play a central role in cancer progression and resistance to therapy in diverse tumor types...
  12. Zhang Y, Nagata Y, Yu G, Nguyen H, Jones M, Toselli P, et al. Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression. Blood. 2004;103:3717-26 pubmed
    ..In contrast, survivin, an Aurora-B/AIM-1 coregulator of mitosis, is not detected at any stage of the endomitotic cell cycle, and in ..
  13. Lim M, Zhong C, Yang S, Bell A, Cohen M, Roy Burman P. Runx2 regulates survivin expression in prostate cancer cells. Lab Invest. 2010;90:222-33 pubmed publisher
    ..protein-7 (BMP7) could protect prostate cancer C4-2B cells from serum starvation-induced apoptosis via survivin induction. Here, for the first time, we identify Runx2 as a key regulator of survivin transcription...
  14. Liston P, Fong W, Korneluk R. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene. 2003;22:8568-80 pubmed
    ..This paper reviews the structure and function of the IAP family members and their inhibitors, and surveys the available evidence for IAP dysregulation in cancer. ..
  15. Conway E, Pollefeyt S, Cornelissen J, DeBaere I, Steiner Mosonyi M, Ong K, et al. Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions. Blood. 2000;95:1435-42 pubmed
    b>Survivin is a member of the inhibitor of apoptosis protein (IAP) family that is believed to play a role in oncogenesis...
  16. Altznauer F, Martinelli S, Yousefi S, Thürig C, Schmid I, Conway E, et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med. 2004;199:1343-54 pubmed
    b>Survivin has received great attention due to its expression in many human tumors and its potential as a therapeutic target in cancer...
  17. Fukuda S, Singh P, Moh A, Abe M, Conway E, Boswell H, et al. Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3. Blood. 2009;114:394-403 pubmed publisher
    Internal tandem duplication mutations in the Flt3 tyrosine kinase gene (ITD-Flt3) and overexpression of Survivin are frequently found in patients with acute myeloid leukemia (AML)...
  18. Adida C, Crotty P, McGrath J, Berrebi D, Diebold J, Altieri D. Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol. 1998;152:43-9 pubmed
    ..A novel apoptosis inhibitor of the IAP gene family, designated survivin, was recently found in all of the most common human cancers but not in normal, terminally differentiated adult ..
  19. Li F, Altieri D. Transcriptional analysis of human survivin gene expression. Biochem J. 1999;344 Pt 2:305-11 pubmed
    ..In this study, we have investigated the basal transcriptional requirements of the survivin gene, an IAP (inhibitor of apoptosis) prominently up-regulated in cancer...
  20. Lechler P, Wu X, Bernhardt W, Campean V, Gastiger S, Hackenbeck T, et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol. 2007;171:1483-98 pubmed
    The inhibitor of apoptosis protein survivin is of critical importance for regulation of cellular division and survival...
  21. Sun S, Wei L, Li M, Lin S, Xu B, Liang X, et al. Perturbation of survivin expression affects chromosome alignment and spindle checkpoint in mouse oocyte meiotic maturation. Cell Cycle. 2009;8:3365-72 pubmed
    b>Survivin is a member of inhibitors of apoptosis proteins (IAPs), which have multiple regulatory functions in mitosis, but its roles in meiosis remain unknown...
  22. Terasaki Y, Terasaki M, Urushiyama H, Nagasaka S, Takahashi M, Kunugi S, et al. Role of survivin in acute lung injury: epithelial cells of mice and humans. Lab Invest. 2013;93:1147-63 pubmed publisher
    b>Survivin, an inhibitor of apoptosis, regulates cell division and is a potential target for anticancer drugs because many cancers express high survivin levels...
  23. Xing Z, Conway E, Kang C, Winoto A. Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis. J Exp Med. 2004;199:69-80 pubmed
    b>Survivin is an inhibitor of apoptosis protein that also functions during mitosis. It is expressed in all common tumors and tissues with proliferating cells, including thymus...
  24. Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, et al. Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol. 2009;182:6744-52 pubmed publisher
    ..targets of costimulatory signals in primary T cells are the anti-apoptotic bcl-2 family molecule Bcl-x(L), and survivin, an inhibitor of apoptosis family member that might regulate both cell division and survival...
  25. Dohi T, Salz W, Costa M, Ariyan C, Basadonna G, Altieri D. Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. EMBO Rep. 2006;7:438-43 pubmed
    b>Survivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive...
  26. Leung C, Xu Y, Mularski B, Liu H, Gurbuxani S, Crispino J. Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med. 2007;204:1603-11 pubmed
    b>Survivin, which is the smallest member of the inhibitor of apoptosis protein (IAP) family, is a chromosomal passenger protein that mediates the spindle assembly checkpoint and cytokinesis, and also functions as an inhibitor of apoptosis...
  27. Fukuda S, Mantel C, Pelus L. Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and -independent pathways. Blood. 2004;103:120-7 pubmed
    The cyclin-dependent kinase inhibitor p21WAF1/Cip1 and Survivin enhance granulocyte macrophage colony-forming unit (CFU-GM) cell cycle and proliferation and have been implicated as antiapoptotic proteins...
  28. Baratchi S, Kanwar R, Cheung C, Kanwar J. Proliferative and protective effects of SurR9-C84A on differentiated neural cells. J Neuroimmunol. 2010;227:120-32 pubmed publisher
    Targeting survivin has the ability to inhibit apoptosis and regulate mitosis for the protection of neuronal cells, and it offers several advantages for neuronal repair and protection...
  29. Mehrotra S, Languino L, Raskett C, Mercurio A, Dohi T, Altieri D. IAP regulation of metastasis. Cancer Cell. 2010;17:53-64 pubmed publisher
    ..Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis...
  30. Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol. 2012;14:1203-11 pubmed publisher
    ..Mechanistically, c-Fos induces SIRT6 transcription, which represses survivin by reducing histone H3K9 acetylation and NF-?B activation...
  31. Kawamura K, Sato N, Fukuda J, Kodama H, Kumagai J, Tanikawa H, et al. Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos. Dev Biol. 2003;256:331-41 pubmed
    ..b>Survivin, a member of the IAP family, is capable of binding to caspases to modulate their functions...
  32. Fukuda S, Foster R, Porter S, Pelus L. The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells. Blood. 2002;100:2463-71 pubmed
    The inhibitor of the apoptosis protein (IAP) survivin is expressed in proliferating cells such as fetal tissues and cancers. We previously reported that survivin is expressed and growth factor regulated in normal adult CD34(+) cells...
  33. Uren A, Wong L, Pakusch M, Fowler K, Burrows F, Vaux D, et al. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol. 2000;10:1319-28 pubmed
    b>Survivin is a mammalian protein that carries a motif typical of the inhibitor of apoptosis (IAP)proteins, first identified in baculoviruses...
  34. Heallen T, Zhang M, Wang J, Bonilla Claudio M, Klysik E, Johnson R, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011;332:458-61 pubmed publisher
    ..Furthermore, the Hippo effector Yap interacts with β-catenin on Sox2 and Snai2 genes. These data uncover a nuclear interaction between Hippo and Wnt signaling that restricts cardiomyocyte proliferation and controls heart size. ..
  35. Cheung C, Martin I, Zenger K, Donald J, Thomson P, Moran C, et al. Quantitative trait loci for steady-state platelet count in mice. Mamm Genome. 2004;15:784-97 pubmed
    ..These results represent the first published use of a genetic linkage-based approach in a mouse model toward the identification of genetic factors that regulate platelet count. ..
  36. Fernández J, Rodríguez D, Valenzuela M, Calderon C, Urzúa U, Munroe D, et al. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription. Mol Cancer. 2014;13:209 pubmed publisher
    ..b>Survivin, another protein involved in angiogenesis, is strongly expressed in most human cancers, where it promotes tumor ..
  37. Kita A, Nakahara T, Yamanaka K, Nakano K, Nakata M, Mori M, et al. Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma. Leuk Res. 2011;35:787-92 pubmed publisher
    YM155, a novel small-molecule that down-regulates survivin, exhibits broad, potent antitumor activity against a range of human tumors. We evaluated the activity of YM155 in aggressive non-Hodgkin lymphoma...
  38. Bertino P, Panigada M, Soprana E, Bianchi V, Bertilaccio S, Sanvito F, et al. Fowlpox-based survivin vaccination for malignant mesothelioma therapy. Int J Cancer. 2013;133:612-23 pubmed publisher
    b>Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues...
  39. Byrd K, Lough K, Patel J, Descovich C, Curtis T, Williams S. LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development. Development. 2016;143:2803-17 pubmed publisher
    ..Thus, LGN has crucial tissue-specific functions in patterning surface ectoderm and its appendages by controlling division orientation. ..
  40. Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development. 2008;135:4059-69 pubmed publisher
  41. Gualco E, Urbanska K, Perez Liz G, Sweet T, Peruzzi F, Reiss K, et al. IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors. Cell Death Differ. 2010;17:439-51 pubmed publisher
    ..wt-IGF-IR, the brain and dorsal root ganglia of ko-IGF-IR embryos showed low levels of the antiapoptotic protein Survivin, accompanied by elevated numbers of apoptotic neurons and an earlier differentiation phenotype...
  42. Wen Q, Leung C, Huang Z, Small S, Reddi A, Licht J, et al. Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood. 2009;114:153-6 pubmed publisher
    b>Survivin is a member of the chromosome passenger complex, which plays an important role in chromosome alignment, separation, and cytokinesis...
  43. Schwab K, Patterson L, Aronow B, Luckas R, Liang H, Potter S. A catalogue of gene expression in the developing kidney. Kidney Int. 2003;64:1588-604 pubmed
    ..This work creates a catalogue of the gene expression states of the developing mouse kidney and its microdissected subcomponents. ..
  44. Damiani D, Goffinet A, ALBERTS A, Tissir F. Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors. Nat Commun. 2016;7:13509 pubmed publisher
    ..Our data identify Diaph3 as a major guard of cortical progenitors, unravel novel functions of Diaphanous formins and add insights into the pathobiology of microcephaly. ..
  45. Abe M, Pelus L, Singh P, Hirade T, Onishi C, Purevsuren J, et al. Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells. PLoS ONE. 2016;11:e0158290 pubmed publisher
  46. Miletic A, Jellusova J, Cato M, Lee C, Baracho G, Conway E, et al. Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells. J Immunol. 2016;196:2195-204 pubmed publisher
    b>Survivin is a member of the inhibitor of apoptosis family of proteins and a biomarker of poor prognosis in aggressive B cell non-Hodgkin's lymphoma. In addition to its role in inhibition of apoptosis, survivin also regulates mitosis...
  47. Lotti R, Palazzo E, Petrachi T, Dallaglio K, Saltari A, Truzzi F, et al. Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo. Int J Mol Sci. 2016;17: pubmed publisher
    ..Since survivin, a KSC marker, is highly expressed in SCC-SC, we evaluate its role in SCC-SC cell growth and SCC models...
  48. Tsuneki M, Madri J. Adhesion molecule-mediated hippo pathway modulates hemangioendothelioma cell behavior. Mol Cell Biol. 2014;34:4485-99 pubmed publisher
    ..Here we report on the roles of adherens junction molecule modulation of survivin and the Hippo pathway in the proliferation and apoptosis of a murine hemangioendothelioma (EOMA) cell...
  49. Li X, Zhang X, Li X, Ding F, Ding J. The role of survivin in podocyte injury induced by puromycin aminonucleoside. Int J Mol Sci. 2014;15:6657-73 pubmed publisher
    b>Survivin is a member of the inhibitor of apoptosis protein family, which uniquely promotes mitosis and regulates apoptosis in cancer cells. Recent studies have demonstrated that survivin also expresses in several normal adult cells...
  50. Choi J, Kim K, Park S, Choi B. Granulocyte macrophage colony-stimulating factor shows anti-apoptotic activity via the PI3K-NF-?B-HIF-1?-survivin pathway in mouse neural progenitor cells. Mol Neurobiol. 2014;49:724-33 pubmed publisher
    ..siRNAs and chromatin immunoprecipitation (ChIP) showed that HIF-1? was responsible for the induced expression of survivin, a member of the inhibitor of apoptosis proteins (IAPs)...
  51. Ene A, Park S, Edelmann W, Taketo T. Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression. Dev Biol. 2013;377:213-23 pubmed publisher
    ..We conclude that the mitochondrial apoptotic pathway mediated by caspase 9 is constitutively activated in oocytes and renders the elimination of oocytes with meiotic errors, which can be captured by the cleavage of PARP1. ..
  52. McCrann D, Ravid K. Survivin localization during endomitosis of high ploidy mouse megakaryocytes. Blood. 2010;116:2192-3 pubmed publisher
  53. Yuan Q, Wang C, Mao Y, Zhang P, Shi H, Li Z, et al. Enhanced tumor radiosensitivity by a survivin dominant-negative mutant. Oncol Rep. 2010;23:97-103 pubmed
    Radiosensitivity of tumors is due to a complex interaction of various factors, it has been reported that survivin also acts as a constitutive and inducible radioresistance factor in a panel of tumor cells and approaches designed to ..
  54. Kedinger V, Meulle A, Zounib O, Bonnet M, Gossart J, Benoit E, et al. Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases. BMC Cancer. 2013;13:338 pubmed publisher
    ..b>Survivin and cyclin B1, both involved in cell survival and proliferation and frequently deregulated in human cancers, are ..
  55. Wang R, Zheng Y, Kim H, Xu X, Cao L, Luhasen T, et al. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell. 2008;32:11-20 pubmed publisher
    ..We further demonstrated that mammary tumors from Brca1 mutant mice have low levels of Sirt1 and high levels of Survivin, which is reversed by induced expression of Brca1...
  56. Zhao X, Cao M, Lu Z, Wang T, Ren Y, Liu C, et al. Small-molecule inhibitor sorafenib regulates immunoreactions by inducing survival and differentiation of bone marrow cells. Innate Immun. 2016;22:493-502 pubmed publisher
    ..of murine bone marrow cells (BMCs) in a dose-dependent manner by up-regulating the anti-apoptotic protein survivin. Sorafenib induces differentiation of BMCs into suppressive dendritic cells that inhibit autologous T-cell ..
  57. Liu C, Liang B, Wang Q, Wu J, Zou M. Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin. J Biol Chem. 2010;285:15346-55 pubmed publisher
    ..Concomitantly, AMPK activation increased the expression of both Bcl-2 and Survivin, two potent anti-apoptotic proteins...
  58. Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res. 1997;57:4063-9 pubmed
    ..In summary, we report a cDNA whose expression supports cell viability after withdrawal of growth factors. The corresponding native protein may function as a novel inhibitor of apoptosis. ..
  59. Blanc Brude O, Teissier E, Castier Y, Leseche G, Bijnens A, Daemen M, et al. IAP survivin regulates atherosclerotic macrophage survival. Arterioscler Thromb Vasc Biol. 2007;27:901-7 pubmed
    ..We hypothesized that inhibitor of apoptosis protein (IAP) survivin regulates macrophage death in atherosclerosis...
  60. Fukuda S, Pelus L. Activated H-Ras regulates hematopoietic cell survival by modulating Survivin. Biochem Biophys Res Commun. 2004;323:636-44 pubmed
    b>Survivin expression and Ras activation are regulated by hematopoietic growth factors...
  61. Mukhopadhyay P, Greene R, Zacharias W, Weinrich M, Singh S, Young W, et al. Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004;70:912-26 pubmed
    ..This gene expression profiling study identifies a number of potentially unique developmental participants and serves as a valuable aid in deciphering the complex molecular mechanisms crucial for mammalian orofacial development. ..
  62. Huang A, Yue D, Liao D, Cheng L, Ma J, Wei Y, et al. SurvivinT34A increases the therapeutic efficacy of arsenic trioxide in mouse hepatocellular carcinoma models. Oncol Rep. 2016;36:3283-3290 pubmed publisher
    ..b>Survivin is the strongest inhibitor of apoptosis protein over-expressed in tumors, which has been proposed as an ..
  63. Lee J, Kim T, Yang T, Koo B, Oh S, Lee K, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27:1231-42 pubmed publisher
    ..Collectively, these data provide compelling evidence that WW45 is a key mediator of MST1 signalling in the coordinate coupling of proliferation arrest with terminal differentiation for proper epithelial tissue development in mammals. ..
  64. AbouAlaiwi W, Muntean B, Ratnam S, Joe B, Liu L, Booth R, et al. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014;129:660-72 pubmed publisher
    ..b>Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or ..
  65. Alekseenko I, Pleshkan V, Kopantzev E, Stukacheva E, Chernov I, Vinogradova T, et al. Activity of the upstream component of tandem TERT/survivin promoters depends on features of the downstream component. PLoS ONE. 2012;7:e46474 pubmed publisher
    We spliced the promoters of the human telomerase and human survivin genes (PhTERT and PhSurv, respectively) widely used for gene therapy and known to have the broadest cancer type spectrum of activity...
  66. LaCasse E, Baird S, Korneluk R, MacKenzie A. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 1998;17:3247-59 pubmed
    ..The strongest evidence for IAP involvement in cancer is seen in the IAP called survivin. Although not observed in adult differentiated tissue, survivin is present in most transformed cell lines and ..
  67. Bracht T, Hagemann S, Loscha M, Megger D, Padden J, Eisenacher M, et al. Proteome analysis of a hepatocyte-specific BIRC5 (survivin)-knockout mouse model during liver regeneration. J Proteome Res. 2014;13:2771-82 pubmed publisher
    The Baculoviral IAP repeat-containing protein 5 (BIRC5), also known as inhibitor of apoptosis protein survivin, is a member of the chromosomal passenger complex and a key player in mitosis...
  68. Song K, Kim T, Kim H, Kim J, Kim H, Kwon H, et al. Molecular cloning and characterization of a novel inhibitor of apoptosis protein from Xenopus laevis. Biochem Biophys Res Commun. 2003;301:236-42 pubmed
    ..It exhibited striking amino acid sequence similarity with human survivin, mouse TIAP, and recently found Xenopus survivin, especially a part of BIR domain was highly conserved...
  69. Hayun M, Naor Y, Weil M, Albeck M, Peled A, Don J, et al. The immunomodulator AS101 induces growth arrest and apoptosis in multiple myeloma: association with the Akt/survivin pathway. Biochem Pharmacol. 2006;72:1423-31 pubmed
    ..The present study examined the anti-tumoral activity of AS101 in MM by targeting the Akt/Survivin signaling pathway, crucial for survival...
  70. Amiri S, Movahedin M, Mowla S, Hajebrahimi Z, Tavallaei M. Differential gene expression and alternative splicing of survivin following mouse sciatic nerve injury. Spinal Cord. 2009;47:739-44 pubmed publisher
    ..05). Survivin140 is the main variant expressed after injury, accompanied by a low expression of survivin40 (P<0.05). There was no expression of the survivin121 variant after injury...
  71. Andersson S, Svensson M, Erlandsson M, Dehlin M, Andersson K, Bokarewa M. Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis. PLoS ONE. 2012;7:e47668 pubmed publisher
    ..Flt3L changed the profile of survivin splice variants, increasing transcription of the short survivin40 in the bone marrow...
  72. Pelikan R, Iwata J, Suzuki A, Chai Y, Hacia J. Identification of candidate downstream targets of TGF? signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013;114:796-807 pubmed publisher