Birc2

Summary

Gene Symbol: Birc2
Description: baculoviral IAP repeat-containing 2
Alias: AW146227, Api1, Api2, Birc3, C-IAP1, C330006D17Rik, HIAP1, HIAP2, IAP1, IAP2, MIAP1, MIAP2, MIHB, MIHC, RNF48, cIAP1, cIAP2, mcIAP1, baculoviral IAP repeat-containing protein 2, IAP-2, RING-type E3 ubiquitin transferase BIRC2, apoptosis inhibitor 2, baculoviral IAP repeat-containing 3, cellular inhibitor of apoptosis 1, inhibitor of apoptosis protein 2, mIAP-2
Species: mouse
Products:     Birc2

Top Publications

  1. Potts P, Singh S, Knezek M, Thompson C, Deshmukh M. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol. 2003;163:789-99 pubmed
    ..These data identify a critical function of endogenous XIAP in regulating apoptosis in mammalian cells. ..
  2. Matsuzawa A, Tseng P, Vallabhapurapu S, Luo J, Zhang W, Wang H, et al. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008;321:663-8 pubmed publisher
    ..molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2), IkappaB kinase regulatory subunit IKKgamma (also called NEMO), and mitogen-activated protein kinase (MAPK) ..
  3. Ma O, Cai W, Zender L, Dayaram T, Shen J, Herron A, et al. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. Cancer Res. 2009;69:2559-67 pubmed publisher
    ..genes on this amplicon, the matrix metalloproteinase gene MMP13 and the antiapoptotic genes Birc2 (cIAP1) and Birc3 (cIAP2), show elevated expression in mouse and human osteosarcomas...
  4. Prakash H, Becker D, Böhme L, Albert L, Witzenrath M, Rosseau S, et al. cIAP-1 controls innate immunity to C. pneumoniae pulmonary infection. PLoS ONE. 2009;4:e6519 pubmed publisher
    ..Our findings thus suggest a new immunoregulatory role of cIAP-1 in the course of bacterial infection. ..
  5. Gardam S, Turner V, Anderton H, Limaye S, Basten A, Koentgen F, et al. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011;117:4041-51 pubmed publisher
    ..In vitro data indicate that these signals are controlled by the homologous RING finger proteins cIAP1 and cIAP2, in collaboration with TRAF2 and TRAF3...
  6. Liston P, Fong W, Korneluk R. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene. 2003;22:8568-80 pubmed
    ..This paper reviews the structure and function of the IAP family members and their inhibitors, and surveys the available evidence for IAP dysregulation in cancer. ..
  7. Rumble J, Bertrand M, Csomos R, Wright C, Albert L, Mak T, et al. Apoptotic sensitivity of murine IAP-deficient cells. Biochem J. 2008;415:21-5 pubmed publisher
    ..we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli.
  8. Varfolomeev E, Goncharov T, Fedorova A, Dynek J, Zobel K, Deshayes K, et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem. 2008;283:24295-9 pubmed publisher
    ..The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. c-IAP1 and c-IAP2 are recruited to tumor necrosis factor receptor 1 (TNFR1)-associated complexes where they can regulate ..
  9. Bertrand M, Doiron K, Labbe K, Korneluk R, Barker P, Saleh M. Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity. 2009;30:789-801 pubmed publisher
    ..Macrophages derived from Birc2(-/-) or Birc3(-/-) mice, or colonocytes depleted of cIAP1 or cIAP2 by RNAi, were defective in NOD signaling and displayed sharp ..

More Information

Publications63

  1. Vince J, Wong W, Khan N, Feltham R, Chau D, Ahmed A, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell. 2007;131:682-93 pubmed
    ..is blocked by the caspase 8 inhibitor crmA and that IAP antagonists activate NF-kappaB signaling via inhibtion of cIAP1. In sensitive tumor lines, IAP antagonist induced NF-kappaB-stimulated production of TNFalpha that killed cells in ..
  2. Csomos R, Brady G, Duckett C. Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem. 2009;284:20531-9 pubmed publisher
    ..The autoubiquitination of c-IAP1 is blocked upon coexpression with TNF receptor-associated factor (TRAF) 2, and this is achieved by inhibition of ..
  3. Conze D, Albert L, Ferrick D, Goeddel D, Yeh W, Mak T, et al. Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol. 2005;25:3348-56 pubmed
    Inhibitor of apoptosis proteins (IAPs) c-IAP1 and c-IAP2 were identified as part of the tumor necrosis factor receptor 2 (TNFR2) signaling complex and have been implicated as intermediaries in tumor necrosis factor alpha signaling...
  4. Ishigaki S, Liang Y, Yamamoto M, Niwa J, Ando Y, Yoshihara T, et al. X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration. J Neurochem. 2002;82:576-84 pubmed
    ..These results suggest that XIAP plays a role in the apoptotic mechanism in the progression of disease in mutant SOD1 Tg mice and holds therapeutic possibilities for FALS. ..
  5. Rothe M, Pan M, Henzel W, Ayres T, Goeddel D. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995;83:1243-52 pubmed
    ..the biochemical purification and subsequent molecular cloning of two novel TNFR2-associated proteins, designated c-IAP1 and c-IAP2, that are closely related mammalian members of the inhibitor of apoptosis protein (IAP) family ..
  6. Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, et al. Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells. Proc Natl Acad Sci U S A. 2011;108:9472-7 pubmed publisher
    ..These functions of ARIA might offer a unique therapeutic potential. ..
  7. Enwere E, Holbrook J, Lejmi Mrad R, Vineham J, Timusk K, Sivaraj B, et al. TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-?B signaling pathway. Sci Signal. 2012;5:ra75 pubmed publisher
    ..Loss of cellular inhibitor of apoptosis 1 (cIAP1) protein led to constitutive activation of the noncanonical NF-?B pathway and an increase in ..
  8. Tigno Aranjuez J, Bai X, Abbott D. A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. Mol Cell Biol. 2013;33:146-58 pubmed publisher
    ..Inhibitor-of-apoptosis (IAP) proteins, particularly cIAP1, are essential mediators of NOD2 signaling, and in this work, we describe a molecular mechanism for cIAP1's ..
  9. Wong W, Vince J, Lalaoui N, Lawlor K, Chau D, Bankovacki A, et al. cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014;123:2562-72 pubmed publisher
    ..To define the role of IAPs in myelopoiesis, we generated a mouse with cIAP1, cIAP2, and XIAP deleted in the myeloid lineage...
  10. Shekhar T, Miles M, Gupte A, Taylor S, Tascone B, Walkley C, et al. IAP antagonists sensitize murine osteosarcoma cells to killing by TNF?. Oncotarget. 2016;7:33866-86 pubmed publisher
    ..IAP antagonists, including SM-164, lacked mutagenic activity. These data suggest that drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNF?, ..
  11. Suzuki S, Suzuki T, Mimuro H, Mizushima T, Sasakawa C. Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. EMBO Rep. 2018;19:89-101 pubmed publisher
    ..Here, we show that GLMN specifically binds cellular inhibitor of apoptosis proteins 1 and 2 (cIAP1 and cIAP2), members of the inhibitor of apoptosis (IAP) family of RING-E3 ligases, which results in reduced E3 ligase ..
  12. Liston P, Lefebvre C, Fong W, Xuan J, Korneluk R. Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes. Genomics. 1997;46:495-503 pubmed
    ..to chromosome 9A2, which is syntenic with portions of the human 11q22-q23 region containing the human homologues HIAP1 and HIAP2...
  13. Vince J, Pantaki D, Feltham R, Mace P, Cordier S, Schmukle A, et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J Biol Chem. 2009;284:35906-15 pubmed publisher
    Tumor necrosis factor (TNF) receptor-associated factor-2 (TRAF2) binds to cIAP1 and cIAP2 (cIAP1/2) and recruits them to the cytoplasmic domain of several members of the TNF receptor (TNFR) superfamily, including the TNF-TNFR1 ligand-..
  14. Giardino Torchia M, Conze D, Ashwell J. c-IAP1 and c-IAP2 redundancy differs between T and B cells. PLoS ONE. 2013;8:e66161 pubmed publisher
    Cellular Inhibitors of Apoptosis 1 and 2 (c-IAP1 and c-IAP2) are ubiquitin protein ligases (E3s) that constitutively ubiquitinate and induce proteasomal-mediated degradation of NF-?B Inducing Kinase (NIK) and repress non-canonical NF-?B ..
  15. Mace P, Linke K, Feltham R, Schumacher F, Smith C, Vaux D, et al. Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. J Biol Chem. 2008;283:31633-40 pubmed publisher
    ..The RING domain at the C terminus of IAP proteins is pivotal. Here we report the crystal structures of the cIAP2 RING domain homodimer alone, and bound to the ubiquitin-conjugating (E2) enzyme UbcH5b...
  16. Mosley J, Keri R. Splice variants of mIAP1 have an enhanced ability to inhibit apoptosis. Biochem Biophys Res Commun. 2006;348:1174-83 pubmed
    ..Herein, we show that murine c-IAP1 (mIAP1) undergoes alterative splicing, generating two truncated proteins; one that lacks the CARD and RING domains (mIAP1-..
  17. Qi Y, Xia P. Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in ?-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP). J Biol Chem. 2012;287:32236-45 pubmed publisher
    ..We report herein a critical role of cellular inhibitor of apoptosis protein-1 (cIAP1) in controlling ?-cell survival under ER stress...
  18. Labbe K, McIntire C, Doiron K, LeBlanc P, Saleh M. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity. 2011;35:897-907 pubmed publisher
    ..Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3) impaired caspase-1 activation after spontaneous or agonist-induced inflammasome assembly, and ..
  19. Enwere E, Boudreault L, Holbrook J, Timusk K, Earl N, LaCasse E, et al. Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice. Hum Mol Genet. 2013;22:867-78 pubmed publisher
    The cellular inhibitor of apoptosis 1 (cIAP1) protein is an essential regulator of canonical and noncanonical nuclear factor ?B (NF-?B) signaling pathways...
  20. Etemadi N, Holien J, Chau D, Dewson G, Murphy J, Alexander W, et al. Lymphotoxin ? induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS J. 2013;280:5283-97 pubmed publisher
    ..Our results imply that the reasons for the conservation of LT? are most likely due either to differential regulation, the ability to signal through Herpes Virus Entry Mediator or the ability of LT? to form heterotrimers with LT?. ..
  21. Mellstrom B, Ceña V, Lamas M, Perales C, Gonzalez C, Naranjo J. Gas1 is induced during and participates in excitotoxic neuronal death. Mol Cell Neurosci. 2002;19:417-29 pubmed
    ..These results indicate that Gas1 is induced by activation of glutamate receptors and is part of the gene expression program directing neuronal death after mild excitotoxic insults. ..
  22. Faye M, Beug S, Graber T, Earl N, Xiang X, Wild B, et al. IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1. Oncogene. 2015;34:1532-41 pubmed publisher
    ..in RMS patient-derived cell lines and in primary tumours where it drives translation of the cellular inhibitor of apoptosis 1 (cIAP1), a key regulator of the nuclear factor-?B signalling pathway and of caspase-8-mediated cell ..
  23. Tseng P, Matsuzawa A, Zhang W, Mino T, Vignali D, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010;11:70-5 pubmed publisher
    ..Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response. ..
  24. Vince J, Chau D, Callus B, Wong W, Hawkins C, Schneider P, et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol. 2008;182:171-84 pubmed publisher
    Synthetic inhibitor of apoptosis (IAP) antagonists induce degradation of IAP proteins such as cellular IAP1 (cIAP1), activate nuclear factor kappaB (NF-kappaB) signaling, and sensitize cells to tumor necrosis factor alpha (TNFalpha)...
  25. Guicciardi M, Werneburg N, Bronk S, Franke A, Yagita H, Thomas G, et al. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS ONE. 2014;9:e92124 pubmed publisher
    ..Together, these data suggest cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells. ..
  26. Malle E, Zammit N, Walters S, Koay Y, Wu J, Tan B, et al. Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity. J Exp Med. 2015;212:1239-54 pubmed publisher
    ..These studies reveal that NIK contributes a central mechanism for β cell failure in diet-induced obesity. ..
  27. Yoshimura F, Luo X, Zhao X, Gerard H, Hudson A. Up-regulation of a cellular protein at the translational level by a retrovirus. Proc Natl Acad Sci U S A. 2008;105:5543-8 pubmed publisher
    ..cells in which this occurs, we have detected an up-regulation of the cellular inhibitor of apoptosis protein 1 (c-IAP1)...
  28. Dong Z, Nishiyama J, Yi X, Venkatachalam M, Denton M, Gu S, et al. Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Biochem J. 2002;364:413-21 pubmed
    ..Alternatively, IAP expression can be regulated at the transcription level. We showed recently the activation of IAP2 transcription by severe hypoxia...
  29. Oberoi T, Dogan T, Hocking J, Scholz R, Mooz J, Anderson C, et al. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012;31:14-28 pubmed publisher
    ..Here, we demonstrate X-linked IAP (XIAP) and cellular IAP1 (c-IAP1) directly bind to Rac1 in a nucleotide-independent manner to promote its polyubiquitination at Lys147 and ..
  30. Kenneth N, Younger J, Hughes E, Marcotte D, Barker P, Saunders T, et al. An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J. 2012;443:355-9 pubmed publisher
    ..which were generated in 129 ES cells, and found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11...
  31. Yamaguchi N, Yokota M, Taguchi Y, Gohda J, Inoue J. cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression. Genes Cells. 2012;17:971-81 pubmed publisher
    ..The over-expression of cIAP1 or cIAP2 in the mouse monocytic cell line Raw264...
  32. Ren J, Shi M, Liu R, Yang Q, Johnson T, Skarnes W, et al. The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proc Natl Acad Sci U S A. 2005;102:565-70 pubmed
    ..We conclude that p53 is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 activates Pidd/caspase-2 and Bax/Bak, leading to mitochondrial apoptosis. ..
  33. Warnakulasuriyarachchi D, Ungureanu N, Holcik M. The translation of an antiapoptotic protein HIAP2 is regulated by an upstream open reading frame. Cell Death Differ. 2003;10:899-904 pubmed
    b>HIAP2 is a multifunctional protein that is critically involved in the regulation of cell survival and apoptosis. Here, we show that HIAP2 5' untranslated region functions as a strong inhibitor of translation...
  34. Deveraux Q, Reed J. IAP family proteins--suppressors of apoptosis. Genes Dev. 1999;13:239-52 pubmed
  35. Vince J, Wong W, Gentle I, Lawlor K, Allam R, O Reilly L, et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity. 2012;36:215-27 pubmed publisher
    ..quot;Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP...
  36. Moulin M, Anderton H, Voss A, Thomas T, Wong W, Bankovacki A, et al. IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J. 2012;31:1679-91 pubmed publisher
    Inhibitor of apoptosis (IAP) proteins cIAP1, cIAP2, and XIAP (X-linked IAP) regulate apoptosis and cytokine receptor signalling, but their overlapping functions make it difficult to distinguish their individual roles...
  37. McPherson A, Snell L, Mak T, Watts T. Opposing roles for TRAF1 in the alternative versus classical NF-?B pathway in T cells. J Biol Chem. 2012;287:23010-9 pubmed publisher
    ..of the classical NF-?B pathway downstream of 4-1BB requires TRAF1, whereas cIAP1 plays a redundant role with cIAP2. Collectively these results demonstrate that TRAF1 plays a critical role in regulating T cell activation both ..
  38. Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development. 2008;135:4059-69 pubmed publisher
  39. Yang Q, Church Hajduk R, Ren J, Newton M, Du C. Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev. 2003;17:1487-96 pubmed
    ..Cleavage of IAPs such as c-IAP1 substantially reduces its ability to inhibit and ubiquitylate caspases...
  40. McComb S, Cheung H, Korneluk R, Wang S, Krishnan L, Sad S. cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ. 2012;19:1791-801 pubmed publisher
    ..These results show that cIAPs have an important role in limiting programmed necrosis of macrophages, which facilitates effective control of a pathogen. ..
  41. Cheng L, Zhou Z, Flesken Nikitin A, Toshkov I, Wang W, Camps J, et al. Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency. Oncogene. 2010;29:5700-11 pubmed publisher
    ..at chromosome band 9A1, a locus orthologous to human 11q22, which contains protooncogenes cIAP1 (Birc2), cIAP2 (Birc3) and Yap1. It is interesting that this amplicon was preferentially detected in carcinomas carrying wild-type Rb...
  42. Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, et al. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ. 2011;18:656-65 pubmed publisher
    ..the IAP family (X-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis proteins-1/-2 (cIAP1 and cIAP2)) are potent suppressors of apoptosis...
  43. LaCasse E, Baird S, Korneluk R, MacKenzie A. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 1998;17:3247-59 pubmed
    ..The IAPs have been shown to be induced by NF-kappaB or v-Rel in multiple cell lines and conversely, HIAP1 and HIAP2 have been shown to activate NF-kappaB possibly forming a positive feed-back loop...
  44. Götz R, Wiese S, Takayama S, Camarero G, Rossoll W, Schweizer U, et al. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci. 2005;8:1169-78 pubmed
    ..Our data show that Bag1 is a physiological mediator of extracellular survival signals linked to the cellular mechanisms that prevent apoptosis in hematopoietic and neuronal progenitor cells. ..
  45. Ebert G, Preston S, Allison C, Cooney J, Toe J, Stutz M, et al. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A. 2015;112:5797-802 pubmed publisher
    ..Animals with a liver-specific cIAP1 and total cIAP2 deficiency efficiently control HBV infection compared with WT mice...
  46. Blackwell K, Zhang L, Workman L, Ting A, Iwai K, Habelhah H. Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed I?B kinase activation. Mol Cell Biol. 2013;33:1901-15 pubmed publisher
    Tumor necrosis factor alpha (TNF-?)-induced NF-?B activation has been believed to depend on TRAF2- and cIAP1-mediated RIP1 ubiquitination...
  47. Ene A, Park S, Edelmann W, Taketo T. Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression. Dev Biol. 2013;377:213-23 pubmed publisher
    ..We conclude that the mitochondrial apoptotic pathway mediated by caspase 9 is constitutively activated in oocytes and renders the elimination of oocytes with meiotic errors, which can be captured by the cleavage of PARP1. ..
  48. Tan B, Zammit N, Yam A, Slattery R, Walters S, Malle E, et al. Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor ?B and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells. Diabetologia. 2013;56:520-32 pubmed publisher
    ..Birc gene control of cell signalling was studied in beta cell lines, and in islets from Birc2(-/-) and Birc3(-/-) mice, and from Birc3(-/-) Birc2? beta cell mice that selectively lack Birc2 and Birc3 (double ..
  49. Heallen T, Zhang M, Wang J, Bonilla Claudio M, Klysik E, Johnson R, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011;332:458-61 pubmed publisher
    ..Furthermore, the Hippo effector Yap interacts with β-catenin on Sox2 and Snai2 genes. These data uncover a nuclear interaction between Hippo and Wnt signaling that restricts cardiomyocyte proliferation and controls heart size. ..
  50. Paschall A, Zimmerman M, Torres C, Yang D, Chen M, Li X, et al. Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression. BMC Cancer. 2014;14:24 pubmed publisher
    ..BV6 in sensitization of colon carcinoma cells to Fas-mediated apoptosis by inducing proteasomal degradation of cIAP1 and xIAP proteins...
  51. Hostager B, Fox D, Whitten D, Wilkerson C, Eipper B, Francone V, et al. HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE. 2010;5:e11380 pubmed publisher
  52. Song H, Mak K, Topol L, Yun K, Hu J, Garrett L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010;107:1431-6 pubmed publisher
  53. Hamanaka R, Bobrovnikova Marjon E, Ji X, Liebhaber S, Diehl J. PERK-dependent regulation of IAP translation during ER stress. Oncogene. 2009;28:910-20 pubmed publisher
    ..the ER stress-induced apoptotic program through the induction of cellular inhibitor of apoptosis (cIAP1 and cIAP2) proteins...
  54. Kawamura K, Sato N, Fukuda J, Kodama H, Kumagai J, Tanikawa H, et al. Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos. Dev Biol. 2003;256:331-41 pubmed
    ..These results indicate that survivin is an essential antiapoptotic gene expressed in preimplantation embryos and could protect the embryos from apoptosis by inhibiting an apoptotic pathway involving caspases. ..