Bin1

Summary

Gene Symbol: Bin1
Description: bridging integrator 1
Alias: ALP-1, Amphl, BRAMP-2, SH3P9, myc box-dependent-interacting protein 1, SH3 domain-containing protein 9, amphiphysin 2, amphiphysin II, amphiphysin-like protein
Species: mouse
Products:     Bin1

Top Publications

  1. Sakamuro D, Elliott K, Wechsler Reya R, Prendergast G. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996;14:69-77 pubmed
    b>BIN1 is a novel protein that interacts with the functionally critical Myc box regions at the N terminus of the MYC oncoprotein...
  2. Hong T, Yang H, Zhang S, Cho H, Kalashnikova M, Sun B, et al. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med. 2014;20:624-32 pubmed publisher
    Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is a T-tubule protein associated with calcium channel trafficking that is downregulated in failing hearts...
  3. Hong T, Smyth J, Gao D, Chu K, Vogan J, Fong T, et al. BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol. 2010;8:e1000312 pubmed publisher
    ..In particular, the membrane scaffolding protein BIN1 functions to initiate T-tubule genesis in skeletal muscle cells...
  4. Lee E, Marcucci M, Daniell L, Pypaert M, Weisz O, Ochoa G, et al. Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science. 2002;297:1193-6 pubmed
    ..Amphiphysin isoforms have a putative role in membrane deformation at endocytic sites. An isoform of amphiphysin 2 concentrated at T-tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells...
  5. Chang M, Boulden J, Katz J, Wang L, Meyer T, Soler A, et al. Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer. Cancer Res. 2007;67:7605-12 pubmed
    ..b>Bin1 is a prototypic member of the BAR adapter gene family that functions in vesicle dynamics and nuclear processes...
  6. Muller A, Baker J, DuHadaway J, Ge K, Farmer G, Donover P, et al. Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol Cell Biol. 2003;23:4295-306 pubmed
    The mammalian Bin1/Amphiphysin II gene encodes an assortment of alternatively spliced adapter proteins that exhibit markedly divergent expression and subcellular localization profiles...
  7. Laury Kleintop L, Mulgrew J, Heletz I, Nedelcoviciu R, Chang M, Harris D, et al. Cardiac-specific disruption of Bin1 in mice enables a model of stress- and age-associated dilated cardiomyopathy. J Cell Biochem. 2015;116:2541-51 pubmed publisher
    ..model of heart failure based on cardiac-specific deletion of the prototypical mammalian BAR adapter-encoding gene Bin1, a modifier of age-associated disease...
  8. Thomas S, Mercado J, DuHadaway J, DiGuilio K, Mullin J, Prendergast G. Novel Colitis Immunotherapy Targets Bin1 and Improves Colon Cell Barrier Function. Dig Dis Sci. 2016;61:423-32 pubmed publisher
    ..Building on genetic evidence that attenuation of the Bin1 (Bridging integrator 1) gene can limit UC pathogenicity in the mouse, we pursued Bin1 targeting as a therapeutic ..
  9. Reynolds J, Chiang D, Wang W, Beavers D, Dixit S, Skapura D, et al. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013;100:44-53 pubmed publisher
    ..In particular, JPH2 may be critical in anchoring the invaginating sarcolemma to the sarcoplasmic reticulum, thereby enabling the maturation of the TT network. ..

More Information

Publications33

  1. Chang M, Boulden J, Sutanto Ward E, DuHadaway J, Soler A, Muller A, et al. Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Res. 2007;67:100-7 pubmed
    ..The Bin1 gene encodes a nucleocytosolic adapter protein that interacts with and suppresses the cell transforming activity of ..
  2. Sparks A, Hoffman N, McConnell S, Fowlkes D, Kay B. Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996;14:741-4 pubmed
    ..The isolation of entire repertoires of modular domain-containing proteins will prove invaluable in genome analysis and in bringing new targets into drug discovery programs. ..
  3. Kadlec L, Pendergast A. The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. Proc Natl Acad Sci U S A. 1997;94:12390-5 pubmed
    ..ALP1 has high homology to BIN1, a recently cloned myc-interacting protein, and also shows significant homology to amphiphysin, a neuronal protein ..
  4. Sarret P, Esdaile M, McPherson P, Schonbrunn A, Kreienkamp H, Beaudet A. Role of amphiphysin II in somatostatin receptor trafficking in neuroendocrine cells. J Biol Chem. 2004;279:8029-37 pubmed
    ..To investigate the potential role of amphiphysin II in cellular trafficking of G protein-coupled somatostatin (SRIF) receptors, we generated an AtT-20 cell line ..
  5. Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, et al. BIN1 regulates BACE1 intracellular trafficking and amyloid-? production. Hum Mol Genet. 2016;25:2948-2958 pubmed
    b>BIN1 is a genetic risk factor of late-onset Alzheimer disease (AD), which was identified in multiple genome-wide association studies...
  6. Cassimere E, Pyndiah S, Sakamuro D. The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage. Cell Death Differ. 2009;16:1641-53 pubmed publisher
    ..Here, we show that the c-MYC-interacting proapoptotic tumor suppressor, BIN1, is transcriptionally activated by E2F1 and mediates E2F1-induced apoptosis in response to DNA damage...
  7. Falcone S, Roman W, Hnia K, Gache V, Didier N, Lainé J, et al. N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy. EMBO Mol Med. 2014;6:1455-75 pubmed publisher
    Mutations in amphiphysin-2/BIN1, dynamin 2, and myotubularin are associated with centronuclear myopathy (CNM), a muscle disorder characterized by myofibers with atypical central nuclear positioning and abnormal triads...
  8. Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed publisher
    ..Two late-onset AD risk factors, Bin1 and CD2AP, are regulators of endocytic trafficking, but it is unclear how their endocytic function regulates A? ..
  9. Leprince C, Le Scolan E, Meunier B, Fraisier V, Brandon N, de Gunzburg J, et al. Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci. 2003;116:1937-48 pubmed
    ..our knowledge of amphiphysin function, we performed a two-hybrid screen with the N-terminal part of murine amphiphysin 2 (residues 1-304)...
  10. Fernando P, Sandoz J, Ding W, De Repentigny Y, Brunette S, Kelly J, et al. Bin1 SRC homology 3 domain acts as a scaffold for myofiber sarcomere assembly. J Biol Chem. 2009;284:27674-86 pubmed publisher
    ..Here we explored the hypothesis that modular domain proteins such as Bin1 coordinate protein interactions to promote sarcomere formation...
  11. Di Paolo G, Sankaranarayanan S, Wenk M, Daniell L, Perucco E, Caldarone B, et al. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron. 2002;33:789-804 pubmed
    ..amphiphysin 1 knockout mice and found that lack of amphiphysin 1 causes a parallel dramatic reduction of amphiphysin 2 selectively in brain. Cell-free assembly of endocytic protein scaffolds is defective in mutant brain extracts...
  12. Fu Y, Shaw S, Naami R, Vuong C, Basheer W, Guo X, et al. Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads. Circulation. 2016;133:388-97 pubmed publisher
    ..Given that bridging integrator 1 (BIN1) organizes t-tubule microfolds and facilitates CaV1...
  13. Mao N, Steingrimsson E, Duhadaway J, Wasserman W, Ruiz J, Copeland N, et al. The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2. Genomics. 1999;56:51-8 pubmed
    We cloned and functionally characterized the murine Bin1 gene as a first step to investigate its physiological roles in differentiation, apoptosis, and tumorigenesis...
  14. D Alessandro M, Hnia K, Gache V, Koch C, Gavriilidis C, Rodriguez D, et al. Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton. Dev Cell. 2015;35:186-98 pubmed publisher
    ..and organ development and is affected in many diseases, including myopathies due to alteration in amphiphysin-2 (BIN1)...
  15. Modregger J, Schmidt A, Ritter B, Huttner W, Plomann M. Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. J Biol Chem. 2003;278:4160-7 pubmed
  16. Nakajo A, Yoshimura S, Togawa H, Kunii M, Iwano T, Izumi A, et al. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. J Cell Biol. 2016;212:297-306 pubmed publisher
    ..a novel Rab8-interacting protein complex containing an EH domain-binding protein 1-like 1 (EHBP1L1), Bin1/amphiphysin II, and dynamin. Biochemical analyses showed that EHBP1L1 directly bound to GTP-loaded Rab8 and Bin1...
  17. Leprince C, Romero F, Cussac D, Vayssiere B, Berger R, Tavitian A, et al. A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. J Biol Chem. 1997;272:15101-5 pubmed
    ..interacting clones that were isolated from a mouse brain cDNA library defines a new protein that was named amphiphysin 2 because of its homology to the previously reported amphiphysin...
  18. Muller A, DuHadaway J, Donover P, Sutanto Ward E, Prendergast G. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med. 2005;11:312-9 pubmed
    ..Here we show that IDO is under genetic control of Bin1, which is attenuated in many human malignancies...
  19. Kumari A, Iwasaki T, Pyndiah S, Cassimere E, Palani C, Sakamuro D. Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation. Cell Death Differ. 2015;22:311-22 pubmed publisher
    ..was sufficient to modify E2F1 by poly(ADP-ribosyl)ation, which stabilized the interaction between E2F1 and the BIN1 tumor suppressor in the nucleus. Accordingly, BIN1 acted as an RB1-independent E2F1 corepressor...
  20. Royer B, Hnia K, Gavriilidis C, Tronchère H, Tosch V, Laporte J. The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies. EMBO Rep. 2013;14:907-15 pubmed publisher
    Myotubularin (MTM1) and amphiphysin 2 (BIN1) are two proteins mutated in different forms of centronuclear myopathy, but the functional and pathological relationship between these two proteins was unknown...
  21. Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen K, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry. 2013;18:1225-34 pubmed publisher
    Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE...
  22. DuHadaway J, Du W, Donover S, Baker J, Liu A, Sharp D, et al. Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1. Oncogene. 2003;22:3578-88 pubmed
    ..Here we offer evidence that the BAR adapter-encoding tumor suppressor gene Bin1 is required for this transformation-selective death program...
  23. Xu B, Fu Y, Liu Y, Agvanian S, Wirka R, Baum R, et al. The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles. PLoS Biol. 2017;15:e2002354 pubmed publisher
    ..In ventricular cardiomyocytes, the membrane deformation protein cardiac bridging integrator 1 (cBIN1 or BIN1+13+17) creates transverse-tubule (t-tubule) membrane microfolds, which facilitate ion channel trafficking and ..
  24. Chang M, Boulden J, Valenzano M, Soler A, Muller A, Mullin J, et al. Bin1 attenuation suppresses experimental colitis by enforcing intestinal barrier function. Dig Dis Sci. 2012;57:1813-21 pubmed publisher
    ..This preclinical study aimed to evaluate an hypothesized role for the tumor suppressor gene Bin1 as a modifier of the severity of experimental colitis...