Bicd2

Summary

Gene Symbol: Bicd2
Description: BICD cargo adaptor 2
Alias: protein bicaudal D homolog 2, bic-D 2, bicaudal D homolog 2
Species: mouse
Products:     Bicd2

Top Publications

  1. Hoogenraad C, Akhmanova A, Howell S, Dortland B, De Zeeuw C, Willemsen R, et al. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J. 2001;20:4041-54 pubmed
    ..We show here that a mammalian homologue of Bicaudal-D, BICD2, binds to the dynamitin subunit of dynactin...
  2. Matanis T, Akhmanova A, Wulf P, del Nery E, Weide T, Stepanova T, et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002;4:986-92 pubmed
    ..BICD1 and BICD2 colocalize with Rab6a on the trans-Golgi network (TGN) and on cytoplasmic vesicles, and associate with Golgi ..
  3. Teuling E, van Dis V, Wulf P, Haasdijk E, Akhmanova A, Hoogenraad C, et al. A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice. Hum Mol Genet. 2008;17:2849-62 pubmed publisher
    ..In this study, we have generated transgenic mice with neuron-specific expression of Bicaudal D2 N-terminus (BICD2-N) to chronically impair dynein/dynactin function...
  4. Splinter D, Tanenbaum M, Lindqvist A, Jaarsma D, Flotho A, Yu K, et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 2010;8:e1000350 pubmed publisher
    b>BICD2 is one of the two mammalian homologues of the Drosophila Bicaudal D, an evolutionarily conserved adaptor between microtubule motors and their cargo that was previously shown to link vesicles and mRNP complexes to the dynein motor...
  5. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..In this study, we focus on dynein-dynactin recruitment to cargo by the conserved motor adaptor Bicaudal D2 (BICD2)...
  6. Loschi M, Leishman C, Berardone N, Boccaccio G. Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci. 2009;122:3973-82 pubmed publisher
    ..Finally, we found that regulation of SG dynamics by dynein and kinesin is conserved in Drosophila. ..
  7. Schlager M, Kapitein L, Grigoriev I, Burzynski G, Wulf P, Keijzer N, et al. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. EMBO J. 2010;29:1637-51 pubmed publisher
    ..These results indicate an important role for BICDR-1 as temporal regulator of secretory trafficking during the early phase of neuronal differentiation. ..
  8. Matsuto M, Kano F, Murata M. Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport. Biochim Biophys Acta. 2015;1853:2592-609 pubmed publisher
    ..Subsequent immunofluorescence analyses indicated decreased amounts of the GTP-bound active form of Rab6 in BICD2-knockdown cells...
  9. GutiƩrrez P, Ackermann B, Vershinin M, McKenney R. Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. J Biol Chem. 2017;292:12245-12255 pubmed publisher

More Information

Publications11

  1. Jaarsma D, van den Berg R, Wulf P, van Erp S, Keijzer N, Schlager M, et al. A role for Bicaudal-D2 in radial cerebellar granule cell migration. Nat Commun. 2014;5:3411 pubmed publisher
    ..Missense mutations in a human BICD homologue, BICD2, have been linked to a dominant mild early onset form of spinal muscular atrophy...
  2. Schroeder C, Ostrem J, Hertz N, Vale R. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. elife. 2014;3:e03351 pubmed publisher
    ..These studies provide the first structural information and insight into the evolutionary origin of the LIC as well as revealing how this critical subunit connects the dynein motor to cargo. ..