Gene Symbol: Bicd1
Description: BICD cargo adaptor 1
Alias: B830009D06Rik, bic-D 1, protein bicaudal D homolog 1, bicaudal D homolog 1
Baens M, Aerssens J, Van Zand K, Van den Berghe H, Marynen P. Isolation and regional assignment of human chromosome 12p cDNAs. Genomics. 1995;29:44-52 pubmed
..Evidence was found for the duplication on 12p of a region containing a polymorphic simple sequence repeat and sequences of two different cDNAs. ..
Baens M, Marynen P. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Genomics. 1997;45:601-6 pubmed
..A PCR-mediated cDNA cloning strategy was applied to obtain the coding sequence of the human homologue (BICD1) and to generate a partial mouse (Bicdh1) cDNA...
Matanis T, Akhmanova A, Wulf P, del Nery E, Weide T, Stepanova T, et al
. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002;4:986-92 pubmed
..In particular, we identified the dynein-dynactin-binding protein Bicaudal-D1 (BICD1), one of the two mammalian homologues of Drosophila Bicaudal-D...
Swift S, Xu J, Trivedi V, Austin K, Tressel S, Zhang L, et al
. A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J Biol Chem. 2010;285:11402-10 pubmed publisher
..Using a yeast two-hybrid screen, we identified Bicaudal D1 (BicD1) as a direct interactor with the C-terminal cytoplasmic domain of PAR1...
Terawaki S, Yoshikane A, Higuchi Y, Wakamatsu K. Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry. Biochem Biophys Res Commun. 2015;460:451-6 pubmed publisher
Bicaudal-D1 (BICD1) is an Î±-helical coiled-coil protein mediating the attachment of specific cargo to cytoplasmic dynein. It plays an essential role in minus end-directed intracellular transport along microtubules...
Loschi M, Leishman C, Berardone N, Boccaccio G. Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci. 2009;122:3973-82 pubmed publisher
..show that impairment of retrograde transport by knockdown of mammalian dynein heavy chain 1 (DHC1) or bicaudal D1 (BicD1) inhibits SG formation and PB growth upon stress, without affecting protein-synthesis blockage...
Terenzio M, Golding M, Russell M, Wicher K, Rosewell I, Spencer Dene B, et al
. Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors. EMBO J. 2014;33:1582-98 pubmed publisher
We have identified a new function for the dynein adaptor Bicaudal D homolog 1 (BICD1) by screening a siRNA library for genes affecting the dynamics of neurotrophin receptor-containing endosomes in motor neurons (MNs)...