Gene Symbol: Bhlhe40
Description: basic helix-loop-helix family, member e40
Alias: Bhlhb2, C130042M06Rik, CR8, Clast5, Dec1, Sharp2, Stra13, Stra14, class E basic helix-loop-helix protein 40, E47 interaction protein 1, basic helix-loop-helix domain containing, class B2, class B basic helix-loop-helix protein 2, cytokine response gene 8, differentially expressed in chondrocytes protein 1, eip1 (E47 interaction protein 1), stimulated by retinoic acid gene 13 protein
Species: mouse
Products:     Bhlhe40

Top Publications

  1. Bode B, Shahmoradi A, Taneja R, Rossner M, Oster H. Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity. J Biol Rhythms. 2011;26:530-40 pubmed publisher
    ..An accessory loop involving the transcription factors DEC1 and DEC2 has been described that also impinges on CLOCK/BMAL1-mediated transactivation...
  2. Beadling C, Cereseto A, Fan W, Naramura M, Smith K. Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival. Oncogene. 2001;20:1771-83 pubmed
    Cellular proliferation and survival are modulated by the expression of specific genes. Cytokine response gene 8 (CR8), which was originally cloned as an IL-2-induced gene in human T lymphocytes, encodes a basic helix--loop--helix (bHLH) ..
  3. Miyazaki K, Miyazaki M, Guo Y, Yamasaki N, Kanno M, Honda Z, et al. The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. J Immunol. 2010;185:7330-9 pubmed publisher
    ..In this paper, we report that the basic helix-loop-helix transcription factor Dec1 is involved in the homeostasis of Treg cells and plays a role in their survival or expansion after adoptive ..
  4. Bhawal U, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, et al. Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1. J Pathol. 2011;224:420-9 pubmed publisher
    DEC1 (also known as Stra13/Bhlhb2/Sharp2) and DEC2 (also known as Bhlhb3/Sharp1) are two paralogous basic helix-loop-helix (bHLH) transcriptional regulators which exhibit a robust circadian gene expression pattern in the suprachiasmatic ..
  5. Seimiya M, Bahar R, Wang Y, Kawamura K, Tada Y, Okada S, et al. Clast5/Stra13 is a negative regulator of B lymphocyte activation. Biochem Biophys Res Commun. 2002;292:121-7 pubmed
    ..Clast5 is identical with Stra13, a recently identified member of the basic helix-loop-helix family of transcription factors...
  6. Fujimoto K, Hamaguchi H, Hashiba T, Nakamura T, Kawamoto T, Sato F, et al. Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements. Int J Mol Med. 2007;19:925-32 pubmed
    ..Gel retardation and luciferase assays showed that Dec2, as well as its related protein Dec1, preferentially binds to class B E-box elements (CACGTG) as a homodimer and represses the transcription of target ..
  7. Bode B, Taneja R, Rossner M, Oster H. Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice. Chronobiol Int. 2011;28:737-50 pubmed publisher
    ..The basic helix-loop-helix transcription factors DEC1 (BHLHE40) and DEC2 (BHLHE41) can interact with this core TTL, forming an accessory feedback mechanism...
  8. St Pierre B, Flock G, Zacksenhaus E, Egan S. Stra13 homodimers repress transcription through class B E-box elements. J Biol Chem. 2002;277:46544-51 pubmed
    A mammalian basic helix-loop-helix protein known variably as Stra13, Sharp2, and Dec1 has been implicated in cell activation, proliferation, and differentiation...
  9. Nakashima A, Kawamoto T, Honda K, Ueshima T, Noshiro M, Iwata T, et al. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 2008;28:4080-92 pubmed publisher
    b>DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear...

More Information


  1. Yun Z, Maecker H, Johnson R, Giaccia A. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2002;2:331-41 pubmed
    ..The HIF-1-regulated gene DEC1/Stra13, a member of the Drosophila hairy/Enhancer of split transcription repressor family, represses PPAR gamma 2 ..
  2. Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, et al. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002;419:841-4 pubmed
    ..We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse ..
  3. Jiang X, Tian F, Du Y, Copeland N, Jenkins N, Tessarollo L, et al. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J Neurosci. 2008;28:1118-30 pubmed publisher
    ..We discovered a sequence within Bdnf promoter 4 that binds the basic helix-loop-helix protein BHLHB2 and is a target for BHLHB2-mediated transcriptional repression...
  4. Sun H, Li L, Vercherat C, Gulbagci N, Acharjee S, Li J, et al. Stra13 regulates satellite cell activation by antagonizing Notch signaling. J Cell Biol. 2007;177:647-57 pubmed
    ..We report that the basic helix-loop-helix transcription factor Stra13 modulates Notch signaling in regenerating muscle...
  5. Rossner M, Oster H, Wichert S, Reinecke L, Wehr M, Reinecke J, et al. Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS ONE. 2008;3:e2762 pubmed publisher
    ..and cell culture experiments, the basic Helix-Loop-Helix (bHLH) transcription factors SHARP-1(Dec2) and SHARP-2(Stra13/Dec1) were proposed as novel negative regulators of the molecular clock...
  6. Kon N, Hirota T, Kawamoto T, Kato Y, Tsubota T, Fukada Y. Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nat Cell Biol. 2008;10:1463-9 pubmed publisher
    ..The resetting was mediated by an immediate-early induction of Dec1, a gene whose physiological role in the function of the circadian clock has been unclear...
  7. Martinez Llordella M, Esensten J, Bailey Bucktrout S, Lipsky R, Marini A, Chen J, et al. CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. J Exp Med. 2013;210:1603-19 pubmed publisher
    ..We show that the transcription factor DEC1 is highly induced in a CD28-dependent manner upon T cell activation, is involved in essential CD4(+) effector T ..
  8. Vercherat C, Chung T, Yalcin S, Gulbagci N, Gopinadhan S, Ghaffari S, et al. Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Hum Mol Genet. 2009;18:4304-16 pubmed publisher
    ..However, the mechanisms leading to muscle degeneration in DMD are poorly understood. Here, we demonstrate that Stra13 protects muscle cells from oxidative damage, and its absence leads to muscle necrosis in response to injury in ..
  9. Grechez Cassiau A, Panda S, Lacoche S, Teboul M, Azmi S, Laudet V, et al. The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J Biol Chem. 2004;279:1141-50 pubmed
    ..Here we show that the basic helix-loop-helix transcriptional repressor Stra13 is rhythmically expressed in mouse peripheral organs...
  10. Ivanov S, Salnikow K, Ivanova A, Bai L, Lerman M. Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13. Oncogene. 2007;26:802-12 pubmed
    DEC1/STRA13 is a bHLH type transcriptional regulator involved with immune regulation, hypoxia response and carcinogenesis...
  11. Thin T, Li L, Chung T, Sun H, Taneja R. Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis. EMBO Rep. 2007;8:401-7 pubmed
    ..In this study, we have identified stimulated with retinoic acid 13 (Stra13), a basic helix-loop-helix transcription factor, as a regulator of ionizing-radiation-induced apoptosis...
  12. Boudjelal M, Taneja R, Matsubara S, Bouillet P, Dolle P, Chambon P. Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev. 1997;11:2052-65 pubmed
    We report the cDNA cloning of Stra13, a novel retinoic acid (RA)-inducible gene from P19 embryonal carcinoma cells that encodes a basic helix-loop-helix (bHLH) protein that shows the highest sequence similarities to the Drosophila Hairy ..
  13. Sun H, Lu B, Li R, Flavell R, Taneja R. Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Nat Immunol. 2001;2:1040-7 pubmed
    b>Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation...
  14. Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, et al. Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. J Biol Chem. 2002;277:50112-20 pubmed
    The mRNA level of basic helix-loop-helix transcription factor DEC1 (BHLHB2)/Stra13/Sharp2 was up-regulated during chondrocyte differentiation in cultures of ATDC5 cells and growth plate chondrocytes, and in growth plate cartilage in vivo...
  15. Wang Y, Rao V, Kok W, Roy D, Sethi S, Ling B, et al. SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest. PLoS ONE. 2012;7:e43137 pubmed publisher
    b>Stra13, a basic helix-loop-helix (bHLH) transcription factor is involved in myriad biological functions including cellular growth arrest, differentiation and senescence...
  16. Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, et al. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004;313:117-24 pubmed
    ..We show here an autofeedback loop of Dec1 encoding a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and ..
  17. Paschaki M, Schneider C, Rhinn M, Thibault Carpentier C, Dembele D, Niederreither K, et al. Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. PLoS ONE. 2013;8:e62274 pubmed publisher
    ..Overall, these data give an overview of the gene expression changes resulting from embryonic RA deficiency, and provide new candidate genes and pathways that may help understanding retinoid-dependent molecular events. ..
  18. Cohen E, Miller M, Wang Z, Moon R, Morrisey E. Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012;139:1931-40 pubmed publisher
    ..These data show that Wnt5a and Wnt11 are essential regulators of the response of second heart field progenitors to Wnt/?-catenin signaling and that they act by restraining Wnt/?-catenin signaling during cardiac development. ..
  19. Garside V, Cullum R, Alder O, Lu D, Vander Werff R, Bilenky M, et al. SOX9 modulates the expression of key transcription factors required for heart valve development. Development. 2015;142:4340-50 pubmed publisher
    ..Together, our data identify SOX9-coordinated transcriptional hierarchies that control cell proliferation and differentiation during valve formation. ..
  20. Azmi S, Sun H, Ozog A, Taneja R. mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J Biol Chem. 2003;278:20098-109 pubmed
    ..Hairy/Enhancer of Split subfamily of bHLH factors and exhibits the highest structural and sequence identity with Stra13. We show that mSharp-1 specifically binds to the E box motif (CANNTG) as a homodimer and acts as a potent ..
  21. Guillaumond F, Lacoche S, Dulong S, Grechez Cassiau A, Filipski E, Li X, et al. Altered Stra13 and Dec2 circadian gene expression in hypoxic cells. Biochem Biophys Res Commun. 2008;369:1184-9 pubmed publisher
    ..Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis ..
  22. Oström M, Loffler K, Edfalk S, Selander L, Dahl U, Ricordi C, et al. Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells. PLoS ONE. 2008;3:e2841 pubmed publisher
  23. St Pierre B, Cooper M, Jiang Z, Zacksenhaus E, Egan S. Dynamic regulation of the Stra13/Sharp/Dec bHLH repressors in mammary epithelium. Dev Dyn. 2004;230:124-30 pubmed
    ..In this study, we have determined that expression of the Stra13/Sharp/Dec basic helix-loop-helix (bHLH) family is dynamically regulated in mammary epithelium...
  24. Lin C, Bradstreet T, Schwarzkopf E, Jarjour N, Chou C, Archambault A, et al. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 2016;213:251-71 pubmed publisher
    ..We have previously shown that Th cells require the transcription factor Bhlhe40 to mediate experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis...
  25. Dear T, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, et al. Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene. 1997;14:891-8 pubmed
    ..A cDNA encoding part of the nucleolin protein sequence interacted with the E47 basic-helix-loop-helix only when fused to a beta-galactosidase tag. ..
  26. Fischer B, Azim K, Hurtado Chong A, Ramelli S, Fernández M, Raineteau O. E-proteins orchestrate the progression of neural stem cell differentiation in the postnatal forebrain. Neural Dev. 2014;9:23 pubmed publisher
  27. Baier P, Brzózka M, Shahmoradi A, Reinecke L, Kroos C, Wichert S, et al. Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders. PLoS ONE. 2014;9:e110310 pubmed publisher
    ..The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40 has been shown to regulate homeostatic sleep drive ..
  28. MacLean H, Kronenberg H. Expression of Stra13 during mouse endochondral bone development. Gene Expr Patterns. 2004;4:633-6 pubmed
    We have examined the expression of the basic helix-loop-helix factor Stra13 (DEC1/Sharp2) during endochondral bone development in the mouse. Stra13 expression was examined by in situ hybridization in the tibia from E14.5-E18...
  29. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol. 2009;11:951-7 pubmed publisher
    ..These findings reveal a regulatory network controlling CPC expansion and cell fate that involves unanticipated functions of beta-catenin, Notch1 and Isl1 that may be leveraged for regenerative approaches involving CPCs. ..
  30. Hamaguchi H, Fujimoto K, Kawamoto T, Noshiro M, Maemura K, Takeda N, et al. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem J. 2004;382:43-50 pubmed
    ..Transcripts of Dec2, as well as those of its related gene Dec1, exhibit a striking circadian oscillation in the suprachiasmatic nucleus, and Dec2 inhibits transcription from the ..
  31. Bek M, Wahle S, Muller B, Benzing T, Huber T, Kretzler M, et al. Stra13, a prostaglandin E2-induced gene, regulates the cellular redox state of podocytes. FASEB J. 2003;17:682-4 pubmed
    ..suppressive-subtractive hybridization method, we isolated a differentially expressed clone that was identified as Stra13, a recently described retinoic acid-inducible gene...
  32. Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S. Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein. J Biol Chem. 2015;290:29707-16 pubmed publisher
    ..Here we performed microarray analyses and identified the basic helix-loop-helix family transcription factor Bhlhe40 as a candidate mediator of the myogenic inhibitory effect of hypoxia...
  33. Zhu Z, Wang Y, Ge D, Lu M, Liu W, Xiong J, et al. Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway. CNS Neurosci Ther. 2017;23:736-747 pubmed publisher
    Differentiated embryonic chondrocyte gene 1 (DEC1) is involved in the neuronal differentiation and development...
  34. Fraidenraich D, Stillwell E, Romero E, Wilkes D, Manova K, Basson C, et al. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science. 2004;306:247-52 pubmed
    ..Thus, ES cells have the potential to reverse congenital defects through Id-dependent local and long-range effects in a mammalian embryo. ..
  35. Butler M, Honma S, Fukumoto T, Kawamoto T, Fujimoto K, Noshiro M, et al. Dec1 and Dec2 expression is disrupted in the suprachiasmatic nuclei of Clock mutant mice. J Biol Rhythms. 2004;19:126-34 pubmed
    b>DEC1 and DEC2 are basic helix-loop-helix transcription factors that functionally resemble negative feedback components of the mammalian circadian clock...
  36. Abbas H, Maccio D, Coskun S, Jackson J, Hazen A, SILLS T, et al. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010;7:606-17 pubmed publisher
    ..p16 was also stabilized because of ROS, and its loss increased cell cycling and partially rescued hematopoiesis and survival. Thus, Mdm2 is required to control ROS-induced p53 levels for sustainable hematopoiesis. ..
  37. Takeshita S, Suzuki T, Kitayama S, Moritani M, Inoue H, Itakura M. Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation. Genes Genet Syst. 2012;87:253-64 pubmed
    ..analyzed genomic variants of these genes and gene expression in the muscle, liver, and EWAT and identified that Bhlhe40 gene expression in muscle is decreased in congenic mice...
  38. Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, et al. The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009;76:1360-9 pubmed publisher
    The basic helix-loop-helix proteins differentiated embryo chondrocyte 1 (DEC1) and DEC2 are involved in circadian rhythm control...
  39. Lin C, Bradstreet T, Schwarzkopf E, Sim J, Carrero J, Chou C, et al. Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation. Nat Commun. 2014;5:3551 pubmed publisher
    ..Here we demonstrate that mice deficient for the basic helix-loop-helix (bHLH) transcription factor Bhlhe40 (Bhlhe40(-/-)) are resistant to the induction of EAE...
  40. Shen L, Cui A, Xue Y, Cui Y, Dong X, Gao Y, et al. Hepatic differentiated embryo-chondrocyte-expressed gene 1 (Dec1) inhibits sterol regulatory element-binding protein-1c (Srebp-1c) expression and alleviates fatty liver phenotype. J Biol Chem. 2014;289:23332-42 pubmed publisher
    ..In this study, we show that Dec1, a critical regulator of circadian rhythm, negatively regulates hepatic Srebp-1c expression...
  41. Kanda M, Yamanaka H, Kojo S, Usui Y, Honda H, Sotomaru Y, et al. Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-? production in iNKT cells. Proc Natl Acad Sci U S A. 2016;113:E3394-402 pubmed publisher
    ..Here, we report that basic helix-loop-helix transcription factor family, member e40 (Bhlhe40), is an important regulator for IFN-? production in iNKT cells...
  42. Noshiro M, Furukawa M, Honma S, Kawamoto T, Hamada T, Honma K, et al. Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice. J Biol Rhythms. 2005;20:404-18 pubmed
    b>DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the ..
  43. Ozaki N, Noshiro M, Kawamoto T, Nakashima A, Honda K, Fukuzaki Dohi U, et al. Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by ROR? and their roles in adipogenesis. Genes Cells. 2012;17:109-21 pubmed publisher
    b>DEC1 and DEC2, members of the basic helix-loop-helix superfamily, are involved in various biological phenomena including clock systems, cell differentiation and metabolism...
  44. Sun H, Mattei M, Taneja R. Assignment of stra13 to the sub-telomeric region of mouse chromosome 6 by in situ hybridization. Cytogenet Cell Genet. 1999;87:211-2 pubmed
  45. Dow L, Fisher J, O Rourke K, Muley A, Kastenhuber E, Livshits G, et al. Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol. 2015;33:390-394 pubmed publisher
    ..Further, we show that this inducible CRISPR (iCRISPR) system can be used effectively to create biallelic mutation in multiple target loci and, thus, provides a flexible and fast platform to study loss-of-function phenotypes in vivo. ..
  46. Bouillet P, Oulad Abdelghani M, Vicaire S, Garnier J, Schuhbaur B, Dolle P, et al. Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995;170:420-33 pubmed
    ..We also report the sequence and expression pattern in mouse embryos and adult tissues of one of these novel RA-inducible genes, Stra1, and show that it corresponds to the mouse ligand for the Cek5 receptor protein-tyrosine kinase. ..
  47. Hu J, Mao Z, He S, Zhan Y, Ning R, Liu W, et al. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3?/?-catenin integrated signaling pathway. Biochem Pharmacol. 2017;136:109-121 pubmed publisher
    ..We have also shown that dexamethasone (a glucocorticoid) suppressed and icariin induced DEC1, a structurally distinct helix-loop-helix protein...
  48. Noshiro M, Usui E, Kawamoto T, Sato F, Nakashima A, Ueshima T, et al. Liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression. Genes Cells. 2009;14:29-40 pubmed publisher
    DEC1 (BHLHB2/Stra13/Sharp2)-a basic helix-loop-helix transcription factor-is known to be involved in various biological phenomena including clock systems and metabolism...
  49. Fujita Y, Makishima M, Bhawal U. Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. Biochem Biophys Res Commun. 2016;469:477-82 pubmed publisher
    Human differentiated embryo chondrocyte expressed gene 1 (DEC1) is frequently used as a marker of senescence in vivo...
  50. Chung S, Kao C, Villarroya F, Chang H, Chang H, Hsiao S, et al. Bhlhe40 Represses PGC-1α Activity on Metabolic Gene Promoters in Myogenic Cells. Mol Cell Biol. 2015;35:2518-29 pubmed publisher
    ..Here we found that PGC-1α directly interacted with Bhlhe40, a basic helix-loop-helix (bHLH) transcriptional repressor induced by hypoxia, and protects SKM from ROS damage, ..
  51. Kreslavsky T, Vilagos B, Tagoh H, Poliakova D, Schwickert T, Wöhner M, et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017;18:442-455 pubmed publisher
    ..Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in controlling B-1a cell differentiation...
  52. Chambers D, Wilson L, Alfonsi F, Hunter E, Saxena U, Blanc E, et al. Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6 pubmed publisher
    ..These findings give the first genome-wide insight into the complexity of gene expression during patterning of the developing hindbrain. ..
  53. Park Y, Park H. Differentiated embryo chondrocyte 1 (DEC1) represses PPAR?2 gene through interacting with CCAAT/enhancer binding protein ? (C/EBP?). Mol Cells. 2012;33:575-81 pubmed publisher
    b>DEC1 is a transcription repressor that is induced by Hypoxia-Inducible Factor-?/? (HIF-?/?)...