Gene Symbol: Bgn
Description: biglycan
Alias: DSPG1, PG-S1, PGI, SLRR1A, biglycan, bone/cartilage proteoglycan I
Species: mouse
Products:     Bgn

Top Publications

  1. Hayashi Y, Liu C, Jester J, Hayashi M, Wang I, Funderburgh J, et al. Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-alpha signaling. Dev Biol. 2005;277:222-34 pubmed
    ..In this study, we showed that transgenic mice overexpressing biglycan under the keratocan promoter exhibited exposure keratitis and premature eye opening from noninfectious eyelid ..
  2. Inkson C, Ono M, Bi Y, Kuznetsov S, Fisher L, Young M. The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells. Cells Tissues Organs. 2009;189:153-7 pubmed publisher
    b>Biglycan (BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN...
  3. Amenta A, Yilmaz A, Bogdanovich S, McKechnie B, Abedi M, Khurana T, et al. Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice. Proc Natl Acad Sci U S A. 2011;108:762-7 pubmed publisher
    ..Here we show that the extracellular matrix protein biglycan regulates utrophin expression in immature muscle and that recombinant human biglycan (rhBGN) increases utrophin ..
  4. Babelova A, Moreth K, Tsalastra Greul W, Zeng Brouwers J, Eickelberg O, Young M, et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem. 2009;284:24035-48 pubmed publisher
    ..b>Biglycan, a ubiquitous leucine-rich repeat proteoglycan of the extracellular matrix, interacts with TLR2/4 on macrophages...
  5. Ward M, Ajuwon K. Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin. Cell Prolif. 2011;44:343-51 pubmed publisher
    ..Pre-adipocytes were seeded on plates coated with biglycan and decorin and were allowed to differentiate...
  6. Nielsen K, Allen M, Bloomfield S, Andersen T, Chen X, Poulsen H, et al. Biglycan deficiency interferes with ovariectomy-induced bone loss. J Bone Miner Res. 2003;18:2152-8 pubmed
    b>Biglycan is a matrix proteoglycan with a possible role in bone turnover...
  7. Chen X, Allen M, Bloomfield S, Xu T, Young M. Biglycan-deficient mice have delayed osteogenesis after marrow ablation. Calcif Tissue Int. 2003;72:577-82 pubmed
    b>Biglycan (bgn) is a small proteoglycan in skeletal tissue that binds and regulates collagen and TGF-beta activities...
  8. Chen X, Shi S, Xu T, Robey P, Young M. Age-related osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cells. J Bone Miner Res. 2002;17:331-40 pubmed
    b>Biglycan (bgn) is an extracellular matrix proteoglycan that is enriched in bone and other skeletal connective tissues. Previously, we generated bgn-deficient mice and showed that they developed age-dependent osteopenia...
  9. Bianco P, Fisher L, Young M, Termine J, Robey P. Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990;38:1549-63 pubmed
    The messenger RNAs and core proteins of the two small chondroitin/dermatan sulfate proteoglycans, biglycan and decorin, were localized in developing human bone and other tissues by both 35S-labeled RNA probes and antibodies directed ..

More Information


  1. Wallace J, Rajachar R, Chen X, Shi S, Allen M, Bloomfield S, et al. The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific. Bone. 2006;39:106-16 pubmed
    b>Biglycan (bgn) is a small leucine-rich proteoglycan (SLRP) enriched in the extracellular matrix of skeletal tissues...
  2. Chen X, Fisher L, Robey P, Young M. The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation. FASEB J. 2004;18:948-58 pubmed
    b>Biglycan (bgn) is a small leucine-rich proteoglycan enriched in extracellular matrices of skeletal tissues. Bgn-deficient mice develop age-related osteopenia with a phenotype that resembles osteoporosis and premature arthritis...
  3. Adapala V, Adedokun S, Considine R, Ajuwon K. Acute inflammation plays a limited role in the regulation of adipose tissue COL1A1 protein abundance. J Nutr Biochem. 2012;23:567-72 pubmed publisher
    ..induced by obesity and acute inflammation by lipopolysaccharide (LPS) challenge on ECM genes including biglycan (BGN), collagen 1A1 (COL1A1) and COL6A1, major ECM genes in adipose tissue...
  4. Lechner B, Lim J, Mercado M, Fallon J. Developmental regulation of biglycan expression in muscle and tendon. Muscle Nerve. 2006;34:347-55 pubmed
    b>Biglycan is an extracellular ligand for the dystrophin-associated protein complex (DAPC) that is upregulated in both dystrophic and regenerating muscle...
  5. Mercado M, Amenta A, Hagiwara H, Rafii M, Lechner B, Owens R, et al. Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS. FASEB J. 2006;20:1724-6 pubmed
    ..The constituents of the DAPC must be targeted to the sarcolemma in order to properly function. Biglycan is an ECM molecule that associates with the DAPC...
  6. Schaefer L, Babelova A, Kiss E, Hausser H, Baliova M, Krzyzankova M, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest. 2005;115:2223-33 pubmed
    b>Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its biological role has not been elucidated in detail...
  7. Corsi A, Xu T, Chen X, Boyde A, Liang J, Mankani M, et al. Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. J Bone Miner Res. 2002;17:1180-9 pubmed
    Decorin (dcn) and biglycan (bgn), two members of the family of small leucine-rich proteoglycans (SLRPs), are the predominant proteoglycans expressed in skin and bone, respectively...
  8. Ameye L, Aria D, Jepsen K, Oldberg A, Xu T, Young M. Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J. 2002;16:673-80 pubmed
    ..In vivo interactions of biglycan and fibromodulin, two SLRPs highly expressed in tendons and bones, were investigated by generating biglycan/..
  9. Bowe M, Mendis D, Fallon J. The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle. J Cell Biol. 2000;148:801-10 pubmed
    ..microsequencing to be the Torpedo ortholog of the small leucine-rich repeat chondroitin sulfate proteoglycan biglycan. Biglycan binding to alpha-dystroglycan was confirmed by coimmunoprecipitation with both native and recombinant ..
  10. Melchior Becker A, Dai G, Ding Z, Schäfer L, Schrader J, Young M, et al. Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J Biol Chem. 2011;286:17365-75 pubmed publisher
    ..The small leucine-rich proteoglycan (SLRP), biglycan (bgn), has been shown to be critically involved in these processes...
  11. Young M, Bi Y, Ameye L, Chen X. Biglycan knockout mice: new models for musculoskeletal diseases. Glycoconj J. 2002;19:257-62 pubmed
    b>Biglycan is a Class I Small Leucine Rich Proteoglycans (SLRP) that is localized on human chromosome Xq28-ter...
  12. Liu C, Aschbacher Smith L, Barthelery N, Dyment N, Butler D, Wylie C. Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon. Tissue Eng Part A. 2012;18:598-608 pubmed publisher
    ..We found that collagen I, fibromodulin, and tenomodulin were expressed throughout the tendon, whereas tenascin-C, biglycan, and cartilage oligomeric protein were concentrated in the insertion site during this period...
  13. Xu T, Bianco P, Fisher L, Longenecker G, Smith E, Goldstein S, et al. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 1998;20:78-82 pubmed
    ..b>Biglycan (encoded by the gene Bgn) is an ECM proteoglycan that is enriched in bone and other non-skeletal connective ..
  14. Frey H, Moreth K, Hsieh L, Zeng Brouwers J, Rathkolb B, Fuchs H, et al. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J. 2017;34:393-404 pubmed publisher
    ..In this study, we generated a novel transgenic mouse model, in which biglycan was constitutively overexpressed and secreted by hepatocytes (BGN Tg), thereby providing a constant ..
  15. Heegaard A, Corsi A, Danielsen C, Nielsen K, Jorgensen H, Riminucci M, et al. Biglycan deficiency causes spontaneous aortic dissection and rupture in mice. Circulation. 2007;115:2731-8 pubmed
    ..Analysis of pedigrees however has indicated that it may be also inherited as an X-linked trait. The biglycan gene, found on chromosome X in humans and mice, encodes a small leucine-rich proteoglycan involved in the ..
  16. Tasheva E, Ke A, Deng Y, Jun C, Takemoto L, Koester A, et al. Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004;10:403-16 pubmed
    ..Intriguingly, decreased gene expression was observed with two SLRP family members, biglycan and condroadherin, as well as with several stress-response proteins, including gammaA-crystallin, hemoglobin ..
  17. Chen H, Chen J, Yu S, Li H, Yang P, Su C, et al. Transcriptome analysis in blastocyst hatching by cDNA microarray. Hum Reprod. 2005;20:2492-501 pubmed
    ..E-cadherin, neuronal cell adhesion molecule (NCAM), lectin, galactose binding, soluble 7 (Lgals7), vanin 3 and biglycan], epigenetic regulators (Dnmt1, and SIN3 yeast homolog A), stress response regulators (heme oxygenase 1) and ..
  18. Henry S, Takanosu M, Boyd T, Mayne P, Eberspaecher H, Zhou W, et al. Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family. J Biol Chem. 2001;276:12212-21 pubmed
    ..The deduced amino acid sequence is about 50% identical (and 70% similar) to decorin and biglycan. However, asporin does not contain a serine/glycine dipeptide sequence required for the assembly of O-linked ..
  19. Rafii M, Hagiwara H, Mercado M, Seo N, Xu T, Dugan T, et al. Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. J Cell Physiol. 2006;209:439-47 pubmed
    ..Here we show that the small leucine-rich repeat (LRR) proteoglycan biglycan binds to alpha- and gamma-sarcoglycan as judged by ligand blot overlay and co-immunoprecipitation assays...
  20. Mammoto T, Mammoto A, Jiang A, Jiang E, Hashmi B, Ingber D. Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. Dev Dyn. 2015;244:713-23 pubmed publisher
  21. Chen S, Birk D. The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. FEBS J. 2013;280:2120-37 pubmed publisher
    ..SLRPs regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracellular matrix and cellular functions, with an impact on tissue function. ..
  22. Myren M, Kirby D, Noonan M, Maeda A, Owens R, Ricard Blum S, et al. Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin. Matrix Biol. 2016;52-54:141-150 pubmed publisher
    The small proteoglycan biglycan (Bgn) is highly expressed in the organic matrix of bone and plays a role in bone formation. Previous work implicated Bgn in vessel growth during bone healing [1]...
  23. Tang T, Thompson J, Wilson P, Yoder M, Mueller J, Fischer J, et al. Biglycan deficiency: increased aortic aneurysm formation and lack of atheroprotection. J Mol Cell Cardiol. 2014;75:174-80 pubmed publisher
    ..Prior studies have suggested a role for biglycan in aneurysms and in atherosclerosis...
  24. Wadhwa S, Embree M, Ameye L, Young M. Mice deficient in biglycan and fibromodulin as a model for temporomandibular joint osteoarthritis. Cells Tissues Organs. 2005;181:136-43 pubmed
    ..We present in greater detail one animal model that is deficient in two extracellular matrix (ECM) proteoglycans, biglycan (BGN) and fibromodulin (FMOD). Doubly deficient BGN/FMOD mice develop premature TMJ osteoarthritis (OA)...
  25. Ye Y, Hu W, Guo F, Zhang W, Wang J, Chen A. Glycosaminoglycan chains of biglycan promote bone morphogenetic protein-4-induced osteoblast differentiation. Int J Mol Med. 2012;30:1075-80 pubmed publisher
    b>Biglycan (BGN) has been reported to promote bone morphogenetic protein-4 (BMP-4) stimulated osteoblastic differentiation. However, the underlying mechanism has yet to be fully elucidated...
  26. Ye L, Macdougall M, Zhang S, Xie Y, Zhang J, Li Z, et al. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004;279:19141-8 pubmed
    ..Taken together, these studies suggest that DMP-1 is essential for later dentinogenesis during postnatal development. ..
  27. Wu Z, Aron A, Macksoud E, Iozzo R, Hai C, Lechner B. Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. PLoS ONE. 2012;7:e29627 pubmed publisher
    ..Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of reproductive ..
  28. Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, et al. Biglycan is required for adaptive remodeling after myocardial infarction. Circulation. 2008;117:1269-76 pubmed publisher
    ..The present study investigates the role of the small leucine-rich proteoglycan biglycan during cardiac extracellular matrix remodeling and cardiac hemodynamics after MI...
  29. Goetsch S, Hawke T, Gallardo T, Richardson J, Garry D. Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration. Physiol Genomics. 2003;14:261-71 pubmed
    ..6 and 7], the fetal myogenic program (Myod1, Myf5, Myf6), and the biomatrix (procollagen genes, Mmp3, Mmp9, biglycan, periostin) during muscle regeneration...
  30. Nikdin H, Olsson M, Hultenby K, Sugars R. Osteoadherin accumulates in the predentin towards the mineralization front in the developing tooth. PLoS ONE. 2012;7:e31525 pubmed publisher
    ..of OSAD in the developing mouse tooth using immunohistochemistry and compared its expression with other SLRPs, biglycan (BGN), decorin (DCN) and fibromodulin (FMD)...
  31. Dunkman A, Buckley M, Mienaltowski M, Adams S, Thomas S, Satchell L, et al. Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol. 2013;32:3-13 pubmed publisher
    ..In addition, the roles of decorin and biglycan in the aging process were analyzed using transgenic mice at both mature and aged time points...
  32. Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B. Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol. 2014;35:266-75 pubmed publisher
    ..Notably, a subtype of Ehlers-Danlos Syndrome is caused by expression of abnormal biglycan and decorin proteoglycans...
  33. Bi Y, Nielsen K, Kilts T, Yoon A, A Karsdal M, Wimer H, et al. Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts. Bone. 2006;38:778-86 pubmed
    ..We have previously shown that the extracellular matrix protein, biglycan (Bgn), plays an important role in the differentiation of osteoblast precursors...
  34. Moreth K, Brodbeck R, Babelova A, Gretz N, Spieker T, Zeng Brouwers J, et al. The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest. 2010;120:4251-72 pubmed publisher
    ..Here, we have shown that the proteoglycan biglycan triggers CXCL13 expression via TLR2/4 in macrophages and dendritic cells...
  35. Frey H, Schroeder N, Manon Jensen T, Iozzo R, Schaefer L. Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J. 2013;280:2165-79 pubmed publisher
    ..In this review, we critically assess the signaling events induced by the proteoglycans biglycan, decorin, lumican and versican as well as hyaluronan during inflammation...
  36. Wegrowski Y, Pillarisetti J, Danielson K, Suzuki S, Iozzo R. The murine biglycan: complete cDNA cloning, genomic organization, promoter function, and expression. Genomics. 1995;30:8-17 pubmed
    b>Biglycan is a ubiquitous chondroitin/dermatan sulfate proteoglycan that belongs to a growing family of proteins harboring leucine-rich repeats...
  37. Zhang G, Chen S, Goldoni S, Calder B, Simpson H, Owens R, et al. Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem. 2009;284:8888-97 pubmed publisher
    Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in regulation of collagen fibril and matrix assembly...
  38. Robinson K, Sun M, Barnum C, Weiss S, Huegel J, Shetye S, et al. Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol. 2017;64:81-93 pubmed publisher
    The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of decorin and biglycan in tendon homeostasis...
  39. Raefski A, Carone B, Kaur A, Krueger W, O Neill M. Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice. J Mol Neurosci. 2007;32:111-9 pubmed
    ..In silico pathway analysis of both X-linked and autosomal mis-regulated genes suggests that modulation of Wnt signaling is a critical factor in the normal growth and development of the amygdala. ..
  40. Heegaard A, Gehron Robey P, Vogel W, Just W, Widom R, Schøller J, et al. Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox. J Bone Miner Res. 1997;12:2050-60 pubmed
    The transcriptional regulation of human biglycan expression under normal and pathological conditions was studied. The 5'-flanking regions of the human and mouse genes were isolated and analyzed; the two promoter regions share 81% identity...
  41. Ross M, Bruggeman L, Hanss B, Sunamoto M, Marras D, Klotman M, et al. Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. J Biol Chem. 2003;278:33248-55 pubmed
    ..Thus, podocan defines a new class within the SLR protein family and is a previously unrecognized component of the sclerotic glomerular lesion that develops in the course of experimental HIVAN. ..
  42. Hsieh L, Frey H, Nastase M, Tredup C, Hoffmann A, Poluzzi C, et al. Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol. 2016;49:61-81 pubmed publisher
    b>Biglycan, a ubiquitous proteoglycan, acts as a danger signal when released from the extracellular matrix...
  43. Zvackova I, Matalova E, Lesot H. Regulators of Collagen Fibrillogenesis during Molar Development in the Mouse. Front Physiol. 2017;8:554 pubmed publisher
    ..The patterns of decorin, biglycan, and fibromodulin, all members of the SLRPs family and interacting with collagens XIIa and XIVa, were ..
  44. Calmus M, Macksoud E, Tucker R, Iozzo R, Lechner B. A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin. Reproduction. 2011;142:183-94 pubmed publisher
    ..In particular, an EDS variant is caused by a genetic mutation resulting in abnormal secretion of biglycan and decorin, two small leucine-rich proteoglycans highly expressed in reproductive tissues...
  45. Wen X, Zou Y, Luo W, Goldberg M, Moats R, Conti P, et al. Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec (Hoboken). 2008;291:1246-53 pubmed publisher
    Previously, it was shown that the volume of forming enamel of molar teeth in biglycan-null mice was greater than that in genetically matched wild-type mice...
  46. Kiel M, Radice G, Morrison S. Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell. 2007;1:204-17 pubmed publisher
    ..Only N-cadherin-negative bone marrow cells exhibited HSC activity in irradiated mice. Finally, biglycan-deficient mice had significant reductions in trabecular bone and osteoblasts but showed no defects in ..
  47. Scott I, Imamura Y, Pappano W, Troedel J, Recklies A, Roughley P, et al. Bone morphogenetic protein-1 processes probiglycan. J Biol Chem. 2000;275:30504-11 pubmed
    ..b>Biglycan, a small leucine-rich proteoglycan, is a nonfibrillar extracellular matrix component with functions that include ..
  48. Dupuis L, McCulloch D, McGarity J, Bahan A, Wessels A, Weber D, et al. Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol. 2011;357:152-64 pubmed publisher
  49. Wadhwa S, Bi Y, Ortiz A, Embree M, Kilts T, Iozzo R, et al. Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice. Bone. 2007;40:861-6 pubmed
    b>Biglycan (Bgn) and decorin (Dcn) are highly expressed in numerous tissues in the craniofacial complex. However, their expression and function in the cranial sutures are unknown...
  50. Chen S, Young M, Chakravarti S, Birk D. Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly. Matrix Biol. 2014;35:103-11 pubmed publisher
    The corneal stroma is enriched in small leucine-rich proteoglycans (SLRPs), including both class I (decorin and biglycan) and class II (lumican, keratocan and fibromodulin)...
  51. Chatterjee A, Faust C, Herman G. Genetic and physical mapping of the biglycan gene on the mouse X chromosome. Mamm Genome. 1993;4:33-6 pubmed
    A human cDNA for biglycan (BGN) has recently been mapped to proximal Xq28...
  52. Bischof A, Yuksel D, Mammoto T, Mammoto A, Krause S, Ingber D. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integr Biol (Camb). 2013;5:1045-56 pubmed publisher
    ..Analysis of two of these molecules previously implicated in cancer regulation--biglycan and tenascin C--revealed that addition of biglyan can mimic the tumor normalization response, and that siRNA ..
  53. Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy Ordonez E, et al. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol. 2016;101:145-155 pubmed publisher
    b>Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role in stabilizing fibrotic scars after experimental myocardial infarction...
  54. Berendsen A, Fisher L, Kilts T, Owens R, Robey P, Gutkind J, et al. Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A. 2011;108:17022-7 pubmed publisher
    ..In the present study, we show that a member of the small leucine-rich proteoglycan family, biglycan, enhances canonical Wnt signaling by mediating Wnt function via its core protein...
  55. Levin M, Chatterjee A, Pragliola A, Worley K, Wehnert M, Zhuchenko O, et al. A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28. Genome Res. 1996;6:465-77 pubmed
  56. Embree M, Kilts T, Ono M, Inkson C, Syed Picard F, Karsdal M, et al. Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis. Am J Pathol. 2010;176:812-26 pubmed publisher
    ..we used a genetic mouse model of temporomandibular joint osteoarthritis that is deficient in two ECM proteins, biglycan and fibromodulin (Bgn(-/0)Fmod(-/-))...
  57. Liu C, Breidenbach A, Aschbacher Smith L, Butler D, Wylie C. A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse. PLoS ONE. 2013;8:e65411 pubmed publisher
    ..These studies provide new insights into the role of Hh signaling during tendon development. ..
  58. Shintani S, Sato A, Toyosawa S, O hUigin C, Klein J. Biglycan-like extracellular matrix genes of agnathans and teleosts. J Mol Evol. 2000;51:363-73 pubmed publisher
    b>Biglycan and decorin are two members of a family of small extracellular matrix proteoglycans characterized by the presence of 10 leucine-rich repeats and one or two attachment sites for glucosaminoglycans...
  59. Säämänen A, Salminen H, Rantakokko A, Heinegard D, Vuorio E. Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint. Biochem J. 2001;355:577-85 pubmed
    ..As fibromodulin is deposited closer to cells than decorin, it may have a primary role in collagen fibrillogenesis, whereas decorin might be involved in the maintenance of fibril structures in the interterritorial matrix. ..
  60. Vrljicak P, Cullum R, Xu E, Chang A, Wederell E, Bilenky M, et al. Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. PLoS ONE. 2012;7:e40815 pubmed publisher
    ..Our findings support a role for TWIST1 in the differentiation of AVC mesenchyme post-EMT in the mouse, and suggest that TWIST1 can exert its function by direct DNA binding to activate valve specific gene expression. ..
  61. Amenta A, Creely H, Mercado M, Hagiwara H, McKechnie B, Lechner B, et al. Biglycan is an extracellular MuSK binding protein important for synapse stability. J Neurosci. 2012;32:2324-34 pubmed publisher
    ..Here we examine a novel role for the extracellular matrix protein biglycan in synapse stability...
  62. Chen X, Bian X, Teslovich T, Stephan D, Young M. Dissection of the sets of genes that control the behavior of biglycan-deficient pre-osteoblasts using oligonucleotide microarrays. Bone. 2005;37:192-203 pubmed
    b>Biglycan (bgn) is a small leucine-rich proteoglycan (SLPR) that is enriched in the extracellular matrix of skeletal tissues. Bgn-deficient mice develop age-related osteopenia with a phenotype that resembles osteoporosis...
  63. Coram R, Stillwagon S, Guggilam A, Jenkins M, Swanson M, Ladd A. Muscleblind-like 1 is required for normal heart valve development in vivo. BMC Dev Biol. 2015;15:36 pubmed publisher
    ..Together, these data indicate that MBNL1 plays a conserved role in negatively regulating TGFβ signaling, and is required for normal valve morphogenesis and homeostasis in vivo. ..
  64. Chatterjee A, Faust C, Molinari Storey L, Kiochis P, Poustka A, Herman G. A 2.3-Mb yeast artificial chromosome contig spanning from Gabra3 to G6pd on the mouse X chromosome. Genomics. 1994;21:49-57 pubmed
    ..This contig represents the largest one assembled to date in the mouse. It should facilitate the isolation of genes in the region and may aid in the completion of a physical contig for the homologous human region, Xq28. ..
  65. Dourte L, Pathmanathan L, Mienaltowski M, Jawad A, Birk D, Soslowsky L. Mechanical, compositional, and structural properties of the mouse patellar tendon with changes in biglycan gene expression. J Orthop Res. 2013;31:1430-7 pubmed publisher
    ..In this study, biglycan gene expression was varied in a dose dependent manner using biglycan null, biglycan heterozygote and wild type ..
  66. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..Also, decorin and biglycan were doubled in Aspn-/- skin...
  67. Berendsen A, Pinnow E, Maeda A, Brown A, McCartney Francis N, Kram V, et al. Biglycan modulates angiogenesis and bone formation during fracture healing. Matrix Biol. 2014;35:223-31 pubmed publisher
    Matrix proteoglycans such as biglycan (Bgn) dominate skeletal tissue and yet its exact role in regulating bone function is still unclear. In this paper we describe the potential role of (Bgn) in the fracture healing process...
  68. Haruyama N, Sreenath T, Suzuki S, Yao X, Wang Z, Wang Y, et al. Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol. 2009;28:129-36 pubmed publisher
    ..Using DSPP/biglycan (Dspp(-/-)Bgn(-/0)) and DSPP/decorin (Dspp(-/-)Dcn(-/-)) double knockout mice, here we determined that the ..
  69. de Miranda de Araujo L, Horgan C, Aron A, Iozzo R, Lechner B. Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. Mol Reprod Dev. 2015;82:387-96 pubmed publisher
    ..Abnormal expression of biglycan and decorin, two extracellular matrix proteoglycans, leads to preterm birth and aberrant fetal membrane ..
  70. Nuka S, Zhou W, Henry S, Gendron C, Schultz J, Shinomura T, et al. Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage. 2010;18:88-96 pubmed publisher
    ..Epn-deficient mice were generated by disrupting the Epn gene in mouse embryonic stem cells. Epn/biglycan (Bgn) double-deficient mice were produced by crossing Epn-deficient mice with Bgn-deficient mice...
  71. Rau W, Just W, Vetter U, Vogel W. A dinucleotide repeat in the mouse biglycan gene (EST) on the X chromosome. Mamm Genome. 1994;5:395-6 pubmed
  72. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016;7:12503 pubmed publisher
    ..Mesenchymal stem cells overexpressing Mkx promote functional AF regeneration in a mouse AF defect model, with abundant collagen fibril formation. Our results indicate a therapeutic strategy for AF regeneration. ..
  73. Moreth K, Frey H, Hubo M, Zeng Brouwers J, Nastase M, Hsieh L, et al. Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol. 2014;35:143-51 pubmed publisher
    ..Here we show that production of soluble biglycan, a small leucine-rich proteoglycan, is induced during reperfusion and that it functions as endogenous agonist of ..
  74. Ameye L, Young M. Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases. Glycobiology. 2002;12:107R-16R pubmed
    ..their functions in vivo, mice deficient in one or two of the four most prominent and widely expressed SLRPs (biglycan, decorin, fibromodulin, and lumican) were recently generated...
  75. Furukawa T, Ito K, Nuka S, Hashimoto J, Takei H, Takahara M, et al. Absence of biglycan accelerates the degenerative process in mouse intervertebral disc. Spine (Phila Pa 1976). 2009;34:E911-7 pubmed publisher
    A study of the histologic changes of the intervertebral discs (IVDs) in biglycan (Bgn)-deficient mice. In this study, we investigate whether the absence of Bgn accelerates the degenerative process in mouse intervertebral disc (IVD)...
  76. Dunkman A, Buckley M, Mienaltowski M, Adams S, Thomas S, Kumar A, et al. The injury response of aged tendons in the absence of biglycan and decorin. Matrix Biol. 2014;35:232-8 pubmed publisher
    Recent studies have demonstrated that the small leucine-rich proteoglycans (SLRPs) biglycan and decorin impact tendon development, aging and healing in mature mice...