beta catenin

Summary

Gene Symbol: beta catenin
Description: catenin (cadherin associated protein), beta 1
Alias: Bfc, Catnb, Mesc, beta-catenin, catenin beta-1
Species: mouse

Top Publications

  1. ncbi Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
  2. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
  3. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
  4. pmc Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice
    Tamara Grigoryan
    Max Delbück Center for Molecular Medicine, 13125 Berlin, Germany
    Genes Dev 22:2308-41. 2008
  5. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
  6. ncbi beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    Dietmar Zechner
    Max Delbrück Center of Molecular Medicine, Robert Rossle Str 10, 13125, Berlin, Germany
    Dev Biol 258:406-18. 2003
  7. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
  8. pmc Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 12:528-41. 2007
  9. doi LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain
    Marta B Wisniewska
    International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    J Neurosci 30:4957-69. 2010
  10. ncbi Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development
    Joo Seop Park
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:2533-9. 2007

Detail Information

Publications174 found, 100 shown here

  1. ncbi Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    Timothy F Day
    Geneti Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 8:739-50. 2005
    ..Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification...
  2. ncbi Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
    V Brault
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 128:1253-64. 2001
    ..Our results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development...
  3. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  4. pmc Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice
    Tamara Grigoryan
    Max Delbück Center for Molecular Medicine, 13125 Berlin, Germany
    Genes Dev 22:2308-41. 2008
    ..Our review summarizes what has been learned from genetic studies of the Wnt pathway by the analysis of conditional beta-catenin loss- and gain-of-function mice...
  5. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  6. ncbi beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
    Dietmar Zechner
    Max Delbrück Center of Molecular Medicine, Robert Rossle Str 10, 13125, Berlin, Germany
    Dev Biol 258:406-18. 2003
    ..beta-Catenin signals are thus essential for the maintenance of proliferation of neuronal progenitors, controlling the size of the progenitor pool, and impinging on the decision of neuronal progenitors to proliferate or to differentiate...
  7. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  8. pmc Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 12:528-41. 2007
    ..These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system...
  9. doi LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain
    Marta B Wisniewska
    International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    J Neurosci 30:4957-69. 2010
    ..We propose that beta-catenin contributes to neuronal excitability not only by a local action at the synapse but also by activating gene expression in thalamic neurons...
  10. ncbi Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development
    Joo Seop Park
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:2533-9. 2007
    ..However, the failure of induced mesenchyme with high levels of beta-catenin activity to form epithelial structures suggests that modulating canonical signaling may be crucial for the cellular transition to the renal vesicle...
  11. pmc Wnt signaling regulates pancreatic beta cell proliferation
    Ingrid C Rulifson
    Department of Developmental Biology, Oncology Division, Stanford University, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 104:6247-52. 2007
    ..Thus, Wnt signaling is both necessary and sufficient for islet beta cell proliferation, and our study provides previously unrecognized evidence of a mechanism governing endocrine pancreas growth and function...
  12. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  13. pmc Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    Tea Fevr
    Ecole Polytechnique Federale de Lausanne, ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Mol Cell Biol 27:7551-9. 2007
    ..This challenges attempts to target aberrant Wnt signaling as a new therapeutic strategy to treat colorectal cancer...
  14. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  15. ncbi Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    Anjen Chenn
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 297:365-9. 2002
    ....
  16. pmc Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:2949-55. 2008
    ..The identification of beta-catenin as a key pro-ovarian and anti-testis signaling molecule will further our understanding of the mechanisms controlling sex determination and the molecular mechanisms that lead to sex-reversal...
  17. pmc Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
    Courtney M Karner
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Genet 41:793-9. 2009
    ..Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes...
  18. pmc Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression
    Peter Westenskow
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 136:2505-10. 2009
    ....
  19. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  20. pmc Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors
    Silvia Maretto
    Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 100:3299-304. 2003
    ..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
  21. ncbi Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
    Mattias Backman
    Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, University of Oslo, The National Hospital, 0027 Oslo, Norway
    Dev Biol 279:155-68. 2005
    ..Thus, our data suggest that canonical Wnt signals are involved in maintaining the identity of the pallium by controlling expression of dorsal markers and by suppressing ventral programs from being activated in pallial progenitor cells...
  22. ncbi Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo
    Othman A Mohamed
    Department of Biology, McGill University Health Center, Royal Victoria Hospital, Montreal, QC, Canada
    Dev Dyn 231:416-24. 2004
    ....
  23. ncbi Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    Hongliang Hu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:49-60. 2005
    ..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development...
  24. ncbi Desmoplakin is essential in epidermal sheet formation
    V Vasioukhin
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Cell Biol 3:1076-85. 2001
    ..DP is therefore required for assembly of functional desmosomes, maintaining cytoskeletal architecture and reinforcing membrane attachments essential for stable intercellular adhesion...
  25. doi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...
  26. ncbi Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis
    Kameswaran Surendran
    Department of Pediatrics, Washington University School of Medicine, 5th Floor MPRB, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Am Soc Nephrol 16:2373-84. 2005
    ....
  27. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
  28. ncbi Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
    Gregoire Jeannet
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Lausanne, Switzerland
    Blood 111:142-9. 2008
    ..These data provide the first evidence that hematopoietic cells can transduce canonical Wnt signals in the combined absence of beta- and gamma-catenin...
  29. ncbi Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing
    Sophia S Cheon
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Exp Cell Res 293:267-74. 2004
    ....
  30. pmc Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
    Monica Cobas
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Exp Med 199:221-9. 2004
    ..In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis...
  31. ncbi Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells
    Yukinari Takao
    Department of Stem Cell Biology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    Biochem Biophys Res Commun 353:699-705. 2007
    ..These results suggest that up-regulating Nanog through interaction with Oct-3/4 involves beta-catenin in the LIF- and Wnt-mediated maintenance of ES cell self-renewal...
  32. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  33. pmc Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo
    Michael Buchert
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
    PLoS Genet 6:e1000816. 2010
    ..Together, the present genotype-phenotype analysis suggests tissue-specific response levels for the Wnt/beta-catenin pathway that regulate both physiological and pathophysiological conditions...
  34. ncbi Essential role of beta-catenin in postnatal bone acquisition
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:21162-8. 2005
    ..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts...
  35. pmc Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Mol Cell Biol 25:9063-72. 2005
    ..These results indicate that PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated...
  36. ncbi Lack of beta-catenin affects mouse development at gastrulation
    H Haegel
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 121:3529-37. 1995
    ..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer...
  37. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
    ..Thus, our results indicate that FGF10 plays a pivotal role in maintaining epithelial progenitor cell proliferation as well as coordinating alveolar smooth muscle cell formation and vascular development...
  38. pmc A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition
    Sara Howard
    MRC National Institute for Medical Research, London, United Kingdom
    PLoS ONE 6:e23899. 2011
    ..Lastly we present data suggesting that cadherins are required for augmented activation of the Wnt/β-catenin pathway in vivo. This suggests that cadherins play a crucial role in β-catenin-dependent transcription...
  39. ncbi Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin
    A Cadoret
    Institut Cochin de Génétique Moléculaire INSERM U129, 75014 Paris, France
    Cancer Res 61:3245-9. 2001
    ..Thus, the key target genes of the beta-catenin signaling pathway in the liver remain to be identified...
  40. doi Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
    Tamara Holowacz
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
    Eur J Neurosci 33:1366-75. 2011
    ..These data reveal that β-catenin is not required for the maintenance or differentiation of NSCs, but is required for the adhesion and survival of neural progenitor cells...
  41. pmc beta-Catenin has sequential roles in the survival and specification of ventral dermis
    Jennifer Ohtola
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 135:2321-9. 2008
    ..Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles of beta-catenin/Wnt signaling in dermal development...
  42. doi Lack of beta-catenin in early life induces abnormal glucose homeostasis in mice
    S Dabernat
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Diabetologia 52:1608-17. 2009
    ..However, little is known about the involvement of beta-catenin in the endocrine or exocrine function of the mature pancreas. We report for the first time the impact of beta-catenin deletion in the pancreatic beta cells...
  43. pmc Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex
    R M Kypta
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    J Cell Biol 134:1519-29. 1996
    ..We propose that changes in tyrosine phosphorylation of beta-catenin mediated by TrkA and LAR-PTPs control cadherin adhesive function during processes such as neurite outgrowth...
  44. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    ..Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth...
  45. pmc The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
    Laura L Yates
    Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 19:2251-67. 2010
    ....
  46. pmc Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver
    Xinping Tan
    Department of Pathology, University of Pittsburgh, School of Medicine, Pennsylvania 15261, USA
    Gastroenterology 129:285-302. 2005
    ..Wnt/beta-catenin activation is observed in normal liver development, regeneration, and liver cancer. Our aim was to elucidate the regulation and mechanism of this pathway in liver...
  47. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    ..Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina...
  48. ncbi Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development
    Jessica Dessimoz
    Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Case Postale, CH 1066 Epalinges s Lausanne, Switzerland
    Curr Biol 15:1677-83. 2005
    ..These effects are likely to be due to the function of beta-catenin at the membrane. Mice later recover from pancreatitis and regenerate normal pancreas and duodenal villi from the wild-type (wt) cells that escape beta-catenin deletion...
  49. pmc Beta-catenin interacts with MyoD and regulates its transcription activity
    Chang Hoon Kim
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th St, CB2803, Augusta, GA 30912, USA
    Mol Cell Biol 28:2941-51. 2008
    ..These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway...
  50. pmc β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..Taken together these data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition...
  51. pmc Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype
    Lorenza Ciani
    Departments of Medical Genetics and Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Cell Biol 23:3575-82. 2003
    ..Our results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development...
  52. pmc COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis
    Masashi Okamura
    Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4 6 1, Komaba, Meguro ku, Tokyo 153 8904, Japan
    Proc Natl Acad Sci U S A 106:5819-24. 2009
    ..Our experiments define the COUP-TFII/SMRT complex as a previously unappreciated component of the linear pathway that directly links Wnt/beta-catenin signaling to repression of PPARgamma gene expression and the inhibition of adipogenesis...
  53. pmc Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    Ethan David Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2538-49. 2009
    ..Together, these data define a Wnt/Tnc/Pdgfr signaling axis that is critical for smooth muscle development and disease progression in the lung...
  54. pmc Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
    Frauke Drees
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 123:903-15. 2005
    ..These results indicate a new role for alpha-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion...
  55. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  56. ncbi Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells
    Hye Youn Lee
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 303:1020-3. 2004
    ..Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a beta-catenin-dependent manner. Thus, the role of Wnt/beta-catenin in stem cells is cell-type dependent...
  57. pmc Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development
    Susan M Kiefer
    John Cochran Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Development 137:3099-106. 2010
    ..These studies indicate that Sall1-dependent signals from the metanephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate branching...
  58. ncbi Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells
    Helen Petropoulos
    Department of Biochemistry, Medical Sciences Building, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 277:15393-9. 2002
    ..Therefore, Wnt signaling, acting via beta-catenin, is necessary and sufficient for skeletal myogenesis in P19 cells...
  59. pmc The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599
    J Cell Biol 118:681-91. 1992
    ..The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed...
  60. pmc Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development
    Courtney M Karner
    Department of Internal Medicine Nephrology and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA
    Development 138:1247-57. 2011
    ..These findings provide novel insights into the molecular mechanisms that regulate progenitor cell differentiation during normal and pathological conditions...
  61. pmc Beta-catenin levels influence rapid mechanical responses in osteoblasts
    Natasha Case
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 283:29196-205. 2008
    ..Thus, beta-catenin serves as both a modulator and effector of mechanical signals in bone cells...
  62. ncbi ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 10:573-84. 2002
    ..The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers...
  63. doi The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine
    Elsa Kress
    Universite de Lyon, Universite Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, INRA, CNRS, Institut de Génomique Fonctionnelle de Lyon, 69364 Lyon, France
    J Biol Chem 284:1234-41. 2009
    ..Moreover, we describe in this study a novel mechanism of action of sFRP2, responsible for the activation of beta-catenin signaling...
  64. pmc beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
    Takashi Okuda
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:13479-84. 2007
    ..Collectively, these findings suggest that the cadherin-beta-catenin complex is an integral component of synaptic strength regulation and plays a basic role in coupling synapse function and spine morphology...
  65. ncbi Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region
    Markus Panhuysen
    Institute of Developmental Genetics, GSF Research Center for Environment and Health, 85764 Neuherberg, Germany
    Mol Cell Neurosci 26:101-11. 2004
    ..We suggest that Wnt1 acts as a regulator of proliferation of specific precursor populations in the developing mid-/hindbrain region and is only secondarily involved in maintenance of the mid-/hindbrain organizer...
  66. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  67. ncbi Maternal beta-catenin and E-cadherin in mouse development
    Wilhelmine N de Vries
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Development 131:4435-45. 2004
    ..This developmental deficit is alleviated by the simultaneous absence of maternal E-cadherin, suggesting that E-cadherin regulates nuclear beta-catenin availability during embryonic genome activation...
  68. doi Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    Ilaria Malanchi
    Ecole Polytechnique Fédérale de Lausanne ISREC Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 452:650-3. 2008
    ..Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas...
  69. pmc Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ....
  70. pmc β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
    Kevin F Kelly
    Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada
    Cell Stem Cell 8:214-27. 2011
    ..Collectively, our data suggest previously underappreciated, divergent TCF-dependent and TCF-independent roles for β-catenin in ESCs...
  71. pmc The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 61:42-56. 2009
    ..Thus, APC is an essential regulator of radial glial polarity and is critical for the construction of cerebral cortex in mammals...
  72. ncbi Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development
    Dirk Junghans
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 233:528-39. 2005
    ..In summary, we demonstrate that beta-catenin mediates cell-cell adhesion in the early telencephalon and is vital for maintaining the structural integrity of the neuroepithelium...
  73. doi Defining the function of beta-catenin tyrosine phosphorylation in cadherin-mediated cell-cell adhesion
    Junji Tominaga
    Division of Cellular Interactions, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Genes Cells 13:67-77. 2008
    ..We also demonstrate that tyrosine phosphorylation of beta-catenin might regulate cadherin-mediated cell adhesion in a more complicated way than previously expected...
  74. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..Our findings demonstrate that beta-catenin signaling regulates proliferation and survival of cardiac progenitors...
  75. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  76. pmc Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons
    Mianzhi Tang
    VA Medical Center and Department of Pathology, University of California San Francisco, San Francisco, CA 94121, USA
    Development 136:2027-38. 2009
    ..They also suggest that beta-catenin-mediated signaling pathways can be targeted to promote and expand DA neurons in cell-based therapeutic strategies...
  77. ncbi The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression
    Tohru Kimura
    Department of Pathology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 300:545-53. 2006
    ..Our results show that the suppression of Wnt/beta-catenin signaling is a prerequisite for the normal development of PGCs...
  78. doi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..Together, these data demonstrate that beta-catenin performs essential functions during renal branching morphogenesis via control of a hierarchy of genes that control ureteric branching...
  79. ncbi alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion
    B Janssens
    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology VIB Ghent University, B 9000 Ghent, Belgium
    J Cell Sci 114:3177-88. 2001
    ..We propose that alphaT-catenin is necessary for the formation of stretch-resistant cell-cell adhesion complexes, in particular, muscle cells...
  80. ncbi Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells
    Yoshitaka Fukunaga
    Division of Cellular Interactions, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Cell Struct Funct 30:25-34. 2005
    ..Moreover it was suggested that beta-catenin or plakoglobin is required not only for the cell adhesion activity but also for the stable expression and cell surface localization of E-cadherin...
  81. doi Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction
    Pauliina M Munne
    Developmental Biology Program, Institute of Biotechnology, PO Box 56, University of Helsinki, FIN 00014, Helsinki, Finland
    Development 136:393-402. 2009
    ..Considering the role of mesenchyme in tooth induction and the design of tissue engineering protocols, our work may have uncovered how delicate control of tissue quantities alone influences the outcome between induction and inhibition...
  82. pmc Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 123:1352-62. 2010
    ..Thus, Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability...
  83. doi Beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos
    Andreas Hierholzer
    Max Planck Institute of Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    Dev Dyn 239:191-9. 2010
    ..We found that beta-catenin is required for the correct localization of N-cadherin at the membrane of neural ectodermal cells and that its absence causes a disintegration of the neural tube...
  84. pmc Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2
    Bo Gao
    National Human Genome Research Institute, Bethesda, MD 20892, USA
    Dev Cell 20:163-76. 2011
    ..Our studies have provided new insight to Robinow syndrome, Brachydactyly Type B1, and spinal bifida which are caused by mutations in human ROR2, WNT5A, or VANGL...
  85. ncbi Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling
    M Herzig
    Research Institute of Molecular Pathology, Vienna, Austria
    Oncogene 26:2290-8. 2007
    ..Together, the data indicate that signals other than beta-catenin/Tcf-mediated Wnt signaling are induced by the loss of E-cadherin during tumor progression in Rip1Tag2 transgenic mice...
  86. ncbi Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
    Brian Bierie
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 22:3875-87. 2003
    ..This suggests that the transdifferentiation into squamous metaplasias is an early response of endoderm-derived cells to beta-catenin, and that the development of intra-acinous hyperplasias or neoplastic foci is a later event...
  87. ncbi Biochemical interactions in the wnt pathway
    M J Seidensticker
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122, Berlin, Germany
    Biochim Biophys Acta 1495:168-82. 2000
    ..This review discusses the mechanisms that silence the pathway in cells that do not receive a wnt signal and goes on to describe the regulatory steps involved in the activation of the pathway...
  88. pmc Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis
    I Ahmad
    Department of Uro Oncology, The Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland
    Cell Death Dis 2:e124. 2011
    ..Taken together these data definitively show Ras pathway activation strongly cooperates with Wnt signalling to drive UCC in vivo...
  89. ncbi Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes
    Jibin Zhou
    Cardiovascular Research Institute, South Dakota Health Research Foundation, 1100 East 21st St, Suite 700, Sioux Falls, SD 57105, USA
    Am J Physiol Heart Circ Physiol 292:H270-6. 2007
    ..The results suggest that upregulation of gamma-catenin can compensate for the loss of beta-catenin in cardiomyocytes to maintain normal cardiac structure and function...
  90. pmc MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors
    Brigitte Teissedre
    Departments of Cell Biology and Dermatology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 4:e4537. 2009
    ..They further suggest that Hedgehog pathway activation maybe a critical component and useful indicator of breast tumors arising from unopposed Wnt1 ligand...
  91. pmc H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes
    J Espada
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Cell Biol 146:967-80. 1999
    ..These results indicate that H-Ras activation induces the relocalization and cytoplasmic stabilization of beta-catenin by a mechanism involving its interaction with PI3K...
  92. doi Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma
    Cassandra R Diegel
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49504, USA
    Cancer Res 70:9143-52. 2010
    ..Because rapamycin analogues are approved for treating other types of human malignancies, our findings suggest that rapamycin therapy should be evaluated for treating patients with salivary gland acinic cell carcinoma...
  93. ncbi beta-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
    Horst Posthaus
    Institute of Animal Pathology, University of Bern, Länggassstr 122, 3012 Bern, Switzerland
    J Cell Sci 115:4587-95. 2002
    ..Taken together, our results demonstrate that epidermal proliferation and adhesion are independent of beta-catenin...
  94. ncbi Expression and cell membrane localization of catenins during mouse preimplantation development
    M Ohsugi
    Max Planck Institut fur Immunbiologie, Freiburg, Federal Republic of Germany
    Dev Dyn 206:391-402. 1996
    ....
  95. pmc beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells
    Michael J Nemeth
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 4442, USA
    Stem Cells 27:1109-19. 2009
    ..From these data, we propose a model in which beta-catenin in the microenvironment is required noncell autonomously for long-term maintenance of hematopoietic progenitors...
  96. ncbi Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells
    Roman Anton
    Institute for Biochemistry and Molecular Biology, Ulm University, D 89069 Ulm, Germany
    FEBS Lett 581:5247-54. 2007
    ..During differentiation, activation of the Wnt/beta-catenin pathway influences formation of mesoderm and cardiomyocytes in a time and dose dependent manner...
  97. pmc The role of Axin2 in calvarial morphogenesis and craniosynostosis
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Development 132:1995-2005. 2005
    ..The craniofacial anomalies caused by the Axin2 mutation are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis...
  98. pmc Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias
    Keiko Miyoshi
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:219-24. 2002
    ..These data demonstrate that the activation of beta-catenin signaling induces a program that results in loss of mammary epithelial cell differentiation and induction of epidermal structures...
  99. ncbi The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly...
  100. pmc Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
    Maria Grazia Lampugnani
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    J Cell Biol 161:793-804. 2003
    ..In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor...
  101. doi Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex
    Atsushi Kuwahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 137:1035-44. 2010
    ..These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex...

Research Grants92

  1. Mechanisms of endoderm specification along the A-P axis
    James Wells; Fiscal Year: 2009
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  2. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2001
    ..These experiments are expected to identify potential protein/DNA targets for therapies aimed at providing countermeasures to derangements in muscle phenotypes and growth patterns attributable to muscle diseases. ..
  3. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2007
    ..abstract_text> ..
  4. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2004
    ..abstract_text> ..
  5. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  6. TRAIL Mediated Apoptosis in Renal Cell Carcinoma
    Peter Clark; Fiscal Year: 2007
    ..abstract_text> ..
  7. Epithelial Cell Structure in Vertebrate Development
    Jeffrey Hildebrand; Fiscal Year: 2006
    ..Together, these avenues of research should shed new light on pathways that control epithelial biology during the course of normal and adult life. ..
  8. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI; Fiscal Year: 2007
    ....
  9. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah Millar; Fiscal Year: 2005
    ..Understanding the roles of these key signaling molecules in developing and mature skin will provide us with new insight into normal skin and hair follicle biology and disease states including hair loss diseases and skin cancers. ..
  10. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah Millar; Fiscal Year: 2007
    ....
  11. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA MISRA; Fiscal Year: 2007
    ....
  12. WNT signals in developing and postnatal teeth
    Sarah Millar; Fiscal Year: 2007
    ..These experiments will help to place WNT signals in the network of regulatory factors that control tooth development, and will test the potential use of WNT activation in strategies for tooth or enamel regeneration. ..
  13. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2007
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  14. Role of Wnt/Frizzled signaling during eye development
    Sabine Fuhrmann; Fiscal Year: 2007
    ..We will use a reporter of Wnt/beta catenin signaling in transgenic Xenopus and mouse embryos to define when and where during eye development this ..
  15. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2007
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..
  16. mTOR Signaling Pathways
    Thomas Sturgill; Fiscal Year: 2009
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  17. Epithelial Cell Structure in Vertebrate Development
    Jeffrey D Hildebrand; Fiscal Year: 2010
    ..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
  18. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....
  19. Intercellular signaling in embryonic and postnatal mammary gland development
    Sarah Millar; Fiscal Year: 2009
    ..We will test this hypothesis by examining the effects of null mutations of non-canonical pathway components on mammary development in vivo. ..
  20. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  21. Suicide Endophenotypes and Molecular Mechanisms of Lithium Action
    Todd D Gould; Fiscal Year: 2010
    ..This application proposes experiments in the context of endophenotype strategies that will reveal molecular mechanisms whereby lithium acts to exert its therapeutics effects. ..
  22. Mechanisms Controlling RPE Development
    Sabine Fuhrmann; Fiscal Year: 2010
    ..Together, the goal of experiments proposed here will advance our understanding of the signals that control RPE development and may provide clues for new putative targets for therapeutic treatment of degenerative diseases in the eye. ..
  23. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  24. Role for Wnt/beta-catenin signaling in alveolar repair and fibrosis
    Cara J Gottardi; Fiscal Year: 2011
    ..Thus, new insights into the mechanisms of pulmonary fibrosis are needed to generate novel therapeutic treatments. ..
  25. WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH
    Sarah E Millar; Fiscal Year: 2010
    ..abstract_text> ..
  26. Colon Cell Differentiation: NAB and MUC2 Gene Expression
    Anna Velcich; Fiscal Year: 2009
    ..5. Finally, we will extend our use of microarray technology to determine how NaB perturbs profiles of gene expression that define lineage specific differentiation (Velcich et al., submitted). ..
  27. Imaging self-renewal and transformation in hematopoietic stem cells
    Tannishtha Reya; Fiscal Year: 2009
    ..Public Health Relevance The research proposed here will allow for in vivo monitoring of the signals and niche components that contribute ..
  28. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea I McClatchey; Fiscal Year: 2010
    ..These studies will advance our understanding of the molecular cause of NF2 and of the biology of ErbB receptors that have been widely implicated in human cancer. ..
  29. Inactivation of the Muc2 gene and colorectal cancer
    Anna Velcich; Fiscal Year: 2005
    ....