beta carotene 15 15 dioxygenase

Summary

Gene Symbol: beta carotene 15 15 dioxygenase
Description: beta-carotene 15,15'-monooxygenase
Alias: Bcdo, Bcdo1, CMO1, Cmoi, beta-CD, betaCMOOX, beta,beta-carotene 15,15'-dioxygenase, beta,beta-carotene 15,15'-monooxygenase, beta-carotene 15, 15'-dioxygenase 1, beta-carotene 15,15' dioxygenase, beta-carotene cleavage enzyme, beta-carotene dioxygenase 1, carotenoid-15,15'-oxygenase
Species: mouse

Top Publications

  1. ncbi Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids
    J Paik
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 276:32160-8. 2001
  2. pmc Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene
    Yvonne G J van Helden
    Department of Human and Animal Physiology, Wageningen University, PO Box 338, 6700 AH, Wageningen, The Netherlands
    Cell Mol Life Sci 67:2039-56. 2010
  3. pmc ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production
    Glenn P Lobo
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44160, USA
    FASEB J 24:1656-66. 2010
  4. pmc Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice
    Brian L Lindshield
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 138:2367-71. 2008
  5. ncbi Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene
    Ana Boulanger
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 2740, USA
    FASEB J 17:1304-6. 2003
  6. ncbi CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice
    Susanne Hessel
    Institute of Biology I, Animal Physiology and Neurobiology, Hauptstrasse 1, D 79104 Freiburg, Germany
    J Biol Chem 282:33553-61. 2007
  7. ncbi Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase
    T M Redmond
    Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:6560-5. 2001
  8. pmc In vitro and in vivo characterization of retinoid synthesis from beta-carotene
    Yvette Fierce
    Department of Comparative Medicine, University of Washington, Raitt Hall 324, Seattle, WA 98195, USA
    Arch Biochem Biophys 472:126-38. 2008
  9. ncbi Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity
    Eugenia Poliakov
    Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, MD 20892 0706, USA
    J Biol Chem 280:29217-23. 2005
  10. pmc An interaction between carotene-15,15'-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone
    Nikki A Ford
    Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    Int J Cancer 131:E143-8. 2012

Scientific Experts

  • Kingsley Osuala
  • T Michael Redmond
  • Eugenia Poliakov
  • Yvonne G J van Helden
  • Adrian Wyss
  • Johannes von Lintig
  • Susanne Hessel
  • Jaume Amengual
  • Jaap Keijer
  • Nikki A Ford
  • Frederik J Van Schooten
  • M Luisa Bonet
  • William S Blaner
  • Wei Zhang
  • Youn Kyung Kim
  • A Wyss
  • Evelien Kramer
  • Georg Lietz
  • Joan Ribot
  • Roger W L Godschalk
  • John W Erdman
  • Igor Shmarakov
  • Sandra G Heil
  • Xing Hua Li
  • Glenn P Lobo
  • Roseann Piantedosi
  • Yuxia Cui
  • Anne Eichinger
  • Yvette Fierce
  • Yusuke Seino
  • Brian L Lindshield
  • Regina Goralczyk
  • Atsuko Takeda
  • Ana Boulanger
  • Johanna M Lampert
  • Nancy Engelmann Moran
  • Joshua W Smith
  • J Paik
  • Steven K Clinton
  • W Yan
  • Stacey Chung
  • W Hunziker
  • A Friedlein
  • Hans J M Swarts
  • Jong Sun Kang
  • Erwan Gouranton
  • Gyu Un Bae
  • Lesley Wassef
  • Loredana Quadro
  • Mingi Hong
  • Robert S Krauss
  • Jean Francois Landrier
  • H Bachmann
  • Peter C H Hollman
  • Andreu Palou
  • M Wyss
  • Hongfeng Jiang
  • R Brugger
  • Aldona Dembinska-Kiec
  • Beata Kiec-Wilk
  • Ursula Razny
  • Steven J Schwartz
  • Annelies Bunschoten
  • Lanyue Zhang
  • Krzysztof Palczewski
  • Lewis P Rubin
  • Alexander R Moise
  • Robert W Curley
  • Roger W Godschalk
  • Noa Noy
  • Earl H Harrison
  • Katja Teerds
  • Diana N D'Ambrosio
  • Matthew K Fleshman
  • Ken M Riedl
  • Zhi Ping Bai
  • Jun Jie Zhu
  • Jonathan H Freedman
  • Ayako Takeuchi
  • Takaya Abe
  • Yutaka Oiso
  • Hiroshi Kiyonari
  • Toshihiko Iwanaga
  • Takashi Miki
  • Yoshihisa Takahashi
  • Chi Hua Lu
  • Susumu Seino
  • Milena de Morais Vieira
  • Wakako Fujimoto
  • Keita Kimura

Detail Information

Publications26

  1. ncbi Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids
    J Paik
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 276:32160-8. 2001
    ..5 and 8.5 days postcoitus. This work offers new insights for understanding the biochemistry of carotene cleavage to retinoids...
  2. pmc Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene
    Yvonne G J van Helden
    Department of Human and Animal Physiology, Wageningen University, PO Box 338, 6700 AH, Wageningen, The Netherlands
    Cell Mol Life Sci 67:2039-56. 2010
    ..This suggests that effects of BC may depend on inter-individual variations in BC-metabolizing enzymes, such as the frequently occurring human polymorphisms in BCMO1...
  3. pmc ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production
    Glenn P Lobo
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44160, USA
    FASEB J 24:1656-66. 2010
    ....
  4. pmc Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice
    Brian L Lindshield
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 138:2367-71. 2008
    ..In conclusion, CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels...
  5. ncbi Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene
    Ana Boulanger
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 2740, USA
    FASEB J 17:1304-6. 2003
    ....
  6. ncbi CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice
    Susanne Hessel
    Institute of Biology I, Animal Physiology and Neurobiology, Hauptstrasse 1, D 79104 Freiburg, Germany
    J Biol Chem 282:33553-61. 2007
    ..Two different carotenoid-cleaving enzymes were identified in mammals, the classical carotenoid-15,15'-oxygenase (CMO1) and a putative carotenoid-9',10'-oxygenase (CMO2)...
  7. ncbi Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase
    T M Redmond
    Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:6560-5. 2001
    ..Identification of beta-CD in an accessible model organism will create new opportunities to study vitamin A metabolism...
  8. pmc In vitro and in vivo characterization of retinoid synthesis from beta-carotene
    Yvette Fierce
    Department of Comparative Medicine, University of Washington, Raitt Hall 324, Seattle, WA 98195, USA
    Arch Biochem Biophys 472:126-38. 2008
    ..Our studies provide new insights into the regulation of BCMO1 activity and the physiological role of BCMO1 in living organisms...
  9. ncbi Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity
    Eugenia Poliakov
    Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, MD 20892 0706, USA
    J Biol Chem 280:29217-23. 2005
    ..These data are discussed in the context of the predicted structure for the related eubacterial apocarotenal oxygenase...
  10. pmc An interaction between carotene-15,15'-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone
    Nikki A Ford
    Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    Int J Cancer 131:E143-8. 2012
    ..Furthermore, carefully controlled studies with tomato products and lycopene in genetically defined murine models may elucidate important diet × genetic interactions that may impact prostate cancer risk...
  11. pmc Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism
    Kingsley Osuala
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida 32827, USA
    Physiol Genomics 44:934-47. 2012
    ....
  12. pmc Boc modifies the holoprosencephaly spectrum of Cdo mutant mice
    Wei Zhang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dis Model Mech 4:368-80. 2011
    ....
  13. ncbi An electrokinetic route to rapid synthesis of nickel hydroxide and nickel oxide nanotubes
    Xing Hua Li
    Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    J Nanosci Nanotechnol 10:5191-5. 2010
    ..The transmission electron microscope (TEM) and scanning electron microscope (SEM) were used to characterize the morphology and structure of the nanotubes...
  14. pmc β-Carotene and its cleavage enzyme β-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues
    Youn Kyung Kim
    Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA
    FASEB J 25:1641-52. 2011
    ..Carotene is the major human dietary provitamin A. β-Carotene-15,15'-oxygenase (CMOI) has been proposed as the main enzyme generating retinoid from β-carotene in vivo...
  15. pmc Beta-carotene reduces body adiposity of mice via BCMO1
    Jaume Amengual
    Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición CIBEROBN, Palma de Mallorca, Spain
    PLoS ONE 6:e20644. 2011
    ..Our study evidences an important role of BC for the control of body adiposity in mice and identifies Bcmo1 as critical molecular player for the regulation of PPARγ activity in adipocytes...
  16. pmc Beta-carotene affects gene expression in lungs of male and female Bcmo1 (-/-) mice in opposite directions
    Yvonne G J van Helden
    Human and Animal Physiology, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
    Cell Mol Life Sci 68:489-504. 2011
    ..Moreover, effects of BC may depend on the presence of frequent human BCMO1 polymorphisms, since these effects were not found in wild-type mice...
  17. doi Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice
    Yvonne G J van Helden
    Wageningen University, The Netherlands
    Carcinogenesis 31:1329-37. 2010
    ..A role for BC in the innervated PNEC cluster might be of particular importance in smoke-induced carcinogenesis since PNEC-derived lung cancer is highly associated with tobacco smoke...
  18. pmc Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid
    Igor Shmarakov
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arch Biochem Biophys 504:3-10. 2010
    ..Collectively, our data establish that HSCs are an important cellular site for β-carotene accumulation and metabolism within the liver...
  19. pmc Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase
    Eugenia Poliakov
    National Eye Institute, NIH, Bethesda, MD 20892 0608, USA
    BMC Biochem 10:31. 2009
    ..Enzymatic activity was measured in vitro using His-tag purified proteins and in vivo in a beta-carotene-accumulating E. coli system...
  20. pmc Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene expression
    Yuxia Cui
    Comparative Genomics Group, Laboratory of Molecular Toxicology, NIEHS, National Institutes of Health, Durham, North Carolina 27709, USA
    J Biol Chem 284:24925-32. 2009
    ..These results indicate that cadmium-induced teratogenicity may be due to the ability of the metal to increase the levels of retinoic acid by disrupting the expression of retinoic acid-metabolizing genes...
  21. ncbi Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression
    Yusuke Seino
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 283:4905-11. 2008
    ..These data suggest that Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine...
  22. ncbi Measurement of retinoids and beta-carotene 15,15'-dioxygenase activity in HR-1 hairless mouse skin with UV exposure
    Atsuko Takeda
    Department of Pediatrics, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:69-72. 2003
    ..In conclusion, the elevation of beta-carotene 15,15'-dioxygenase activity in hairless mice after UV exposure may be a response to reduction of the skin retinoid concentration...
  23. ncbi Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis
    Johanna M Lampert
    Neurobiology and Animal Physiology, Institute of Biology I, University of Freiburg, D 79104 Freiburg, Germany
    Development 130:2173-86. 2003
    ....
  24. ncbi Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium
    W Yan
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA
    Genomics 72:193-202. 2001
    ..beta,beta-Carotene-15,15'-dioxygenase (Bcdo), the enzyme that catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules, plays an ..
  25. pmc Expression pattern and localization of beta,beta-carotene 15,15'-dioxygenase in different tissues
    A Wyss
    F Hoffmann La Roche Ltd, Vitamins and Fine Chemicals Division, 4070 Basel, Switzerland
    Biochem J 354:521-9. 2001
    ..These new findings demonstrate that beta,beta-carotene 15,15'-dioxygenase is also expressed in epithelial structures, where it serves to provide the tissue-specific vitamin A supply...
  26. ncbi Cloning and expression of beta,beta-carotene 15,15'-dioxygenase
    A Wyss
    Vitamins and Fine Chemicals Division, F Hoffmann LaRoche Ltd, Basel, 4070, Switzerland
    Biochem Biophys Res Commun 271:334-6. 2000
    ..We cloned the first eukaryotic beta,beta-carotene 15,15'-dioxygenase which symmetrically cleaves beta-carotene at the 15,15'-double bond...