Gene Symbol: Bet1
Description: Bet1 golgi vesicular membrane trafficking protein
Alias: AW555236, Bet-1, BET1 homolog, blocked early in transport 1 homolog, golgi vesicular membrane-trafficking protein p18
Hay J, Chao D, Kuo C, Scheller R. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997;89:149-58 pubmed
..We propose that these protein interactions determine vesicle docking/fusion fidelity between the endoplasmic reticulum and Golgi. ..
Loh E, Peter F, Subramaniam V, Hong W. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. J Cell Sci. 2005;118:1209-22 pubmed
..Gel filtration analysis demonstrates that Bet3 exists in two distinct pools in the cytosol, the high-molecular-weight pool may represent the TRAPP complex, whereas the other probably represents the monomeric Bet3. ..
Zhang T, Wong S, Tang B, Xu Y, Peter F, Subramaniam V, et al
. The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. J Cell Biol. 1997;139:1157-68 pubmed
..Antibodies against rbet1 inhibit ER-Golgi transport only when they are added before the EGTA-sensitive stage. These results suggest that rbet1 may be involved in the docking process of ER-derived vesicles with the cis-Golgi membrane. ..
Zhang T, Hong W. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. J Biol Chem. 2001;276:27480-7 pubmed
..Three SNAREs, syntaxin 5, GS28, and Bet1, are specifically associated with Ykt6 as revealed by co-immunoprecipitation, suggesting that these four SNAREs ..
Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka Saito N, et al
. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Nat Genet. 2006;38:101-6 pubmed
..This indicates that Peg10 is critical for mouse parthenogenetic development and provides the first direct evidence of an essential role of an evolutionarily conserved retrotransposon-derived gene in mammalian development...