Bdnf

Summary

Gene Symbol: Bdnf
Description: brain derived neurotrophic factor
Alias: brain-derived neurotrophic factor
Species: mouse
Products:     Bdnf

Top Publications

  1. Rohe M, Synowitz M, Glass R, Paul S, Nykjaer A, Willnow T. Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci. 2009;29:15472-8 pubmed publisher
    ..Using screening approaches in primary neurons, we identified brain-derived neurotrophic factor (BDNF) as a major inducer of Sorla that activates receptor gene transcription through the ERK (extracellular regulated ..
  2. Jang S, Liu X, Yepes M, Shepherd K, Miller G, Liu Y, et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A. 2010;107:2687-92 pubmed publisher
    Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
  3. Ito A, Nosrat C. Gustatory papillae and taste bud development and maintenance in the absence of TrkB ligands BDNF and NT-4. Cell Tissue Res. 2009;337:349-59 pubmed publisher
    ..Both brain-derived neurotrophic factor (BDNF) null-mutated and neurotrophin-4 (NT-4) null-mutated mice exhibit peripheral gustatory deficits...
  4. Lau A, Irier H, Gu J, Tian D, Ku L, Liu G, et al. Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proc Natl Acad Sci U S A. 2010;107:15945-50 pubmed publisher
    Expression of the brain-derived neurotrophic factor (BDNF) is under tight regulation to accommodate its intricate roles in controlling brain function...
  5. Wu Y, Williamson R, Li Z, Vicario A, Xu J, Kasai M, et al. Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms. J Neurochem. 2011;116:1112-21 pubmed publisher
    Dendritic trafficking and translation of brain-derived neurotrophic factor (BDNF) transcripts play a key role in mediating synaptic plasticity...
  6. Dean C, Liu H, Dunning F, Chang P, Jackson M, Chapman E. Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nat Neurosci. 2009;12:767-76 pubmed publisher
    ..We found that syt-IV localized to brain-derived neurotrophic factor (BDNF)-containing vesicles in hippocampal neurons...
  7. Di Lieto A, Rantamäki T, Vesa L, Yanpallewar S, Antila H, Lindholm J, et al. The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development. PLoS ONE. 2012;7:e32869 pubmed publisher
    Previous studies suggest that the responsiveness of TrkB receptor to BDNF is developmentally regulated in rats...
  8. Gourley S, Howell J, Rios M, DiLeone R, Taylor J. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learn Mem. 2009;16:756-60 pubmed publisher
    ..We show brain-derived neurotrophic factor (bdnf) knock-down in the prelimbic, but not orbitofrontal, cortex accelerates the initial extinction of instrumental ..
  9. Massa S, Yang T, Xie Y, Shi J, Bilgen M, Joyce J, et al. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010;120:1774-85 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function...
  10. Heinrich C, Lähteinen S, Suzuki F, Anne Marie L, Huber S, Haussler U, et al. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiol Dis. 2011;42:35-47 pubmed publisher
    ..been associated with the pathophysiology of MTLE are known to be regulated by brain-derived neurotrophic factor (BDNF) in the healthy brain and an excess of this neurotrophin could therefore play a critical role in MTLE development...

Detail Information

Publications78

  1. Rohe M, Synowitz M, Glass R, Paul S, Nykjaer A, Willnow T. Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci. 2009;29:15472-8 pubmed publisher
    ..Using screening approaches in primary neurons, we identified brain-derived neurotrophic factor (BDNF) as a major inducer of Sorla that activates receptor gene transcription through the ERK (extracellular regulated ..
  2. Jang S, Liu X, Yepes M, Shepherd K, Miller G, Liu Y, et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A. 2010;107:2687-92 pubmed publisher
    Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
  3. Ito A, Nosrat C. Gustatory papillae and taste bud development and maintenance in the absence of TrkB ligands BDNF and NT-4. Cell Tissue Res. 2009;337:349-59 pubmed publisher
    ..Both brain-derived neurotrophic factor (BDNF) null-mutated and neurotrophin-4 (NT-4) null-mutated mice exhibit peripheral gustatory deficits...
  4. Lau A, Irier H, Gu J, Tian D, Ku L, Liu G, et al. Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proc Natl Acad Sci U S A. 2010;107:15945-50 pubmed publisher
    Expression of the brain-derived neurotrophic factor (BDNF) is under tight regulation to accommodate its intricate roles in controlling brain function...
  5. Wu Y, Williamson R, Li Z, Vicario A, Xu J, Kasai M, et al. Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms. J Neurochem. 2011;116:1112-21 pubmed publisher
    Dendritic trafficking and translation of brain-derived neurotrophic factor (BDNF) transcripts play a key role in mediating synaptic plasticity...
  6. Dean C, Liu H, Dunning F, Chang P, Jackson M, Chapman E. Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nat Neurosci. 2009;12:767-76 pubmed publisher
    ..We found that syt-IV localized to brain-derived neurotrophic factor (BDNF)-containing vesicles in hippocampal neurons...
  7. Di Lieto A, Rantamäki T, Vesa L, Yanpallewar S, Antila H, Lindholm J, et al. The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development. PLoS ONE. 2012;7:e32869 pubmed publisher
    Previous studies suggest that the responsiveness of TrkB receptor to BDNF is developmentally regulated in rats...
  8. Gourley S, Howell J, Rios M, DiLeone R, Taylor J. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learn Mem. 2009;16:756-60 pubmed publisher
    ..We show brain-derived neurotrophic factor (bdnf) knock-down in the prelimbic, but not orbitofrontal, cortex accelerates the initial extinction of instrumental ..
  9. Massa S, Yang T, Xie Y, Shi J, Bilgen M, Joyce J, et al. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010;120:1774-85 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function...
  10. Heinrich C, Lähteinen S, Suzuki F, Anne Marie L, Huber S, Haussler U, et al. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiol Dis. 2011;42:35-47 pubmed publisher
    ..been associated with the pathophysiology of MTLE are known to be regulated by brain-derived neurotrophic factor (BDNF) in the healthy brain and an excess of this neurotrophin could therefore play a critical role in MTLE development...
  11. HARLOW D, Yang H, Williams T, Barlow L. Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn. 2011;240:309-23 pubmed publisher
    In mice, BDNF provided by the developing taste epithelium is required for gustatory neuron survival following target innervation...
  12. Rantamäki T, Vesa L, Antila H, Di Lieto A, Tammela P, Schmitt A, et al. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS ONE. 2011;6:e20567 pubmed publisher
    Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this phenomenon remains unclear...
  13. Wu L, Fan Y, Li S, Li X, Zhou X. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J Biol Chem. 2010;285:5614-23 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and synaptic plasticity...
  14. Ma L, Lopez G, Krimm R. Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental period. J Neurosci. 2009;29:3354-64 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is expressed in epithelial targets of gustatory neurons (i.e...
  15. Sadakata T, Shinoda Y, Oka M, Sekine Y, Sato Y, Saruta C, et al. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. Proc Natl Acad Sci U S A. 2012;109:21104-9 pubmed publisher
    ..protein for secretion 2 (CAPS2 or CADPS2) potently promotes the release of brain-derived neurotrophic factor (BDNF)...
  16. Holm M, Nieto Gonzalez J, Vardya I, Vaegter C, Nykjaer A, Jensen K. Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. J Neurosci. 2009;29:12412-8 pubmed publisher
    Mature BDNF and its precursor proBDNF may both be secreted to exert opposite effects on synaptic plasticity in the hippocampus...
  17. Autry A, Adachi M, Cheng P, Monteggia L. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry. 2009;66:84-90 pubmed publisher
    ..The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking...
  18. Xu Z, Sun Y, Li H, Lim Y, Zhong J, Zhou X. Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice. Eur J Neurosci. 2011;33:1376-84 pubmed publisher
    ..Migration of cerebellar granule cells (CGCs) requires multiple factors. Mature brain-derived neurotrophic factor (BDNF) positively regulates the proliferation, migration, survival and differentiation of CGCs in rodents...
  19. Blurton Jones M, Kitazawa M, Martinez Coria H, Castello N, Muller F, Loring J, et al. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009;106:13594-9 pubmed publisher
    ..involves a robust enhancement of hippocampal synaptic density, mediated by brain-derived neurotrophic factor (BDNF). Gain-of-function studies show that recombinant BDNF mimics the beneficial effects of NSC transplantation...
  20. Kaneko M, Xie Y, An J, Stryker M, Xu B. Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J Neurosci. 2012;32:4790-802 pubmed publisher
    ..Here we report that the local synthesis of brain-derived neurotrophic factor (BDNF) in dendrites plays an important role in this process...
  21. Thirumangalathu S, HARLOW D, Driskell A, Krimm R, Barlow L. Fate mapping of mammalian embryonic taste bud progenitors. Development. 2009;136:1519-28 pubmed publisher
    ..Finally, using Bdnf null mice, which lose neurons that innervate taste buds, we demonstrate that Shh-expressing taste bud progenitors ..
  22. Chiaruttini C, Vicario A, Li Z, Baj G, Braiuca P, Wu Y, et al. Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation. Proc Natl Acad Sci U S A. 2009;106:16481-6 pubmed publisher
    Alternatively spliced brain-derived neurotrophic factor (BDNF) transcripts are targeted to distinct cellular compartments in neurons but the mechanisms underlying this sorting are unknown...
  23. Patel A, Krimm R. BDNF is required for the survival of differentiated geniculate ganglion neurons. Dev Biol. 2010;340:419-29 pubmed publisher
    In mice lacking functional brain-derived neurotrophic factor (BDNF), the number of geniculate ganglion neurons, which innervate taste buds, is reduced by one-half...
  24. Heyden A, Ionescu M, Romorini S, Kracht B, Ghiglieri V, Calabresi P, et al. Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels. Cell Tissue Res. 2011;346:11-26 pubmed publisher
    ..and of other forebrain structures was accompanied by increased levels of brain-derived neurotrophic factor (BDNF)...
  25. Uutela M, Lindholm J, Louhivuori V, Wei H, Louhivuori L, Pertovaara A, et al. Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. Genes Brain Behav. 2012;11:513-23 pubmed publisher
    ..As brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of FXS we examined the effects of reduced BDNF expression on the behavioral ..
  26. Javeri S, Rodi M, Tary Lehmann M, Lehmann P, Addicks K, Kuerten S. Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis. Clin Immunol. 2010;137:181-9 pubmed publisher
    The role of brain-derived neurotrophic factor (BDNF) in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still unclear...
  27. Vigers A, Amin D, Talley Farnham T, Gorski J, Xu B, Jones K. Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior. Neuroscience. 2012;212:1-18 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) plays important roles in the development, maintenance, and plasticity of the mammalian forebrain...
  28. Choi D, Maguschak K, Ye K, Jang S, Myers K, Ressler K. Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A. 2010;107:2675-80 pubmed publisher
    ..deletion, and pharmacological rescue with a TrkB agonist, we examined the role of a primary candidate mechanism, BDNF, in conditioned fear...
  29. Pan N, Jahan I, Kersigo J, Kopecky B, Santi P, Johnson S, et al. Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res. 2011;275:66-80 pubmed publisher
    ..This pattern of innervation by sensory neurons is maintained at least until P14, but fibers target the few Myo7a positive cells found in later stages. ..
  30. Chen B, Wang X, Wang Z, Wang Y, Chen L, Luo Z. Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/?-catenin signaling pathway. J Neurosci Res. 2013;91:30-41 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) has critical functions in promoting survival, expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation mechanism is still not fully understood...
  31. Patel A, Huang T, Krimm R. Lingual and palatal gustatory afferents each depend on both BDNF and NT-4, but the dependence is greater for lingual than palatal afferents. J Comp Neurol. 2010;518:3290-301 pubmed publisher
    ..About 50% of these neurons die in Bdnf(-/-) mice and Ntf4/5(-/-) mice. Bdnf(-/-)/Ntf4/5(-/-) double mutants lose 90-95% of geniculate ganglion neurons...
  32. Carretón O, Giralt A, Torres Peraza J, Brito V, Lucas J, Gines S, et al. Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels. Exp Neurol. 2012;237:335-45 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is a key player in learning and memory processes. However, little is known about brain area-specific functions of this neurotrophin...
  33. English C, Vigers A, Jones K. Genetic evidence that brain-derived neurotrophic factor mediates competitive interactions between individual cortical neurons. Proc Natl Acad Sci U S A. 2012;109:19456-61 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is a secreted protein important for development and function of neocortical circuitry...
  34. Xiao J, Wong A, Willingham M, van den Buuse M, Kilpatrick T, Murray S. Brain-derived neurotrophic factor promotes central nervous system myelination via a direct effect upon oligodendrocytes. Neurosignals. 2010;18:186-202 pubmed publisher
    ..We investigated whether brain-derived neurotrophic factor (BDNF) is implicated, by first confirming that BDNF heterozygous mice exhibit delayed CNS myelination during early ..
  35. Zajac M, Pang T, Wong N, Weinrich B, Leang L, Craig J, et al. Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice. Hippocampus. 2010;20:621-36 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its expression is complex due to multiple 5' untranslated exons which are separately spliced to a common coding exon to form unique mRNA transcripts...
  36. Allen M, Bird C, Feng W, Liu G, Li W, Perrone Bizzozero N, et al. HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PLoS ONE. 2013;8:e55718 pubmed publisher
    Complex regulation of brain-derived neurotrophic factor (BDNF) governs its intricate functions in brain development and neuronal plasticity...
  37. Louhivuori V, Vicario A, Uutela M, Rantamäki T, Louhivuori L, Castren E, et al. BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse. Neurobiol Dis. 2011;41:469-80 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF) and its TrkB receptors play a central role in neuronal maturation and plasticity...
  38. Castello N, Green K, LaFerla F. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter A? or tau pathology. PLoS ONE. 2012;7:e39566 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is a neurotrophin critically involved in cell survival, synaptic plasticity, and memory...
  39. Vondran M, Clinton Luke P, Honeywell J, Dreyfus C. BDNF+/- mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain. Glia. 2010;58:848-56 pubmed publisher
    Previous work indicated that brain-derived neurotrophic factor (BDNF), through the trkB receptor, increases DNA synthesis in oligodendrocyte (OLG) progenitor cells (OPCs) and differentiation of postmitotic OLGs of the basal forebrain (BF)...
  40. Fritzsch B, Dillard M, Lavado A, Harvey N, Jahan I. Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS ONE. 2010;5:e9377 pubmed publisher
    ..These results identify a dual role of Prox1 during inner ear development; growth of the canal cristae and fiber guidance of Type II fibers along supporting cells in the cochlea. ..
  41. Linker R, Lee D, Demir S, Wiese S, Kruse N, Siglienti I, et al. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain. 2010;133:2248-63 pubmed publisher
    ..Our data imply a functional role of brain-derived neurotrophic factor in autoimmune demyelination by mediating axon protection...
  42. Vondran M, Singh H, Honeywell J, Dreyfus C. Levels of BDNF impact oligodendrocyte lineage cells following a cuprizone lesion. J Neurosci. 2011;31:14182-90 pubmed publisher
    Previous work in culture has shown that basal forebrain (BF) oligodendrocyte (OLG) lineage cells respond to BDNF by increasing DNA synthesis and differentiation...
  43. Orefice L, Waterhouse E, Partridge J, Lalchandani R, Vicini S, Xu B. Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines. J Neurosci. 2013;33:11618-32 pubmed publisher
    ..The gene for brain-derived neurotrophic factor (BDNF) produces two pools of mRNA, with either a short or long 3' untranslated region (3' UTR)...
  44. Peng S, Garzon D, Marchese M, KLEIN W, Ginsberg S, Francis B, et al. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci. 2009;29:9321-9 pubmed publisher
    Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the progression of Alzheimer's disease (AD)...
  45. Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, Matsumoto T, Wiese S, et al. Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci. 2010;30:1739-49 pubmed publisher
    Although brain-derived neurotrophic factor (BDNF) is linked with an increasing number of conditions causing brain dysfunction, its role in the postnatal CNS has remained difficult to assess...
  46. Coppola V, Kucera J, Palko M, Martinez de Velasco J, Lyons W, Fritzsch B, et al. Dissection of NT3 functions in vivo by gene replacement strategy. Development. 2001;128:4315-27 pubmed
    ..receptor interactions in vivo, we have replaced the Nt3 gene with the gene for brain-derived neurotrophic factor (BDNF), a TrkB ligand. As in NT3 and TrkC null mice, the proprioception system of these mutants failed to assemble...
  47. Ballas N, Grunseich C, Lu D, Speh J, Mandel G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell. 2005;121:645-657 pubmed publisher
    ..Thus, a multistage repressor mechanism controls the orderly expression of genes during development while still permitting fine tuning in response to specific stimuli. ..
  48. ElShamy W, Ernfors P. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development. J Neurosci. 1997;17:8667-75 pubmed
    The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4) are crucial target-derived factors controlling the survival of peripheral sensory neurons during the ..
  49. Yang J, Siao C, Nagappan G, Marinic T, Jing D, McGrath K, et al. Neuronal release of proBDNF. Nat Neurosci. 2009;12:113-5 pubmed publisher
    Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions...
  50. Zhao J, Seereeram A, Nassar M, Levato A, Pezet S, Hathaway G, et al. Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Mol Cell Neurosci. 2006;31:539-48 pubmed
    ..Here, we used the Cre-loxP system to delete BDNF in most nociceptive sensory neurons. Conditional null animals were healthy with no sensory neuron loss...
  51. Gines S, Bosch M, Marco S, Gavalda N, Diaz Hernandez M, Lucas J, et al. Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. Eur J Neurosci. 2006;23:649-58 pubmed
    Deficits of neurotrophic support caused by reduced levels of brain-derived neurotrophic factor (BDNF) have been implicated in the selective vulnerability of striatal neurones in Huntington's disease (HD)...
  52. Jiang X, Tian F, Du Y, Copeland N, Jenkins N, Tessarollo L, et al. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J Neurosci. 2008;28:1118-30 pubmed publisher
    Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated in the pathophysiology of ..
  53. Kablar B, Belliveau A. Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. Dev Dyn. 2005;234:659-69 pubmed
  54. Li Y, Luikart B, Birnbaum S, Chen J, Kwon C, Kernie S, et al. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron. 2008;59:399-412 pubmed publisher
  55. Krimm R, Miller K, Kitzman P, Davis B, Albers K. Epithelial overexpression of BDNF or NT4 disrupts targeting of taste neurons that innervate the anterior tongue. Dev Biol. 2001;232:508-21 pubmed
    Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are essential for the survival of geniculate ganglion neurons, which provide the sensory afferents for taste buds of the anterior tongue and palate...
  56. Wiechers B, Gestwa G, Mack A, Carroll P, Zenner H, Knipper M. A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and mice. J Neurosci. 1999;19:3033-42 pubmed
    ..We observed a spatiotemporal change in the localization of brain-derived neurotrophic factor (BDNF) protein and mRNA, which correlated with the reorganization of fibers...
  57. Croll S, Suri C, Compton D, Simmons M, Yancopoulos G, Lindsay R, et al. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience. 1999;93:1491-506 pubmed
    ..The results also support the hypothesis that excess brain-derived neurotrophic factor could be pro-convulsant in the limbic system. ..
  58. Gauthier L, Charrin B, Borrell Pages M, Dompierre J, Rangone H, Cordelières F, et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell. 2004;118:127-38 pubmed
    ..Here, we show that huntingtin specifically enhances vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules...
  59. Sun H, Oakley B. Development of anterior gustatory epithelia in the palate and tongue requires epidermal growth factor receptor. Dev Biol. 2002;242:31-43 pubmed
    ..mice having null mutations for epidermal growth factor receptor (egfr(-/-)), brain-derived neurotrophic factor (bdnf(-/-)), or both...
  60. Xu B, Goulding E, Zang K, Cepoi D, Cone R, Jones K, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003;6:736-42 pubmed
    ..balance, and obesity has been observed in mice with mutations in the gene for brain-derived neurotrophic factor (BDNF)...
  61. Sadakata T, Mizoguchi A, Sato Y, Katoh Semba R, Fukuda M, Mikoshiba K, et al. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci. 2004;24:43-52 pubmed
    ..from mouse cerebella contained significant amounts of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and chromogranin B but not marker proteins for synaptic vesicle synaptophysin and synaptotagmin...
  62. Hong E, McCord A, Greenberg M. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron. 2008;60:610-24 pubmed publisher
    ..Here, we demonstrate that introduction of a subtle knockin mutation into the mouse Bdnf gene that blocks the ability of the activity-regulated factor CREB to bind Bdnf promoter IV results in an animal in ..
  63. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, et al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003;302:890-3 pubmed
    ..We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the ..
  64. Pozzo Miller L, Gottschalk W, Zhang L, McDermott K, Du J, Gopalakrishnan R, et al. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci. 1999;19:4972-83 pubmed
    Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS)...
  65. Singh K, Park K, Hong E, Kramer B, Greenberg M, Kaplan D, et al. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008;11:649-58 pubmed publisher
    ..which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause ..
  66. Cheng A, Wang S, Cai J, Rao M, Mattson M. Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol. 2003;258:319-33 pubmed
    ..Brain-derived neurotrophic factor (BDNF) reduced NPC proliferation and increased the expression of neuronal NO synthase (nNOS) in differentiating neurons...
  67. Liu I, Lyons W, Mamounas L, Thompson R. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. J Neurosci. 2004;24:7958-63 pubmed
    In this study, brain-derived neurotrophic factor (BDNF) heterozygous knock-outs were tested on fear conditioning, and their wild-type littermates were used as controls...
  68. Berton O, McClung C, DiLeone R, Krishnan V, Renthal W, Russo S, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006;311:864-8 pubmed
    ..Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development of this experience-dependent social aversion...
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    Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene...
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