Bdh2

Summary

Gene Symbol: Bdh2
Description: 3-hydroxybutyrate dehydrogenase, type 2
Alias: 1810026B04Rik, Dhrs6, 3-hydroxybutyrate dehydrogenase type 2, R-beta-hydroxybutyrate dehydrogenase, dehydrogenase/reductase (SDR family) member 6
Species: mouse
Products:     Bdh2

Top Publications

  1. Devireddy L, Hart D, Goetz D, Green M. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell. 2010;141:1006-17 pubmed publisher
    ..We find that the murine enzyme responsible for 2,5-DHBA synthesis, BDH2, is the homolog of bacterial EntA, which catalyzes 2,3-DHBA production during enterobactin biosynthesis...
  2. Liu Z, Reba S, Chen W, Porwal S, Boom W, Petersen R, et al. Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. J Exp Med. 2014;211:1197-213 pubmed publisher
    ..Thus, reciprocal regulation of 24p3 and mammalian siderophore is a protective mechanism limiting microbial access to iron. ..
  3. Liu Z, Velpula K, Devireddy L. 3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron. FEBS J. 2014;281:2410-21 pubmed publisher
    ..depletion of the mammalian siderophore by inhibiting expression of the 3-hydroxybutyrate dehydrogenase-2 gene (Bdh2) results in abnormal accumulation of intracellular iron, increased oxidative stress, and mitochondrial iron ..
  4. Liu Z, Ciocea A, Devireddy L. Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice. Mol Cell Biol. 2014;34:2533-46 pubmed publisher
    ..3-OH butyrate dehydrogenase (BDH2), a member of the short-chain dehydrogenase (SDR) family of reductases, catalyzes a rate-limiting step in the ..