Bcr

Summary

Gene Symbol: Bcr
Description: breakpoint cluster region
Alias: 5133400C09Rik, AI561783, AI853148, mKIAA3017, breakpoint cluster region protein, breakpoint cluster region homolog
Species: mouse
Products:     Bcr

Top Publications

  1. Ngo V, Korner H, Gunn M, Schmidt K, Riminton D, Cooper M, et al. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med. 1999;189:403-12 pubmed
    ..Together these findings indicate that LTalpha1beta2 and TNF are required for the development and function of B and T zone stromal cells that make chemokines necessary for lymphocyte compartmentalization in the spleen. ..
  2. Oh D, Han S, Seo J, Lee J, Choi J, Groffen J, et al. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J Neurosci. 2010;30:14134-44 pubmed publisher
    ..Breakpoint cluster region (BCR) is a Rac GTPase-activating protein known to form a fusion protein with the c-Abl tyrosine kinase in Philadelphia ..
  3. Cunnick J, Schmidhuber S, Chen G, Yu M, Yi S, Cho Y, et al. Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009;29:5742-50 pubmed publisher
    b>Bcr and Abr are GTPase-activating proteins for the small GTPase Rac. Both proteins are expressed in cells of the innate immune system, including neutrophils and macrophages...
  4. Voncken J, van Schaick H, Kaartinen V, Deemer K, Coates T, Landing B, et al. Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995;80:719-28 pubmed
    Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis...
  5. Kaartinen V, Nagy A, Gonzalez Gomez I, Groffen J, Heisterkamp N. Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn. 2002;223:517-25 pubmed
    ..the biological function of two closely related GTPase activating proteins for the Cdc42/Rac GTPases, Abr and Bcr, we generated a mouse strain deficient in both of these proteins...
  6. Park A, Oh D, Lim S, Choi J, Moon J, Yu D, et al. Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT. J Cell Sci. 2012;125:4518-31 pubmed publisher
    ..Rac1 is a member of the Rho GTPase family that serve as regulators of neuronal development. Breakpoint cluster region protein (BCR) is a Rac1 GTPase-activating protein that is abundantly expressed in the central nervous system...
  7. Reuther J, Reuther G, Cortez D, Pendergast A, Baldwin A. A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev. 1998;12:968-81 pubmed
    b>Bcr-Abl is a chimeric oncoprotein that is strongly implicated in acute lymphoblastic (ALL) and chronic myelogenous leukemias (CML)...
  8. Kaartinen V, Gonzalez Gomez I, Voncken J, Haataja L, Faure E, Nagy A, et al. Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development. 2001;128:4217-27 pubmed
    ..Here we demonstrate that the simultaneous disruption of two negative regulators of Rac, Abr and Bcr, in mice leads to specific abnormalities in postnatal cerebellar development...
  9. Cho Y, Cunnick J, Yi S, Kaartinen V, Groffen J, Heisterkamp N. Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol. 2007;27:899-911 pubmed
    Small GTPases of the Rho family are key regulators of phagocytic leukocyte function. Abr and Bcr are homologous, multidomain proteins...

More Information

Publications80

  1. Ghaffari S, Daley G, Lodish H. Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays. Leukemia. 1999;13:1200-6 pubmed
    The expression of the BCR-ABL fusion oncoprotein in primitive hematopoietic cells results in chronic myeloid leukemia...
  2. Heisterkamp N, Groffen J. Duplication of the bcr and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 1988;16:8045-56 pubmed
    The Philadelphia (Ph') translocation involves rearrangement of the bcr gene located on chromosome 22. Hybridization experiments revealed the presence of multiple bcr gene-related loci within the human genome...
  3. Dasu T, Sindhava V, Clarke S, Bondada S. CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. Mol Immunol. 2009;46:2655-65 pubmed publisher
    ..B-1 cells, like peritoneal B-1 cells, are defective in Ca(2+) release upon B cell activation by co-cross-linking BCR and CD19...
  4. Liu J, Joha S, Idziorek T, Corm S, Hetuin D, Philippe N, et al. BCR-ABL mutants spread resistance to non-mutated cells through a paracrine mechanism. Leukemia. 2008;22:791-9 pubmed publisher
    ..This sequential treatment can lead to BCR-ABL mutations conferring broad resistance to kinase inhibitors...
  5. Ko J, Patel N, Ikawa T, Kawamoto H, Frank O, Rivera R, et al. Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative disease. Proc Natl Acad Sci U S A. 2008;105:12967-72 pubmed publisher
    ..Collectively, these studies show that suppression of E-protein activity interferes with the development of BCR-ABL-mediated MPD.
  6. Lin F, Monaco G, Sun T, Liu J, Lin H, Stephens C, et al. BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model. Oncogene. 2001;20:1873-81 pubmed
    It is well accepted that the Bcr-Abl oncoprotein encoded by the Philadelphia chromosome is responsible for causing chronic myelogenous leukemia (CML)...
  7. Katkere B, Rosa S, Drake J. The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation. J Biol Chem. 2012;287:16636-44 pubmed publisher
    B cell receptor (BCR)-mediated antigen (Ag) processing and presentation lead to B cell-T cell interactions, which support affinity maturation and immunoglobulin class switching...
  8. Tao W, Lin H, Sun T, Samanta A, Arlinghaus R. BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. Oncogene. 2008;27:3194-200 pubmed
    Oncogenic transformation of hematopoietic cells by the Bcr-Abl oncoprotein directly involves the activation Jak2 tyrosine kinase and the Stat5 transcription factor...
  9. Fioretos T, Voncken J, Baram T, Kamme F, Groffen J, Heisterkamp N. Regional localization and developmental expression of the BCR gene in rodent brain. Cell Mol Biol Res. 1995;41:97-102 pubmed
    The BCR gene is implicated in the development of Ph-positive leukemia through its fusion with the nonreceptor tyrosine kinase gene ABL...
  10. Königsberger S, Prodöhl J, Stegner D, Weis V, Andreas M, Stehling M, et al. Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state. EMBO J. 2012;31:3363-74 pubmed publisher
    ..proper selection of developing B cells at central and peripheral checkpoints, demonstrating critical dependence on BCR signalling quality...
  11. Poovassery J, Bishop G. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J Immunol. 2012;189:1757-64 pubmed publisher
    ..b>BCR signals prevent and overcome TLR7 tolerance...
  12. Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, et al. Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl. Blood. 1997;89:2745-56 pubmed
    ..human chronic myelogenous leukemia, pp135 was constitutively tyrosine-phosphorylated and associated with Shc and Bcr-Abl...
  13. Lee W, Sacharidou A, Behling Kelly E, Oltmann S, Zhu W, Ahmed M, et al. PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. PLoS ONE. 2015;10:e0124494 pubmed publisher
    ..Tandem affinity purification-mass spectrometry revealed that PDZK1 interacts with breakpoint cluster region kinase (Bcr), which contains a C-terminal PDZ binding sequence and is known to enhance responses to PDGF in VSM...
  14. Novak R, Jacob E, Haimovich J, Avni O, Melamed D. The MAPK/ERK and PI3K pathways additively coordinate the transcription of recombination-activating genes in B lineage cells. J Immunol. 2010;185:3239-47 pubmed publisher
    Rag-1 and Rag-2 are essential for the construction of the BCR repertoire. Regulation of Rag gene expression is tightly linked with BCR expression and signaling during B cell development...
  15. Illert A, Albers C, Kreutmair S, Leischner H, Peschel C, Miething C, et al. Grb10 is involved in BCR-ABL-positive leukemia in mice. Leukemia. 2015;29:858-68 pubmed publisher
    The SH2-containing adaptor protein Grb10 was first identified in a yeast screen as a new binding partner for BCR-ABL and associates with BCR-ABL in a tyrosine-dependent manner...
  16. Melkus M, Bennaceur Griscelli A, Valogne Y, Flamant S, Chomel J, Sorel N, et al. Biological effects of T315I-mutated BCR-ABL in an embryonic stem cell-derived hematopoiesis model. Exp Hematol. 2013;41:335-45.e3 pubmed publisher
    ..To study the effects of T315I-mutated breakpoint cluster region-abelson (BCR-ABL) in a primitive hematopoietic stem cell, we have used the murine embryonic stem cell (mESC)-derived ..
  17. Castellanos A, Pintado B, Weruaga E, Arevalo R, Lopez A, Orfao A, et al. A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Blood. 1997;90:2168-74 pubmed
    b>BCR-ABL(p190) oncogene is the result of a reciprocal translocation between chromosomes 9 and 22 and is associated with B-cell acute lymphoblastic leukemia (B-ALL) in humans...
  18. Akahane D, Tauchi T, Okabe S, Nunoda K, Ohyashiki K. Activity of a novel Aurora kinase inhibitor against the T315I mutant form of BCR-ABL: in vitro and in vivo studies. Cancer Sci. 2008;99:1251-7 pubmed publisher
    ..investigated the activity of a novel Aurora kinase inhibitor, VE-465, against leukemia cells expressing wild-type BCR-ABL or the T315I mutant form of BCR-ABL...
  19. Poovassery J, Vanden Bush T, Bishop G. Antigen receptor signals rescue B cells from TLR tolerance. J Immunol. 2009;183:2974-83 pubmed publisher
    ..However, it has not been studied in detail in B lymphocytes. In addition to the BCR, B cells express almost all known TLRs and respond robustly to many TLR ligands...
  20. Cuesta Dominguez A, Ortega M, Ormazábal C, Santos Roncero M, Galán Díez M, Steegmann J, et al. Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PLoS ONE. 2012;7:e32451 pubmed publisher
    ..Recent reports described a BCR-JAK2 fusion gene in fatal chronic and acute myeloid leukemia, but the functional behavior of the chimeric protein ..
  21. Bryda E, Ling H, Rathbun D, Burmeister M, Flaherty L. Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3. Genomics. 1996;35:425-30 pubmed
    ..2 cM distal to D10Mit115 and 0.8 cM proximal to D10Mit173. In addition, five genes, Cdc2a, Col6a1, Col6a2, Bcr, and Ank3 were mapped in both this jcpk intercross and a (BALB/c x CAST/Ei)F1 x BALB/c backcross...
  22. Gray E, Petsalaki E, James D, Bagshaw R, Stacey M, Rocks O, et al. Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. J Biol Chem. 2014;289:35397-408 pubmed publisher
    ..to mass spectrometry (IP-MS) from cultured cells revealed a prominent association of SH2D5 with breakpoint cluster region protein, a RacGAP that is also highly expressed in brain...
  23. Glekas A, Pillarsetty N, Punzalan B, Khan N, Smith Jones P, Larson S. In vivo imaging of Bcr-Abl overexpressing tumors with a radiolabeled imatinib analog as an imaging surrogate for imatinib. J Nucl Med. 2011;52:1301-7 pubmed publisher
    ..is known to inhibit the dysregulated proliferation of chronic myeloid leukemia, which is associated with the Bcr-Abl kinase; in gastrointestinal stromal tumors, imatinib is known to act via c-Kit kinase inhibition...
  24. Voncken J, Baram T, Gonzales Gomez I, van Schaick H, Shih J, Chen K, et al. Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998;2:577-83 pubmed
    ..Here we establish that mice lacking bcr, a known GTPase activating protein for Rac, exhibit a defect in the regulation of both hormonal and behavioral ..
  25. Yu M, Gong D, Lim M, Arutyunyan A, Groffen J, Heisterkamp N. Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS ONE. 2012;7:e49756 pubmed publisher
    b>Bcr and Abr are GTPase activating proteins that specifically downregulate activity of the small GTPase Rac in restricted cell types in vivo...
  26. Skalet A, Isler J, King L, Harding H, Ron D, Monroe J. Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate. J Biol Chem. 2005;280:39762-71 pubmed
    ..We identify B cell receptor (BCR) signaling as an unexpected physiologic UPR trigger and demonstrate that in mature B cells, BCR stimulation induces ..
  27. Badger Brown K, Gillis L, Bailey M, Penninger J, Barber D. CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing. Leukemia. 2013;27:1146-54 pubmed publisher
    b>BCR-ABL induces chronic myeloid leukemia (CML) through the aberrant regulation of multiple signaling substrates. Previous research has shown that BCR-ABL mediates down-modulation of CBL-B protein levels...
  28. Yun S, Jung K, Kim S, Fang Z, Son M, Yan H, et al. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Lett. 2014;348:50-60 pubmed publisher
    Imatinib is a selective breakpoint cluster region-Abelson (BCR-ABL) tyrosine kinase inhibitor (TKI) that has significantly improved the prognosis of patients with chronic myeloid leukemia (CML)...
  29. Iotti G, Ferrari Amorotti G, Rosafio C, Corradini F, Lidonnici M, Ronchetti M, et al. Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells. Oncogene. 2007;26:3482-91 pubmed
    Transformation of hematopoietic cells by the BCR/ABL oncogene is caused by perturbation of signal transduction pathways leading to altered patterns of gene expression and activity...
  30. Boulos N, Mulder H, Calabrese C, Morrison J, Rehg J, Relling M, et al. Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2011;117:3585-95 pubmed publisher
    The introduction of cultured p185(BCR-ABL)-expressing (p185+) Arf (-/-) pre-B cells into healthy syngeneic mice induces aggressive acute lymphoblastic leukemia (ALL) that genetically and phenotypically mimics the human disease...
  31. Grebien F, Hantschel O, Wojcik J, Kaupe I, Kovacic B, Wyrzucki A, et al. Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell. 2011;147:306-19 pubmed publisher
    Chronic myelogenous leukemia (CML) is caused by the constitutively active tyrosine kinase Bcr-Abl and treated with the tyrosine kinase inhibitor (TKI) imatinib. However, emerging TKI resistance prevents complete cure...
  32. Thia K, Jenkins N, Gilbert D, Copeland N, Smyth M. The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10. Immunogenetics. 1995;41:47-9 pubmed
  33. Zhu Q, Heisterkamp N, Groffen J. Unique organization of the human BCR gene promoter. Nucleic Acids Res. 1990;18:7119-25 pubmed
    The promoter of the human BCR gene, regulating the transcription of the chimeric BCR/ABL mRNA in leukemia, has been isolated and characterized. A region of 1...
  34. Slupianek A, Nowicki M, Koptyra M, Skorski T. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst). 2006;5:243-50 pubmed
    The oncogenic BCR/ABL tyrosine kinase facilitates the repair of DNA double-strand breaks (DSBs). We find that after gamma-irradiation BCR/ABL-positive leukemia cells accumulate more DSBs in comparison to normal cells...
  35. Zobeley E, Sufalko D, Adkins S, Burmeister M. Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10. Genomics. 1998;50:260-6 pubmed
    ..In addition, nine different genes (Ank3, Bcr, Gnaz, Tfam, Mif, Mmp11, Dcoh, Pyp, and Gstt2) were mapped and eliminated genetically as candidate genes for av...
  36. Kusio Kobialka M, Wolanin K, Podszywalow Bartnicka P, Sikora E, Skowronek K, McKenna S, et al. Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Apoptosis. 2012;17:950-63 pubmed publisher
    Chronic myeloid leukemia (CML) is a disorder of hematopoietic stem cells caused by the expression of BCR-ABL. Loss of p53 has not been implicated as important for the development of CML...
  37. Brott B, Alessandrini A, Largaespada D, Copeland N, Jenkins N, Crews C, et al. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differ. 1993;4:921-9 pubmed
    ..Recombinant MEK2 produced in bacteria phosphorylates a kinase-inactive Erk-1 on tyrosine and threonine, whereas a kinase-inactive mutant MEK2 does not. These findings suggest that MEK2 is a member of a multigene family. ..
  38. Gordon M. Biological consequences of the BCR/ABL fusion gene in humans and mice. J Clin Pathol. 1999;52:719-22 pubmed
  39. Kovesdi D, Angyal A, Huber K, Szili D, Sarmay G. T-bet is a new synergistic meeting point for the BCR and TLR9 signaling cascades. Eur J Immunol. 2014;44:887-93 pubmed publisher
    The importance of the BCR and TLR9 in autoimmunity and in the production of auto-antibodies is well established but the underlying molecular mechanism still needs to be determined...
  40. Krause D, Lazarides K, von Andrian U, Van Etten R. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med. 2006;12:1175-80 pubmed
    ..Here we show that CD44 expression is increased on mouse stem-progenitor cells expressing BCR-ABL and that CD44 contributes functional E-selectin ligands...
  41. Lin H, Monaco G, Sun T, Ling X, Stephens C, Xie S, et al. Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia. Oncogene. 2005;24:3246-56 pubmed
    A variety of experimental evidence including findings in various mouse models indicates that the BCR-ABL oncogene is the cause of chronic myeloid leukemia (CML)...
  42. Wang Y, Wang J, Sun Y, Wu Q, Fu Y. Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells. J Immunol. 2001;166:330-7 pubmed
    ..Thus, the development and maintenance of these lymphoid structures depend on a delicate interaction between TNF and LT from different subsets of lymphocytes...
  43. Fierro F, Taubenberger A, Puech P, Ehninger G, Bornhauser M, Muller D, et al. BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells. J Mol Biol. 2008;377:1082-93 pubmed publisher
    The expression of the fusion protein BCR/ABL is a hallmark of chronic myeloid leukemia. BCR/ABL is a constitutively active tyrosine kinase influencing cell proliferation, apoptosis, and differentiation...
  44. Alexis J, Wang N, Che W, Lerner Marmarosh N, Sahni A, Korshunov V, et al. Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells. Circ Res. 2009;104:69-78 pubmed publisher
    b>Bcr is a serine/threonine kinase activated by platelet-derived growth factor that is highly expressed in the neointima after vascular injury...
  45. Kostenko E, Olabisi O, Sahay S, Rodriguez P, Whitehead I. Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol. 2006;26:8964-75 pubmed
  46. Huang P, Chen C, Hsu I, Salim S, Kao S, Cheng C, et al. Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation. PLoS ONE. 2015;10:e0116372 pubmed publisher
    ..b>Breakpoint cluster region protein (Bcr), a Rho GTPase regulator, was identified as a Hap1-interacting partner...
  47. Katsoulidis E, Sassano A, Majchrzak Kita B, Carayol N, Yoon P, Jordan A, et al. Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells. J Biol Chem. 2008;283:10793-803 pubmed publisher
    ..We report that BCR-ABL transformation of hematopoietic cells results in suppression of IFN-dependent responses, including ..
  48. Um K, Niu S, Duman J, Cheng J, Tu Y, Schwechter B, et al. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014;29:701-15 pubmed publisher
    ..Here, we identify a regulatory complex composed of a Rac-GEF (Tiam1) and a Rac-GAP (Bcr) that cooperate to control excitatory synapse development...
  49. Bozza M, Kolakowski L, Jenkins N, Gilbert D, Copeland N, David J, et al. Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes. Genomics. 1995;27:412-9 pubmed
    ..The mouse Mif gene maps to the middle region of chromosome 10, between Bcr and S100b, which have been mapped to human chromosomes 22q11 and 21q22.3, respectively...
  50. Voncken J, Kaartinen V, Groffen J, Heisterkamp N. Bcr/Abl associated leukemogenesis in bcr null mutant mice. Oncogene. 1998;16:2029-32 pubmed
    The BCR gene contributes to Philadelphia-positive leukemogenesis via a number of discrete mechanisms, one of which may be through interaction of its normal gene product with the Bcr/Abl oncoprotein...
  51. Kapfhamer D, Burmeister M. Genetic map of the region around grizzled (gr) and mocha (mh) on mouse chromosome 10, homologous to human 19p13.3. Genomics. 1994;23:635-42 pubmed
    ..These closely linked markers should provide entry points for positional cloning of the gr and mh genes. The region linked to grizzled is homologous to a gene-rich region on human Chromosome 19p13.3. ..
  52. Mallo M, Steingrimsson E, Copeland N, Jenkins N, Gridley T. Genomic organization, alternative polyadenylation, and chromosomal localization of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Genomics. 1994;21:194-201 pubmed
    ..Primer extension analysis and ribonuclease protection assays show that Grg has a major transcription start site situated down-stream of putative binding motifs for the transcription factors Sp1, E2A, and PuF. ..
  53. Jena N, Deng M, Sicinska E, Sicinski P, Daley G. Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells. Cancer Res. 2002;62:535-41 pubmed
    Chronic myeloid leukemia is caused by the tyrosine kinase oncoprotein BCR/ABL...
  54. Vicente Dueñas C, Barajas Diego M, Romero Camarero I, González Herrero I, Flores T, Sanchez Garcia I. Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice. Oncotarget. 2012;3:261-6 pubmed
    ..Here, we used telomerase deficient mice to determine the requirement for telomerase in CML induced by BCR-ABL in mouse models of CML...
  55. Watanabe T, Hotta C, Koizumi S, Miyashita K, Nakabayashi J, Kurotaki D, et al. The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia. Cancer Res. 2013;73:6642-53 pubmed publisher
    b>BCR-ABL tyrosine kinase inhibitors (TKI) have dramatically improved therapy for chronic myelogenous leukemia (CML). However, several problems leading to TKI resistance still impede a complete cure of this disease...
  56. Synowiec E, Hoser G, Wójcik K, Pawlowska E, Skorski T, BÅ‚asiak J. UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib. Int J Mol Sci. 2015;16:18111-28 pubmed publisher
    Chronic myeloid leukemia (CML) cells express the active BCR-ABL1 protein, which has been targeted by imatinib in CML therapy, but resistance to this drug is an emerging problem...
  57. Walz C, Ahmed W, Lazarides K, Betancur M, Patel N, Hennighausen L, et al. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. Blood. 2012;119:3550-60 pubmed publisher
    ..a conditional null mutation in the Stat5a/b gene locus to determine the requirement for STAT5 in MPNs induced by BCR-ABL1 and JAK2(V617F) in retroviral transplantation models of CML and PV...
  58. Walter M, Ries R, Armstrong J, Park J, Mardis E, Ley T. Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2. Blood. 2007;109:1237-40 pubmed
    Expression of a bcr-3 isoform of retinoic acid receptor alpha-promyelocytic leukemia (RARalpha-PML) in mice expressing a bcr-1 isoform of PML-RARalpha is associated with increased penetrance of murine acute promyelocytic leukemia (APL) ..
  59. Singh D, Kumar D, Siddiqui Z, Basu S, Kumar V, Rao K. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell. 2005;121:281-93 pubmed
    ..We show here that the Ca2+ and reactive oxygen intermediates generated upon BCR activation rapidly engage in a cooperative interaction that acts in a feedback manner to amplify the early signal ..
  60. Yu Q, Brain J, Laneuville P, Osmond D. Suppressed apoptosis of pre-B cells in bone marrow of pre-leukemic p190bcr/abl transgenic mice. Leukemia. 2001;15:819-27 pubmed
    ..p190bcr/abl may thus promote leukemogenesis by permitting aberrant cells generated during early B cell development to evade a normal quality checkpoint and negative selection. ..
  61. Wu Q, Wang Y, Wang J, Hedgeman E, Browning J, Fu Y. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med. 1999;190:629-38 pubmed
    ..Taken together, these results support the notion that the signaling via LTbetaR by membrane LTalpha/beta is required for the presence of DCs in lymphoid tissues. ..
  62. Hoek K, Carlesso G, Clark E, Khan W. Absence of mature peripheral B cell populations in mice with concomitant defects in B cell receptor and BAFF-R signaling. J Immunol. 2009;183:5630-43 pubmed publisher
    ..mature B lymphocytes from early (T1) and late transitional (T2) precursors requires cooperative signaling through BCR and B cell-activating factor receptor 3 (BR3)...
  63. Crowley J, Stadanlick J, Cambier J, Cancro M. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood. 2009;113:1464-73 pubmed publisher
    These studies investigate how interactions between the BCR and FcgammaRIIB affect B lymphocyte stimulator (BLyS) recep-tor expression and signaling...
  64. Foley S, Hildenbrand Z, Soyombo A, Magee J, Wu Y, Oravecz Wilson K, et al. Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep. 2013;5:51-60 pubmed publisher
    ..CML) and some acute lymphoblastic leukemias are characterized by the t(9;22) chromosome, which encodes the BCR/ABL oncogene...
  65. Kharas M, Janes M, Scarfone V, Lilly M, Knight Z, Shokat K, et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2008;118:3038-50 pubmed publisher
    ..cases of pre-B cell acute lymphoblastic leukemia (pre-B-ALL) are caused by the Philadelphia (Ph) chromosome-encoded BCR-ABL oncogene, and these tend to have a poor prognosis...
  66. Devireddy L, Gazin C, Zhu X, Green M. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell. 2005;123:1293-305 pubmed
    ..We find, unexpectedly, that the BCR-ABL oncoprotein activates expression of 24p3 and represses 24p3R expression, rendering BCR-ABL(+) cells refractory ..
  67. Dash A, Williams I, Kutok J, Tomasson M, Anastasiadou E, Lindahl K, et al. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A. 2002;99:7622-7 pubmed
    Constitutive activation of tyrosine kinases, such as the BCR/ABL fusion associated with t(9;22)(q34;q22), is a hallmark of chronic myeloid leukemia (CML) syndromes in humans...
  68. Alagramam K, Kwon H, Cacheiro N, Stubbs L, Wright C, Erway L, et al. A new mouse insertional mutation that causes sensorineural deafness and vestibular defects. Genetics. 1999;152:1691-9 pubmed
    ..The mutant locus was mapped to a region on mouse chromosome 10, where other spontaneous, recessive mutations causing deafness in mice have been mapped. ..
  69. Pear W, Miller J, Xu L, Pui J, Soffer B, Quackenbush R, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 1998;92:3780-92 pubmed
    Expression of the 210-kD bcr/abl fusion oncoprotein can cause a chronic myelogenous leukemia (CML)-like disease in mice receiving bone marrow cells transduced by bcr/abl-encoding retroviruses...
  70. Kapfhamer D, Miller D, Lambert S, Bennett V, Glover T, Burmeister M. Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. Genomics. 1995;27:189-91 pubmed
    ..backcross analysis, mapping Ank3 to mouse Chromosome 10, between microsatellite marker D10Mit31 and the Bcr gene. This interval is known to comprise a region syntenic to human 10q...
  71. Zhuang C, Tang H, Dissanaike S, Cobos E, Tao Y, Dai Z. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis. J Biol Chem. 2011;286:38614-26 pubmed publisher
    ..We found that the Bcr-Abl-stimulated F-actin assembly is abrogated during mitosis...