Bcl6

Summary

Gene Symbol: Bcl6
Description: B cell leukemia/lymphoma 6
Alias: Bcl5, B-cell lymphoma 6 protein homolog, B-cell leukemia/lymphoma 5
Species: mouse
Products:     Bcl6

Top Publications

  1. Fukuda T, Yoshida T, Okada S, Hatano M, Miki T, Ishibashi K, et al. Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med. 1997;186:439-48 pubmed
    The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells...
  2. Baumjohann D, Okada T, Ansel K. Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol. 2011;187:2089-92 pubmed publisher
    ..The transcriptional repressor BCL6 is required for T(FH) responses, but the kinetics of BCL6 protein expression in activated CD4(+) T cells have not ..
  3. Yu R, Wang X, Pixley F, Yu J, Dent A, Broxmeyer H, et al. BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood. 2005;105:1777-84 pubmed
    ..Our work also suggests that BCL-6 prevents abnormal Th2 differentiation by suppressing basal level IL-6 production in antigen-presenting cells (APCs). ..
  4. Nurieva R, Chung Y, Martinez G, Yang X, Tanaka S, Matskevitch T, et al. Bcl6 mediates the development of T follicular helper cells. Science. 2009;325:1001-5 pubmed publisher
    ..Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells...
  5. Poholek A, Hansen K, Hernandez S, Eto D, Chandele A, Weinstein J, et al. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 2010;185:313-26 pubmed publisher
    ..programmed death receptor-1 (PD-1) and synthesis of IL-21, require upregulation of the transcriptional repressor Bcl6 for their development and function in B cell maturation in germinal centers...
  6. Toney L, Cattoretti G, Graf J, Merghoub T, Pandolfi P, Dalla Favera R, et al. BCL-6 regulates chemokine gene transcription in macrophages. Nat Immunol. 2000;1:214-20 pubmed
    ..Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity. ..
  7. Sawant D, Wu H, Kaplan M, Dent A. The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway. Mol Immunol. 2013;54:435-42 pubmed publisher
    The transcriptional repressor Bcl6 is a critical regulator of T helper cell fate, and inhibits Th2-type inflammation. We have found that microRNA-21 (miR-21) is a novel target gene for Bcl6 in Treg cells...
  8. Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, et al. Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med. 2012;209:2079-97 pubmed publisher
    ..Using conditional Bcl6 ablation, we demonstrate that these cells are generated through proliferative expansion early after immunization in ..
  9. Yoshida K, Sakamoto A, Yamashita K, Arguni E, Horigome S, Arima M, et al. Bcl6 controls granzyme B expression in effector CD8+ T cells. Eur J Immunol. 2006;36:3146-56 pubmed
    b>Bcl6, a sequence-specific transcriptional repressor, is important for generation and maintenance of memory CD8(+) T cells...

More Information

Publications70

  1. Ichii H, Sakamoto A, Kuroda Y, Tokuhisa T. Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. J Immunol. 2004;173:883-91 pubmed
    ..The molecular mechanism involved in the generation of these cells remains elusive. Because Bcl6 plays a role in the generation and maintenance of memory CD8(+) T cells, we further examined this role in the ..
  2. Oestreich K, Huang A, Weinmann A. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med. 2011;208:1001-13 pubmed publisher
  3. Pepper M, Pagán A, Igyarto B, Taylor J, Jenkins M. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity. 2011;35:583-95 pubmed publisher
    ..areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular helper cells depended on the Bcl6 transcription factor and inducible costimulator ligand on B cells...
  4. Zhang Y, Laz E, Waxman D. Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol. 2012;32:880-96 pubmed publisher
    ..Here we elucidate the dynamic, sex-dependent binding of STAT5 and the GH/STAT5-regulated repressor BCL6 to mouse liver chromatin genome wide, revealing a counteractive interplay between these two regulators of sex ..
  5. Nahar R, Ramezani Rad P, Mossner M, Duy C, Cerchietti L, Geng H, et al. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011;118:4174-8 pubmed publisher
    ..of pre-B cell receptor signaling induces cell-cycle exit through up-regulation of the transcriptional repressor BCL6. Inducible activation of BCL6 downstream of the pre-B cell receptor results in transcriptional repression of MYC ..
  6. Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, et al. Bcl6 is required for the development of mouse CD4+ and CD8?+ dendritic cells. J Immunol. 2011;186:255-63 pubmed publisher
    Th2-type inflammation spontaneously shown in Bcl6-knockout (KO) mice is mainly caused by bone marrow (BM)-derived nonlymphoid cells. However, the function of dendritic cells (DCs) in Bcl6-KO mice has not been reported...
  7. Dent A, Hu Li J, Paul W, Staudt L. T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc Natl Acad Sci U S A. 1998;95:13823-8 pubmed
    ..BCL-6, a transcriptional repressor that can bind to the same DNA binding motifs as STAT transcription factors, seems to regulate TH2 responses in vivo by a pathway independent of IL-4 and STAT6. ..
  8. Cimmino L, Martins G, Liao J, Magnusdottir E, Grunig G, Perez R, et al. Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression. J Immunol. 2008;181:2338-47 pubmed
    ..show that Blimp-1 binds directly to a distal regulatory region in the ifng gene and at multiple sites in tbx21 and bcl6 genes...
  9. Hollister K, Kusam S, Wu H, Clegg N, Mondal A, Sawant D, et al. Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol. 2013;191:3705-11 pubmed publisher
    The transcriptional repressor Bcl6 controls development of the follicular Th cell (T(FH)) lineage, but the precise mechanisms by which Bcl6 regulates this process are unclear...
  10. Broxmeyer H, Sehra S, Cooper S, Toney L, Kusam S, Aloor J, et al. Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol. 2007;27:5275-85 pubmed
    ..Since both BAZF- and BCL-6-deficient mice have defects in CD8 T-cell differentiation, we hypothesize that both BCL-6 and BAZF regulate HPC homeostasis by an indirect pathway involving CD8 T cells. ..
  11. Allman D, Jain A, Dent A, Maile R, Selvaggi T, Kehry M, et al. BCL-6 expression during B-cell activation. Blood. 1996;87:5257-68 pubmed
    ..These observations suggest that the germinal center reaction provides unique activation signals to B cells that allow for continued, high-level BCL-6 expression. ..
  12. Kojima S, Hatano M, Okada S, Fukuda T, Toyama Y, Yuasa S, et al. Testicular germ cell apoptosis in Bcl6-deficient mice. Development. 2001;128:57-65 pubmed
    b>Bcl6 protein has been detected in testicular germ cells, mainly spermatocytes, of normal mice, but its physiological role is largely unknown...
  13. Johnston R, Poholek A, DiToro D, Yusuf I, Eto D, Barnett B, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 2009;325:1006-10 pubmed publisher
    ..We found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo T(FH) differentiation and T cell help to B cells in ..
  14. Huang C, Hatzi K, Melnick A. Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nat Immunol. 2013;14:380-8 pubmed publisher
    ..Here we found that genetic replacement with mutated Bcl6 encoding Bcl-6 that cannot bind corepressors to its BTB domain resulted in disruption of the formation of GCs and ..
  15. Lee S, Rigby R, Zotos D, Tsai L, Kawamoto S, Marshall J, et al. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J Exp Med. 2011;208:1377-88 pubmed publisher
    ..In conclusion, Bcl-6(+) T cells are necessary at B cell priming to form extrafollicular antibody responses, and these pre-GC Tfh cells can be distinguished phenotypically from GC Tfh cells...
  16. Liao W, Spolski R, Li P, Du N, West E, Ren M, et al. Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. Proc Natl Acad Sci U S A. 2014;111:3508-13 pubmed publisher
    ..IL-2 also inhibited B cell lymphoma 6 (BCL6) expression, and overexpression of BCL6 impaired Th9 differentiation...
  17. Toyama H, Okada S, Hatano M, Takahashi Y, Takeda N, Ichii H, et al. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity. 2002;17:329-39 pubmed
    ..We show here that Bcl6-deficient B cells, which cannot develop germinal centers, differentiated into IgM and IgG1 memory B cells in the ..
  18. Yu D, Rao S, Tsai L, Lee S, He Y, Sutcliffe E, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity. 2009;31:457-68 pubmed publisher
    ..Thus, Bcl-6 positively directs Tfh cell differentiation, through combined repression of miRNAs and transcription factors...
  19. Meyer R, Laz E, Su T, Waxman D. Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol. 2009;23:1914-26 pubmed publisher
    The transcriptional repressor Bcl6 is a male-specific rat liver gene product and one of 24 early GH-response genes encoding DNA-binding proteins...
  20. Ye B, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet. 1997;16:161-70 pubmed
    ..Altered expression of BCL-6 in lymphoma represents a deregulation of the pathway normally leading to B cell proliferation and germinal centre formation. ..
  21. Ichii H, Sakamoto A, Hatano M, Okada S, Toyama H, Taki S, et al. Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nat Immunol. 2002;3:558-63 pubmed
    ..These data suggest that Bcl-6, which is essential for memory B cell development in germinal centers, is a key molecule for the establishment not only of memory T cells but also of the peripheral T cell compartment in infancy. ..
  22. Mondal A, Sawant D, Dent A. Transcriptional repressor BCL6 controls Th17 responses by controlling gene expression in both T cells and macrophages. J Immunol. 2010;184:4123-32 pubmed publisher
    The transcriptional repressor protein BCL6 regulates T cell differentiation by repressing Th2 responses and promoting follicular Th cell responses. However, little is known about the role of BCL6 in Th17 responses...
  23. Choi Y, Yang J, Yusuf I, Johnston R, Greenbaum J, Peters B, et al. Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol. 2013;190:4014-26 pubmed publisher
    ..These data support the hypothesis that CD4 and CD8 T cells share core aspects of a memory cell precursor gene expression program involving Bcl6, and a strong relationship exists between Tfh cells and memory CD4 T cell development.
  24. Fukuda T, Miki T, Yoshida T, Hatano M, Ohashi K, Hirosawa S, et al. The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. Oncogene. 1995;11:1657-63 pubmed
    ..The BCL6 gene has been isolated from the chromosomal breakpoint in these lymphomas...
  25. Yoshida T, Fukuda T, Okabe S, Hatano M, Miki T, Hirosawa S, et al. The BCL6 gene is predominantly expressed in keratinocytes at their terminal differentiation stage. Biochem Biophys Res Commun. 1996;228:216-20 pubmed
    We analyzed the expression of the BCL6 gene in mouse tissues by in situ hybridization. The expression was strong in the upper layer but undetectable in the basal layer of epidermis from adult mice...
  26. Barish G, Yu R, Karunasiri M, Ocampo C, Dixon J, Benner C, et al. Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev. 2010;24:2760-5 pubmed publisher
  27. Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity. 2011;34:961-72 pubmed publisher
    The transcription factor Bcl6 is essential for the development of germinal center (GC) B cells and follicular helper T (Tfh) cells...
  28. Wang X, Li Z, Naganuma A, Ye B. Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proc Natl Acad Sci U S A. 2002;99:15018-23 pubmed
    ..Our results not only demonstrate an important mechanism governing the expression of BCL-6, but also explain how BCL-6 is deregulated in a large number of DLBCL patients, providing a better understanding of BCL-6-related lymphomagenesis. ..
  29. Staudt L, Dent A, Shaffer A, Yu X. Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6. Int Rev Immunol. 1999;18:381-403 pubmed
    ..The BCL-6 protein is a potent transcriptional repressor which presumably controls lymphocyte differentiation and induces lymphomas by regulating the expression of key downstream target genes. ..
  30. Harris M, Chang C, Berton M, Danial N, Zhang J, Kuehner D, et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol. 1999;19:7264-75 pubmed
    ..Thus, BCL-6 can modulate the transcription of selective Stat6-dependent IL-4 responses, including IgE class switching in B cells. ..
  31. Linterman M, Beaton L, Yu D, Ramiscal R, Srivastava M, Hogan J, et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med. 2010;207:353-63 pubmed publisher
    ..In contrast to the requirement for IL-21 in the follicular response to sheep red blood cells, a purely extrafollicular antibody response to Salmonella dominated by IgG2a was intact in the absence of IL-21...
  32. Basso K, Schneider C, Shen Q, Holmes A, Setty M, Leslie C, et al. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. J Exp Med. 2012;209:2455-65 pubmed publisher
    The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose de-regulation is involved in lymphomagenesis...
  33. Cattoretti G, Pasqualucci L, Ballon G, Tam W, Nandula S, Shen Q, et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell. 2005;7:445-55 pubmed
    ..DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation...
  34. Dent A, Shaffer A, Yu X, Allman D, Staudt L. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 1997;276:589-92 pubmed
    ..Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies. ..
  35. Barish G, Yu R, Karunasiri M, Becerra D, Kim J, Tseng T, et al. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012;15:554-62 pubmed publisher
    ..We show that the transcriptional repressor Bcl6 is an anti-inflammatory regulator whose loss in bone marrow of Ldlr(-/-) mice results in severe atherosclerosis and ..
  36. Oestreich K, Mohn S, Weinmann A. Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol. 2012;13:405-11 pubmed publisher
    ..Thus, IL-2-signaling regulates the Bcl-6-Blimp-1 axis in T(H)1 cells to maintain flexibility with a T(FH) cell-like gene profile. ..
  37. Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim Y, et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med. 2011;208:2163-74 pubmed publisher
    ..Here, we identified the BCL6 protooncogene as a critical effector downstream of FoxO in self-renewal signaling of CML-initiating cells...
  38. Duan S, Cermak L, Pagan J, Rossi M, Martinengo C, di Celle P, et al. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature. 2012;481:90-3 pubmed publisher
    b>BCL6 is the product of a proto-oncogene implicated in the pathogenesis of human B-cell lymphomas...
  39. Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, et al. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med. 2013;19:1014-22 pubmed publisher
    ..gene rearrangement, pre-B cell receptor signaling ends BACH2-mediated negative selection through B cell lymphoma 6 (BCL6)-mediated repression of p53...
  40. Chen Y, Lin G, Huo J, Barney D, Wang Z, Livshiz T, et al. Computational and functional analysis of growth hormone (GH)-regulated genes identifies the transcriptional repressor B-cell lymphoma 6 (Bc16) as a participant in GH-regulated transcription. Endocrinology. 2009;150:3645-54 pubmed publisher
    ..It also contains the most strongly repressed gene in the profile, B cell lymphoma 6 (Bcl6), a transcriptional repressor...
  41. Liu X, Yan X, Zhong B, Nurieva R, Wang A, Wang X, et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med. 2012;209:1841-52, S1-24 pubmed
    ..helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor...
  42. Wei F, Zaprazna K, Wang J, Atchison M. PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells. Mol Cell Biol. 2009;29:4612-22 pubmed publisher
    b>BCL6 is a transcriptional repressor crucial for germinal center formation. BCL6 represses transcription by a variety of mechanisms by binding to specific DNA sequences or by recruitment to DNA by protein interactions...
  43. Choi Y, Kageyama R, Eto D, Escobar T, Johnston R, Monticelli L, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity. 2011;34:932-46 pubmed publisher
    ..demonstrate that inducible costimulator (ICOS) provides a critical early signal to induce the transcription factor Bcl6, and Bcl6 then induces CXCR5, the canonical feature of Tfh cells...
  44. Taylor J, Pape K, Jenkins M. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J Exp Med. 2012;209:597-606 pubmed publisher
    ..These results demonstrate that early IgM(+) and swIg(+) memory B cells are products of a GC-independent pathway, whereas later switched Ig(+) memory B cells are products of GC cells...
  45. Kusam S, Toney L, Sato H, Dent A. Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J Immunol. 2003;170:2435-41 pubmed
    ..These data also point to a novel regulatory mechanism for BCL-6 separate from transcriptional repression. ..
  46. Kitayama D, Sakamoto A, Arima M, Hatano M, Miyazaki M, Tokuhisa T. A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21. Mol Immunol. 2008;45:1337-45 pubmed
    ..b>Bcl6, a sequence specific transcriptional repressor, is highly expressed in germinal center B cells and suppresses ..
  47. Wei Y, Zhu M, Corbalán Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:796-803 pubmed publisher
    ..Therefore, targeting the interaction between miR-155 and B-cell leukemia/lymphoma 6 may be a promising approach to inhibit the progression of atherosclerosis. ..
  48. Donnarumma T, Young G, Merkenschlager J, Eksmond U, Bongard N, Nutt S, et al. Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus. Cell Rep. 2016;17:1571-1583 pubmed publisher
    ..heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (encoding TCF-1) and by the expression of the inhibitory receptors PD-1 and LAG3...
  49. Davies J, Hawe N, Kabarowski J, Huang Q, Zhu J, Brand N, et al. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene. 1999;18:365-75 pubmed
  50. Xu F, Kang Y, Zhuang N, Lu Z, Zhang H, Xu D, et al. Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program. Sci Rep. 2016;6:18778 pubmed publisher
    ..Remarkably, Bcl6 specifically binds to the interferon-regulatory factor (IRF)7 loci and restrains its transcription, thereby ..
  51. Bassil R, Orent W, Olah M, Kurdi A, Frangieh M, Buttrick T, et al. BCL6 controls Th9 cell development by repressing Il9 transcription. J Immunol. 2014;193:198-207 pubmed publisher
    The transcriptional repressor B cell lymphoma 6 (BCL6) is required for the development of Th follicular cells, and it has been shown to suppress Th2 cell differentiation. We demonstrate that BCL6 is a key regulator of Th9 cell development...
  52. Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel K, Lanzavecchia A, et al. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013;38:596-605 pubmed publisher
  53. Bunker J, Flynn T, Koval J, Shaw D, Meisel M, McDonald B, et al. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity. 2015;43:541-53 pubmed publisher
    ..These data demonstrate exquisite targeting of distinct commensal bacteria by multiple layers of humoral immunity and reveal a specialized function of the B1b lineage in TI mucosal IgA responses. ..
  54. Pixley F, Xiong Y, Yu R, Sahai E, Stanley E, Ye B. BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J Cell Sci. 2005;118:1873-83 pubmed
    b>BCL6 is a potent transcriptional repressor that plays important roles in germinal center formation, T helper cell differentiation and lymphomagenesis and regulates expression of several chemokine genes in macrophages...
  55. Ying Z, Mei M, Zhang P, Liu C, He H, Gao F, et al. Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription. J Immunol. 2015;195:1538-47 pubmed publisher
    ..Abnormal expression of germinal center genes (i.e., Bcl6, Prdm1, and Irf4) was detected in conditional knockout mice...
  56. Xin N, Fu L, Shao Z, Guo M, Zhang X, Zhang Y, et al. RNA interference targeting Bcl-6 ameliorates experimental autoimmune myasthenia gravis in mice. Mol Cell Neurosci. 2014;58:85-94 pubmed publisher
    ..In-vivo transduction of lenti-siRNA-Bcl6 ameliorates the severity of ongoing EAMG with decreased Tfh cells, Bcl-6 and IL-21 expression, and leads to ..
  57. Yang Z, Sullivan B, Allen C. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity. 2012;36:857-72 pubmed publisher
    ..Most IgE(+) PCs were short lived and showed reduced affinity maturation, revealing intrinsic mechanisms that restrict the IgE antibody response...
  58. Kim J, Kim D, Chang W, Choe J, Kim J, Park C, et al. Wnt5a is secreted by follicular dendritic cells to protect germinal center B cells via Wnt/Ca2+/NFAT/NF-?B-B cell lymphoma 6 signaling. J Immunol. 2012;188:182-9 pubmed publisher
    ..Our data support that Wnt5a is a novel survival factor for GC B cells and might be a potential target for the regulation of B cell immunity...
  59. Glauser D, Schlegel W. The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cells. J Recept Signal Transduct Res. 2009;29:293-8 pubmed publisher
    ..Thus, in pancreatic beta-cells, the FoxO/Bcl6/cyclin D2 pathway connects nutrient and growth factor status to cell cycle control, and may therefore be considered ..
  60. Lin G, LaPensee C, Qin Z, Schwartz J. Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Mol Cell Endocrinol. 2014;395:19-31 pubmed publisher
    ..transcription activator STAT5 (Signal Transducer and Activator of Transcription 5) and the transcription repressor BCL6 (B-Cell Lymphoma 6)...
  61. Takahara T, Matsuo K, Seto M, Nakamura S, Tsuzuki S. Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model. Cancer Sci. 2016;107:1572-1580 pubmed publisher
    ..Given that BCL6 and BCL2 expression and/or function are often deregulated in human lymphoma, we examined the possible synergy ..