Bcl2l1

Summary

Gene Symbol: Bcl2l1
Description: BCL2-like 1
Alias: Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, bcl-x, B-cell leukemia/lymphoma x, anti-apoptosis regulatory protein, apoptosis regulator Bcl-X, bcl-2-like protein 1, bcl2-L-1
Species: mouse

Top Publications

  1. pmc Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
    Lihua He
    College of Optometry, Department of Biology, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 100:1022-7. 2003
  2. pmc Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    M Chiara Maiuri
    INSERM U848, Villejuif, France
    EMBO J 26:2527-39. 2007
  3. pmc Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
    Stefan P Glaser
    The Walter and Eliza Hall Institute, Parkville, Melbourne, Victoria 3052, Australia
    Genes Dev 26:120-5. 2012
  4. ncbi bcl-xL and RAG genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes
    Penelope Tsimbouri
    Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK
    Oncogene 21:5182-7. 2002
  5. pmc Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival
    Caroline H Yi
    Department of Cell Biology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cell 146:607-20. 2011
  6. pmc Bcl-XL and Bcl-2 repress a common pathway of cell death
    D T Chao
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 182:821-8. 1995
  7. pmc Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver
    Hayato Hikita
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatology 50:1217-26. 2009
  8. pmc Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin
    Melissa M Rhodes
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Blood 106:1857-63. 2005
  9. pmc Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice
    Wan Cheung Cheung
    Cell Signaling Technology Inc, Beverly, Massachusetts, USA
    J Clin Invest 113:1763-73. 2004
  10. ncbi Participation of FLIP, RIP and Bcl-x(L) in Fas-mediated T-cell death
    M Djerbi
    Department of Immunology, The Wenner Gren Institute, University of Stockholm, Stockholm, Sweden
    Scand J Immunol 66:410-21. 2007

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. pmc Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
    Lihua He
    College of Optometry, Department of Biology, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 100:1022-7. 2003
    ..These results have relevance for therapies in a wide variety of progressive retinal and neuronal degenerations where Ca(2+) overload, lead exposure, andor mitochondrial dysfunction occur...
  2. pmc Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    M Chiara Maiuri
    INSERM U848, Villejuif, France
    EMBO J 26:2527-39. 2007
    ..BH3-only proteins and pharmacological BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin-1 and Bcl-2 or Bcl-X(L)...
  3. pmc Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
    Stefan P Glaser
    The Walter and Eliza Hall Institute, Parkville, Melbourne, Victoria 3052, Australia
    Genes Dev 26:120-5. 2012
    ..Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML...
  4. ncbi bcl-xL and RAG genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes
    Penelope Tsimbouri
    Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK
    Oncogene 21:5182-7. 2002
    ..These data shed new light on the potential contribution of EBNA-1 to EBV associated tumorigenicity as well as to the viral life cycle and open a potential avenue for therapeutic intervention...
  5. pmc Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival
    Caroline H Yi
    Department of Cell Biology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cell 146:607-20. 2011
    ..We propose that acetyl-CoA serves as a signaling molecule that couples apoptotic sensitivity to metabolism by regulating protein N-alpha-acetylation...
  6. pmc Bcl-XL and Bcl-2 repress a common pathway of cell death
    D T Chao
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 182:821-8. 1995
    ..Immunoprecipitation indicated that Bcl-xL, like Bcl-2, heterodimerized with the death-promoting molecule Bax in thymocytes. This in vivo model argues that Bcl-xL, like Bcl-2, functions in a common pathway to repress cell death...
  7. pmc Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver
    Hayato Hikita
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatology 50:1217-26. 2009
    ..5 of embryogenesis and rapidly died within 1 day after birth, developing hepatic failure evidenced by increased levels of blood ammonia and bilirubin...
  8. pmc Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin
    Melissa M Rhodes
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Blood 106:1857-63. 2005
    ..Bcl-x(L) is not required for heme synthesis and does not mediate the antiapoptotic effects of erythropoietin, but it prevents ineffective erythropoiesis due to apoptosis in late-stage, hemoglobin-synthesizing erythroblasts...
  9. pmc Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice
    Wan Cheung Cheung
    Cell Signaling Technology Inc, Beverly, Massachusetts, USA
    J Clin Invest 113:1763-73. 2004
    ..Our findings demonstrate that the enforced expression of Myc and Bcl-X(L) by Ig enhancers with peak activity in plasma cells generates a mouse model of human PCN that recapitulates some features of human multiple myeloma...
  10. ncbi Participation of FLIP, RIP and Bcl-x(L) in Fas-mediated T-cell death
    M Djerbi
    Department of Immunology, The Wenner Gren Institute, University of Stockholm, Stockholm, Sweden
    Scand J Immunol 66:410-21. 2007
    ..These results indicate that yet uncharacterized signalling pathways from the Fas receptor are critically involved in lymphoproliferative and autoimmune disease observed in lpr mice and autoimmune lymphoproliferative syndrome patients...
  11. pmc Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages
    T Kodama
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cell Death Differ 19:1856-69. 2012
    ..In conclusion, Mcl-1 and Bcl-xL regulate the survival of the megakaryocytic lineage, which is critically important for preventing lethal or severe hemorrhage in both developing and adult mice...
  12. doi Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptide
    Amir Sharabi
    The Weizmann Institute of Science, Rehovot 76100, Israel
    J Autoimmun 34:87-95. 2010
    ..We conclude that Bcl-xL is required for the development and function of CD4 Treg, which ameliorate lupus following treatment with a tolerogenic peptide...
  13. pmc Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells
    Hongbin Deng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Tian Tan Xi Li, Beijing 100050, China
    Int J Biochem Cell Biol 43:409-15. 2011
    ..Replacement of threonine 201 by alanine in Bad promoted Epo withdrawal-induced apoptosis. Thus, our results provide a molecular mechanism by which JNK1 contributes to the survival of erythroid cells...
  14. ncbi Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses
    Tetsuo Takehara
    Department of Molecular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Gastroenterology 127:1189-97. 2004
    ..The aim of this study was to explore the function of Bcl-xL in hepatocytes using the Cre-loxP system and to analyze the consequences of long-term apoptosis in hepatocytes...
  15. ncbi Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene
    D A Grillot
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Immunol 158:4750-7. 1997
    ..12 and K562 cell lines. The remarkable similarity between the genomic regions of bcl-2 and bcl-x suggests that these genes have evolved from a common ancestral gene or through gene duplication...
  16. pmc Mcl-1 is essential for germinal center formation and B cell memory
    Ingela Vikstrom
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Science 330:1095-9. 2010
    ..We investigated the consequences of deleting genes encoding the anti-apoptotic molecules Mcl1 and Bcl2l1 (Bcl-x(L)) from B cells using an inducible system synchronized with expression of activation-induced cytidine ..
  17. pmc Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer
    Jeffrey H Hager
    Diabetes and Hellen Diller Family Comprehensive Cancer Centers, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e4455. 2009
    ....
  18. pmc BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets
    Takahiro Kodama
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:13905-13. 2011
    ..Despite residing in platelets, BH3-only activator proteins Bid and Bim are dispensable for Bax activation and mitochondrial apoptosis...
  19. ncbi Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene
    W Fang
    Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    Immunity 4:291-9. 1996
    ..This analysis also demonstrated that immunoglobulin gene rearrangement is less precise than previously appreciated...
  20. pmc Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons
    Sarah B Berman
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Cell Biol 184:707-19. 2009
    ..Deficits in these Bcl-x(L)-dependent mechanisms may be critical in neuronal dysfunction during the earliest phases of neurodegeneration, long before commitment to cell death...
  21. ncbi Regulation of Bcl-xL expression by H2O2 in cardiac myocytes
    Donna M Valks
    National Heart and Lung Institute Division Cardiac Medicine Section, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
    J Biol Chem 278:25542-7. 2003
    ..These data demonstrate that the Bcl-x gene is selectively responsive to oxidative stress, and the response is mediated through distal promoter regions...
  22. pmc Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis
    Li Xue
    Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:6925-30. 2002
    ..Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis...
  23. ncbi Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing
    W Fang
    Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA
    Immunity 9:35-45. 1998
    ..These studies suggest that Bcl-x may have a distinct role in controlling survival at the immature stage of B cell development and demonstrate that tolerance is preserved when self-reactive B cells escape central deletion...
  24. pmc The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages
    Ivan Dzhagalov
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 181:521-8. 2008
    ..Furthermore, we demonstrate that Mcl-1 functions together with Bcl-xL to promote double-positive thymocyte survival. Thus, Mcl-1 is a critical anti-apoptotic factor for the survival of T cells at multiple stages in vivo...
  25. ncbi Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation
    K D Walton
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mech Dev 109:281-93. 2001
    ..Concomitant deletion of the bax gene did not significantly modify the Bcl-x phenotype. Our results suggest that Bcl-x is not essential during mammopoiesis, but is critical for controlled apoptosis during the first phase of involution...
  26. ncbi GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivo
    Sakie Hosoya-Ohmura
    Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
    J Biol Chem 281:32820-30. 2006
    ..These data thus show a functional incompatibility between hematopoietic and endodermal GATA factors in vivo and provide evidence indicating specific roles of the C-terminal region of GATA-1 in primitive erythropoiesis...
  27. pmc Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    Simon N Willis
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Genes Dev 19:1294-305. 2005
    ..The finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the Bcl-2 family...
  28. pmc Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors
    Chi Li
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:9830-5. 2002
    ..These results suggest that even under non-apoptotic conditions, expression of Bcl-2-family proteins influences a signaling network that links changes in mitochondrial metabolism to alterations in nuclear gene expression...
  29. ncbi Magnetic resonance diffusion tensor microimaging reveals a role for Bcl-x in brain development and homeostasis
    Jiangyang Zhang
    Department of Radiology, Division of Nuclear Magnetic Resonance Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:1881-8. 2005
    ..Thus, this technique serves as a powerful tool to efficiently localize temporal and spatial manifestation of morphological phenotype...
  30. ncbi The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes
    Nu Zhang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:6967-73. 2005
    ..These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism...
  31. ncbi bcl-xL is critical for dendritic cell survival in vivo
    Huiming Hon
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
    J Immunol 173:4425-32. 2004
    ..Taken together, our work demonstrates that the bcl-x(L) isoform is critical for survival of skin-derived, Ag-bearing DC in vivo...
  32. pmc Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells
    Yanan Zhu
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:7681-6. 2004
    ..Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules...
  33. pmc Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers
    Seon Yong Jeong
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1414, USA
    EMBO J 23:2146-55. 2004
    ..The C-terminal tail of Bcl-x(L) is also required to mediate Bcl-x(L)/Bax heterodimer formation. Both mitochondrial import and antiapoptotic activity of different Bcl-x(L) mutants correlate with their ability to form homodimers...
  34. ncbi The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
    Xinqi Liu
    Howard Hughes Medical Institute, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Immunity 19:341-52. 2003
    ..Our results suggest a way in which both Bim and Bax/Bak might be required for activated T cell apoptosis...
  35. ncbi Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly
    K U Wagner
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bldg 8, Rm 107, Bethesda, MD 20892 0822, USA
    Development 127:4949-58. 2000
    ..Mice conditionally deficient in Bcl-x permitted us for the first time to study the effects of Bcl-x deficiency on cell proliferation, maturation and survival under physiological conditions in an adult animal...
  36. ncbi Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis
    E B Rucker
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 14:1038-52. 2000
    ..These findings demonstrate that the balance of Bcl-x and Bax control PGC survival and apoptosis...
  37. pmc Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
    D A Grillot
    Department of Pathology, University of Michigan, Ann Arbor 48109 0608, USA
    J Exp Med 182:1973-83. 1995
    ..In contrast to Bcl-2, which has been implicated in the maintenance of mature T cells, Bcl-xL appears to provide a survival signal for the maintenance of more immature CD4+CD8+ thymocytes before positive selection...
  38. ncbi Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells
    K Heermeier
    Laboratory of Biochemistry and Metabolism, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1812, USA
    Mech Dev 56:197-207. 1996
    ..These findings point to a significant role for Bax and Bcl-xS in the regulation of apoptosis of secretory alveolar cells during involution...
  39. ncbi The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors
    P Naik
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0534, USA
    Genes Dev 10:2105-16. 1996
    ..Thus, down-modulation of apoptosis selectively contributes to late steps in a tumorigenesis pathway...
  40. ncbi Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
    N Motoyama
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
    Science 267:1506-10. 1995
    ..The life-span of immature lymphocytes, but not mature lymphocytes, was shortened. Thus, Bcl-x functions to support the viability of immature cells during the development of the nervous and hematopoietic systems...
  41. ncbi bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria
    M Gonzalez-Garcia
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    Development 120:3033-42. 1994
    ..Based on its tissue and developmental patterns of expression, it appears that bcl-x may play an important role in the regulation of cell death during development and tissue homeostasis...
  42. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
  43. pmc Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression
    Baohua Zhao
    Department of Microbiology and Immunology and Pennsylvania State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 182:6744-52. 2009
    ..The data provide new insights into why costimulatory signals might need to be sustained over time and suggest a potential novel approach to augment cellular immunotherapy for cancer...
  44. doi EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency
    E F Lee
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Death Differ 15:1609-18. 2008
    ..These results demonstrate how levels of BH3-only proteins, target affinity and the spectrum of neutralization of pro-survival proteins all contribute to killing activity...
  45. ncbi MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains
    K O Tan
    Institute of Molecular and Cell Biology, 30 Medical Dr, Singapore 117609, Republic of Singapore
    J Biol Chem 276:2802-7. 2001
    ..These data suggest that MAP-1 mediates apoptosis through a mechanism that involves binding to Bax...
  46. pmc bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation
    N Motoyama
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Exp Med 189:1691-8. 1999
    ..However, prominent cell death of bcl-x-/- EryP and EryD occurred when the cells matured. The data show that the antiapoptotic function of bcl-x acts at the very end of erythroid maturation...
  47. ncbi Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion
    Y P Zhou
    Department of Medicine, Section of Endocrinology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 278:E340-51. 2000
    ....
  48. pmc Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1
    Marc A Kerenyi
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria
    Blood 112:3878-88. 2008
    ..Both genes were demonstrated to be direct transcriptional targets of Stat5. This establishes an unexpected mechanistic link between EpoR/Jak/Stat signaling and iron metabolism, processes absolutely essential for erythropoiesis and life...
  49. pmc bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice
    D A Grillot
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Exp Med 183:381-91. 1996
    ..Induction of Bcl-xL after signaling through surface IgM and CD40 appears to provide mature B cells with an additional protective mechanism against apoptotic signals associated with antigen-induced activation and proliferation...
  50. ncbi Role of bcl-X(L) in the control of apoptosis in murine myeloma cells
    E R Gauthier
    Canadian Red Cross Blood Transfusion Service, Quebec, Canada
    Cancer Res 56:1451-6. 1996
    ..These results indicate a predominant role of bcl-X(L) in preventing apoptosis in myeloma cells and suggest that the expression of bcl-2 or bcl-X(L) genes in B-cell tumors depends on the differentiation stage of the precursor normal cell...
  51. pmc BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins
    Chunyan Xu
    Program on Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:11477-84. 2008
    ..The findings reveal a hierarchy of functional interactions of BI-1 with Bcl-2/Bax family proteins in regulating ER Ca(2+) homeostasis...
  52. ncbi BID: a novel BH3 domain-only death agonist
    K Wang
    Department of Medicine and Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 10:2859-69. 1996
    ..This BH3-only molecule supports BH3 as a death domain and favors a model in which BID represents a death ligand for the membrane-bound receptor BAX...
  53. pmc DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH
    Rui Zhao
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
    PLoS Biol 5:e1. 2007
    ..Our findings also suggest novel approaches to cancer therapy...
  54. pmc Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis
    Yoshinori Takahashi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 25:9369-82. 2005
    ..Taken together, these findings support the notion that Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis...
  55. ncbi Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL
    Jae Won Shim
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, Korea
    J Neurosci 24:843-52. 2004
    ..These data suggest a role for Bcl-XL during in vitro midbrain DA neuron differentiation and provide an improved system for cell transplantation in a preclinical animal model of Parkinson's disease...
  56. ncbi Expression of bcl-x during mouse B cell differentiation and following activation by various stimuli
    M S Choi
    National Institute for Medical Research, London, GB
    Eur J Immunol 26:676-82. 1996
    ....
  57. pmc FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development
    Rizwanul Haque
    Department of Microbiology and Immunology and Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Arthritis Res Ther 12:R66. 2010
    ..In this study, we generated therapeutically active Tregs with an increased life span and hence greater therapeutic potential...
  58. ncbi A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells
    X F Yang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 7:629-39. 1997
    ..Identification of Bcl-x gamma helps provide a molecular explanation of T cell activation and death after antigen engagement...
  59. pmc Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes
    A M Dahl
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:2031-8. 2000
    ..These results indicate that the various functions of CD28 can be dissociated, and provide an experimental approach for testing the roles of downstream signals in the functions of cellular receptors such as CD28...
  60. pmc Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation
    Jie Yan
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Cell 152:304-15. 2013
    ..Our results reveal that IKK inhibits TNFα-induced apoptosis through two distinct but cooperative mechanisms: activation of the survival factor NF-κB and inactivation of the proapoptotic BH3-only BAD protein...
  61. ncbi Cisplatin and TNF-alpha downregulate transcription of Bcl-xL in murine malignant mesothelioma cells
    Simon A Fox
    Pharmacogenetics Laboratory, School of Pharmacy, Curtin University of Technology and West Australian Biomedical Research Institute, Bentley, WA, Australia
    Biochem Biophys Res Commun 337:983-91. 2005
    ..The findings of the present study provide insights into apoptotic mechanisms in mesothelioma cells and show similar patterns of gene expression to that reported in the human disease...
  62. pmc Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis
    Rebecca M Ream
    The Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 184:2401-9. 2010
    ..This process of CD8(+) T cell activation, proliferation, and differentiation followed by rapid cell death may represent a novel mechanism of altered peptide ligand-induced apoptosis programmed by initial Ag receptor engagement...
  63. pmc The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice
    Mitsuyasu Iwasawa
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Clin Invest 119:3149-59. 2009
    ....
  64. ncbi Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL
    Huimin Xie
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 175:7981-8. 2005
    ..beta-Catenin/TCF is thus able to act as a signal to up-regulate Bcl-xL levels in DP thymocytes, resulting in their enhanced survival...
  65. pmc Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli
    Emma M Carrington
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    Diabetes 58:2316-23. 2009
    ..We investigated the importance of Bcl-xL for beta-cells by deleting the Bcl-x gene specifically in beta-cells and analyzing their survival in vivo and in culture...
  66. pmc Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors
    Sefat E Khuda
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 181:7537-49. 2008
    ....
  67. pmc Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion
    Yi Chieh Nancy Du
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 5:e276. 2007
    ..In addition, myosin Va was identified as a novel Bcl-xL-interacting protein that might mediate the effects of Bcl-xL on tumor cell migration and invasion...
  68. pmc AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
    Alexander L Kovalchuk
    Laboratory of Cancer Biology and Genetics, Cancer Genomics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2989-3001. 2007
    ..In contrast, the second was T(12;15) negative, but had an elevated N-Myc expression caused by a paracentric inversion of chromosome 12. Thus, novel mechanisms juxtapose Ig and Myc-family genes in AID-deficient plasma cell tumors...
  69. pmc Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells
    N Solvason
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Exp Med 187:1081-91. 1998
    ..Furthermore, our results link one of the immunodeficient traits caused by mutant Btk with the failure to properly regulate Bcl-xL...
  70. ncbi Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause
    Xuxia Wu
    Section for Obstetrics and Gynecology, Department of Women s and Children s Health, Uppsala University, SE 751 85 Uppsala, Sweden
    J Steroid Biochem Mol Biol 80:77-83. 2002
    ..These proteins are suggested to interact with each other in the regulation of programmed cell death, apoptosis, but their specific role in growth control of uterine leiomyomas remains to be investigated...
  71. pmc Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
    Girish V Putcha
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 157:441-53. 2002
    ..e., BID and BAD) do not contribute to BAX-dependent cyt c release or apoptosis caused by TFD...
  72. pmc A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death
    R Carrio
    Servicio de Inmunologia, H U Marqués de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Am J Pathol 149:2133-42. 1996
    ..Furthermore, its distribution in multiple tissues of the embryo suggests that A1 plays a role in the regulation of physiological cell death during embryonic development...
  73. ncbi Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration
    R M Joseph
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Invest Ophthalmol Vis Sci 37:2434-46. 1996
    ..To test the hypothesis that overexpression of genes coding for the anti-apoptotic proteins Bcl-2 or Bcl-XL in photoreceptor cells may prevent or delay photoreceptor degenerations...
  74. ncbi BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    Nika N Danial
    Howard Hughes Medical Institute, Dana Faber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:952-6. 2003
    ..This combination of proteomics, genetics and physiology indicates an unanticipated role for BAD in integrating pathways of glucose metabolism and apoptosis...
  75. pmc Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia
    J S Kuhl
    Department of Medicine, Stanford University School of Medicine, CA 94305 5306, USA
    Br J Cancer 75:268-74. 1997
    ....
  76. pmc The Erk2 MAPK regulates CD8 T cell proliferation and survival
    Warren N D'Souza
    Department of Cellular and Molecular Medicine, Division of Biological Science, Molecular Biology Section, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 181:7617-29. 2008
    ..These studies ascribe multifaceted functions specific to Erk2 in CD8 T cell activation, proliferation, and survival...
  77. pmc Bclx regulates the survival of double-positive thymocytes
    A Ma
    Howard Hughes Medical Institute, Children s Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 92:4763-7. 1995
    The bclx gene has been shown to regulate programmed cell death in vitro...
  78. pmc bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death
    M Gonzalez-Garcia
    Department of Pathology and Anatomy, University of Michigan Medical School, Ann Arbor 48109, USA
    Proc Natl Acad Sci U S A 92:4304-8. 1995
    ..Thus, Bcl-x proteins appear to play an important role in the regulation of neuronal survival in the adult CNS...
  79. pmc Epithelial cell expression of BCL-2 family proteins predicts mechanisms that regulate Helicobacter pylori-induced pathology in the mouse stomach
    Susan J Hagen
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Lab Invest 88:1227-44. 2008
    ....
  80. doi Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling
    Tatsuaki Mizutani
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Hematol 36:255-64. 2008
    ....
  81. ncbi A Bcl-xL transgene promotes malignant conversion of chemically initiated skin papillomas
    J C Pena
    Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, University of Chicago, Illinois 60637, USA
    Cancer Res 58:2111-6. 1998
    ..In contrast, Bcl-xL overexpression can dramatically increase the malignant conversion rate of benign tumors, suggesting that inhibition of apoptosis can contribute to tumor progression...
  82. doi Bcl-XL mediates epidermal growth factor dependent cell survival in HC11 mammary epithelial cells
    Leonardo Romorini
    Departamento de Quimica Biologica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biochim Biophys Acta 1793:496-505. 2009
    ..In fact, HC11 cells unable to express bcl-X, die even in the presence of EGF. In this context, Bcl-XL emerges as a key anti-apoptotic molecule critical for mediating EGF cell survival...
  83. pmc Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis
    Junghee Lee
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    FASEB J 23:1739-49. 2009
    ..This survival pathway may contribute to the glial survival and activation seen in the spinal cord of ALS patients...
  84. ncbi Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist
    R Hegde
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 273:7783-6. 1998
    ..The apoptotic activity of Blk is also inhibited by a dominant negative caspase-9, suggesting that Blk induces apoptosis through activation of the cytochrome c-Apaf-1-caspase-9 pathway...
  85. pmc Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia
    Douglas J Hilton
    Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 113:5599-604. 2009
    ..The data suggest potential utility of c-Myb/p300 as a target for therapeutic intervention in thrombocytopenia of diverse origins...
  86. ncbi Steroid hormones induce bcl-X gene expression through direct activation of distal promoter P4
    Luciana Rocha Viegas
    Departamento de Química Biológica de la Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and CONICET, Argentina
    J Biol Chem 279:9831-9. 2004
    ..This observation correlates with the induction of the bcl-X(L) mRNA, suggesting that P4 is one of the bcl-X promoters responsible for the generation of this antiapoptotic isoform...
  87. ncbi Bcl-X is the major pleiotropic anti-apoptotic gene activated by retroviral insertion mutagenesis in an IL-3 dependent bone marrow derived cell line
    J Thomas
    Immunologie Cellulaire, LBMC de L ENS Lyon, CNRS UMR49 INRA LA 913, France
    Oncogene 16:1399-408. 1998
    ..They also suggest that the Bcl-2 family of genes might be the only one capable of inhibiting apoptosis induced by multiple pathways without inducing cell proliferation...
  88. ncbi Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors
    G Middleton
    School of Biological and Medical Sciences, University of St Andrews, Scotland
    Development 122:695-701. 1996
    ..Our results also argue that the relative amounts of Bcl-2 and Bax are critical in regulating neuronal survival...
  89. ncbi Chromosomal assignment of the Bcl2-related genes, Bcl2l and Bax, in the mouse and rat
    Y Matsuda
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Cytogenet Cell Genet 74:107-10. 1996
    The Bcl2-related genes, Bax and Bcl2l (formerly called Bclx), are involved in the regulation of apoptotic cell death, and the chromosome location of these two genes was determined in the mouse and rat by fluorescence in situ ..
  90. ncbi Bcl-x expression influences keratinocyte cell survival but not terminal differentiation
    J C Pena
    Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
    Cell Growth Differ 8:619-29. 1997
    ..Taken together, these findings demonstrate that although the terminal differentiation program is not altered by Bcl-x, acute stress responses within the skin can be influenced by regulators of apoptosis such as Bcl-x...
  91. pmc Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene
    S P Tzung
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Am J Pathol 150:1985-95. 1997
    ..In summary, the expression profiles of Bcl-2 family members during liver regeneration suggest a cell-cycle-dependent regulation as well as a physiological role for these apoptosis-modulating genes during growth and proliferation...
  92. ncbi Bcl-2 family proteins
    J C Reed
    The Burnham Institute, La Jolla, California 92037, USA
    Oncogene 17:3225-36. 1998
    ....
  93. ncbi 1-BP inhibits NF-kappaB activity and Bcl-xL expression in astrocytes in vitro and reduces Bcl-xL expression in the brains of rats in vivo
    Y Yoshida
    Department of Immunology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Neurotoxicology 28:381-6. 2007
    ..These results suggest that subchronic inhalation exposure to 1-BP vapor may affect the Bcl-xL expression in astrocytes...
  94. ncbi Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms
    Andrew Finch
    Cancer Research Institute and Department of Cellular and Molecular Pharmacology, UCSF Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, California 94143, USA
    Cancer Cell 10:113-20. 2006
    ..Bcl-xL and p19 ARF loss together synergize to further accelerate Myc oncogenesis. Thus, differing lesions cooperate oncogenically with Myc by discrete mechanisms that can themselves synergize with each other...
  95. ncbi The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis
    A Rebollo
    Centro Nacional de Biotecnologia, Department of Immunology and Oncology, Campus de Cantoblanco, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 167:6366-73. 2001
    ..On the contrary, cells that overexpress Bcl-xL and Aiolos are unable to block apoptosis in the absence of IL-4. We propose a model for the regulation of the Bcl-xL anti-apoptotic role via Aiolos...
  96. ncbi Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells
    Leonard J Buccellato
    Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 279:6753-60. 2004
    ..Bax activation at the mitochondrial membrane requires the generation of ROS and can be prevented by the overexpression of Bcl-XL...
  97. ncbi Bcl-x is required for proper development of the mouse substantia nigra
    Joseph M Savitt
    Institute for Cell Engineering, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:6721-8. 2005
    ..Surprisingly, surviving neurons were found that lacked Bcl-x immunoreactivity, thereby demonstrating that this gene is dispensable for the ongoing survival of a subpopulation of catecholaminergic cells...
  98. ncbi Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system
    M Krajewska
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 9:145-57. 2002
    ..Among the Bcl-2 family proteins only Bid and Bcl-XL continue to be expressed at high levels in the adult brain...
  99. ncbi Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts
    Helmut Dolznig
    Division of Molecular Biology, Institute of Medical Biochemistry, 1030 Vienna, Austria
    Curr Biol 12:1076-85. 2002
    ..Here we address whether Epo function during terminal maturation involves a cytokine-independent "default program," requiring only apoptosis inhibition through Epo-dependent upregulation of Bcl-X(L)...
  100. ncbi [Apoptotic characteristics of spleen lymphocyte in mice irradiated by lethal dose and its relationship to the expression of Bax and Bcl-XL proteins]
    Yu fang Cui
    Department of Immunology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:109-12. 2005
    ..To observe the apoptotic characteristics of mouse spleen lymphocyte after lethal dose gamma-irradiation and its relationship to the expression of Bax and Bcl-XL proteins...
  101. ncbi Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation
    Xiao Feng Yang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Immunol 39:45-55. 2002
    ..The ability receptor-induced signals to regulate the splicing pattern of the complex Bcl-x gene may allow T-cells to respond appropriately to antigenic stimuli...

Research Grants35

  1. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2007
    ..Furthermore, they might reveal whether a combinatorial therapy of pan-ErbB tyrosine kinase inhibitors and Jak2 inhibitors would be beneficial for the treatment of ErbB2-positive breast cancers. ..
  2. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2007
    ..Therefore, understanding the normal functions of bcl-2 during nephrogenesis and the consequences of its interaction with paxillin will give us important insight into kidney morphogenesis and pathogenesis. ..
  3. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika Danial; Fiscal Year: 2009
    ..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..
  4. Stapled Antigens for HIV-1 Vaccination
    LOREN WALENSKY; Fiscal Year: 2009
    ....
  5. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2010
    ..Furthermore, they might reveal whether a combinatorial therapy of pan-ErbB tyrosine kinase inhibitors and Jak2 inhibitors would be beneficial for the treatment of ErbB2-positive breast cancers. ..
  6. Tsg101 - a Modulator of ErbB2 Signaling in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2010
    ..The genetic and molecular studies outlined in this application will help to predict the potential value of Tsg101 as a therapeutic target before a drug will be developed and tested in preclinical trials. ..
  7. A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactom
    LOREN WALENSKY; Fiscal Year: 2009
    ....
  8. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika N Danial; Fiscal Year: 2010
    ..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..
  9. PROTEIN INTERACTION EXTENDS THE CELL DEATH PATHWAY
    LOREN DAVID WALENSKY; Fiscal Year: 2010
    ..Ultimately, we aim to harness the fresh insights from these studies to generate prototype therapeutics that reactivate BAX-mediated apoptosis in human cancer. ..
  10. Tsg101 - a Modulator of ErbB2 Signaling in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2009
    ..The genetic and molecular studies outlined in this application will help to predict the potential value of Tsg101 as a therapeutic target before a drug will be developed and tested in preclinical trials. ..
  11. Stapled Antigens for HIV-1 Vaccination
    LOREN DAVID WALENSKY; Fiscal Year: 2010
    ....
  12. Dissecting the Death Pathway in the Islet beta-cell
    Nika Danial; Fiscal Year: 2005
    ..abstract_text> ..
  13. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2006
    ..abstract_text> ..
  14. PROTEIN INTERACTION EXTENDS THE CELL DEATH PATHWAY
    LOREN WALENSKY; Fiscal Year: 2006
    ..The current proposal will dissect this pro-apoptotic cascade by identifying the precise downstream molecules that mediate the mitochondrial demise and detailing their mechanism of action. ..
  15. BAD Intergrates Glycolysis and Apoptosis
    Nika Danial; Fiscal Year: 2007
    ..Danial's development as an independent investigator. Dr. Korsmeyer, a world leader in the fields of oncogenesis and apoptosis, has an excellent record of training and fostering independent investigators. ..
  16. Targeting Apoptosis by Chemical Design
    LOREN WALENSKY; Fiscal Year: 2007
    ..Walensky's development as an independent investigator at the interface of these notable fields. ..
  17. A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactom
    LOREN DAVID WALENSKY; Fiscal Year: 2010
    ....