Bcl2

Summary

Gene Symbol: Bcl2
Description: B cell leukemia/lymphoma 2
Alias: AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik, B-cell leukemia/lymphoma 2, apoptosis regulator Bcl-2
Species: mouse

Top Publications

  1. ncbi Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    Joseph T Opferman
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Department of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 426:671-6. 2003
  2. ncbi MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:33175-82. 2008
  3. ncbi Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
    Scott A Oakes
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:105-10. 2005
  4. ncbi Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    M Vila
    Department of Neurology, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:2837-42. 2001
  5. ncbi The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores
    Nathan R Brady
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    FEBS J 274:3184-97. 2007
  6. ncbi Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    Z N Oltvai
    Howard Hughes Medical Institute Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 74:609-19. 1993
  7. ncbi The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
    T Yang
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755 3835
    J Cell Biol 128:1173-84. 1995
  8. ncbi Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells
    F Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
    Int J Cancer 76:523-30. 1998
  9. ncbi Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
  10. ncbi Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
    Piera Pasinelli
    Day Laboratory for Neuromuscular Research, Department of Neurology, Harvard Medical School, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 43:19-30. 2004

Research Grants

  1. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2010
  2. STUDY OF DIABETIC RETINOPATHY
    Timothy Kern; Fiscal Year: 2007
  3. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
  4. Controlling the BCL-2 Pathway of Mitochondrial Apoptosis
    Anthony Letai; Fiscal Year: 2007
  5. BAD Intergrates Glycolysis and Apoptosis
    Nika Danial; Fiscal Year: 2007
  6. MOUSE MODELS TO STUDY THE ROLE OF TRAF1 AND TRAF2 IN THE ETIOLOGY OF LEUKEMIA
    Juan Zapata; Fiscal Year: 2007
  7. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2007
  8. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2007
  9. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2007
  10. Inflammatory and Chemotactic Cytokines in Bronchopulmonary Dysplasia
    Vedang Londhe; Fiscal Year: 2007

Detail Information

Publications119 found, 100 shown here

  1. ncbi Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    Joseph T Opferman
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Department of Pathology and Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 426:671-6. 2003
    ..Thus, MCL-1, which selectively inhibits the proapoptotic protein BIM, is essential both early in lymphoid development and later on in the maintenance of mature lymphocytes...
  2. ncbi MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:33175-82. 2008
    ..These findings indicate TLR signaling via its adaptor proteins reduces the binding of Beclin 1 to Bcl-2 by recruiting Beclin 1 into the TLR-signaling complex leading to autophagy...
  3. ncbi Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
    Scott A Oakes
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Brigham and Women s Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:105-10. 2005
    ..These findings support a model in which BCL-2 family members regulate IP3R-1 phosphorylation to control the rate of ER Ca(2+) leak from intracellular stores...
  4. ncbi Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    M Vila
    Department of Neurology, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:2837-42. 2001
    ..This study demonstrates that Bax plays a critical role in the MPTP neurotoxic process and suggests that targeting Bax may provide protective benefit in the treatment of Parkinson's disease...
  5. ncbi The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores
    Nathan R Brady
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    FEBS J 274:3184-97. 2007
    ..Moreover, we identify calcium homeostasis as an essential component of the autophagic response to nutrient deprivation...
  6. ncbi Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    Z N Oltvai
    Howard Hughes Medical Institute Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 74:609-19. 1993
    ..Overexpressed Bax also counters the death repressor activity of Bcl-2. These data suggest a model in which the ratio of Bcl-2 to Bax determines survival or death following an apoptotic stimulus...
  7. ncbi The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
    T Yang
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755 3835
    J Cell Biol 128:1173-84. 1995
    ..A burst of expression of mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells differentiating along the monocyte/macrophage pathway...
  8. ncbi Down-regulation of c-myc and bcl-2 gene expression in PU.1-induced apoptosis in murine erythroleukemia cells
    F Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
    Int J Cancer 76:523-30. 1998
    ..Our results suggest that a reduction of at least 2 important apoptosis-inhibiting factors, c-Myc and Bcl-2, is involved in PU.1-induced apoptosis in MEL cells...
  9. ncbi Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  10. ncbi Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
    Piera Pasinelli
    Day Laboratory for Neuromuscular Research, Department of Neurology, Harvard Medical School, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuron 43:19-30. 2004
    ..These findings provide new insights into the anti-apoptotic function of SOD1 and suggest that entrapment of Bcl-2 by large SOD1 aggregates may deplete motor neurons of this anti-apoptotic protein...
  11. ncbi Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
    Arvind Rajpal
    Department of Molecular and Cell Biology, Division of Immunology and Cancer Research Laboratory, 469 LSA, University of California, Berkeley, CA 94720 3200, USA
    EMBO J 22:6526-36. 2003
    ..Thus Nur77-mediated apoptosis in T cells involves Bcl-2 independent transcriptional activation of several known and novel apoptotic pathways...
  12. ncbi Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:1570-81. 2004
    ..These results indicate that any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only proteins...
  13. ncbi Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells
    Yanan Zhu
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:7681-6. 2004
    ..Our results indicate that, in T cells, Bim function is regulated by interaction with Bcl-2 family members on mitochondria rather than by sequestration to the microtubules...
  14. ncbi Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
    ..These data raise the possibility that Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis...
  15. ncbi Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A
    X Deng
    Sealy Center for Oncology and Hematology and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 273:34157-63. 1998
    ..H7 and FDC-P1/ER myeloid cells by stimulating proliferation and suppressing apoptosis. Recently, we discovered that Bcl2 is phosphorylated at an evolutionarily conserved serine residue (Ser70) after treatment with the survival agonists ..
  16. ncbi Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
    Rebecca L H Bigelow
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:1197-205. 2004
    ..These studies further suggest that one consequence of the deregulation of shh signaling in BCC is the up-regulation of bcl-2...
  17. ncbi Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell
    Y Matsuzaki
    Department of Immunology, University of Tsukuba, Ibaraki, Japan
    Blood 89:853-62. 1997
    ..In addition, lymphopoiesis from fetal liver HSC appears to be less dependent on bcl-2 than adult bone marrow HSC...
  18. ncbi Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic mice
    A de La Coste
    Institut National de la Santé et de la Recherche, U129, ICGM, université Paris V René Descartes, France
    Cancer Res 59:5017-22. 1999
    ..Thus, we have shown that Bcl-2 can have a tumor suppressor effect in vivo on c-myc-induced hepatocarcinogenesis during the emergence of neoplastic foci...
  19. ncbi Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation
    J Rodriguez-Villanueva
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston 77077, USA
    Oncogene 16:853-63. 1998
    ..bcl-2 mice compared to control littermates following initiation with DMBA and promotion with TPA. Together these results support a role for bcl-2 in the pathogenesis of NMSC...
  20. ncbi Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein
    K Antoku
    Department of Medicine, Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute, BST E1055, 211 Lothrop Street, Pittsburgh, Pennsylvania 15213 2582, USA
    Biochem Biophys Res Commun 286:1003-10. 2001
    ....
  21. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001
    ..These results demonstrate that Bim levels set the threshold for initiation of apoptosis in several tissues and suggest that degenerative diseases might be alleviated by blocking BH3-only proteins...
  22. ncbi Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain
    Tzong Shoon Wu
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    J Immunol 168:705-12. 2002
    ..The reduced Bcl-2 content in CD8(+) cells might result in survival defect and contribute to the reduction of CD8(+) cells in IL-15Ralpha(-/-)mice...
  23. ncbi Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    K Akashi
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Cell 89:1033-41. 1997
    ..We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development...
  24. ncbi Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    Anthony Letai
    Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 2:183-92. 2002
    ..These data support a two-class model for BH3 domains: BID-like domains that "activate" BAX, BAK and BAD-like domains that "sensitize" by occupying the pocket of antiapoptotic members...
  25. ncbi Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  26. ncbi Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H
    M Nonaka
    Department of Immunobiology, Kanazawa University, Japan
    Genomics 15:535-42. 1993
    ..In addition, a significant structural similarity between FXIII-b and complement factor H is described...
  27. ncbi Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    D J Veis
    Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 75:229-40. 1993
    ..The abnormalities in these loss of function mice argue that Bcl-2 is a death repressor molecule functioning in an antioxidant pathway...
  28. ncbi Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice
    G P Linette
    Department of Medicine, Howard Hughes Medical Institute at Washington University, St Louis, MO 63110, USA
    Blood 86:1255-60. 1995
    ..These data provide support for the thesis that violation of homeostasis through the repression of cell death can be a primary mechanism of tumorigenesis in multiple lineages...
  29. ncbi A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
    Siva Kumar Kolluri
    Cancer Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cancer Cell 14:285-98. 2008
    ..NuBCP-9s act as molecular switches to dislodge the Bcl-2 BH4 domain, exposing its BH3 domain, which in turn blocks the activity of antiapoptotic Bcl-X(L)...
  30. ncbi bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Victoria, Australia
    Cell 67:889-99. 1991
    ..These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes...
  31. ncbi Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 88:8661-5. 1991
    The biological functions of the BCL2 gene were investigated in transgenic mice harboring human BCL2 cDNA under the control of an immunoglobulin heavy chain enhancer (E mu)...
  32. ncbi Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
    Jerry E Chipuk
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Proc Natl Acad Sci U S A 105:20327-32. 2008
    ..Our data show that the induction of apoptosis by inhibition of the anti-apoptotic BCL-2 repertoire requires "covert" levels of direct activators of BAX and BAK at the OMM...
  33. ncbi bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
    C L Sentman
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 67:879-88. 1991
    ..This transgenic model indicates that multiple death pathways operate within the thymus that can be distinguished by their dependence on bcl-2...
  34. ncbi Bcl-2 initiates a new category of oncogenes: regulators of cell death
    S J Korsmeyer
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110
    Blood 80:879-86. 1992
  35. ncbi Collaboration of pim-1 and bcl-2 in lymphomagenesis
    D Acton
    Division of Molecular Genetics of The Netherlands Cancer Institute, Amsterdam
    Curr Top Microbiol Immunol 182:293-8. 1992
  36. ncbi Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    Michael Certo
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 9:351-65. 2006
    ..Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival...
  37. ncbi Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1
    Marie Lundholm
    Department of Medical Biosciences, Division of Medical and Clinical Genetics, Umea University, Sweden
    Diabetes 55:538-44. 2006
    ..Instead, as previously shown, higher ICOS levels in NOD mice appear to be controlled by gene(s) in the Idd5.1 region, possibly a polymorphism in the Icos gene itself...
  38. ncbi Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis
    H Rossiter
    Department of Dermatology, University of Vienna Medical School, Vienna, A 1090, Austria
    Cancer Res 61:3619-26. 2001
    ..We conclude that, despite its antiapoptotic function, bcl-2, overexpressed in basal epidermal keratinocytes, exerts a paradoxical retardation on the development of skin tumors induced by chemical carcinogens and particularly by UVB...
  39. ncbi Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice
    K Nakayama
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Science 261:1584-8. 1993
    ..T and B cells with no Bcl-2 disappeared from the bone marrow, thymus, and periphery by 4 weeks of age. Thus, Bcl-2 was dispensable for lymphocyte maturation, but was required for a stable immune system after birth...
  40. ncbi Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
    K Nakayama
    Howard Hughes Medical Institute, Department of Medicine, St Louis, MO
    Proc Natl Acad Sci U S A 91:3700-4. 1994
    ..Surprisingly, the nervous system, intestines, and skin appear normal despite the fact that these organs show high levels of endogenous Bcl-2 expression in normal mice...
  41. ncbi Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation
    G P Linette
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 93:9545-52. 1996
    ..Thus, select genetic aberrations in the apoptotic pathway reveal a cell autonomous coregulation of activation...
  42. ncbi The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes
    Nu Zhang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:6967-73. 2005
    ..These results indicate that Bcl-x is dispensable for the generation of effector and memory T lymphocytes and suggest that costimulation of T lymphocytes promotes their survival through a Bcl-x(L) independent mechanism...
  43. ncbi Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis
    Michael Klüppel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Development 132:3989-4003. 2005
    ..Our study demonstrates an important biological role of differential chondroitin sulfation in mammalian development...
  44. ncbi Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis
    Yoshinori Takahashi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 25:9369-82. 2005
    ..Taken together, these findings support the notion that Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax/Bak activator, and loss of this proapoptotic molecule may contribute to tumorigenesis...
  45. ncbi p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association
    Shenghao Jin
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:24698-705. 2005
    ..These signals are specific for Pak1, because Src-activated Raf-1 only stimulates the MAP kinase cascade. Thus, our data identify the molecular connections of a Pak1-Raf-1-BAD pathway that is involved in cell survival signaling...
  46. ncbi Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2
    Xiaobo Lei
    The Laboratory of Apoptosis and Cancer Biology, Institute of Zoology, Chinese Academy of Sciences, Bei Si Huan Xi Road 25, Haidian District, Beijing 100080, PR China
    FASEB J 20:2147-9. 2006
    ..We conclude that gossypol converts the antiapoptotic molecule Bcl-2 into a proapoptotic molecule that can mediate the release of cyto c and induce apoptosis...
  47. ncbi Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1
    Olivier Boulard
    Institut National de la Sante et de la Recherche Medicale, Unité 25, Hopital Necker Enfants Malades, Paris, France
    J Immunol 168:4192-201. 2002
    ..1 in females and on chr.7 in males, probably because of the latent autoimmune predisposition of the NZW strain. Altogether these findings reflect the complexity and heterogeneity of human SS...
  48. ncbi B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice
    Cornelia Brunner
    Department of Physiological Chemistry, University of Ulm, D 89081 Ulm, Germany
    J Exp Med 197:1205-11. 2003
    ..b>Bcl2 expression is strongly reduced in BOB.1/OBF.1-deficient pre-B cells. When BOB.1/OBF...
  49. ncbi Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy
    J Brayer
    Department of Oral Biology, University of Florida, Gainesville 32610, USA
    J Rheumatol 27:1896-904. 2000
    ..We investigated if these 2 autoimmune diseases share a genetic predisposition...
  50. ncbi Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice
    M E Haywood
    Imperial College School of Medicine, London, UK
    Arthritis Rheum 43:349-55. 2000
    ..To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice...
  51. ncbi Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development
    T M Michaelidis
    Department of Neurochemistry, Max Planck Institute for Psychiatry, Planegg Martinsried, Federal Republic of Germany
    Neuron 17:75-89. 1996
    ....
  52. ncbi Bcl-2 protein expression during murine development
    D V Novack
    Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Pathol 145:61-73. 1994
    ..The wide distribution of Bcl-2 in the developing mouse suggests that many immature cells require a death repressor molecule or that Bcl-2 may have roles beyond regulating developmental cell death...
  53. ncbi Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
    S Takayama
    La Jolla Cancer Research Foundation, California 92037
    Cell 80:279-84. 1995
    ....
  54. ncbi Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    T Miyashita
    La Jolla Cancer Research Foundation, Cancer Research Center, CA 92037
    Oncogene 9:1799-805. 1994
    ..The findings suggest a potential mechanism by which p53 regulates apoptosis, as well as responses to radiation and chemotherapeutic drugs in cancer...
  55. ncbi Bcl-2 and Bax function independently to regulate cell death
    C M Knudson
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 16:358-63. 1997
    ..In contrast, overexpression of Bcl-2 still repressed apoptosis in the absence of Bax. While an in vivo competition exists between Bax and Bcl-2, each is able to regulate apoptosis independently...
  56. ncbi Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice
    H J Garchon
    INSERM U 25, Hopital Necker, Pairs, France
    Nature 353:260-2. 1991
    ..Here we report a close association of periinsulitis with a third non-MHC locus mapping to chromosome 1. Successive stages in the progression of diabetic disease thus appear to be controlled by distinct genes or sets of genes...
  57. ncbi Developmental regulation of bcl-2 expression in the thymus
    N C Moore
    Centre for Clinical Research in Immunology and Signalling, Medical School, University of Birmingham, U K
    Immunology 81:115-9. 1994
    ..The possible implications of these changes in bcl-2 expression regarding other facets of thymocyte development will be discussed...
  58. ncbi Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity
    H Nakajima
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    J Immunol 162:782-90. 1999
    ....
  59. ncbi Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice
    E Maraskovsky
    Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Cell 89:1011-9. 1997
    ..These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2...
  60. ncbi Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
    M Kondo
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:155-62. 1997
    ..Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of gamma(c)-related receptors...
  61. ncbi The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2
    V Porciatti
    Istituto di Neurofisiologia del Consiglio Nazionale delle Ricerche, Pisa, Italy
    Proc Natl Acad Sci U S A 93:14955-9. 1996
    ..Neuronal survival is a necessary condition in the challenge for promoting regeneration and eventually restoring neuronal function...
  62. ncbi Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma
    Paula Ferrer
    Department of Physiology, University of Valencia, 46010 Valencia, Spain
    J Biol Chem 282:2880-90. 2007
    ..Direct NO-induced cytotoxicity and ceramide-induced mitochondrial permeability transition and apoptosis activation can explain the increased endothelium-induced death of Bcl-2-depleted B16M-F10 cells...
  63. ncbi Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
    T Miyazaki
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 81:223-31. 1995
    ..These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation...
  64. ncbi Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
    Weiguo Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 5:50. 2005
    ..However, the molecular mechanism underlying this inhibition has not been fully elucidated. In this report, we analyze the effect of maspin on tumor cell apoptosis under several stress conditions...
  65. ncbi Thioredoxin-1 protects against hyperoxia-induced apoptosis in cells of the alveolar walls
    Tadaaki Yamada
    Department of Respiratory Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Pulm Pharmacol Ther 20:650-9. 2007
    ..Thioredoxin-1 (TRX-1) is a small ubiquitous protein that acts as an important radical scavenger. We investigated the effect of TRX-1 on apoptosis in hyperoxia-induced lung injury...
  66. ncbi Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad
    V S Ratts
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 136:3665-8. 1995
    ....
  67. ncbi Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Proc Natl Acad Sci U S A 102:9655-60. 2005
    ..of apoptosis through the release of Rad9 from damaged chromatin during the S phase of the cell cycle, allowing Rad9-Bcl2 association and induction of proapoptotic Bax protein...
  68. ncbi Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
    J M Boyd
    Institute for Molecular Virology, St Louis University Health Sciences Center, Missouri 63110
    Cell 79:341-51. 1994
    ..Our results suggest that two diverse proteins, the E1B 19 kDa and the Bcl-2 proteins, promote cell survival through interaction with a common set of cellular proteins...
  69. ncbi Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences
    Giovanna De Chiara
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Biol Chem 281:21353-61. 2006
    ..Thus, Bcl-2 phosphorylation by activated p38 MAPK is a key event in the early induction of apoptosis under conditions of cellular stress...
  70. ncbi Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms
    P Hughes
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Cell Death Differ 13:1123-7. 2006
    ..Loss of one Bcl-2 allele did not influence the PKD1del34 phenotype significantly. We conclude that loss of PKD1 and loss of Bcl-2 elicit PKD through distinct mechanisms...
  71. ncbi Apoptosis and autoimmunity
    N Ogawa
    Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7874, USA
    J Autoimmun 8:1-19. 1995
  72. ncbi Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 32:3-7. 2006
    ....
  73. ncbi Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo
    Tracey H Wagner
    Department of Anesthesiology, School of Medicine, Washington University in St Louis, St Louis, MO 63110, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1751-9. 2007
    ..In addition, our data suggest that the ability of bcl-2 overexpression to improve survival in sepsis in this model is related in part to prevention of sepsis-induced alterations in spleen transcriptional responses...
  74. ncbi Anti-tumor activity of polysaccharides isolated from Patrinia scabra Bunge on U14 cervical carcinoma bearing mice
    Wen Zong Lu
    College of Animal Science, Northwest Agriculture and Forestry University, Yangling, Shaanxi Province, China
    Am J Chin Med 37:933-44. 2009
    ..w.) showed the up-regulation of p53 and Bax, and significant inhibition of Bcl-2 in tumor tissues. It suggests a possible mechanism of the inhibitory effect of PSB-P2 on tumor growth...
  75. ncbi Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis
    Nidhi Nigam
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, M G Marg, P O Box 80, Lucknow 226001, India
    Cancer Chemother Pharmacol 65:687-96. 2010
    ....
  76. ncbi c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2
    Xiaoming Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 19:340-7. 2009
    ..Our results provide novel insight into the mechanism regulating the survival of positively selecting thymocytes...
  77. ncbi Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation
    Yuxing Zhao
    Department of Pharmacology and Cancer Biology, Sarah W Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 283:36344-53. 2008
    ....
  78. ncbi Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma
    M Negrini
    Cell 49:455-63. 1987
    ..Expression is tissue-specific in adult tissues: spleen and thymus express the highest level of mbcl-2 transcripts. The mbcl-2 gene maps to mouse chromosome 1...
  79. ncbi p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis
    M Donaldson
    Monocyte Trafficking Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 145, USA
    Cell Death Differ 16:125-38. 2009
    ....
  80. ncbi Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage
    M Potter
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
    Genomics 2:257-62. 1988
    ....
  81. ncbi Sexual differentiation of vasopressin innervation of the brain: cell death versus phenotypic differentiation
    Geert J De Vries
    Center for Neuroendocrine Studies, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:4632-7. 2008
    ..However, even though Bcl-2 overexpression increased VP cell number, it did not affect fiber density. Thus, a compensatory mechanism may control total septal innervation regardless of the number of contributing cells...
  82. ncbi Bim regulates BCR-induced entry of B cells into the cell cycle
    Andrew Craxton
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Eur J Immunol 37:2715-22. 2007
    ..Our results suggest that the balance of pro- and anti-apoptotic Bcl-2 family proteins is critical for controlling both cell cycle progression and apoptosis in B cells...
  83. ncbi Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells
    Min Wu
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Cancer Res 67:6278-85. 2007
    ..Nuclear Factor-kappaB (NF-kappaB) and its target gene BCL2, which are overexpressed in 70% to 75% of pancreatic cancers, have recently been implicated in invasive phenotype...
  84. ncbi Bcl-2 gene family and the regulation of programmed cell death
    X M Yin
    Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Cold Spring Harb Symp Quant Biol 59:387-93. 1994
  85. ncbi Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Melbourne, Australia
    Blood 109:4907-13. 2007
    ..These results have implications for the treatment of hematopoietic tumors, particularly those that are not caused by Bcl-2 overexpression...
  86. ncbi Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro
    W Zhang
    Department of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Calcif Tissue Int 80:111-22. 2007
    ..Mineralization was significantly decreased in TG cultures, with less osteoblast apoptosis, compared to WT. Thus, Bcl-2 seems to have multiple roles in modulating osteoblast activities...
  87. ncbi Regulation of the lifespan in dendritic cell subsets
    Min Chen
    Department of Immunology, Baylor College of Medicine, One Baylor Plaza, N920, Houston, TX 77030, USA
    Mol Immunol 44:2558-65. 2007
    ..Signaling from toll-like receptors (TLRs) up-regulated Bcl-xL and improved DC survival. Our data suggest that differential expression of apoptosis signaling molecules regulates the lifespan of different DC subsets...
  88. ncbi Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone
    Yuichi Nagase
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Ann N Y Acad Sci 1192:330-7. 2010
    ..Interestingly, the anabolic effect of parathyroid hormone (PTH) was not observed in Bcl-2(-/-)Bim(+/-) mice. This data demonstrates that Bcl-2 is indispensable for the anabolic activity of PTH in bone...
  89. ncbi Adenovirus-mediated bcl-2 gene transfer inhibits renal ischemia/reperfusion induced tubular oxidative stress and apoptosis
    Chiang Ting Chien
    Department of Medical Research, National Taiwan University Hospital and National Taiwan University Colleage of Medicine, Taipei
    Am J Transplant 5:1194-203. 2005
    ..Our results suggest that Adv-bcl-2 gene transfer significantly reduces ischemia/reperfusion induced oxidative injury in the kidney...
  90. ncbi Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
    Girish V Putcha
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 157:441-53. 2002
    ..e., BID and BAD) do not contribute to BAX-dependent cyt c release or apoptosis caused by TFD...
  91. ncbi Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system
    M Krajewska
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 9:145-57. 2002
    ..Among the Bcl-2 family proteins only Bid and Bcl-XL continue to be expressed at high levels in the adult brain...
  92. ncbi Skin-derived nerve growth factor blocks programmed cell death in the trigeminal ganglia but does not enhance neuron proliferation
    H F Figueiredo
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0298, USA
    Mech Dev 109:205-14. 2001
    ..Analysis of RNA and protein expression suggests this block in cell death is mediated via the anti-apoptotic protein bcl-2...
  93. ncbi Apoptosis of chondrocytes in transgenic mice lacking collagen II
    C Yang
    Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Exp Cell Res 235:370-3. 1997
    ..In addition, the results suggest that apoptosis may play a role in degenerative connective tissue diseases such as osteoarthritis in which there is extensive tissue loss...
  94. ncbi Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development
    L G Pinon
    School of Biological and Medical Sciences, University of St Andrews, Fife, UK
    Development 124:4173-8. 1997
    ....
  95. ncbi Bcl-2 accelerates the maturation of early sensory neurons
    G Middleton
    School of Biological and Medical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9AJ, Scotland
    J Neurosci 18:3344-50. 1998
    ..These findings indicate that Bcl-2 expression is required for the normal progression of a particular early maturational change in embryonic sensory neurons...
  96. ncbi Neurodegeneration in the animal model of Menkes' disease involves Bcl-2-linked apoptosis
    L Rossi
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Neuroscience 103:181-8. 2001
    ..On the basis of these findings, we propose that down-regulation of Bcl-2 can cause neurodegeneration triggered by mitochondrial damage due to copper depletion during brain development in Mo(br/y) mice...
  97. ncbi Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, Calif USA
    Cells Tissues Organs 168:233-45. 2001
    ..Taken together, our experimental results indicate that IL-6 signaling is important to SMG developmental homeostasis...
  98. ncbi Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
    M Narita
    Department of Medical Genetics, Biomedical Research Center, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 95:14681-6. 1998
    ..Taken together, these findings suggest that proapoptotic Bcl-2 family proteins, including Bax and Bak, induce the mitochondrial PT and cytochrome c release by interacting with the PT pores...
  99. ncbi Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis
    J A Dominov
    Myogenesis Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Dev Dyn 220:18-26. 2001
    ..Thus, Bcl-2 function is required for particular stages of fetal and postnatal myogenesis...
  100. ncbi Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations
    G Middleton
    School of Biomedical Sciences, Biomedical Building, University of St Andrews, St Andrews, Fife KY16 9AJ, Scotland
    Eur J Neurosci 12:819-27. 2000
    ..Our results therefore suggest that the relative independence of Bcl-2 and Bax in regulating neuronal survival differs from one population of neurons to another...
  101. ncbi Hu-Bcl-2 transgenic mice with supernumerary neurons exhibit timing impairment in a complex motor task
    L Rondi-Reig
    Laboratoire de Neurobiologie de Développement, Institut des Neurosciences, Universite P and M Curie, 9 quai Saint Bernard, 75005 Paris, France
    Eur J Neurosci 11:2285-90. 1999
    ..This is the first indication that altered developmental cell death and the consequent neuronal surplus can impair complex behaviour in the adult animal...

Research Grants78

  1. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2010
    ..and differentiation (hTCEpi cells), this application tests the novel unifying hypothesis that Np63 regulates BCL2 directed apoptotic cell death in the corneal epithelium by transcriptional repression of IGFBP3 through three ..
  2. STUDY OF DIABETIC RETINOPATHY
    Timothy Kern; Fiscal Year: 2007
    ..Steps downstream of peroxynitrite and prostaglandin production responsible for hyperglycemia-mediated death of retinal capillary cells then will be investigated. ..
  3. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier Kocher; Fiscal Year: 2007
    ....
  4. Controlling the BCL-2 Pathway of Mitochondrial Apoptosis
    Anthony Letai; Fiscal Year: 2007
    ..Finally, we will use the mitochondrial, cellular and mouse assays developed above to test the efficacy and specificity of BH3 mimetics of both small molecule and peptidomimetic origin. ..
  5. BAD Intergrates Glycolysis and Apoptosis
    Nika Danial; Fiscal Year: 2007
    ..Danial's development as an independent investigator. Dr. Korsmeyer, a world leader in the fields of oncogenesis and apoptosis, has an excellent record of training and fostering independent investigators. ..
  6. MOUSE MODELS TO STUDY THE ROLE OF TRAF1 AND TRAF2 IN THE ETIOLOGY OF LEUKEMIA
    Juan Zapata; Fiscal Year: 2007
    ..2. To assess the role of TRAF1 in predisposing B cells to malignancy and 3. Characterization of the CLL-like lymphoproliferative disorder caused by overexpression of TRAF2DN and Bcl-2 in B cells. ..
  7. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2007
    The broad aim of this project is to use genetically modified mice to clarify the roles of opposing factions of the Bcl2 family in apoptosis and malignancy...
  8. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2007
    ..Aim 2: Evaluate the contribution(s) of Bcl 2 family proteins to protection of pulmonary epithelial and microvascular endothelial cells in vitro...
  9. Bcl-2 & Branching Morphogenesis
    Christine Sorenson; Fiscal Year: 2007
    ..Therefore, understanding the normal functions of bcl-2 during nephrogenesis and the consequences of its interaction with paxillin will give us important insight into kidney morphogenesis and pathogenesis. ..
  10. Inflammatory and Chemotactic Cytokines in Bronchopulmonary Dysplasia
    Vedang Londhe; Fiscal Year: 2007
    ..End of Abstract) ..
  11. Role of PDZK1 in lipid metabolism and atherosclerosis.
    Olivier N Kocher; Fiscal Year: 2010
    ....
  12. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika N Danial; Fiscal Year: 2010
    ..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..
  13. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    DANIELLE ROBERTSON; Fiscal Year: 2009
    ..and differentiation (hTCEpi cells), this application tests the novel unifying hypothesis that Np63 regulates BCL2 directed apoptotic cell death in the corneal epithelium by transcriptional repression of IGFBP3 through three ..
  14. The impact of growth modulation of liver carcinogenesis
    Xiao Ming Yin; Fiscal Year: 2009
    ....
  15. GENETIC REGULATION OF FOLATE RESPONSIVE BIRTH DEFECTS
    Richard Finnell; Fiscal Year: 2009
    ..The hypothesis that the Folbp1 receptor functions in complexes with other proteins within the lipid raft of the cell membrane to act as a signaling molecule challenges existing preconceptions concerning the function of this protein. ..
  16. The Dual Role of Pro-apoptotic BAD in Insulin Secretion and Beta Cell Survival
    Nika Danial; Fiscal Year: 2009
    ..The studies described in this proposal may lead to identification of a new therapeutic target in diabetes. ..
  17. High-Content Cell-Based Screening for Modulators of Autophagy
    Xiao Ming Yin; Fiscal Year: 2007
    ..Our long term hope is that the knowledge and the materials developed through this study will be valuable for future clinical applications. ..
  18. Bc1-2 Family Proteins in the Ischemic Neuronal Injury
    Xiao Ming Yin; Fiscal Year: 2006
    ..To characterize the molecular interactions of Bid and Bax in inducing dysfunction of mitochondria isolated from the brain. ..
  19. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2004
    ....
  20. ONCOGENE-INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1993
    ..The results will be directly relevant to many human lymphomas and leukemias and have wide ramifications for malignancy in general...
  21. FOLATE RECEPTORS IN CRANIOFACIAL MALFORMATIONS
    Richard Finnell; Fiscal Year: 2002
    ..abstract_text> ..
  22. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1999
    ....
  23. DIABETIC RETINOPATHY
    Timothy Kern; Fiscal Year: 1999
    ....
  24. Bc1-2 Family Proteins in the Ischemic Neuronal Injury
    Xiao Ming Yin; Fiscal Year: 2003
    ..To characterize the molecular interactions of Bid and Bax in inducing dysfunction of mitochondria isolated from the brain. ..
  25. Dissecting the Death Pathway in the Islet beta-cell
    Nika Danial; Fiscal Year: 2005
    ..abstract_text> ..
  26. MOUSE MODELS TO STUDY MULIBREY NANISM
    Juan Zapata; Fiscal Year: 2005
    ..study the developmental and phenotypic alterations of trim37 knock out and FINmajor-mutated trim37 mice. These mice will be the foundation for further studies on the biology and etiology of Mulibrey Nanism. ..
  27. Patterns of gene expression in Mulibrey Nanism
    Juan Zapata; Fiscal Year: 2005
    ..Specific Aim 2, is there any alteration in the patterns of gene expression induced by cytokines in normal and Mulibrey Nanism fibroblasts? Specific Aim 3, what is the role of TRIM37 in regulating gene expression? ..
  28. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2009
    The broad aim of this project is to use genetically modified mice to clarify the roles of opposing factions of the Bcl2 family in apoptosis and malignancy...
  29. A Novel Strategy for Defining and Targeting Cancer Addiction to Anti-Apoptotic BC
    Anthony G Letai; Fiscal Year: 2010
    ..Such a strategy has the promise to improve treatment of cancer by making treatment more selective for cancer cells, and therefore less toxic to normal, healthy tissues. ..
  30. A Novel Strategy for Defining and Targeting Cancer Addiction to Anti-Apoptotic BC
    Anthony Letai; Fiscal Year: 2007
    ..Such a strategy has the promise to improve treatment of cancer by making treatment more selective for cancer cells, and therefore less toxic to normal, healthy tissues. ..
  31. The Role of BCL-2 in Corneal Epithelial Cell Shedding
    DANIELLE ROBERTSON; Fiscal Year: 2007
    ..4) That events leading to increased apoptosis such as UV light signal surface cell apoptosis through the phosphorylation of BCL-2. ..