Bccip

Summary

Gene Symbol: Bccip
Description: BRCA2 and CDKN1A interacting protein
Alias: 1110013J05Rik, TOK-1, BRCA2 and CDKN1A-interacting protein
Species: mouse
Products:     Bccip

Top Publications

  1. Lu H, Huang Y, Mehrotra S, Droz Rosario R, Liu J, Bhaumik M, et al. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 2011;7:e1002291 pubmed publisher
    b>BCCIP is a BRCA2- and CDKN1A(p21)-interacting protein that has been implicated in the maintenance of genomic integrity...
  2. Huang Y, Lu H, Liu S, Droz Rosario R, Shen Z. Requirement of mouse BCCIP for neural development and progenitor proliferation. PLoS ONE. 2012;7:e30638 pubmed publisher
    ..BCCIP is a BRCA2 and CDKN1A interacting protein implicated in HR and inhibition of DNA replication stress...
  3. Huang Y, Dai L, Gaines D, Droz Rosario R, Lu H, Liu J, et al. BCCIP suppresses tumor initiation but is required for tumor progression. Cancer Res. 2013;73:7122-33 pubmed publisher
    ..Using a BRCA2-interacting protein BCCIP as the platform, we found that a conditional BCCIP knockdown and concomitant p53 deletion caused rapid development ..
  4. Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
    ..In this work, we demonstrate BCCIP, especially BCCIPα, as a previously unidentified component of the mitotic spindle pole and the centrosome...