Bcat1

Summary

Gene Symbol: Bcat1
Description: branched chain aminotransferase 1, cytosolic
Alias: BCATc, Eca39, BCAT(c), branched-chain-amino-acid aminotransferase, cytosolic
Species: mouse

Top Publications

  1. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
  2. ncbi An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence
    N Benvenisty
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115
    Genes Dev 6:2513-23. 1992
  3. ncbi Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
    Pengxiang She
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cell Metab 6:181-94. 2007
  4. ncbi Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Pisa, Italy
    Gene Expr Patterns 7:485-90. 2007
  5. ncbi Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Via Moruzzi 1, 56100 Pisa, Italy
    Brain Res 1108:12-8. 2006
  6. ncbi ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
    Jer Yuarn Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    J Clin Invest 113:434-40. 2004
  7. ncbi Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6
    Christina H Grimm
    Unité de Génétique Moléculaire Murine, Institut Pasteur 25 rue du Docteur Roux, F 75724, Paris Cedex 15, France
    Autoimmunity 36:241-6. 2003
  8. ncbi Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response
    Durvanei Augusto Maria
    Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo, Brazil
    Oncogene 22:426-32. 2003
  9. ncbi Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping
    S Weggen
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Oncogene 20:2023-31. 2001
  10. ncbi Characterization of murine BCAT genes: Bcat1, a c-Myc target, and its homolog, Bcat2
    T Ben-Yosef
    Department of Genetics, Hebrew University of Jerusalem, Israel
    Mamm Genome 9:595-7. 1998

Detail Information

Publications16

  1. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
    ..defined a core Pas1 haplotype with 42 tightly linked markers, including intragenic polymorphisms in five genes (Bcat1, Lrmp, Las1, Ghiso, and Kras2) and amino-acid changes in three genes (Lrmp, Las1, Lmna-rs1)...
  2. ncbi An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence
    N Benvenisty
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115
    Genes Dev 6:2513-23. 1992
    ..This target gene encodes an anonymous cDNA (ECA39) found previously to be amplified in a teratocarcinoma cell line.
  3. ncbi Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle
    Pengxiang She
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cell Metab 6:181-94. 2007
    ..These observations suggest that elevated BCAAs and/or loss of BCAA catabolism in peripheral tissues play an important role in regulating insulin sensitivity and energy expenditure...
  4. ncbi Expression of cytosolic branched chain aminotransferase (BCATc) mRNA in the developing mouse brain
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Pisa, Italy
    Gene Expr Patterns 7:485-90. 2007
    ..Two BCAT isoforms have been identified: one cytosolic (BCATc) and one mitochondrial (BCATm)...
  5. ncbi Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice
    Stefania Castellano
    Istituto di Neuroscienze del C N R, Via Moruzzi 1, 56100 Pisa, Italy
    Brain Res 1108:12-8. 2006
    ..BCAT exists in two isoforms: one cytosolic (BCATc), mainly expressed in the nervous system, and the other mitochondrial (BCATm), present in a greater number of ..
  6. ncbi ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
    Jer Yuarn Wu
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
    J Clin Invest 113:434-40. 2004
    ..Metabolomics-guided screening, coupled with ENU mutagenesis, is a powerful approach in uncovering novel enzyme deficiencies and recognizing important pathways of genetic metabolic disorders...
  7. ncbi Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6
    Christina H Grimm
    Unité de Génétique Moléculaire Murine, Institut Pasteur 25 rue du Docteur Roux, F 75724, Paris Cedex 15, France
    Autoimmunity 36:241-6. 2003
    ..which are implicated in the immune system and/or in the control of cell proliferation rates, such as Lrmp (Jaw1), Bcat1 and Kras2 that map to the Idd6 candidate region...
  8. ncbi Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response
    Durvanei Augusto Maria
    Laboratorio de Immunogenetica, Instituto Butantan, Sao Paulo, Brazil
    Oncogene 22:426-32. 2003
    ..These results provide a model to explore the mechanism underlying inherited predisposition to lung cancer in the context of a link to inflammation...
  9. ncbi Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping
    S Weggen
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Oncogene 20:2023-31. 2001
    ..We propose that this simple cloning strategy may serve as a powerful tool for the isolation of genes implicated in known chromosomal aberrations in primary tumors and tumor cell lines...
  10. ncbi Characterization of murine BCAT genes: Bcat1, a c-Myc target, and its homolog, Bcat2
    T Ben-Yosef
    Department of Genetics, Hebrew University of Jerusalem, Israel
    Mamm Genome 9:595-7. 1998
  11. ncbi Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins
    I Ben-Porath
    Department of Genetics, Hebrew University of Jerusalem, Givat Ram, Israel
    Gene 183:69-75. 1996
    ..Thus, we present a novel family of membrane glycoproteins, one member of which is closely associated with proliferation and another with growth arrest...
  12. ncbi ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast
    O Schuldiner
    Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Israel
    Proc Natl Acad Sci U S A 93:7143-8. 1996
    ..To further characterize the ECA39 gene, we set out to determine the evolutionary conservation of its regulatory and coding sequences...
  13. ncbi Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme
    S M Hutson
    Department of Biochemistry, Wake Forest University Medical Center, Winston Salem, North Carolina 27157, USA
    J Biol Chem 270:30344-52. 1995
    The cDNA for the rat cytosolic branched chain aminotransferase (BCATc) has been cloned. The BCATc cDNA encodes a polypeptide of 410 amino acids with a calculated molecular mass of 46.0 kDa...
  14. ncbi A cDNA clone overexpressed and amplified in a mouse teratocarcinoma line
    O Niwa
    Research Institute for Nuclear Medicine and Biology, Hiroshima University, Japan
    Nucleic Acids Res 18:6709. 1990
  15. ncbi Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion
    Yingsheng Zhou
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:33718-26. 2010
    ..Thus, KICSIS and LSIS occur by enhancing the metabolism of glutamine/glutamate to α-ketoglutarate, which, in turn, is metabolized to produce the intracellular signals such as ATP and NADPH for insulin secretion...
  16. ncbi Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
    ..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...