Gene Symbol: Bcar1
Description: breast cancer anti-estrogen resistance 1
Alias: AI385681, Cas, Crkas, breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, p130 Cas, p130cas, v-crk-associated tyrosine kinase substrate
Species: mouse
Products:     Bcar1

Top Publications

  1. Chang L, Huang C, Cheng C, Chen B, Chen H. Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth. J Biomed Sci. 2005;12:571-85 pubmed
    ..of the Y397F mutant in v-Src-transformed FAK(-/-) cells selectively led to a decrease in the level of p130(Cas), but not other focal adhesion proteins such as talin, vinculin, and paxillin...
  2. Kira M, Sano S, Takagi S, Yoshikawa K, Takeda J, Itami S. STAT3 deficiency in keratinocytes leads to compromised cell migration through hyperphosphorylation of p130(cas). J Biol Chem. 2002;277:12931-6 pubmed
    ..Analyses with immunoprecipitation revealed that p130(cas) was constitutively hyperphosphorylated on tyrosine residues, while other focal adhesion molecules such as focal ..
  3. Brinkman A, van der Flier S, Kok E, Dorssers L. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst. 2000;92:112-20 pubmed
    ..Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein. Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23...
  4. Polte T, Hanks S. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A. 1995;92:10678-82 pubmed
    ..interact with FAK via their Src homology 3 (SH3) domains: a v-Crk-associated tyrosine kinase substrate (Cas), p130Cas, and a still uncharacterized protein, FIPSH3-2, which contains an SH3 domain closely related to that of p130Cas...
  5. Brabek J, Constancio S, Shin N, Pozzi A, Weaver A, Hanks S. CAS promotes invasiveness of Src-transformed cells. Oncogene. 2004;23:7406-15 pubmed
    b>CAS ('Crk-associated substrate') is an Src substrate found at sites of integrin-mediated cell adhesion and linked to cell motility and survival...
  6. Huang J, Sakai R, Furuichi T. The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol Biol Cell. 2006;17:3187-96 pubmed
    Crk-associated substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispensable for the regulation of the actin cytoskeletal organization and cell migration in fibroblasts...
  7. Honda H, Oda H, Nakamoto T, Honda Z, Sakai R, Suzuki T, et al. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet. 1998;19:361-5 pubmed
    b>p130Cas (Cas), the protein encoded by the Crkas gene (also known as Cas), is an adaptor molecule with a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region...
  8. Dey T, Mann M, Goldmann W. Comparing mechano-transduction in fibroblasts deficient of focal adhesion proteins. Biochem Biophys Res Commun. 2011;413:541-4 pubmed publisher
    ..FA-deficient MEFs showed morphological changes and levels of apoptosis of the order: focal adhesion kinase>p130Cas>vinculin compared to wildtype cells...
  9. Liu F, Sells M, Chernoff J. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Mol Cell Biol. 1998;18:250-9 pubmed
    We have recently shown that protein tyrosine phosphatase 1B (PTP1B) associates with the docking protein p130Cas in 3Y1 rat fibroblasts. This interaction is mediated by a proline-rich sequence on PTP1B and the SH3 domain on p130Cas...

More Information


  1. Janostiak R, Tolde O, Bruhová Z, Novotny M, Hanks S, Rosel D, et al. Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness. Mol Biol Cell. 2011;22:4256-67 pubmed publisher
    Crk-associated substrate (CAS) is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes and plays an important role in invasiveness of Src-transformed cells...
  2. Polte T, Hanks S. Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. J Biol Chem. 1997;272:5501-9 pubmed
    The focal adhesion kinase (FAK) and Crk-associated substrate, p130(Cas) (Cas), have been implicated in diverse signaling pathways including those mediated by integrins, G-protein-coupled receptors, tyrosine kinase receptors, and the v-..
  3. Schlaepfer D, Broome M, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997;17:1702-13 pubmed
    ..Tyr) and Grb2 binding to FAK were reduced, whereas the tyrosine phosphorylation of another signaling protein, p130cas, was not detected in the Src- cells...
  4. Yogo K, Mizutamari M, Mishima K, Takenouchi H, Ishida Kitagawa N, Sasaki T, et al. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology. 2006;147:3307-17 pubmed
    ..b>Cas and c-Cbl, known to function in podosomes of osteoclasts, were identified as novel proteins binding to the SHIP SH2 ..
  5. Kawauchi K, Tan W, Araki K, Abu Bakar F, Kim M, Fujita H, et al. p130Cas-dependent actin remodelling regulates myogenic differentiation. Biochem J. 2012;445:323-32 pubmed publisher
    ..In the present study we show that the Src family kinase substrate p130Cas (Cas is Crk-associated substrate) influences actin remodelling and concomitant muscle-specific gene expression, ..
  6. Nagai Y, Osawa K, Fukushima H, Tamura Y, Aoki K, Ohya K, et al. p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption. J Bone Miner Res. 2013;28:2449-62 pubmed publisher
    b>p130Cas, Crk-associated substrate (Cas), is an adaptor/scaffold protein that plays a central role in actin cytoskeletal reorganization...
  7. Roy S, Ruest P, Hanks S. FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation. J Cell Biochem. 2002;84:377-88 pubmed
    ..portray FAK as a major v-Src substrate that also plays a role in recruiting v-Src to phosphorylate substrates CAS (Crk-associated substrate) and paxillin...
  8. Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho Leal M, Forni G, et al. p130Cas is an essential transducer element in ErbB2 transformation. FASEB J. 2010;24:3796-808 pubmed publisher
    The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells...
  9. Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, et al. Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice. Am J Physiol Cell Physiol. 2013;304:C541-7 pubmed publisher
    ..quot; We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays ..
  10. Xing L, Donlin L, Miller R, Alexandropoulos K. The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability. Mol Cell Biol. 2004;24:4581-92 pubmed
  11. Sakakibara A, Hattori S, Nakamura S, Katagiri T. A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells. J Biol Chem. 2003;278:6012-7 pubmed
    Chat (Cas/HEF1-associated signal transducer) is a novel adaptor protein with an N-terminal Src homology-2 domain and C-terminal Cas/HEF1 association domain...
  12. Ballestrem C, Erez N, Kirchner J, Kam Z, Bershadsky A, Geiger B. Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci. 2006;119:866-75 pubmed
    ..Here we studied molecular interactions and tyrosine phosphorylation of paxillin, Crk-associated substrate (CAS), and focal adhesion kinase (FAK) in focal adhesions...
  13. Zhang C, Miller D, Guibao C, Donato D, Hanks S, Zheng J. Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin. J Biol Chem. 2017;292:18281-18289 pubmed publisher
    The Cas family scaffolding protein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signaling to promote cell motility, invasion, proliferation, and survival...
  14. Rivera G, Antoku S, Gelkop S, Shin N, Hanks S, Pawson T, et al. Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl Acad Sci U S A. 2006;103:9536-41 pubmed
    ..Analysis of tyrosine-phosphorylated proteins demonstrated that Crk-associated substrate (p130(Cas)), not the activated PDGFbetaR itself, is the major Nck SH2 domain-binding protein in PDGF-B-stimulated cells...
  15. Kabuyama Y, Langer S, Polvinen K, Homma Y, Resing K, Ahn N. Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. Mol Cell Proteomics. 2006;5:1359-67 pubmed
    ..of PTP1B, inactivates phosphotyrosine phosphatase activity, and up-regulates tyrosine phosphorylation of p130Cas, a key mediator of focal adhesion turnover and cell migration...
  16. Gotoh T, Cai D, Tian X, Feig L, Lerner A. p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J Biol Chem. 2000;275:30118-23 pubmed
    ..Work by others has implicated both the human homologue of AND-34, BCAR3, and human p130(Cas), BCAR1, in the resistance of breast cancer cells to the anti-estrogen tamoxifen...
  17. Freitas F, Jeschke M, Majstorovic I, Mueller D, Schindler P, Voshol H, et al. Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells. Bone. 2002;30:99-108 pubmed
    ..By purification/mass spectrometry and by immunodepletion, p130 protein was identified as p130 Cas (Crk-associated protein), a Src substrate and a protein involved in signaling by cell-adhesion receptors, ..
  18. Jeong D, Lee E, Song W, Kim W. The 31-kDa caspase-generated cleavage product of p130Cas antagonizes the action of MyoD during myogenesis. Biochem Biophys Res Commun. 2014;444:509-13 pubmed publisher
    ..Here, we report that a 31-kDa caspase-generated cleavage product of Crk-associated substrate (p130Cas), herein called 31-kDa, is downregulated during muscle cell differentiation...
  19. Zhao M, Vuori K. The docking protein p130Cas regulates cell sensitivity to proteasome inhibition. BMC Biol. 2011;9:73 pubmed publisher
    The focal adhesion protein p130Cas (Cas) activates multiple intracellular signaling pathways upon integrin or growth factor receptor ligation...
  20. Funasaka K, Ito S, Hasegawa H, Goldberg G, Hirooka Y, Goto H, et al. Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing. FEBS J. 2010;277:3502-13 pubmed publisher
    Integrin-mediated activation of Cdc42 is essential for cell polarization, whereas the integrin adaptor protein Cas is required for cell migration during wound healing...
  21. Kim W, Seok Kang Y, Soo Kim J, Shin N, Hanks S, Song W. The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling. Mol Biol Cell. 2008;19:2135-46 pubmed publisher
    ..signaling counteracts the inhibitory effects of TGF-beta on cell growth and that this effect is mediated by p130Cas (Crk-associated substrate, 130 kDa)...
  22. Sung B, Yeo M, Oh H, Song W. v-Crk induces Rac-dependent membrane ruffling and cell migration in CAS-deficient embryonic fibroblasts. Mol Cells. 2008;25:131-7 pubmed
    Crk-associated substrate (CAS) is a focal adhesion protein that is involved in integrin signaling and cell migration. CAS deficiency reduces the migration and spreading of cells, both of which are processes mediated by Rac activation...
  23. Ambrogio C, Voena C, Manazza A, Piva R, Riera L, Barberis L, et al. p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood. 2005;106:3907-16 pubmed
    ..proteomic approach to search for proteins involved in cytoskeleton remodeling and identified p130Cas (p130 Crk-associated substrate) as a novel interactor of NPM-ALK...
  24. Di Stefano P, Cabodi S, Boeri Erba E, Margaria V, Bergatto E, Giuffrida M, et al. P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell. 2004;15:787-800 pubmed
    ..b>p130Cas, originally identified as a major substrate of v-Src, is a scaffold molecule that interacts with several proteins ..
  25. Hauck C, Hunter T, Schlaepfer D. The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase. J Biol Chem. 2001;276:17653-62 pubmed publisher
    ..These studies establish a functional role for the v-Src SH3 domain in stabilizing an adhesion-independent signaling complex with FAK...
  26. Sorokin A, Reed E. Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1. Biochem J. 1998;334 ( Pt 3):595-600 pubmed
    The docking protein p130(cas) (Crk-associated substrate) forms a stable complex with the adaptor protein CrkII in a tyrosine-phosphorylation-dependent manner...
  27. Lim S, Chen X, Tomar A, Miller N, Yoo J, Schlaepfer D. Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010;285:21526-36 pubmed publisher
    ..This work supports the use of FAK inhibitors to disrupt neovascularization. ..
  28. Hermanto U, Zong C, Li W, Wang L. RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol. 2002;22:2345-65 pubmed
    ..pathways was unaffected, IGF-I-inducible beta1 integrin-associated kinase activity and association of Crk with p130(CAS) were significantly inhibited by RACK1 overexpression...
  29. Tazaki T, Miyazaki K, Hiyama E, Nakamoto T, Sakai R, Yamasaki N, et al. Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice. Genes Cells. 2008;13:145-57 pubmed publisher
    b>p130Cas (Cas, Crk-associated substrate) is an adaptor molecule composed of a Src homology 3 (SH3) domain, a substrate domain (SD) and a Src binding domain (SBD)...
  30. Sun G, Cheng S, Chen M, Lim C, Pallen C. Protein tyrosine phosphatase ? phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. Mol Cell Biol. 2012;32:3776-89 pubmed publisher
    ..This showed that PTP?-Tyr789 regulates the localization of PTP? and the scaffolding protein Cas to adhesion sites where Cas interacts with and is phosphorylated by Src to initiate Cas signaling...
  31. Liu G, Li W, Gao X, Li X, Jurgensen C, Park H, et al. p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci. 2007;27:957-68 pubmed
    ..Here, we report that netrin-1 induces tyrosine phosphorylation of p130(CAS) (Crk-associated substrate)...
  32. Janostiak R, Brabek J, Auernheimer V, Tatárová Z, Lautscham L, Dey T, et al. CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics. Cell Mol Life Sci. 2014;71:727-44 pubmed publisher
    ..Two focal adhesion-associated proteins, Crk-associated substrate (CAS) and vinculin, were both independently shown to be crucial for the ability of cells to transmit mechanical forces ..
  33. Riccomagno M, Sun L, Brady C, Alexandropoulos K, Seo S, Kurokawa M, et al. Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014;81:779-86 pubmed publisher
    ..1-Integrin signaling within migrating GCL cells requires Cas signaling-adaptor proteins, and in the absence of ?1-Integrin or Cas function retinal neurons form ectopic cell ..
  34. Cheng C, Yu K, Chen H, Chen S, Huang C, Chan P, et al. Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas). FEBS Lett. 2004;557:221-7 pubmed
    Crk-associated substrate (Cas) is highly phosphorylated by v-Src and plays a critical role in v-Src-induced cell transformation...
  35. Pratt S, Epple H, Ward M, Feng Y, Braga V, Longmore G. The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol. 2005;168:813-24 pubmed
    ..or function, is defective and there is a selective reduction in the level and tyrosine phosphorylation of FAK, p130Cas, Crk, and Dock180 at nascent focal complexes...
  36. Gonsior C, Binamé F, Frühbeis C, Bauer N, Hoch Kraft P, Luhmann H, et al. Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival. PLoS ONE. 2014;9:e89423 pubmed publisher
    ..to overexpressed active Fyn in the oligodendrocyte precursor cell line Oli-neu, yielded the adaptor molecule p130Cas. We analyzed the function of this Fyn target in oligodendroglial cells and observed that reduction of p130Cas ..
  37. Qiu Z, Cang Y, Goff S. Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci. 2010;30:14430-9 pubmed publisher
    ..Together, these results provide compelling evidence that Abl and Arg play key redundant roles in BM maintenance and cortical lamination in the cerebellum. ..
  38. Dadke S, Chernoff J. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Biochem J. 2002;364:377-83 pubmed
    ..These data show that PTP1B can independently regulate insulin and integrin signals, and that Src might represent a convergence point for regulating signal transduction by this phosphatase. ..
  39. Lo S, Yu Q, Degenstein L, Chen L, Fuchs E. Progressive kidney degeneration in mice lacking tensin. J Cell Biol. 1997;136:1349-61 pubmed
    ..All other tissues appeared normal, suggesting that, in most cases, tensin's diverse functions are redundant and may be compensated for by other focal adhesion proteins. ..
  40. Yeo M, Sung B, Oh H, Park Z, Marcantonio E, Song W. Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS. J Cell Physiol. 2008;214:604-13 pubmed
    We examined the consequences of v-Crk expression in mouse embryo fibroblasts deficient Src family kinases or p130CAS. We found that Src kinases are essential for p130CAS/v-Crk signaling leading to FAK phosphorylation and cell migration ..
  41. Casamassima A, Rozengurt E. Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex. J Biol Chem. 1997;272:9363-70 pubmed
    ..Swiss 3T3 cells with bombesin rapidly induced tyrosine phosphorylation of the p130 Crk-associated substrate (p130(cas))...
  42. Teckchandani A, Laszlo G, Simo S, Shah K, Pilling C, Strait A, et al. Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation. J Cell Sci. 2014;127:509-20 pubmed publisher
    ..We found that Cul5 and Src together stimulate degradation of the Src substrate p130Cas (Crk-associated substrate)...
  43. Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, et al. Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation. Blood. 1997;89:297-306 pubmed
    ..Thus, a direct interaction of CRKL and BCR-ABL is not required for CRKL to become tyrosine phosphorylated by BCR-ABL and suggests that CRKL function may still be required for BCR-ABL function through an indirect interaction. ..
  44. Shaffer J, Sutton R, Bewley G. Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem. 1987;262:12908-11 pubmed
    ..Furthermore, the Csb mutation does not act at the level of gene transcription or mRNA stability, but rather at the level of mRNA translation and/or catalase protein turnover. ..
  45. Lakkakorpi P, Nakamura I, Nagy R, Parsons J, Rodan G, Duong L. Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone. J Biol Chem. 1999;274:4900-7 pubmed
    ..The present study examines the interaction between PYK2 and p130(Cas) (Crk-associated substrate), suggested to be part of the signaling pathway initiated by osteoclast adhesion...
  46. Roselli S, Wallez Y, Wang L, Vervoort V, Pasquale E. The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal. 2010;22:1745-52 pubmed publisher
    The members of the p130Cas (Cas) family are important scaffolding proteins that orchestrate cell adhesion, migration and invasiveness downstream of integrin adhesion receptors and receptor tyrosine kinases by recruiting enzymes and ..
  47. Nakamura I, Jimi E, Duong L, Sasaki T, Takahashi N, Rodan G, et al. Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts. J Biol Chem. 1998;273:11144-9 pubmed
    ..This study examines the role of p130Cas (Crk-associated substrate (Cas)) in actin organization in osteoclasts...
  48. Chen C, Ho Y, Ho H, Chang I, Kirsch K, Chuang Y, et al. Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration. Cardiovasc Res. 2013;100:461-71 pubmed publisher
    ..Mammalian 2-hybrid and co-immunoprecipitation assays demonstrated that CRP2 interacts with p130Cas, a scaffold protein important for lamellipodia formation and cell motility...
  49. Chen S, Wang R, Li Q, Tang D. Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice. Am J Physiol Heart Circ Physiol. 2009;297:H533-9 pubmed publisher
    ..The knockout of Abl diminished the tyrosine phosphorylation of p130 Crk-associated substrate (CAS, an adapter protein associated with smooth muscle contraction) in resistance arteries upon stimulation with ..
  50. Sakakibara A, Hattori S. Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J Biol Chem. 2000;275:6404-10 pubmed
    b>Cas (Crk-associated substrate) and HEF1 (human enhancer of filamentation) are related adaptor proteins that function in integrin-mediated cell adhesion and antigen receptor signaling pathways...
  51. Zouq N, Keeble J, Lindsay J, Valentijn A, Zhang L, Mills D, et al. FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci. 2009;122:357-67 pubmed publisher
    ..However FAK regulates survival through a more restricted set of pathways in the more anoikis-sensitive epithelial cells. Furthermore, we identify a novel role for paxillin in apoptosis suppression. ..
  52. Carter N, Nakamoto T, Hirai H, Hunter T. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol. 2002;4:565-73 pubmed
    ..EphA2, focal adhesion kinase (FAK) and p130(cas) were identified as the major ephrin-dependent phosphotyrosyl proteins during the ephrin-induced morphological ..
  53. Armulik A, Velling T, Johansson S. The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate. Mol Biol Cell. 2004;15:2558-67 pubmed
    ..paxillin, a downstream target of FAK/Src, was unaffected by the beta1 mutation, whereas tyrosine phosphorylation of CAS was strongly reduced...
  54. Stuart L, Bell S, Stewart C, Silver J, Richard J, Goss J, et al. CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. J Biol Chem. 2007;282:27392-401 pubmed
    ..In the present study we identify the focal adhesion-associated proteins p130Cas, Pyk2, and paxillin as novel members of the tyrosine kinase signaling pathway downstream of CD36 and show that ..
  55. Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, et al. p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration. Hepatology. 2010;52:1089-99 pubmed publisher
    b>p130Cas, Crk-associated substrate (Cas), is an adaptor/scaffold protein that plays a central role in actin cytoskeletal reorganization...
  56. Shi J, Casanova J. Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas. Mol Biol Cell. 2006;17:4698-708 pubmed
    ..complexes at sites of bacterial attachment and that both focal adhesion kinase (FAK) and the scaffolding protein p130Cas are required for Salmonella uptake...
  57. Jucker M, McKenna K, da Silva A, Rudd C, Feldman R. The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling. J Biol Chem. 1997;272:2104-9 pubmed
    ..We have now identified one of the macrophage substrates of Fes as the crk-associated substrate (Cas) and a second substrate as a 130-kDa protein that has been previously described as a T cell activation-dependent ..
  58. Nishiya N, Kiosses W, Han J, Ginsberg M. An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol. 2005;7:343-52 pubmed
    ..These findings establish a mechanism for the spatial localization of Rac activity to enhance cell migration. ..
  59. Suzuki Inoue K, Ozaki Y, Kainoh M, Shin Y, Wu Y, Yatomi Y, et al. Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation. J Biol Chem. 2001;276:1643-52 pubmed
    ..Src specifically associates with p130 Crk-associated substrate (Cas) in a manner dependent upon Cas phosphorylation, suggesting that Src is responsible for Cas tyrosine ..
  60. Cai D, Clayton L, Smolyar A, Lerner A. AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol. 1999;163:2104-12 pubmed
    ..One of these tyrosine phosphorylated proteins is identified as p130Cas (Crk-associated substrate), a signaling molecule previously known to bind to a GDP-exchange factor (C3G) and ..
  61. Patwardhan P, Shen Y, Goldberg G, Miller W. Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth. J Biol Chem. 2006;281:20689-97 pubmed
    b>Cas is a multidomain signaling protein that resides in focal adhesions. Cas possesses a large central substrate domain containing 15 repeats of the sequence YXXP, which are phosphorylated by Src...
  62. Shen Y, Khusial P, Li X, Ichikawa H, Moreno A, Goldberg G. SRC utilizes Cas to block gap junctional communication mediated by connexin43. J Biol Chem. 2007;282:18914-21 pubmed
    The Src tyrosine kinase phosphorylates Cas (Crk-associated substrate) to confer anchorage independence and invasive growth potential to transformed cells...
  63. Woodring P, Litwack E, O Leary D, Lucero G, Wang J, Hunter T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol. 2002;156:879-92 pubmed
    ..The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a self-limiting mechanism in the control of actin cytoskeleton dynamics. ..
  64. Donaldson J, Dempsey P, Reddy S, Bouton A, Coffey R, Hanks S. Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res. 2000;256:168-78 pubmed
    Crk-associated substrate (p130(Cas), Cas) is a docking protein first recognized as having elevated phosphotyrosine content in mammalian cells transformed by v-Src and v-Crk oncoproteins...
  65. Curcio M, Batista W, Linares E, Nascimento F, Moraes M, Borges R, et al. Regulatory effects of nitric oxide on Src kinase, FAK, p130Cas, and receptor protein tyrosine phosphatase alpha (PTP-alpha): a role for the cellular redox environment. Antioxid Redox Signal. 2010;13:109-25 pubmed publisher
    The role of NO in regulating the focal adhesion proteins, Src, FAK, p130 Cas, and PTP-alpha, was investigated...