Gene Symbol: Bbc3
Description: BCL2 binding component 3
Alias: PUMA, PUMA/JFY1, bcl-2-binding component 3, BH3-only, Bcl-2 binding component 3, p53 up-regulated modulator of apoptosis
Species: mouse
Products:     Bbc3

Top Publications

  1. Villunger A, Michalak E, Coultas L, Müllauer F, Böck G, Ausserlechner M, et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science. 2003;302:1036-8 pubmed
    ..Two genes induced by this transcription factor, noxa and puma (bbc3), stand out, because they encode BH3-only proteins, proapoptotic members of the Bcl-2 family required to initiate ..
  2. Li J, Lee B, Lee A. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem. 2006;281:7260-70 pubmed
    ..mitochondrial apoptotic pathway, we have discovered that in MEFs, ER stress selectively activates BH3-only proteins PUMA and NOXA at the transcript level through the tumor suppressor gene p53...
  3. Shibue T, Suzuki S, Okamoto H, Yoshida H, Ohba Y, Takaoka A, et al. Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. EMBO J. 2006;25:4952-62 pubmed
    ..Here, we show that Puma and Noxa, the well-known p53-inducible proapoptotic members of the Bcl-2 family, differentially participate in dual ..
  4. Steckley D, Karajgikar M, Dale L, Fuerth B, Swan P, Drummond Main C, et al. Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci. 2007;27:12989-99 pubmed
    ..that, in cortical neurons, oxidative stress induces the expression of the BH3-only members Bim, Noxa, and Puma. Importantly, we have determined that Puma-/- neurons, but not Bim-/- or Noxa-/- neurons, are remarkably resistant ..
  5. McKenzie M, Jamieson E, Jansen E, Scott C, Huang D, Bouillet P, et al. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes. 2010;59:644-52 pubmed publisher
    ..overexpression of the prosurvival protein Bcl-2 or deficiency of the apoptosis initiating BH3-only proteins Bim or Puma, or the downstream apoptosis effector Bax, markedly reduced glucose- or ribose-induced killing of islets...
  6. Wu B, Qiu W, Wang P, Yu H, Cheng T, Zambetti G, et al. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut. 2007;56:645-54 pubmed
    ..p53 upregulated modulator of apoptosis (PUMA) is a p53 downstream target and a member of the BH3-only group of Bcl-2 family proteins...
  7. Bunk E, König H, Bernas T, Engel T, Henshall D, Kirby B, et al. BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death Dis. 2010;1:e15 pubmed publisher
    ..The BH3-only proteins Bim and Puma have been shown to mediate trophic factor withdrawal- and anoikis-induced apoptosis in various systems...
  8. Naik E, Michalak E, Villunger A, Adams J, Strasser A. Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J Cell Biol. 2007;176:415-24 pubmed
    ..lacking individual members of its BH3-only subfamily identified major initiating roles for the p53 targets Noxa and Puma. In the transformed derivatives, where Puma, unexpectedly, was not induced by UVR, Noxa had the dominant role and ..
  9. Clybouw C, Fischer S, Auffredou M, Hugues P, Alexia C, Bouillet P, et al. Regulation of memory B-cell survival by the BH3-only protein Puma. Blood. 2011;118:4120-8 pubmed publisher
    ..In this report, we show that expression of the proapoptotic BH3-only Bcl-2 family member Puma was selectively up-regulated on in vitro activation with antigens or mitogens of both human and mouse B cells...

More Information


  1. Erlacher M, Labi V, Manzl C, Böck G, Tzankov A, Hacker G, et al. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med. 2006;203:2939-51 pubmed
    ..lacking the individual genes identifying rate-limiting roles for Bim (Bcl-2-interacting mediator of cell death) and Puma (p53-up-regulated modulator of apoptosis) in apoptosis induction...
  2. Fricker M, Papadia S, Hardingham G, Tolkovsky A. Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. J Neurochem. 2010;114:772-83 pubmed publisher
    b>Puma (p53 up-regulated modulator of apoptosis) is a BH3-only protein member of the Bcl-2 family that controls apoptosis by regulating the release of pro-apoptotic factors from mitochondria...
  3. Wang P, Qiu W, Dudgeon C, Liu H, Huang C, Zambetti G, et al. PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ. 2009;16:1192-202 pubmed publisher
    ..In this study, we found that p53 upregulated modulator of apoptosis (PUMA), a p53 downstream target and a BH3-only Bcl-2 family member, is directly regulated by NF-kappaB in response to TNF-..
  4. Han J, Flemington C, Houghton A, Gu Z, Zambetti G, Lutz R, et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001;98:11318-23 pubmed
    ..Here, we describe a strongly pro-apoptotic BH3-only protein, designated Bbc3, whose expression increases in response to diverse apoptotic stimuli...
  5. Tuffy L, Concannon C, D Orsi B, King M, Woods I, Huber H, et al. Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition. Mol Cell Biol. 2010;30:5484-501 pubmed publisher
    ..Previously we demonstrated that stabilization of p53 and activation of its target gene, puma (p53-upregulated mediator of apoptosis), mediated proteasome inhibitor-induced apoptosis in cancer cells...
  6. Galehdar Z, Swan P, Fuerth B, Callaghan S, Park D, Cregan S. Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 2010;30:16938-48 pubmed publisher
    ..In the present study, we demonstrate that PUMA, a Bcl-2 homology 3 (BH3)-only member of the Bcl-2 family, is transcriptionally activated in cortical neurons by ER ..
  7. Cregan S, Arbour N, Maclaurin J, Callaghan S, Fortin A, Cheung E, et al. p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. J Neurosci. 2004;24:10003-12 pubmed
    ..Furthermore, the BH3-only proteins Noxa and PUMA exhibit differential regulation by the two transactivation domains...
  8. Garrison S, Jeffers J, Yang C, Nilsson J, Hall M, Rehg J, et al. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol. 2008;28:5391-402 pubmed publisher
    ..A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein...
  9. Kieran D, Woods I, Villunger A, Strasser A, Prehn J. Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A. 2007;104:20606-11 pubmed
    ..Previously, we reported that the activation of the BH3-only protein p53-up-regulated mediator of apoptosis (Puma) was necessary and sufficient for endoplasmic reticulum (ER) stress- and proteasome inhibition-induced apoptosis in ..
  10. Michalak E, Vandenberg C, Delbridge A, Wu L, Scott C, Adams J, et al. Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death. Genes Dev. 2010;24:1608-13 pubmed publisher
    ..Because DNA damage triggers apoptosis through p53-mediated induction of BH3-only proteins Puma and Noxa, we explored their roles in gamma-radiation-induced thymic lymphomagenesis...
  11. Akhtar R, Geng Y, Klocke B, Latham C, Villunger A, Michalak E, et al. BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. J Neurosci. 2006;26:7257-64 pubmed
    ..p53 has been shown to regulate the expression of both Noxa and Puma, two BH3-only proteins, although their involvement in p53-dependent cell death appears to be cell-type and stimulus ..
  12. Chang K, Unsinger J, Davis C, Schwulst S, Muenzer J, Strasser A, et al. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J. 2007;21:708-19 pubmed
    ..death domain (FADD-DN) or Bid-/- and in mice with defective mitochondrial-mediated pathways due to loss of Bim-/-, Puma-/-, or Noxa-/-...
  13. Abbas H, Maccio D, Coskun S, Jackson J, Hazen A, SILLS T, et al. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010;7:606-17 pubmed publisher
    ..p16 was also stabilized because of ROS, and its loss increased cell cycling and partially rescued hematopoiesis and survival. Thus, Mdm2 is required to control ROS-induced p53 levels for sustainable hematopoiesis. ..
  14. Michalak E, Villunger A, Adams J, Strasser A. In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ. 2008;15:1019-29 pubmed publisher
    ..Two transcriptional targets shown to mediate its apoptotic role in several cell types encode Noxa and Puma, BH3-only members of the Bcl-2 family...
  15. Liu D, Ou L, Clemenson G, Chao C, Lutske M, Zambetti G, et al. Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010;12:993-8 pubmed publisher
    ..Furthermore, a deficiency of Puma, which is required for p53-dependent apoptosis after DNA damage, rescues segmental progeria and prevents the ..
  16. Yee K, Wilkinson S, James J, Ryan K, Vousden K. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009;16:1135-45 pubmed publisher
    The p53-inducible BH3-only protein PUMA is a key mediator of p53-dependent apoptosis, and PUMA has been shown to function by activating Bax and mitochondrial outer membrane permeabilization...
  17. Ren D, Tu H, Kim H, Wang G, Bean G, Takeuchi O, et al. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science. 2010;330:1390-3 pubmed publisher
    ..We provide in vivo evidence demonstrating an essential role of the proteins BID, BIM, and PUMA in activating BAX and BAK...
  18. Ghosh A, Klocke B, Ballestas M, Roth K. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE. 2012;7:e39586 pubmed publisher
    ..b>PUMA (p53 upregulated modulator of apoptosis) and BIM (BCL2 interacting mediator of cell death), pro-apoptotic BH3 ..
  19. Jeffers J, Parganas E, Lee Y, Yang C, Wang J, Brennan J, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003;4:321-8 pubmed
    b>Puma encodes a BH3-only protein that is induced by the p53 tumor suppressor and other apoptotic stimuli. To assess its physiological role in apoptosis, we generated Puma knockout mice by gene targeting...
  20. Ekert P, Jabbour A, Manoharan A, Heraud J, Yu J, Pakusch M, et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 2006;108:1461-8 pubmed
    ..IL-3 withdrawal-induced apoptosis, we generated IL-3-dependent cell lines from mice lacking the genes for Bad, Bim, Puma, both Bad and Bim, and both Bax and Bak...
  21. Engel T, Murphy B, Hatazaki S, Jimenez Mateos E, Concannon C, Woods I, et al. Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB J. 2010;24:853-61 pubmed publisher
    ..Expression of p53-up-regulated mediator of apoptosis (Puma), a proapoptotic Bcl-2 homology domain 3-only protein under p53 control, was increased within a few hours of SE...
  22. Coloff J, Mason E, Altman B, Gerriets V, Liu T, Nichols A, et al. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem. 2011;286:5921-33 pubmed publisher
    ..Here, we show that activated Akt relies on glycolysis to inhibit induction of Puma, which was uniquely sensitive to metabolic status among pro-apoptotic Bcl-2 family members and was rapidly up-..
  23. Yee K, Vousden K. Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis. 2008;13:87-95 pubmed
    The BH3-only protein PUMA plays an important role in the activation of apoptosis in response to p53...
  24. Shaltouki A, Freer M, Mei Y, Weyman C. Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis. 2007;12:2143-54 pubmed
    ..and immunoblot analysis, we have determined that the expression level of the pro-apoptotic Bcl2 family member PUMA is elevated when 23A2 myoblasts are cultured in DM...
  25. Wu W, Heinrichs S, Xu D, Garrison S, Zambetti G, Adams J, et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell. 2005;123:641-53 pubmed
    ..irradiation and then protects the damaged cell from apoptosis by directly repressing p53-mediated transcription of puma, a key BH3-only antagonist of the antiapoptotic Bcl-2 proteins...
  26. Cazanave S, Mott J, Elmi N, Bronk S, Werneburg N, Akazawa Y, et al. JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem. 2009;284:26591-602 pubmed publisher
    ..The saturated FFA palmitate, but not the monounsaturated FFA oleate, induces an increase in PUMA mRNA and protein levels. Palmitate induction of PUMA was JNK1-dependent in primary murine hepatocytes...
  27. Erlacher M, Michalak E, Kelly P, Labi V, Niederegger H, Coultas L, et al. BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood. 2005;106:4131-8 pubmed
    ..In various types of cultured cells, 3 BH3-only proteins, namely Puma (p53 up-regulated modulator of apoptosis), Noxa, and Bim (Bcl-2 interacting mediator of cell death), have been ..
  28. Yu J, Zhang L, Hwang P, Kinzler K, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001;7:673-82 pubmed
    Through global profiling of genes that were expressed soon after p53 expression, we identified a novel gene termed PUMA (p53 upregulated modulator of apoptosis)...
  29. Happo L, Cragg M, Phipson B, Haga J, Jansen E, Herold M, et al. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim. Blood. 2010;116:5256-67 pubmed publisher
    ..In nontransformed lymphoid cells, the combined loss of 2 proapoptotic p53 target genes, Puma and Noxa, induces as much resistance to DNA damage as loss of p53 itself...
  30. Hemann M, Zilfou J, Zhao Z, Burgess D, Hannon G, Lowe S. Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A. 2004;101:9333-8 pubmed
    ..Here, we use stable RNA interference to examine the role of PUMA, a p53 target gene and proapoptotic member of the Bcl2 family, in p53-mediated tumor suppression...
  31. Qiu W, Carson Walter E, Liu H, Epperly M, Greenberger J, Zambetti G, et al. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell. 2008;2:576-83 pubmed publisher
    ..We report here a critical role of the BH3-only protein p53 upregulated modulator of apoptosis (PUMA) in the radiosensitivity of intestinal epithelium and pathogenesis of GI syndrome...
  32. Shao L, Sun Y, Zhang Z, Feng W, Gao Y, Cai Z, et al. Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood. 2010;115:4707-14 pubmed publisher
    ..Here, we report one pivotal role of the BH3-only protein Puma in the radiosensitivity of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs)...
  33. Spender L, Carter M, O Brien D, Clark L, Yu J, Michalak E, et al. Transforming growth factor-? directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. J Biol Chem. 2013;288:5198-209 pubmed publisher
    ..Here we show that TGF-? induces the BH3-only activator PUMA to aid induction of the intrinsic cell death pathway...
  34. Cunha D, Igoillo Esteve M, Gurzov E, Germano C, Naamane N, Marhfour I, et al. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes. 2012;61:2763-75 pubmed publisher
    ..and the induction of the BH3-only proteins death protein 5 (DP5) and p53-upregulated modulator of apoptosis (PUMA)...
  35. Yu H, Shen H, Yuan Y, XuFeng R, Hu X, Garrison S, et al. Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation. Blood. 2010;115:3472-80 pubmed publisher
    ..We have examined the role of Puma (p53 up-regulated mediator of apoptosis) in apoptosis of HSCs after radiation injury...
  36. Uo T, Kinoshita Y, Morrison R. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci. 2007;27:12198-210 pubmed
    ..b>PUMA (p53-upregulated modulator of apoptosis) was one such gene induced by camptothecin, and its overexpression was ..
  37. Jabbour A, Heraud J, Daunt C, Kaufmann T, Sandow J, O Reilly L, et al. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ. 2009;16:555-63 pubmed publisher
    ..The BH3-only protein Puma is critical for initiation of IL-3 withdrawal-induced apoptosis, because IL-3-deprived Puma(-/-) cells show ..
  38. Kim S, Yao J, Suyama K, Qian X, Qian B, Bandyopadhyay S, et al. Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis. Cancer Res. 2014;74:3695-706 pubmed publisher
    ..The prosurvival effect of Slug was found to be caused by direct repression of the proapoptotic gene, Puma (Bbc3), by Slug...
  39. Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores E, et al. Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci U S A. 2013;110:7300-5 pubmed publisher
    ..cochleas in mice lacking the critical Bcl-2 homology domain (BH-3) inducers of p53- and p63-mediated apoptosis--Puma, Noxa, or both--are normal...
  40. Doan P, Himburg H, Helms K, Russell J, Fixsen E, Quarmyne M, et al. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med. 2013;19:295-304 pubmed publisher
    ..EGF reduced radiation-induced apoptosis of HSCs and mediated this effect through repression of the proapoptotic protein PUMA. Our findings show that EGFR signaling regulates HSC regeneration after myelosuppressive injury.
  41. Toth A, Jeffers J, Nickson P, Min J, Morgan J, Zambetti G, et al. Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2006;291:H52-60 pubmed
    The p53-upregulated modulator of apoptosis (Puma), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of apoptosis and has been implicated in the pathomechanism of several diseases, ..
  42. Bock F, Krumschnabel G, Manzl C, Peintner L, Tanzer M, Hermann Kleiter N, et al. Loss of PIDD limits NF-?B activation and cytokine production but not cell survival or transformation after DNA damage. Cell Death Differ. 2013;20:546-57 pubmed publisher
    ..Hence, we propose that NF-?B's most notable function after DNA damage in primary cells is related to the release of cytokines, thereby contributing to sterile inflammation. ..
  43. Gomez Lazaro M, Galindo M, Concannon C, Segura M, Fernandez Gomez F, Llecha N, et al. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J Neurochem. 2008;104:1599-612 pubmed Bax protein from the cytosol to mitochondria and with a significant induction of the BH3-only protein PUMA. Experiments in mouse embryonic fibroblasts deficient in Bax or PUMA demonstrated a role for both proteins in 6-..
  44. Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li K, et al. Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins. Cell Death Differ. 2015;22:174-84 pubmed publisher
    ..facilitated the elimination of cells with less memory potential via the additional pro-apoptotic molecules Noxa and Puma. Combined, these data show that Bim controls memory development by limiting the survival of pre-memory effector ..
  45. Oh S, Janknecht R. Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 2012;420:61-5 pubmed publisher
    ..The latter suggests that JMJD5 has oncogenic activity and accordingly JMJD5 is upregulated in leukemias and breast cancer. ..
  46. Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, et al. Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming. Am J Physiol Endocrinol Metab. 2016;310:E1016-26 pubmed publisher
    ..cold preservation and rewarming-induced injury by interrogating the proapoptotic gene BBC3/Bbc3, also known as Puma (p53 upregulated modulator of apoptosis), using three experimental models: 1) bioluminescence imaging of isolated ..
  47. Farrés J, Martin Caballero J, Martinez C, Lozano J, Llacuna L, Ampurdanés C, et al. Parp-2 is required to maintain hematopoiesis following sublethal ?-irradiation in mice. Blood. 2013;122:44-54 pubmed publisher
    ..protective role of Parp-2 against irradiation-induced apoptosis, loss of p53 or the pro-apoptotic BH3-only protein Puma restored survival of irradiated Parp-2-/- mice, whereas loss of Noxa had no such effect...
  48. Kerr J, Hutt K, Michalak E, Cook M, Vandenberg C, Liew S, et al. DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa. Mol Cell. 2012;48:343-52 pubmed publisher
    ..After ?-irradiation, induction of the proapoptotic BH3-only members Puma and Noxa was observed in primordial follicle oocytes from WT and Trp53(-/-) mice but not in those from TAp63-..
  49. Harder J, Libby R. BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina. Mol Neurodegener. 2011;6:50 pubmed publisher
    ..Since the Bcl-2 family members BIM, BID, and BBC3 (PUMA) are powerful direct activators of BAX, we used mice deficient for each of these genes to investigate their ..
  50. Chatoo W, Abdouh M, David J, Champagne M, Ferreira J, Rodier F, et al. The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci. 2009;29:529-42 pubmed publisher
    ..These findings provide a molecular mechanism explaining how Bmi1 regulates free radical concentrations and reveal the biological impact of Bmi1 deficiency on neuronal survival and aging. ..
  51. Gong W, Gohla R, Bowlin K, Koyano Nakagawa N, Garry D, Shi X. Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex. J Biol Chem. 2015;290:15350-61 pubmed publisher
    ..In summary, our studies demonstrate that Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity. ..
  52. Ekoff M, Kaufmann T, Engström M, Motoyama N, Villunger A, Jönsson J, et al. The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood. 2007;110:3209-17 pubmed
    ..In this study we investigated the role of the BH3-only proteins Noxa, Bad, Bim, Bmf, Bid, and Puma in apoptosis of mucosal-like mast cells (MLMCs) and connective tissue-like mast cells (CTLMCs)...
  53. Merino D, Khaw S, Glaser S, Anderson D, Belmont L, Wong C, et al. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood. 2012;119:5807-16 pubmed publisher
    ..These results have profound implications for how BH3-mimetics induce apoptosis and how the use of these compounds can be optimized for treating lymphoid malignancies...
  54. Fischer S, Belz G, Strasser A. BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection. Proc Natl Acad Sci U S A. 2008;105:3035-40 pubmed publisher
    ..In contrast, Puma-deficient mice showed an abnormally prolonged persistence of antigen-specific CD8(+) T cells in the spleen, ..
  55. Nie C, Luo Y, Zhao X, Luo N, Tong A, Liu X, et al. Caspase-9 mediates Puma activation in UCN-01-induced apoptosis. Cell Death Dis. 2014;5:e1495 pubmed publisher
    ..Here we have found that UCN-01 triggers Puma-induced mitochondrial apoptosis pathway. Our data confirmed that Akt-FoxO3a pathway mediated Puma activation...
  56. Garrison S, Phillips D, Jeffers J, Chipuk J, Parsons M, Rehg J, et al. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ. 2012;19:642-9 pubmed publisher
    Using genetically modified mouse models, we report here that p53 upregulated modulator of apoptosis (Puma) and Bcl-2 interacting mediator of cell death (Bim), two pro-apoptotic members of the B-cell lymphoma protein-2 (Bcl-2) family of ..
  57. Nakajima W, Tanaka N. Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1. Biochem Biophys Res Commun. 2011;413:643-8 pubmed publisher
    Tumor suppressor p53 induces apoptosis by transcriptional induction of Noxa and Puma, which encode the proapoptotic BH3-only member of the Bcl-2 family proteins...
  58. Li Y, Feng H, Gu H, Lewis D, Yuan Y, Zhang L, et al. The p53-PUMA axis suppresses iPSC generation. Nat Commun. 2013;4:2174 pubmed publisher
    ..Here we examine the role of PUMA, a pro-apoptotic mediator of p53, during somatic reprogramming in comparison to p21 in the p53 pathway...
  59. Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, et al. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. elife. 2014;3:e02236 pubmed publisher
    ..Our study provides a new paradigm of p53 regulation. ..
  60. Harford T, Shaltouki A, Weyman C. Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis. 2010;15:71-82 pubmed publisher
    ..Finally, MyoD mediated regulation of the apoptotic response to these various stimuli, in both myoblasts and fibroblasts, correlates with the level of induction of the pro-apoptotic Bcl2 family member PUMA.
  61. Lu H, Hou G, Zhang Y, Dai Y, Zhao H. c-Jun transactivates Puma gene expression to promote osteoarthritis. Mol Med Rep. 2014;9:1606-12 pubmed publisher
    ..however, the mechanism underlying chondrocyte apoptosis remains unclear. PUMA is a pro-apoptotic member of the BH3-only subgroup of the Bcl-2 family and is involved in a large number of ..
  62. Sandow J, Jabbour A, Condina M, Daunt C, Stomski F, Green B, et al. Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death Differ. 2012;19:633-41 pubmed publisher
    P53-upregulated modifier of apoptosis (PUMA), a pro-apoptotic member of the Bcl-2 family, is transcriptionally activated by p53 and is a key effector of p53-dependent apoptosis...
  63. Kuroki K, Virard I, Concannon C, Engel T, Woods I, Taki W, et al. Effects of transient focal cerebral ischemia in mice deficient in puma. Neurosci Lett. 2009;451:237-40 pubmed publisher
    ..b>Puma is a potent BH3-only protein that can be induced via p53, FoxO3a and endoplasmic reticulum stress pathways and is ..
  64. Chen S, Zheng J, Hao Q, Yang S, Wang J, Chen H, et al. p53-insensitive PUMA down-regulation is essential in the early phase of liver regeneration after partial hepatectomy in mice. J Hepatol. 2010;52:864-71 pubmed publisher
    Liver regeneration after partial hepatectomy involve proliferation and apoptosis of hepatocytes. PUMA, the well-known proapoptotic member of the Bcl-2 family, can respond to distinct stimuli...
  65. Dai H, Pang Y, Ramirez Alvarado M, Kaufmann S. Evaluation of the BH3-only protein Puma as a direct Bak activator. J Biol Chem. 2014;289:89-99 pubmed publisher
    ..Earlier studies of Puma have yielded equivocal results, with some concluding that it also acts as a direct activator and other studies ..
  66. Labi V, Erlacher M, Kiessling S, Manzl C, Frenzel A, O Reilly L, et al. Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med. 2008;205:641-55 pubmed publisher
    ..Finally, Bmf-deficiency accelerated the development of gamma irradiation-induced thymic lymphomas. Our results demonstrate that Bmf plays a critical role in apoptosis signaling and can function as a tumor suppressor. ..
  67. Michalak E, Jansen E, Happo L, Cragg M, Tai L, Smyth G, et al. Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ. 2009;16:684-96 pubmed publisher
    Evasion of apoptosis contributes importantly to c-Myc-induced tumorigenesis. The BH3-only Bcl-2 family members Puma and Noxa are critical pro-apoptotic transcriptional targets of p53, a major mediator of Myc-induced apoptosis and ..
  68. Margaroli C, Oberle S, Lavanchy C, Scherer S, Rosa M, Strasser A, et al. Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection. Eur J Immunol. 2016;46:1427-37 pubmed publisher
    ..Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection. ..
  69. Maor Nof M, Romi E, Sar Shalom H, Ulisse V, Raanan C, Nof A, et al. Axonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors. Neuron. 2016;92:991-1006 pubmed publisher
    ..negatively regulates the transcription factor p53 and antagonizes the expression of the pro-degenerative factor, Puma (p53 upregulated modulator of apoptosis)...