Genomes and Genes
Gene Symbol: Barx1
Description: BarH-like homeobox 1
Alias: homeobox protein BarH-like 1
- Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomachJ P Tissier-Seta
Laboratoire de Génétique et Physiologie du Développement CNRS Université Aix Marseille II, France
Mech Dev 51:3-15. 1995..murine proteins capable of binding to a regulatory module of the Ncam promoter, we isolated a novel homeobox gene, Barx1, the first vertebrate member of the structural subclass defined by Drosophila BarH1...
- Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleenByeong Moo Kim
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Development 134:3603-13. 2007..b>Barx1 is expressed selectively in fetal stomach mesenchyme and directs differentiation of overlying endoderm...
- Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentitionB L Thomas
Department of Craniofacial Development, Guy s Hospital, London, UK
Development 124:4811-8. 1997..Using molecular markers of branchial arch neural crest (Barx1) and commitment to chondrogenic differentiation (Sox9), we show that this population alters its fate from ..
- Patterning of the murine dentition by homeobox genesB L Thomas
Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
Eur J Oral Sci 106:48-54. 1998..We propose that expression of these genes constitutes an odontogenic homeobox code which patterns the dentition...
- Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchymeA S Tucker
Department of Craniofacial Development, Guy s Hospital, London, United Kingdom
Dev Dyn 212:533-9. 1998....
- Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial archA Trumpp
G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
Genes Dev 13:3136-48. 1999..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
- A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate DevelopmentJingyue Xu
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS Genet 12:e1005769. 2016....
- Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesisJing Zhou
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Development 140:4709-18. 2013..Our data indicate that Pax9 regulates a molecular network involving the Bmp4, Fgf10, Shh and Osr2 pathways to control palatal shelf patterning and morphogenesis...
- Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathwayRyutaro Akiyama
Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA Stem Cell Institute, University of Minnesota, 2001 Sixth Street SE, Minneapolis, MN 55455, USA
Dev Biol 387:37-48. 2014....
- A gene expression atlas of early craniofacial developmentEric W Brunskill
Cincinnati Children s Medical Center, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Dev Biol 391:133-46. 2014....
- Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defectFenglei He
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
Dev Biol 391:170-81. 2014..expression assays showed an altered expression of several facial patterning genes, including Hand2, Dlx2, Msx1, Barx1, Foxc2 and Fgf8, in the maxillary and mandibular processes of the mutants, indicating mis-patterned cranial neural ..
- Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeletonMaiko Matsui
Department of Cell Biology, Duke University Medical Center, Durham NC27710, USA Electronic address
Dev Biol 392:168-81. 2014..Our findings demonstrate multiple roles of Noggin in different domains for craniofacial skeletogenesis, and suggest an indirect mechanism for secondary cleft palate in Nog mutants that may be relevant to human cleft palate as well. ..
- Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiationKatherine Kretovich Billmyre
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina
Dev Dyn 244:564-76. 2015..Multiple extracellular signaling pathways regulate the migration, survival, proliferation, and differentiation of NCC...
- Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1Chenura D Jayewickreme
Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
Dev Biol 405:21-32. 2015Diverse functions of the homeodomain transcription factor BARX1 include Wnt-dependent, non-cell autonomous specification of the stomach epithelium, tracheo-bronchial septation, and Wnt-independent expansion of the spleen primordium...
- FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestineBlair B Madison
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 284:5936-44. 2009..Furthermore, expression of both Foxf1 and Foxl1 is reduced in the Gli2/Gli3 mutant gut. These results provide compelling evidence that Foxf1 and Foxl1 are mediators of the Hh (endoderm) to mesoderm signaling pathway...
- Cdx2 determines the fate of postnatal intestinal endodermEmma J Stringer
Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK
Development 139:465-74. 2012..expression of gastric genes in an intestinal setting that is not accompanied by mesodermal expression of Barx1, which is necessary for gastric morphogenesis...
- Developmental stalling and organ-autonomous regulation of morphogenesisIsabelle Miletich
Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London SE1 6RT, United Kingdom
Proc Natl Acad Sci U S A 108:19270-5. 2011..We identify an interaction between two homeodomain transcription factors, Barx1 and Msx1, which is responsible for setting critical levels of BMP activity in multicusped teeth and provides ..
- Tbx1 regulates oral epithelial adhesion and palatal developmentNoriko Funato
Human Gene Sciences Center, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
Hum Mol Genet 21:2524-37. 2012..Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis...
- Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor familyKazuya Fujita
Department of Pathology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
Int J Dev Biol 57:399-406. 2013....
- Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palateJuhee Jeong
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
Dev Dyn 241:1757-69. 2012..Therefore, we analyzed the morphological, cellular, and molecular changes caused by inactivation of Dlx1 and Dlx2 as related to palate development...
- Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryosTaka Aki K Noguchi
Graduate School of Life and Environmental Sciences, The University of Tsukuba, Japan
Gene Expr Patterns 12:154-63. 2012..These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development. ..
- Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2Yanping Zhang
Department of Biomedical Sciences, TAMHSC Baylor College of Dentistry, Dallas, Texas, USA
Dev Dyn 241:924-40. 2012..To determine the role of Twist1 during mandibular development, we used the Hand2-Cre transgene to conditionally inactivate the gene in the neural crest cells populating the mandibular pharyngeal arch...
- Cdx2 regulates patterning of the intestinal epitheliumStephanie Grainger
Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
Dev Biol 339:155-65. 2010..Further analysis of Cdx1-Cdx2 double mutants suggests that Cdx1 does not play a critical role in the development of the small intestine, at least after E13.5...
- Sfrp controls apicobasal polarity and oriented cell division in developing gut epitheliumMakoto Matsuyama
Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Minatojima Minami, Kobe, Japan
PLoS Genet 5:e1000427. 2009..We propose that Sfrp regulation of Wnt5a signaling controls oriented cell division and apicobasal polarity in the epithelium of developing gut...
- Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in miceBreAnne MacKenzie
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
Dev Biol 328:13-23. 2009..Expression of proximal markers Fgf8 and Barx1 was expanded across the fused BA1...
- Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthoodXiu Ping Wang
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Development 136:1939-49. 2009..In addition, we identify Fgf8, a known tooth initiation marker, as a direct target of Wnt/beta-catenin signaling. These studies identify key mechanistic features responsible for supernumerary tooth formation...
- The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentitionMyrto Denaxa
Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Dev Biol 333:324-36. 2009..Our experiments demonstrate that the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for craniofacial development and patterning of mammalian dentition...
- Hoxa2 plays a direct role in murine palate developmentTara M Smith
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Dev Dyn 238:2364-73. 2009..Hoxa2 also repressed the expression of its downstream targets Msx1, Bmp4, Barx1, and Ptx1 within the palate...
- Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular processAnamaria Balic
Department of Craniofacial Sciences, Division of Pediatric Dentistry, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Dev Dyn 238:2599-613. 2009..These observations together show that, during mandibular morphogenesis, Prx gene products play multiple roles including the cell survival, the region-specific terminal differentiation of Meckelian chondrocytes and osteogenesis...
- Ectoderm, endoderm, and the evolution of heterodont dentitionsAtsushi Ohazama
Department of Craniofacial Development, Dental Institute, King s College London, Guy s Hospital, London, United Kingdom
Genesis 48:382-9. 2010..The two different mechanisms of tooth development may have provided the developmental and genetic diversity on which evolution has acted to produce heterodont dentitions in mammals...
- BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiationThimios A Mitsiadis
Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, 8032 Zurich, Switzerland
Development 137:3025-35. 2010..Together, these results demonstrate that Notch signalling mediated by Jag2 is indispensable for normal tooth development...
- Epithelial dynamics of pancreatic branching morphogenesisAlethia Villasenor
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Development 137:4295-305. 2010..Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ...
- Regulation of mouse stomach development and Barx1 expression by specific microRNAsByeong Moo Kim
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
Development 138:1081-6. 2011..The mesenchymal transcription factor Barx1 controls spleen and stomach morphogenesis and is required to specify stomach-specific epithelium in adjacent ..
- The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatusCongxing Lin
Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Dev Biol 356:40-50. 2011..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
- Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodelingCindy Tsau
The Neurosciences Institute, San Diego, CA 92121, USA
Development 138:3307-17. 2011..Based on our data, we propose a functional network involving Barx2, Fgf10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands...
- Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiationJanghee Woo
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
PLoS ONE 6:e22493. 2011..The homoebox gene Barx1 is highly expressed in prospective stomach mesenchyme and required to specify this organ...
- Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signalingHelen A Thomason
Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
Dev Biol 321:273-82. 2008..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting...
- Distinct functions for Bmp signaling in lip and palate fusion in miceWei Liu
Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
Development 132:1453-61. 2005..Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion...
- Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during developmentF S Jones
Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 94:2632-7. 1997..The homeodomain encoded by Barx2 is 87% identical to that of Barx1, and both genes are related to genes at the Bar locus of Drosophila melanogaster...
- Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenanceM L Mucchielli
Laboratoire de Genetique et Physiologie du Developpement, IBDM CNRS INSERM Université de la Méditerranée, Marseille Cedex 9, 13288, France
Dev Biol 189:275-84. 1997..Finally, we compare Otlx2 expression with that of the recently identified homeodomain transcription factor Barx1 expressed in molar mesenchyme...
- Expression of the transcription factors Otlx2, Barx1 and Sox9 during mouse odontogenesisT A Mitsiadis
Laboratoire de Genetique et Physiologie du Developpement, IBDM, Campus de Luminy Case 907, Marseilles, France
Eur J Oral Sci 106:112-6. 1998..The recently identified homeodomain transcription factor Barx1 is first expressed in mesenchyme of the first branchial arch, but during advanced developmental stages the gene is ..
- Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentitionC A Ferguson
Department of Craniofacial Development, Guy s Hospital, London Bridge, London, SE1 9RT, UK
Genes Dev 12:2636-49. 1998..The early requirement for activin signaling in the mesenchyme in incisor and mandibular molar tooth germs must be carried-out in maxillary molar mesenchyme by other independent signaling pathways...
- Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient miceD E Clouthier
Howard Hughes Medical Institute, Department of Molecular Genetics, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235, USA
Dev Biol 217:10-24. 2000..These ET(A)-dependent factors include the transcription factors goosecoid, Dlx-2, Dlx-3, dHAND, eHAND, and Barx1, but not MHox, Hoxa-2, CRABP1, or Ufd1. In addition, the size of the arches in E10.5 to E11...
- The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB familyD B Edelman
Neurosciences Institute, San Diego, California 92121 and the Department of Neurobiology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 275:21737-45. 2000b>Barx1 and Barx2 are homeodomain proteins originally identified using regulatory elements of genes encoding certain cell adhesion molecules (CAMs)...
- Cloning, characterization, localization, and mutational screening of the human BARX1 geneD B Gould
Department of Medical Genetics, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
Genomics 68:336-42. 2000..The Bar subclass homolog, Barx1, has since been cloned in mouse and in chick...
- Transcriptional activation of beta-tropomyosin mediated by serum response factor and a novel Barx homologue, Barx1b, in smooth muscle cellsM Nakamura
Department of Neuroscience D13, Biomedical Research Center, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita City, Osaka 565 0871, Japan
J Biol Chem 276:18313-20. 2001..Taken together, these results suggest that SRF and Barx1b are coordinately involved in the SMC-specific transcription of the beta-TM gene in the upper digestive organs and their attached arteries...
- Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signalingJosée Aubin
Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Canada
Development 129:4075-87. 2002....
- Specification of jaw subdivisions by Dlx genesMichael J Depew
Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
Science 298:381-5. 2002..We suggest that nested Dlx expression in the arches patterns their proximodistal axes. Evolutionary acquisition and subsequent refinement of jaws may have been dependent on modification of Dlx expression...
- Expression of the neural cell adhesion molecule during mouse tooth developmentNobuko Obara
Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0192, Japan
Connect Tissue Res 43:212-5. 2002..Comparison of the expression patterns of NCAM and transcription factor Barx1 revealed a possibility that Barx1 negatively regulates NCAM expression.
- Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migrationWei Liu
Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030, USA
Development 130:6375-85. 2003..Moreover, our results uncover a new function of Pitx2 in regulation of cell motility in craniofacial development...
- The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neuronsJunji Hirota
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:8751-5. 2004..OSN development appears to be arrested between the terminal differentiation into neurons and the transition to immature neurons. Thus, Lhx2 is required for complete development of OSNs in mice...
- The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2Jacob Hecksher-Sørensen
Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Development 131:4665-75. 2004..We conclude that the SMP is an organiser responsible for the leftward growth of the spleno-pancreatic region and that Bapx1 regulates SMP functions required for pancreatic laterality...
- Primary cilia regulate Shh activity in the control of molar tooth numberAtsushi Ohazama
Department of Craniofacial Development, Dental Institute, King s College London, London SE1 9RT, UK
Development 136:897-903. 2009..Strikingly, the ectopic teeth adopt a size and shape characteristic of premolars, a tooth type that was lost in mice around 50-100 million years ago...
- Threshold-specific requirements for Bmp4 in mandibular developmentWei Liu
Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, 77030, USA
Dev Biol 283:282-93. 2005..Lastly, we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene, previously shown to be Bmp4-responsive, revealing a mechanism for differential regulation of Msx1 and Msx2 by Bmp signaling...
- Expression and regulation of the Msx1 natural antisense transcript during developmentAmélie E Coudert
Laboratoire de Biologie Oro Faciale et Pathologie, INSERM U 0714, Centre de recherches biomédicales des Cordeliers 15 21, rue de l Ecole de Medecine, 75270 Paris Cedex 6, France
Nucleic Acids Res 33:5208-18. 2005..To conclude, this study clearly identifies the Msx1 AS RNA involvement during tooth development and evidences a new degree of complexity in craniofacial developmental biology: the implication of endogenous AS RNAs...
- Barx1 and evolutionary changes in feedingIsabelle Miletich
Department of Craniofacial Development, Dental Institute, Kings College London, UK
J Anat 207:619-22. 2005During mouse embryonic development, the Barx1 homeobox gene is expressed in the mesenchymal cells of molar teeth and stomach...
- Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromesAnne M Moon
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
Dev Cell 10:71-80. 2006..These findings provide mechanistic insight into disrupted intercellular interactions in the pathogenesis of malformations seen in del22q11 syndrome...
- Sonic hedgehog is essential for first pharyngeal arch developmentChihiro Yamagishi
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
Pediatr Res 59:349-54. 2006..observation, downstream transcriptional targets of Fgf8 signaling in neural crest-derived mesenchyme, including Barx1, goosecoid, and Dlx2, were also down-regulated in Shh-null PA1...
- A dosage-dependent role for Spry2 in growth and patterning during palate developmentIan C Welsh
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
Mech Dev 124:746-61. 2007..Expression of the FGF responsive transcription factors Etv5, Msx1, and Barx1, as well as the morphogen Shh, is restricted to specific regions of the developing palate...
- Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defectsKathleen M Loomes
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Dev Dyn 236:2943-51. 2007..Thus, Dll3-Notch1 double heterozygous mice model human congenital scoliosis and craniofacial disorders...
- Smad4 is required to regulate the fate of cranial neural crest cellsSeung O Ko
Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Dev Biol 312:435-47. 2007..Taken together, our data show that TGF-beta/BMP signals rely on Smad-dependent pathways in the ectomesenchyme to mediate epithelial-mesenchymal interactions that control craniofacial organogenesis...
- Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genesThimios A Mitsiadis
Department of Structural and Orofacial Development, Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
Dev Biol 313:887-96. 2008..and developing teeth and analyzed tooth morphology, cell proliferation, apoptosis and expression of Pitx2, Barx1 and Tbx1 in dental tissues of Pitx1-/- mouse embryos...
- TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent mannerHu Zhao
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Dev Biol 320:19-29. 2008..There is an intrinsic requirement for Alk5 signal in regulating the fate of CNC cells during tooth and mandible development...
- Cdx2 initiates histodifferentiation of the midgut endodermEmma J Stringer
Department of Biochemistry, University of Leicester, Leicester, UK
FEBS Lett 582:2555-60. 2008..We demonstrate that the mesoderm adjacent to intestinal heterotopic areas expresses stomach specific Barx1 while the surrounding mesoderm is Barx1 negative...
- Rostral and caudal pharyngeal arches share a common neural crest ground patternMaryline Minoux
Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, Strasbourg, France
Development 136:637-45. 2009..These results provide insights into how facial and throat structures are assembled during development, and have implications for the evolution of the pharyngeal region of the vertebrate head...
- Role of the homeodomain transcription factor Bapx1 in mouse distal stomach developmentMichael P Verzi
Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Gastroenterology 136:1701-10. 2009..b>Barx1, in particular, controls stomach differentiation and morphogenesis...
- The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signalingByeong Moo Kim
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Dev Cell 8:611-22. 2005..The molecular mechanisms behind these interactions are largely unknown. Expression of the conserved homeobox gene Barx1 is restricted to the stomach mesenchyme during gut organogenesis...
- CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORSAnne Moon; Fiscal Year: 2002..Ultimately, this knowledge will help us to understand how alterations in those pathways, whether genetic or environmental, result in congenital malformations in infants and children. ..
- Mutagenesis of Tbx3: a model of ulnar-mammary syndromeAnne M Moon; Fiscal Year: 2010..The flexible model system we propose will be a valuable tool for developmental studies of many organs and lead to a deeper understanding of the genetic and molecular bases of congenital anomalies in humans. ..