Barx1

Summary

Gene Symbol: Barx1
Description: BarH-like homeobox 1
Alias: homeobox protein BarH-like 1
Species: mouse

Top Publications

  1. ncbi Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach
    J P Tissier-Seta
    Laboratoire de Génétique et Physiologie du Développement CNRS Université Aix Marseille II, France
    Mech Dev 51:3-15. 1995
  2. ncbi Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen
    Byeong Moo Kim
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3603-13. 2007
  3. ncbi Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition
    B L Thomas
    Department of Craniofacial Development, Guy s Hospital, London, UK
    Development 124:4811-8. 1997
  4. ncbi Patterning of the murine dentition by homeobox genes
    B L Thomas
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
    Eur J Oral Sci 106:48-54. 1998
  5. ncbi Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme
    A S Tucker
    Department of Craniofacial Development, Guy s Hospital, London, United Kingdom
    Dev Dyn 212:533-9. 1998
  6. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
  7. pmc A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development
    Jingyue Xu
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Genet 12:e1005769. 2016
  8. pmc Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis
    Jing Zhou
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 140:4709-18. 2013
  9. pmc Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway
    Ryutaro Akiyama
    Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA Stem Cell Institute, University of Minnesota, 2001 Sixth Street SE, Minneapolis, MN 55455, USA
    Dev Biol 387:37-48. 2014
  10. pmc A gene expression atlas of early craniofacial development
    Eric W Brunskill
    Cincinnati Children s Medical Center, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 391:133-46. 2014

Research Grants

Scientific Experts

  • Maiko Matsui
  • Juhee Jeong
  • N Obara
  • Anne Moon
  • Myrto Denaxa
  • Thimios A Mitsiadis
  • B L Thomas
  • Byeong Moo Kim
  • Paul T Sharpe
  • Isabelle Miletich
  • Ramesh A Shivdasani
  • Atsushi Ohazama
  • Wei Liu
  • Emma J Stringer
  • Janghee Woo
  • Mina Mina
  • Hu Zhao
  • Jingyue Xu
  • Georg Buchner
  • Katherine Kretovich Billmyre
  • Chenura D Jayewickreme
  • Bruce J Aronow
  • Yu Lan
  • Rulang Jiang
  • Ryutaro Akiyama
  • Eric W Brunskill
  • Fenglei He
  • Jing Zhou
  • Kazuya Fujita
  • Taka Aki K Noguchi
  • Yanping Zhang
  • Noriko Funato
  • Anna Petryk
  • James F Martin
  • Congxing Lin
  • Cindy Tsau
  • Felix Beck
  • Stephanie Grainger
  • Catrin A Pritchard
  • Alethia Villasenor
  • BreAnne MacKenzie
  • Blair B Madison
  • Xiu Ping Wang
  • Maryline Minoux
  • Makoto Matsuyama
  • Tara M Smith
  • Anamaria Balic
  • Michael P Verzi
  • Deepak Srivastava
  • Helen A Thomason
  • Yang Chai
  • Ian C Welsh
  • Robert J Schwartz
  • Seung O Ko
  • Kathleen M Loomes
  • Chihiro Yamagishi
  • Xiaoxia Sun
  • Amélie E Coudert
  • Junji Hirota
  • Jennifer Selever
  • Jacob Hecksher-Sørensen
  • Han Liu
  • Vladimir V Kalinichenko
  • John Klingensmith
  • Sylvia M Evans
  • M Mark Taketo
  • A S Tucker
  • Ling Yang
  • Wei Xiong
  • Yasuhiko Kawakami
  • S Steven Potter
  • Andrew Plassard
  • F S Jones
  • Naoyuki Wada
  • Josée Aubin
  • Shuping Gu
  • Andrew Distasio
  • Hiroko Kawakami
  • Xuefeng Hu
  • Bin Shen
  • Phillip Dexheimer
  • Andrew S Potter
  • Yanding Zhang
  • YiPing Chen
  • Michael J Depew
  • Lu Li
  • Lisong Lin
  • Yoshihito Shimazu
  • Yang Gao
  • Yuuichi Soeno

Detail Information

Publications67

  1. ncbi Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach
    J P Tissier-Seta
    Laboratoire de Génétique et Physiologie du Développement CNRS Université Aix Marseille II, France
    Mech Dev 51:3-15. 1995
    ..murine proteins capable of binding to a regulatory module of the Ncam promoter, we isolated a novel homeobox gene, Barx1, the first vertebrate member of the structural subclass defined by Drosophila BarH1...
  2. ncbi Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen
    Byeong Moo Kim
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3603-13. 2007
    ..b>Barx1 is expressed selectively in fetal stomach mesenchyme and directs differentiation of overlying endoderm...
  3. ncbi Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition
    B L Thomas
    Department of Craniofacial Development, Guy s Hospital, London, UK
    Development 124:4811-8. 1997
    ..Using molecular markers of branchial arch neural crest (Barx1) and commitment to chondrogenic differentiation (Sox9), we show that this population alters its fate from ..
  4. ncbi Patterning of the murine dentition by homeobox genes
    B L Thomas
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
    Eur J Oral Sci 106:48-54. 1998
    ..We propose that expression of these genes constitutes an odontogenic homeobox code which patterns the dentition...
  5. ncbi Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme
    A S Tucker
    Department of Craniofacial Development, Guy s Hospital, London, United Kingdom
    Dev Dyn 212:533-9. 1998
    ....
  6. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
    ..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
  7. pmc A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development
    Jingyue Xu
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Genet 12:e1005769. 2016
    ....
  8. pmc Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis
    Jing Zhou
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 140:4709-18. 2013
    ..Our data indicate that Pax9 regulates a molecular network involving the Bmp4, Fgf10, Shh and Osr2 pathways to control palatal shelf patterning and morphogenesis...
  9. pmc Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway
    Ryutaro Akiyama
    Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA Stem Cell Institute, University of Minnesota, 2001 Sixth Street SE, Minneapolis, MN 55455, USA
    Dev Biol 387:37-48. 2014
    ....
  10. pmc A gene expression atlas of early craniofacial development
    Eric W Brunskill
    Cincinnati Children s Medical Center, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Dev Biol 391:133-46. 2014
    ....
  11. pmc Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect
    Fenglei He
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Biol 391:170-81. 2014
    ..expression assays showed an altered expression of several facial patterning genes, including Hand2, Dlx2, Msx1, Barx1, Foxc2 and Fgf8, in the maxillary and mandibular processes of the mutants, indicating mis-patterned cranial neural ..
  12. pmc Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton
    Maiko Matsui
    Department of Cell Biology, Duke University Medical Center, Durham NC27710, USA Electronic address
    Dev Biol 392:168-81. 2014
    ..Our findings demonstrate multiple roles of Noggin in different domains for craniofacial skeletogenesis, and suggest an indirect mechanism for secondary cleft palate in Nog mutants that may be relevant to human cleft palate as well. ..
  13. doi Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation
    Katherine Kretovich Billmyre
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina
    Dev Dyn 244:564-76. 2015
    ..Multiple extracellular signaling pathways regulate the migration, survival, proliferation, and differentiation of NCC...
  14. pmc Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1
    Chenura D Jayewickreme
    Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Dev Biol 405:21-32. 2015
    Diverse functions of the homeodomain transcription factor BARX1 include Wnt-dependent, non-cell autonomous specification of the stomach epithelium, tracheo-bronchial septation, and Wnt-independent expansion of the spleen primordium...
  15. pmc FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine
    Blair B Madison
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:5936-44. 2009
    ..Furthermore, expression of both Foxf1 and Foxl1 is reduced in the Gli2/Gli3 mutant gut. These results provide compelling evidence that Foxf1 and Foxl1 are mediators of the Hh (endoderm) to mesoderm signaling pathway...
  16. pmc Cdx2 determines the fate of postnatal intestinal endoderm
    Emma J Stringer
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK
    Development 139:465-74. 2012
    ..expression of gastric genes in an intestinal setting that is not accompanied by mesodermal expression of Barx1, which is necessary for gastric morphogenesis...
  17. pmc Developmental stalling and organ-autonomous regulation of morphogenesis
    Isabelle Miletich
    Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London SE1 6RT, United Kingdom
    Proc Natl Acad Sci U S A 108:19270-5. 2011
    ..We identify an interaction between two homeodomain transcription factors, Barx1 and Msx1, which is responsible for setting critical levels of BMP activity in multicusped teeth and provides ..
  18. pmc Tbx1 regulates oral epithelial adhesion and palatal development
    Noriko Funato
    Human Gene Sciences Center, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Hum Mol Genet 21:2524-37. 2012
    ..Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis...
  19. doi Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family
    Kazuya Fujita
    Department of Pathology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
    Int J Dev Biol 57:399-406. 2013
    ....
  20. pmc Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate
    Juhee Jeong
    Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
    Dev Dyn 241:1757-69. 2012
    ..Therefore, we analyzed the morphological, cellular, and molecular changes caused by inactivation of Dlx1 and Dlx2 as related to palate development...
  21. doi Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos
    Taka Aki K Noguchi
    Graduate School of Life and Environmental Sciences, The University of Tsukuba, Japan
    Gene Expr Patterns 12:154-63. 2012
    ..These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development. ..
  22. pmc Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2
    Yanping Zhang
    Department of Biomedical Sciences, TAMHSC Baylor College of Dentistry, Dallas, Texas, USA
    Dev Dyn 241:924-40. 2012
    ..To determine the role of Twist1 during mandibular development, we used the Hand2-Cre transgene to conditionally inactivate the gene in the neural crest cells populating the mandibular pharyngeal arch...
  23. doi Cdx2 regulates patterning of the intestinal epithelium
    Stephanie Grainger
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Dev Biol 339:155-65. 2010
    ..Further analysis of Cdx1-Cdx2 double mutants suggests that Cdx1 does not play a critical role in the development of the small intestine, at least after E13.5...
  24. pmc Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium
    Makoto Matsuyama
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Minatojima Minami, Kobe, Japan
    PLoS Genet 5:e1000427. 2009
    ..We propose that Sfrp regulation of Wnt5a signaling controls oriented cell division and apicobasal polarity in the epithelium of developing gut...
  25. pmc Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice
    BreAnne MacKenzie
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
    Dev Biol 328:13-23. 2009
    ..Expression of proximal markers Fgf8 and Barx1 was expanded across the fused BA1...
  26. pmc Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
    Xiu Ping Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 136:1939-49. 2009
    ..In addition, we identify Fgf8, a known tooth initiation marker, as a direct target of Wnt/beta-catenin signaling. These studies identify key mechanistic features responsible for supernumerary tooth formation...
  27. pmc The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition
    Myrto Denaxa
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 333:324-36. 2009
    ..Our experiments demonstrate that the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for craniofacial development and patterning of mammalian dentition...
  28. doi Hoxa2 plays a direct role in murine palate development
    Tara M Smith
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Dyn 238:2364-73. 2009
    ..Hoxa2 also repressed the expression of its downstream targets Msx1, Bmp4, Barx1, and Ptx1 within the palate...
  29. pmc Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process
    Anamaria Balic
    Department of Craniofacial Sciences, Division of Pediatric Dentistry, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Dev Dyn 238:2599-613. 2009
    ..These observations together show that, during mandibular morphogenesis, Prx gene products play multiple roles including the cell survival, the region-specific terminal differentiation of Meckelian chondrocytes and osteogenesis...
  30. doi Ectoderm, endoderm, and the evolution of heterodont dentitions
    Atsushi Ohazama
    Department of Craniofacial Development, Dental Institute, King s College London, Guy s Hospital, London, United Kingdom
    Genesis 48:382-9. 2010
    ..The two different mechanisms of tooth development may have provided the developmental and genetic diversity on which evolution has acted to produce heterodont dentitions in mammals...
  31. pmc BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation
    Thimios A Mitsiadis
    Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, 8032 Zurich, Switzerland
    Development 137:3025-35. 2010
    ..Together, these results demonstrate that Notch signalling mediated by Jag2 is indispensable for normal tooth development...
  32. pmc Epithelial dynamics of pancreatic branching morphogenesis
    Alethia Villasenor
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 137:4295-305. 2010
    ..Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ...
  33. pmc Regulation of mouse stomach development and Barx1 expression by specific microRNAs
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Development 138:1081-6. 2011
    ..The mesenchymal transcription factor Barx1 controls spleen and stomach morphogenesis and is required to specify stomach-specific epithelium in adjacent ..
  34. pmc The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 356:40-50. 2011
    ..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-β-Catenin signaling in the development of the oral apparatus...
  35. pmc Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling
    Cindy Tsau
    The Neurosciences Institute, San Diego, CA 92121, USA
    Development 138:3307-17. 2011
    ..Based on our data, we propose a functional network involving Barx2, Fgf10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands...
  36. pmc Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation
    Janghee Woo
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22493. 2011
    ..The homoebox gene Barx1 is highly expressed in prospective stomach mesenchyme and required to specify this organ...
  37. doi Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling
    Helen A Thomason
    Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
    Dev Biol 321:273-82. 2008
    ..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting...
  38. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    ..Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion...
  39. pmc Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development
    F S Jones
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:2632-7. 1997
    ..The homeodomain encoded by Barx2 is 87% identical to that of Barx1, and both genes are related to genes at the Bar locus of Drosophila melanogaster...
  40. ncbi Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance
    M L Mucchielli
    Laboratoire de Genetique et Physiologie du Developpement, IBDM CNRS INSERM Université de la Méditerranée, Marseille Cedex 9, 13288, France
    Dev Biol 189:275-84. 1997
    ..Finally, we compare Otlx2 expression with that of the recently identified homeodomain transcription factor Barx1 expressed in molar mesenchyme...
  41. ncbi Expression of the transcription factors Otlx2, Barx1 and Sox9 during mouse odontogenesis
    T A Mitsiadis
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, Campus de Luminy Case 907, Marseilles, France
    Eur J Oral Sci 106:112-6. 1998
    ..The recently identified homeodomain transcription factor Barx1 is first expressed in mesenchyme of the first branchial arch, but during advanced developmental stages the gene is ..
  42. pmc Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition
    C A Ferguson
    Department of Craniofacial Development, Guy s Hospital, London Bridge, London, SE1 9RT, UK
    Genes Dev 12:2636-49. 1998
    ..The early requirement for activin signaling in the mesenchyme in incisor and mandibular molar tooth germs must be carried-out in maxillary molar mesenchyme by other independent signaling pathways...
  43. ncbi Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235, USA
    Dev Biol 217:10-24. 2000
    ..These ET(A)-dependent factors include the transcription factors goosecoid, Dlx-2, Dlx-3, dHAND, eHAND, and Barx1, but not MHox, Hoxa-2, CRABP1, or Ufd1. In addition, the size of the arches in E10.5 to E11...
  44. ncbi The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB family
    D B Edelman
    Neurosciences Institute, San Diego, California 92121 and the Department of Neurobiology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 275:21737-45. 2000
    b>Barx1 and Barx2 are homeodomain proteins originally identified using regulatory elements of genes encoding certain cell adhesion molecules (CAMs)...
  45. ncbi Cloning, characterization, localization, and mutational screening of the human BARX1 gene
    D B Gould
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Genomics 68:336-42. 2000
    ..The Bar subclass homolog, Barx1, has since been cloned in mouse and in chick...
  46. ncbi Transcriptional activation of beta-tropomyosin mediated by serum response factor and a novel Barx homologue, Barx1b, in smooth muscle cells
    M Nakamura
    Department of Neuroscience D13, Biomedical Research Center, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita City, Osaka 565 0871, Japan
    J Biol Chem 276:18313-20. 2001
    ..Taken together, these results suggest that SRF and Barx1b are coordinately involved in the SMC-specific transcription of the beta-TM gene in the upper digestive organs and their attached arteries...
  47. ncbi Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling
    Josée Aubin
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Canada
    Development 129:4075-87. 2002
    ....
  48. ncbi Specification of jaw subdivisions by Dlx genes
    Michael J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Science 298:381-5. 2002
    ..We suggest that nested Dlx expression in the arches patterns their proximodistal axes. Evolutionary acquisition and subsequent refinement of jaws may have been dependent on modification of Dlx expression...
  49. ncbi Expression of the neural cell adhesion molecule during mouse tooth development
    Nobuko Obara
    Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0192, Japan
    Connect Tissue Res 43:212-5. 2002
    ..Comparison of the expression patterns of NCAM and transcription factor Barx1 revealed a possibility that Barx1 negatively regulates NCAM expression.
  50. ncbi Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Blvd, Houston, TX 77030, USA
    Development 130:6375-85. 2003
    ..Moreover, our results uncover a new function of Pitx2 in regulation of cell motility in craniofacial development...
  51. pmc The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons
    Junji Hirota
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:8751-5. 2004
    ..OSN development appears to be arrested between the terminal differentiation into neurons and the transition to immature neurons. Thus, Lhx2 is required for complete development of OSNs in mice...
  52. ncbi The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2
    Jacob Hecksher-Sørensen
    Comparative and Developmental Genetics Section, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 131:4665-75. 2004
    ..We conclude that the SMP is an organiser responsible for the leftward growth of the spleno-pancreatic region and that Bapx1 regulates SMP functions required for pancreatic laterality...
  53. pmc Primary cilia regulate Shh activity in the control of molar tooth number
    Atsushi Ohazama
    Department of Craniofacial Development, Dental Institute, King s College London, London SE1 9RT, UK
    Development 136:897-903. 2009
    ..Strikingly, the ectopic teeth adopt a size and shape characteristic of premolars, a tooth type that was lost in mice around 50-100 million years ago...
  54. ncbi Threshold-specific requirements for Bmp4 in mandibular development
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, 77030, USA
    Dev Biol 283:282-93. 2005
    ..Lastly, we provide evidence that Prx homeobox genes repress expression of an Msx2 transgene, previously shown to be Bmp4-responsive, revealing a mechanism for differential regulation of Msx1 and Msx2 by Bmp signaling...
  55. pmc Expression and regulation of the Msx1 natural antisense transcript during development
    Amélie E Coudert
    Laboratoire de Biologie Oro Faciale et Pathologie, INSERM U 0714, Centre de recherches biomédicales des Cordeliers 15 21, rue de l Ecole de Medecine, 75270 Paris Cedex 6, France
    Nucleic Acids Res 33:5208-18. 2005
    ..To conclude, this study clearly identifies the Msx1 AS RNA involvement during tooth development and evidences a new degree of complexity in craniofacial developmental biology: the implication of endogenous AS RNAs...
  56. pmc Barx1 and evolutionary changes in feeding
    Isabelle Miletich
    Department of Craniofacial Development, Dental Institute, Kings College London, UK
    J Anat 207:619-22. 2005
    During mouse embryonic development, the Barx1 homeobox gene is expressed in the mesenchymal cells of molar teeth and stomach...
  57. pmc Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes
    Anne M Moon
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Dev Cell 10:71-80. 2006
    ..These findings provide mechanistic insight into disrupted intercellular interactions in the pathogenesis of malformations seen in del22q11 syndrome...
  58. ncbi Sonic hedgehog is essential for first pharyngeal arch development
    Chihiro Yamagishi
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Pediatr Res 59:349-54. 2006
    ..observation, downstream transcriptional targets of Fgf8 signaling in neural crest-derived mesenchyme, including Barx1, goosecoid, and Dlx2, were also down-regulated in Shh-null PA1...
  59. pmc A dosage-dependent role for Spry2 in growth and patterning during palate development
    Ian C Welsh
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Mech Dev 124:746-61. 2007
    ..Expression of the FGF responsive transcription factors Etv5, Msx1, and Barx1, as well as the morphogen Shh, is restricted to specific regions of the developing palate...
  60. ncbi Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects
    Kathleen M Loomes
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Dev Dyn 236:2943-51. 2007
    ..Thus, Dll3-Notch1 double heterozygous mice model human congenital scoliosis and craniofacial disorders...
  61. pmc Smad4 is required to regulate the fate of cranial neural crest cells
    Seung O Ko
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 312:435-47. 2007
    ..Taken together, our data show that TGF-beta/BMP signals rely on Smad-dependent pathways in the ectomesenchyme to mediate epithelial-mesenchymal interactions that control craniofacial organogenesis...
  62. ncbi Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes
    Thimios A Mitsiadis
    Department of Structural and Orofacial Development, Institute of Oral Biology, ZZMK, Faculty of Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
    Dev Biol 313:887-96. 2008
    ..and developing teeth and analyzed tooth morphology, cell proliferation, apoptosis and expression of Pitx2, Barx1 and Tbx1 in dental tissues of Pitx1-/- mouse embryos...
  63. pmc TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner
    Hu Zhao
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 320:19-29. 2008
    ..There is an intrinsic requirement for Alk5 signal in regulating the fate of CNC cells during tooth and mandible development...
  64. doi Cdx2 initiates histodifferentiation of the midgut endoderm
    Emma J Stringer
    Department of Biochemistry, University of Leicester, Leicester, UK
    FEBS Lett 582:2555-60. 2008
    ..We demonstrate that the mesoderm adjacent to intestinal heterotopic areas expresses stomach specific Barx1 while the surrounding mesoderm is Barx1 negative...
  65. pmc Rostral and caudal pharyngeal arches share a common neural crest ground pattern
    Maryline Minoux
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, Strasbourg, France
    Development 136:637-45. 2009
    ..These results provide insights into how facial and throat structures are assembled during development, and have implications for the evolution of the pharyngeal region of the vertebrate head...
  66. pmc Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 136:1701-10. 2009
    ..b>Barx1, in particular, controls stomach differentiation and morphogenesis...
  67. ncbi The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:611-22. 2005
    ..The molecular mechanisms behind these interactions are largely unknown. Expression of the conserved homeobox gene Barx1 is restricted to the stomach mesenchyme during gut organogenesis...

Research Grants2

  1. CONDITIONAL MUTAGENESIS OF FIBROBLAST GROWTH FACTORS
    Anne Moon; Fiscal Year: 2002
    ..Ultimately, this knowledge will help us to understand how alterations in those pathways, whether genetic or environmental, result in congenital malformations in infants and children. ..
  2. Mutagenesis of Tbx3: a model of ulnar-mammary syndrome
    Anne M Moon; Fiscal Year: 2010
    ..The flexible model system we propose will be a valuable tool for developmental studies of many organs and lead to a deeper understanding of the genetic and molecular bases of congenital anomalies in humans. ..