band 3

Summary

Gene Symbol: band 3
Description: solute carrier family 4 (anion exchanger), member 1
Alias: Ae1, CD233, Empb3, l11Jus51, band 3 anion transport protein, AE 1, MEB3, anion exchange protein 1, anion exchanger 1, erythrocyte membrane protein band 3, solute carrier family 4 member 1
Species: mouse
Products:     band 3

Top Publications

  1. Stehberger P, Shmukler B, Stuart Tilley A, Peters L, Alper S, Wagner C. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). J Am Soc Nephrol. 2007;18:1408-18 pubmed
    Mutations in the human gene that encodes the AE1 Cl(-)/HCO(3)(-) exchanger (SLC4A1) cause autosomal recessive and dominant forms of distal renal tubular acidosis (dRTA)...
  2. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
  3. Hentges K, Nakamura H, Furuta Y, Yu Y, Thompson D, O BRIEN W, et al. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns. 2006;6:653-65 pubmed
  4. Kile B, Hentges K, Clark A, Nakamura H, Salinger A, Liu B, et al. Functional genetic analysis of mouse chromosome 11. Nature. 2003;425:81-6 pubmed
    ..The mutations reveal new defects in haematopoiesis, craniofacial and cardiovascular development, and fertility. ..
  5. Southgate C, Chishti A, Mitchell B, Yi S, Palek J. Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Nat Genet. 1996;14:227-30 pubmed
    b>Band 3 is the most abundant integral protein of the red blood cell membrane...
  6. Mazza G, el Idrissi M, Coutelier J, Corato A, Elson C, Pfau C, et al. Infection of C3HeB/FeJ mice with the docile strain of lymphocytic choriomeningitis virus induces autoantibodies specific for erythrocyte Band 3. Immunology. 1997;91:239-45 pubmed
    ..eluted autoantibody bound to intact normal RBC and precipitated a 105000 MW component that corresponds to murine Band 3 protein...
  7. Akel A, Wagner C, Kovacikova J, Kasinathan R, Kiedaisch V, Koka S, et al. Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO(3)(-) exchanger AE1. Am J Physiol Cell Physiol. 2007;292:C1759-67 pubmed
    Genetic defects of anion exchanger 1 (AE1) may lead to spherocytic erythrocyte morphology, severe hemolytic anemia, and/or cation leak...
  8. Alvarez B, Kieller D, Quon A, Robertson M, Casey J. Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. Am J Physiol Heart Circ Physiol. 2007;292:H1301-12 pubmed
    b>Anion exchanger 1 (AE1; SLC4A1), the plasma membrane Cl(-)/HCO(3)(-) exchanger of erythrocytes, is also expressed in heart...
  9. Griffin C, Brennan J, Magnuson T. The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008;135:493-500 pubmed

More Information

Publications80

  1. Jensen L, Stuart Tilley A, Peters L, Lux S, Alper S, Breton S. Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999;61:973-80 pubmed
    ..Previous unsuccessful attempts to localize the Cl/HCO(3) anion exchanger AE1 in rat epididymis did not investigate other anion exchanger (AE) isoforms...
  2. Borgese F, Renard C, Gabillat N, Pellissier B, Guizouarn H. Molecular mapping of the conductance activity linked to tAE1 expressed in Xenopus oocyte. Biochim Biophys Acta. 2004;1664:80-7 pubmed
    ..domains involved in the induction of tAE1 channel activity, chimeras have been prepared between mouse and trout AE1. As some constructs were not expressed at the plasma membrane, skate exchanger (skAE1) was used instead of mouse ..
  3. Showe L, Ballantine M, Huebner K. Localization of the gene for the erythroid anion exchange protein, band 3 (EMPB3), to human chromosome 17. Genomics. 1987;1:71-6 pubmed
    We have isolated genomic DNA clones which code for the human erythroid membrane protein band 3 (EMPB3)...
  4. Sun X, Petrovic S. Increased acid load and deletion of AE1 increase Slc26a7 expression. Nephron Physiol. 2008;109:p29-35 pubmed publisher
    ..On the basolateral side of the A-intercalated cells, Slc26a7 co-localizes with the anion exchanger 1 (AE1), a Cl-/HCO3- exchanger that mediates bicarbonate reabsorption in the collecting duct...
  5. Chu H, McKenna M, Krump N, Zheng S, Mendelsohn L, Thein S, et al. Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties. Blood. 2016;128:2708-2716 pubmed
    ..Deoxyhemoglobin (deoxyHb), but not oxyhemoglobin, binds avidly and reversibly to band 3, the major erythrocyte membrane protein...
  6. Woo D, Kurtz I. Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003;15:236-42 pubmed
    ..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control. ..
  7. Toivola D, Krishnan S, Binder H, Singh S, Omary M. Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol. 2004;164:911-21 pubmed
    ..the membrane-proximal markers H,K-ATPase-beta and F-actin, increased and redistributed basolateral anion exchanger AE1/2 protein, and redistributed Na-transporter ENaC-gamma...
  8. Demuth D, Showe L, Ballantine M, Palumbo A, Fraser P, Cioe L, et al. Cloning and structural characterization of a human non-erythroid band 3-like protein. EMBO J. 1986;5:1205-14 pubmed
    ..We describe two cDNA clones encoding a human non-erythroid band 3 protein (HKB3) and the mouse erythrocyte band 3 (MEB3) and show that these proteins are structurally similar...
  9. Raida M, Wendel J, Kojro E, Fahrenholz F, Fasold H, Legrum B, et al. Major proteolytic fragments of the murine band 3 protein as obtained after in situ proteolysis. Biochim Biophys Acta. 1989;980:291-8 pubmed
    Proteolytic fragments of murine band 3 were produced by exposure to extracellular chymotrypsin and intracellular trypsin...
  10. Hall A, Ward F, Shen C, Rowe C, Bowie L, Devine A, et al. Deletion of the dominant autoantigen in NZB mice with autoimmune hemolytic anemia: effects on autoantibody and T-helper responses. Blood. 2007;110:4511-7 pubmed
    ..Here, we determine the contribution of the dominant red blood cell (RBC) autoantigen, the anion exchanger protein Band 3, to the development of NZB autoimmune responses...
  11. Nilson D, Sabatino D, Bodine D, Gallagher P. Major erythrocyte membrane protein genes in EKLF-deficient mice. Exp Hematol. 2006;34:705-12 pubmed
    ..Levels of beta-spectrin, ankyrin, and band 3 mRNA, but not alpha-spectrin, were decreased in EKLF-deficient fetal liver RNA...
  12. Campanella M, Chu H, Wandersee N, Peters L, Mohandas N, Gilligan D, et al. Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. Blood. 2008;112:3900-6 pubmed publisher
    ..Because GE binding sites have been mapped to sequences on the membrane protein, band 3, that are not conserved in other mammalian homologs, the question arose whether GEs can organize into complexes on ..
  13. Jones G, Edmundson H, Wesche D, Saul A. Human erythrocyte Band-3 has an altered N terminus in malaria-resistant Melanesian ovalocytosis. Biochim Biophys Acta. 1990;1096:33-40 pubmed
  14. Brosius F, Alper S, Garcia A, Lodish H. The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide. J Biol Chem. 1989;264:7784-7 pubmed
    We have characterized multiple transcripts from the band 3 gene expressed in rat and mouse kidney. In each species, the major transcript lacks sequence from the first three exons of the band 3 gene...
  15. Kopito R, Lodish H. Primary structure and transmembrane orientation of the murine anion exchange protein. Nature. 1985;316:234-8 pubmed
    The amino-acid sequence of murine band 3, deduced from the nucleotide sequence of a complementary DNA clone, confirms that this integral membrane glycoprotein is composed of two major structural domains which correlate with its dual ..
  16. Zhou Z, DeSensi S, Stein R, Brandon S, Song L, Cobb C, et al. Structure of the cytoplasmic domain of erythrocyte band 3 hereditary spherocytosis variant P327R: band 3 Tuscaloosa. Biochemistry. 2007;46:10248-57 pubmed
    Previous studies have shown that a single P327R point mutation in the cytoplasmic domain of band 3 (cdb3) protein, known as band 3 Tuscaloosa, leads to a reduction in protein 4.2 content of the erythrocyte membrane and hemolytic anemia...
  17. Latour S, Chow L, Veillette A. Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem. 1996;271:22782-90 pubmed
    ..we determined that the ability of Syk and SykB to undergo autophosphorylation and to phosphorylate erythrocyte band 3 in immune complex kinase reactions was at least 100-fold greater than that of Zap-70...
  18. Alloisio N, Maillet P, Carre G, Texier P, Vallier A, Baklouti F, et al. Hereditary spherocytosis with band 3 deficiency. Association with a nonsense mutation of the band 3 gene (allele Lyon), and aggravation by a low-expression allele occurring in trans (allele Genas). Blood. 1996;88:1062-9 pubmed
    ..The condition was associated with a 35% decrease in band 3. The underlying mutation was Arg to stop at codon 150 (CGA-->TGA) and was designated R150X, which defined ..
  19. Kopito R, Andersson M, Lodish H. Multiple tissue-specific sites of transcriptional initiation of the mouse anion antiport gene in erythroid and renal cells. Proc Natl Acad Sci U S A. 1987;84:7149-53 pubmed
    ..used to map the 5' end of mRNA transcripts of the single gene encoding the mouse erythroid anion-exchange protein, band 3. RNA from induced Friend murine erythroleukemia cells contains transcripts whose 5' ends are heterogeneous but ..
  20. Ji P, Lodish H. Ankyrin and band 3 differentially affect expression of membrane glycoproteins but are not required for erythroblast enucleation. Biochem Biophys Res Commun. 2012;417:1188-92 pubmed publisher
    ..Here we use erythroid ankyrin deficient and band 3 knockout mouse models to show that band 3, but not ankyrin, plays an important role in regulating the level of ..
  21. LU J, Qian J, Izvolsky K, Cardoso W. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004;273:418-35 pubmed
    ..Our data suggest that these genes may regulate focal developmental events specific of each of these regions during respiratory tract formation. ..
  22. Love J, Knight A, McAleer M, Todd J. Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res. 1990;18:4123-30 pubmed
    ..This simple approach is extremely useful in linkage and genome mapping studies and will facilitate construction of high resolution maps of both the mouse and human genomes. ..
  23. Alper S, Vandorpe D, Peters L, Brugnara C. Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes. Blood Cells Mol Dis. 2008;41:22-34 pubmed publisher
    ..electroneutral Cl(-) transport mediated by the human erythroid Cl(-)/HCO(3)(-) exchanger, AE1 (SLC4A1, band 3) is >10,000-fold greater than can be accounted for by the Cl(-) conductance of the red cell...
  24. Wu F, Saleem M, Kampik N, Satchwell T, Williamson R, Blattner S, et al. Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol. 2010;21:1456-67 pubmed publisher
    ..Here, we report that nephrin interacts with the bicarbonate/chloride transporter kidney anion exchanger 1 (kAE1), detected by yeast two-hybrid assay and confirmed by immunoprecipitation and co-localization studies...
  25. Mohebbi N, Perna A, van der Wijst J, Becker H, Capasso G, Wagner C. Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone. PLoS ONE. 2013;8:e55286 pubmed publisher
    ..we examined the regulated expression of two functionally related but differentially expressed anion exchangers, AE1 and pendrin, by dietary electrolyte intake and aldosterone...
  26. Huang H, Bauer D, Lelliott P, Greth A, McMorran B, Foote S, et al. A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice. Sci Rep. 2016;6:37197 pubmed publisher
    ..We propose that this bystander effect is due to reduced deformability of Ank-1(MRI61689/+) erythrocytes. This paper highlights the complex roles ankyrin plays in mediating malaria resistance. ..
  27. Bruce L, Ring S, Anstee D, Reid M, Wilkinson S, Tanner M. Changes in the blood group Wright antigens are associated with a mutation at amino acid 658 in human erythrocyte band 3: a site of interaction between band 3 and glycophorin A under certain conditions. Blood. 1995;85:541-7 pubmed
    ..The Wrb antigen appears to involve both red blood cell (RBC) band 3 and glycophorin A (GPA)...
  28. Chen J, Vijayakumar S, Li X, Al Awqati Q. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. J Biol Chem. 1998;273:1038-43 pubmed
    ..This Cl:HCO3 exchanger, kAE1, is an alternately spliced form of the erythroid anion exchanger (AE1, band 3), but unlike band 3 it does not bind ankyrin...
  29. Schofield A, Martin P, Spillett D, Tanner M. The structure of the human red blood cell anion exchanger (EPB3, AE1, band 3) gene. Blood. 1994;84:2000-12 pubmed
    The structure and sequence of the human red blood cell anion exchanger (EPB3, AE1, band 3) gene was determined by analysis of genomic and cDNA clones. The gene extends over 18 kb and consists of 20 exons...
  30. Su Y, Al Lamki R, Blake Palmer K, Best A, Golder Z, Zhou A, et al. Physical and functional links between anion exchanger-1 and sodium pump. J Am Soc Nephrol. 2015;26:400-9 pubmed publisher
    Anion exchanger-1 (AE1) mediates chloride-bicarbonate exchange across the plasma membranes of erythrocytes and, via a slightly shorter transcript, kidney epithelial cells...
  31. Thien C, Bowtell D, Langdon W. Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes. J Immunol. 1999;162:7133-9 pubmed
    ..These findings provide evidence that c-Cbl is involved in the negative regulation of the phosphorylation of LAT and SLP-76 by ZAP-70. ..
  32. Trivedi C, Zhu W, Wang Q, Jia C, Kee H, Li L, et al. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010;19:450-9 pubmed publisher
    ..These results suggest that Gata4 is a nonhistone target of Hdac2-mediated deacetylation and that Hdac2, Hopx, and Gata4 coordinately regulate cardiac myocyte proliferation during embryonic development. ..
  33. Frazar T, Weisbein J, Anderson S, Cline A, Garrett L, Felsenfeld G, et al. Variegated expression from the murine band 3 (AE1) promoter in transgenic mice is associated with mRNA transcript initiation at upstream start sites and can be suppressed by the addition of the chicken beta-globin 5' HS4 insulator element. Mol Cell Biol. 2003;23:4753-63 pubmed
    The anion exchanger protein 1 (AE1; band 3) is an abundant erythrocyte transmembrane protein that regulates chloride-bicarbonate exchange and provides an attachment site for the erythrocyte membrane skeleton on the cytoplasmic domain...
  34. Salomao M, Zhang X, Yang Y, Lee S, Hartwig J, Chasis J, et al. Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proc Natl Acad Sci U S A. 2008;105:8026-31 pubmed publisher
    ..Whereas band 3, the preponderant transmembrane constituent, and proteins known to be associated with it are present in normal or ..
  35. Al Samir S, Papadopoulos S, Scheibe R, Mei├čner J, Cartron J, Sly W, et al. Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1. J Physiol. 2013;591:4963-82 pubmed publisher
    ..investigated the previously published 'metabolon hypothesis' postulating that a close association of the anion exchanger 1 (AE1) and cytosolic carbonic anhydrase II (CAII) exists that greatly increases the transport activity of AE1...
  36. Sun X, Stephens L, Dubose T, Petrovic S. Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4. Am J Physiol Renal Physiol. 2015;309:F120-36 pubmed publisher
    ..transport proteins in intercalated cells (ICs) of the CD and found comparable mRNA expression of kidney anion exchanger 1 (kAE1), pendrin, and the a4 subunit of H(+)-ATPase in GPR4-/- vs. +/+...
  37. Condon M, Feketova E, Machiedo G, Deitch E, Spolarics Z. Augmented erythrocyte band-3 phosphorylation in septic mice. Biochim Biophys Acta. 2007;1772:580-6 pubmed
    ..moieties, was increased in cells from septic animals as compared to controls, indicating that sepsis altered band 3 organization within the RBC membrane...
  38. Stewart A, Chebib F, Akbar S, Salas M, Sonik R, Shmukler B, et al. Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1. Biochem Cell Biol. 2011;89:224-35 pubmed publisher
    The AE1 mutation G701D, associated with recessive distal renal tubular acidosis (dRTA), produces only minimal erythroid phenotype, reflecting erythroid-specific expression of stimulatory AE1 subunit glycophorin A (GPA)...
  39. Song H, Kim W, Lee H, Park E, Han K, Nielsen S, et al. Origin and fate of pendrin-positive intercalated cells in developing mouse kidney. J Am Soc Nephrol. 2007;18:2672-82 pubmed
  40. Yamaguchi Y, Yonemura S, Takada S. Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006;133:4737-48 pubmed
    ..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney. ..
  41. Bartel D, Lepke S, Layh Schmitt G, Legrum B, Passow H. Anion transport in oocytes of Xenopus laevis induced by expression of mouse erythroid band 3 protein--encoding cRNA and of a cRNA derivative obtained by site-directed mutagenesis at the stilbene disulfonate binding site. EMBO J. 1989;8:3601-9 pubmed
    A vector was constructed containing a cDNA for mouse band 3 obtained from Demuth et al. (1986, EMBO J...
  42. Sui Z, Nowak R, Bacconi A, Kim N, Liu H, Li J, et al. Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood. 2014;123:758-67 pubmed publisher
    ..Tmod3-mediated actin remodeling may be required for erythroblast-macrophage adhesion, coordination of cell cycle with differentiation, and F-actin assembly and remodeling during erythroblast enucleation. ..
  43. Risley M, Clowes C, Yu M, Mitchell K, Hentges K. The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development. Dev Biol. 2010;342:146-56 pubmed publisher
    ..As the Mediator complex is a transcriptional co-activator, our results suggest that Med31 functions to promote the transcription of genes required for embryonic growth and cell proliferation. ..
  44. Kang D, Karbach D, Passow H. Anion transport function of mouse erythroid band 3 protein (AE1) does not require acylation of cysteine residue 861. Biochim Biophys Acta. 1994;1194:341-4 pubmed
    Cys-861 of mouse band 3 is equivalent to Cys-843 of human band 3, the only acylated cysteine residue in the anion exchanger AE1 of the red blood cell (Hamasaki et al. (1992) Progress Cell Res. 2, 65-71)...
  45. Boles M, Wilkinson B, Wilming L, Liu B, Probst F, Harrow J, et al. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet. 2009;5:e1000759 pubmed publisher
    ..Our data show that the classical positional mapping approach of disease mutation identification can be extended to large target regions using high-throughput sequencing. ..
  46. Paw B, Davidson A, Zhou Y, Li R, Pratt S, Lee C, et al. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet. 2003;34:59-64 pubmed
    ..Through positional cloning, we show that the ret mutation is in a gene (slc4a1) encoding the anion exchanger 1 (also called band 3 and AE1), an erythroid-specific cytoskeletal protein...
  47. Robledo R, Lambert A, Birkenmeier C, Cirlan M, Cirlan A, Campagna D, et al. Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells. Blood. 2010;115:1804-14 pubmed publisher
    ..Both mutations result in markedly reduced RBC membrane spectrin content, decreased band 3, and absent beta-adducin...
  48. Dilg D, Saleh R, Phelps S, Rose Y, Dupays L, Murphy C, et al. HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3. PLoS ONE. 2016;11:e0161096 pubmed publisher
    ..Thus, we show here that HIRA has locus-specific effects on gene expression and that histone chaperone activity is vital for normal heart development, impinging on pathways regulated by an established cardiac transcription factor. ..
  49. Wandersee N, Tait J, Barker J. Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia. Blood Cells Mol Dis. 2000;26:75-83 pubmed
    ..and 22% in beta-spectrin- and ankyrin-deficient mice, respectively, to 85 to 100% in alpha-spectrin-deficient and band 3 knockout mice...
  50. Kopito R, Andersson M, Lodish H. Structure and organization of the murine band 3 gene. J Biol Chem. 1987;262:8035-40 pubmed
    The Band 3 protein mediates the reversible exchange of chloride and bicarbonate anions across the plasma membrane of erythrocytes, and probably, certain epithelial cells...
  51. Sega M, Chu H, CHRISTIAN J, Low P. Interaction of deoxyhemoglobin with the cytoplasmic domain of murine erythrocyte band 3. Biochemistry. 2012;51:3264-72 pubmed publisher
    ..Because band 3 is thought to be involved in all three processes and because binding of hemoglobin (Hb) to the cytoplasmic domain ..
  52. Inaba M. [Band 3: expanding knowledge on its functions]. Seikagaku. 2001;73:1431-5 pubmed
  53. van den Akker E, Satchwell T, Williamson R, Toye A. Band 3 multiprotein complexes in the red cell membrane; of mice and men. Blood Cells Mol Dis. 2010;45:1-8 pubmed publisher
    The bicarbonate/chloride exchanger band 3 (Anion Exchanger 1, AE1) is the most abundant protein in the erythrocyte membrane, it has an important role in gas exchange and functions as a point of attachment for the cytoskeletons ..
  54. Chernova M, Stewart A, Barry P, Jennings M, Alper S. Mouse Ae1 E699Q mediates SO42-i/anion-o exchange with [SO42-]i-dependent reversal of wild-type pHo sensitivity. Am J Physiol Cell Physiol. 2008;295:C302-12 pubmed publisher
    The SLC4A1/AE1 gene encodes the electroneutral Cl(-)/HCO(3)(-) exchanger of erythrocytes and renal type A intercalated cells...
  55. Song R, Preston G, Ichihara A, Yosypiv I. Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS ONE. 2013;8:e63835 pubmed publisher
    ..kidney hypoplasia, widespread apoptosis of medullary collecting duct cells and decreased expression of Foxi1, AE1 and H(+)-ATPase ?4 mRNA...
  56. Suo W, Zhang N, Wu P, Zhao L, Song L, Shen W, et al. Anti-tumour effects of small interfering RNA targeting anion exchanger 1 in experimental gastric cancer. Br J Pharmacol. 2012;165:135-47 pubmed publisher
    b>Anion exchanger 1 (AE1) is an integral membrane protein found in erythrocytes. Our previous studies have demonstrated that AE1 is expressed in human gastric cancer cells and may be involved in the carcinogenesis of cancer...
  57. Stewart A, Kurschat C, Vaughan Jones R, Shmukler B, Alper S. Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J Physiol. 2007;584:59-73 pubmed
    ..The homologous erythroid/kidney AE1/SLC4A1 polypeptide is insensitive to these regulators...
  58. Dahl N, Jiang L, Chernova M, Stuart Tilley A, Shmukler B, Alper S. Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer. J Biol Chem. 2003;278:44949-58 pubmed
    Cl-/HCO3- exchange activity mediated by the AE1 anion exchanger is reduced by carbonic anhydrase II (CA2) inhibition or by prevention of CA2 binding to the AE1 C-terminal cytoplasmic tail...
  59. Hassoun H, Hanada T, Lutchman M, Sahr K, Palek J, Hanspal M, et al. Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998;91:2146-51 pubmed
    ..a receptor for the malaria parasite Plasmodium falciparum and Sendai virus, and along with the anion transporter, band 3, may contribute to the mechanical properties of the red blood cell membrane...
  60. DeGregorio L, Harshman K, Rosenthal J, Dragani T, Pierotti M. Genetic mapping of the Brca1 gene on mouse chromosome 11. Mamm Genome. 1996;7:242 pubmed
  61. Baldwin M, Li X, Hanada T, Liu S, Chishti A. Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells. Blood. 2015;125:2704-11 pubmed publisher
    ..Our previous studies identified an interaction between the carboxyl-terminus of MSP1 and RBC band 3. Here, by employing phage display technology, we report a novel interaction between the amino-terminus of MSP1 and ..
  62. Oka T, Murata Y, Namba M, Yoshimizu T, Toyomura T, Yamamoto A, et al. a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase subunit a. J Biol Chem. 2001;276:40050-4 pubmed
    ..These results suggest that the V-ATPase, with the a4 isoform, is important for renal acid/base homeostasis. ..
  63. Lepke S, Becker A, Passow H. Mediation of inorganic anion transport by the hydrophobic domain of mouse erythroid band 3 protein expressed in oocytes of Xenopus laevis. Biochim Biophys Acta. 1992;1106:13-6 pubmed
    A cDNA clone of the mouse erythroid band 3 protein encoding the 556 amino acid residues of the hydrophobic domain from Thr-374 to the C-terminal Val-929 is shown by immunoprecipitation to be expressed in Xenopus oocytes...
  64. Alper S, Kopito R, Libresco S, Lodish H. Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J Biol Chem. 1988;263:17092-9 pubmed
    ..However, the only plasma membrane anion exchanger of known identity and sequence is erythroid band 3. Both hybridization and immunologic data support the presence of band 3-related mRNAs and proteins in nonerythroid ..
  65. Wang C, Sato K, Otsuka Y, Otsu W, Inaba M. Clathrin-mediated endocytosis of mammalian erythroid AE1 anion exchanger facilitated by a YXX? or a noncanonical YXXX? motif in the N-terminal stretch. J Vet Med Sci. 2012;74:17-25 pubmed
    To explore the roles of the conserved YXX?-type motif in the erythroid-specific N-terminal stretch of anion exchanger 1 (AE1), cell surface expression and internalization of various mutants derived from murine erythroid AE1 tagged with ..
  66. Kopito R, Lodish H. Structure of the murine anion exchange protein. J Cell Biochem. 1985;29:1-17 pubmed
    A full-length clone encoding the mouse erythrocyte anion exchange protein, band 3, has been isolated from a cDNA library using an antibody against the mature erythrocyte protein. The complete nucleotide sequence has been determined...
  67. Yasuda Y, Sasaki T, Takagawa M, Maeda M, Yasuda M, Atsumi T, et al. Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice. Congenit Anom (Kyoto). 2007;47:22-33 pubmed
    ..This is the first evidence that ectopic Hb synthesis exists and that erythropoietin coregulates erythroid (globin) and nonerythroid (delta-aminolevulinate synthase) genes. ..
  68. Kodippili G, Spector J, Hale J, Giger K, Hughes M, McNagny K, et al. Analysis of the mobilities of band 3 populations associated with ankyrin protein and junctional complexes in intact murine erythrocytes. J Biol Chem. 2012;287:4129-38 pubmed publisher
    Current models of the erythrocyte membrane depict three populations of band 3: (i) a population tethered to spectrin via ankyrin, (ii) a fraction attached to the spectrin-actin junctional complex via adducin, and (iii) a freely diffusing ..
  69. Verlander J, Miller R, Frank A, Royaux I, Kim Y, Weiner I. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Am J Physiol Renal Physiol. 2003;284:F323-37 pubmed
    ..Colocalization of RhBG with carbonic anhydrase II, the thiazide-sensitive transporter, and the anion exchangers AE1 and pendrin demonstrated RhBG immunoreactivity in all CNT cells and all CCD and ICT principal cells...
  70. Stefanovic M, Markham N, Parry E, Garrett Beal L, Cline A, Gallagher P, et al. An 11-amino acid beta-hairpin loop in the cytoplasmic domain of band 3 is responsible for ankyrin binding in mouse erythrocytes. Proc Natl Acad Sci U S A. 2007;104:13972-7 pubmed
    ..of the protein ankyrin, which binds to both spectrin and the cytoplasmic domain of the transmembrane protein band 3. The crystal structure of the cytoplasmic domain of band 3 predicted that the ankyrin binding site was located on ..
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    ..This concept is likely to apply to other animal cell types characterized by plasma membrane expression of the H(+) V-ATPase...