BAFF

Summary

Gene Symbol: BAFF
Description: tumor necrosis factor (ligand) superfamily, member 13b
Alias: BAFF, BLyS, D8Ertd387e, TALL-1, TALL1, THANK, TNFSF20, Tnlg7a, zTNF4, tumor necrosis factor ligand superfamily member 13B, b cell-activating factor, tumor necrosis factor ligand 7a
Species: mouse
Products:     BAFF

Top Publications

  1. Shulga Morskaya S, Dobles M, Walsh M, Ng L, Mackay F, Rao S, et al. B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J Immunol. 2004;173:2331-41 pubmed
    The TNF-related ligand, B cell-activating factor belonging to the TNF family (BAFF), is necessary for normal B cell development and survival, and specifically binds the receptors transmembrane activator and calcium-modulator and ..
  2. Sage A, Tsiantoulas D, Baker L, Harrison J, Masters L, Murphy D, et al. BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2012;32:1573-6 pubmed publisher
    The goal of this study was to assess the role of B-cell activating factor (BAFF) receptor in B-cell regulation of atherosclerosis...
  3. Groom J, Kalled S, Cutler A, Olson C, Woodcock S, Schneider P, et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest. 2002;109:59-68 pubmed
    BAFF (BLyS, TALL-1, THANK, zTNF4) is a member of the TNF superfamily that specifically regulates B lymphocyte proliferation and survival...
  4. Gorelik L, Gilbride K, Dobles M, Kalled S, Zandman D, Scott M. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J Exp Med. 2003;198:937-45 pubmed
    The cellular source of B cell activation factor (BAFF) required for peripheral B cell survival/maturation is unknown...
  5. Moon E, Lee J, Oh S, Ryu S, Kim H, Kwak H, et al. Reactive oxygen species augment B-cell-activating factor expression. Free Radic Biol Med. 2006;40:2103-11 pubmed
    B-cell-activating factor (BAFF) plays a role in mature B-cell generation and maintenance. Lipopolysaccharide (LPS) activates toll-like receptor 4 (TLR4)-dependent signal transduction and induces ROS production...
  6. Hsu B, Harless S, Lindsley R, Hilbert D, Cancro M. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol. 2002;168:5993-6 pubmed
    These studies characterize BLyS responsiveness and receptor expression among transitional and mature peripheral B cells...
  7. Woodland R, Schmidt M, Thompson C. BLyS and B cell homeostasis. Semin Immunol. 2006;18:318-26 pubmed
    ..B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF)...
  8. Zekavat G, Rostami S, Badkerhanian A, Parsons R, Koeberlein B, Yu M, et al. In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice. J Immunol. 2008;181:8133-44 pubmed
    ..In this study we hypothesized that in vivo neutralization of the B lymphocyte stimulator (BLyS/BAFF) may enhance the stringency of TR-->FO selection by increasing TR B cell competition for follicular entry in NOD ..
  9. Magliozzi R, Columba Cabezas S, Serafini B, Aloisi F. Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol. 2004;148:11-23 pubmed
    ..we find that gene expression of CXCL13, a chemokine involved in B-cell recruitment into lymphoid follicles, and BAFF, a key regulator of B-cell survival, is markedly and persistently upregulated in the CNS of mice with relapsing-..
  10. Kalled S. Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production. Semin Immunol. 2006;18:290-6 pubmed
    ..Identification of the B cell survival factor, BAFF, was a key discovery in understanding the survival mechanism for mature B cells in the periphery...

Detail Information

Publications62

  1. Shulga Morskaya S, Dobles M, Walsh M, Ng L, Mackay F, Rao S, et al. B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J Immunol. 2004;173:2331-41 pubmed
    The TNF-related ligand, B cell-activating factor belonging to the TNF family (BAFF), is necessary for normal B cell development and survival, and specifically binds the receptors transmembrane activator and calcium-modulator and ..
  2. Sage A, Tsiantoulas D, Baker L, Harrison J, Masters L, Murphy D, et al. BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2012;32:1573-6 pubmed publisher
    The goal of this study was to assess the role of B-cell activating factor (BAFF) receptor in B-cell regulation of atherosclerosis...
  3. Groom J, Kalled S, Cutler A, Olson C, Woodcock S, Schneider P, et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest. 2002;109:59-68 pubmed
    BAFF (BLyS, TALL-1, THANK, zTNF4) is a member of the TNF superfamily that specifically regulates B lymphocyte proliferation and survival...
  4. Gorelik L, Gilbride K, Dobles M, Kalled S, Zandman D, Scott M. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. J Exp Med. 2003;198:937-45 pubmed
    The cellular source of B cell activation factor (BAFF) required for peripheral B cell survival/maturation is unknown...
  5. Moon E, Lee J, Oh S, Ryu S, Kim H, Kwak H, et al. Reactive oxygen species augment B-cell-activating factor expression. Free Radic Biol Med. 2006;40:2103-11 pubmed
    B-cell-activating factor (BAFF) plays a role in mature B-cell generation and maintenance. Lipopolysaccharide (LPS) activates toll-like receptor 4 (TLR4)-dependent signal transduction and induces ROS production...
  6. Hsu B, Harless S, Lindsley R, Hilbert D, Cancro M. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol. 2002;168:5993-6 pubmed
    These studies characterize BLyS responsiveness and receptor expression among transitional and mature peripheral B cells...
  7. Woodland R, Schmidt M, Thompson C. BLyS and B cell homeostasis. Semin Immunol. 2006;18:318-26 pubmed
    ..B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF)...
  8. Zekavat G, Rostami S, Badkerhanian A, Parsons R, Koeberlein B, Yu M, et al. In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice. J Immunol. 2008;181:8133-44 pubmed
    ..In this study we hypothesized that in vivo neutralization of the B lymphocyte stimulator (BLyS/BAFF) may enhance the stringency of TR-->FO selection by increasing TR B cell competition for follicular entry in NOD ..
  9. Magliozzi R, Columba Cabezas S, Serafini B, Aloisi F. Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol. 2004;148:11-23 pubmed
    ..we find that gene expression of CXCL13, a chemokine involved in B-cell recruitment into lymphoid follicles, and BAFF, a key regulator of B-cell survival, is markedly and persistently upregulated in the CNS of mice with relapsing-..
  10. Kalled S. Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production. Semin Immunol. 2006;18:290-6 pubmed
    ..Identification of the B cell survival factor, BAFF, was a key discovery in understanding the survival mechanism for mature B cells in the periphery...
  11. Kawasaki K, Abe M, Tada F, Tokumoto Y, Chen S, Miyake T, et al. Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. Lab Invest. 2013;93:311-21 pubmed publisher
    ..We previously showed that the serum level of B-cell-activating factor (BAFF) was increased in patients with nonalcoholic steatohepatitis...
  12. Zhang M, Ko K, Lam Q, Lo C, Srivastava G, Zheng B, et al. Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis. Int Immunol. 2005;17:1081-92 pubmed
    B cell-activating factor (BAFF), a member of tumor necrosis factor family cytokines, has been shown to enhance the maturation and survival of peripheral B cells...
  13. Lesley R, Xu Y, Kalled S, Hess D, Schwab S, Shu H, et al. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity. 2004;20:441-53 pubmed
    ..Here we demonstrate that autoantigen binding B cells have increased dependence on BAFF for survival...
  14. Duong B, Ota T, Ait Azzouzene D, Aoki Ota M, VELA J, Huber C, et al. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J Immunol. 2010;184:4143-58 pubmed publisher
    ..halted at the transitional B cell population 1 to 2 stage, a block that could not be rescued by either Bcl-2 or BAFF overexpression...
  15. Mackay F, Leung H. The role of the BAFF/APRIL system on T cell function. Semin Immunol. 2006;18:284-9 pubmed
    b>BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas...
  16. Meyer Bahlburg A, Andrews S, Yu K, Porcelli S, Rawlings D. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J Exp Med. 2008;205:155-68 pubmed publisher
    ..subpopulation exhibits further augmentation in mitogenic responses and B cell-activating factor of the TNF family (BAFF) receptor expression...
  17. Stohl W, Jacob N, Quinn W, Cancro M, Gao H, Putterman C, et al. Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity. J Immunol. 2008;181:833-41 pubmed
    ..Remarkably, superimposing genetic deficiency of BAFF (B cell-activating factor belonging to the TNF family) onto CD152 deficiency did not substantially attenuate ..
  18. Brink R. Regulation of B cell self-tolerance by BAFF. Semin Immunol. 2006;18:276-83 pubmed
    ..b>BAFF is required for mature B cell development and survival but causes B cell hyperplasia and autoimmunity when it is ..
  19. Mecklenbrauker I, Kalled S, Leitges M, Mackay F, Tarakhovsky A. Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature. 2004;431:456-61 pubmed
    ..We show that treatment of B cells with the potent B-cell survival factor BAFF ('B-cell-activating factor belonging to the TNF family') prevents nuclear accumulation of PKCdelta...
  20. Scholz J, Crowley J, Tomayko M, Steinel N, O Neill P, Quinn W, et al. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci U S A. 2008;105:15517-22 pubmed publisher
    ..antibody to determine whether preimmune versus antigen-experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation and survival...
  21. Bossen C, Schneider P. BAFF, APRIL and their receptors: structure, function and signaling. Semin Immunol. 2006;18:263-75 pubmed
    b>BAFF, APRIL and their receptors play important immunological roles, especially in the B cell arm of the immune system...
  22. Yang M, Sun L, Wang S, Ko K, Xu H, Zheng B, et al. Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol. 2010;184:3321-5 pubmed publisher
    ..B cell-activating factor (BAFF), a member of TNF family cytokines, is a key regulator for B cell maturation and function...
  23. Ota M, Duong B, Torkamani A, Doyle C, Gavin A, Ota T, et al. Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol. 2010;185:4128-36 pubmed publisher
    The TNF-family cytokine BAFF (BLyS) promotes B lymphocyte survival and is overexpressed in individuals with systemic lupus erythematosus and Sjögren's Syndrome...
  24. Mackay F, Woodcock S, Lawton P, Ambrose C, Baetscher M, Schneider P, et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999;190:1697-710 pubmed
    ..b>BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro...
  25. Schneider P, Mackay F, Steiner V, Hofmann K, Bodmer J, Holler N, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999;189:1747-56 pubmed
    ..Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells...
  26. Ye Q, Wang L, Wells A, Tao R, Han R, Davidson A, et al. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol. 2004;34:2750-9 pubmed
    Binding of the TNF family member, B cell activating factor (BAFF), to its receptor (BAFF-R, TNFRSF13C) is required for generation and maintenance of mature B cells, but there are no data as to any role for the BAFF/BAFF-R pathway in T ..
  27. Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1:252-6 pubmed
    ..maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding...
  28. Gross J, Johnston J, Mudri S, Enselman R, Dillon S, Madden K, et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000;404:995-9 pubmed
    ..b>zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor (TNF) ligand family that is a potent co-..
  29. Kim M, Kim D, Do M. B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages. Exp Mol Med. 2013;45:e4 pubmed publisher
    3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-? and rosiglitazone...
  30. Kim Y, Choi B, Cheon H, Do M. B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation. Exp Mol Med. 2009;41:208-16 pubmed publisher
    B cell activation factor (BAFF) is a novel member of the TNF ligand superfamily, mainly produced by myeloid cells. BAFF has been shown to participate in B-cell survival and B- and T-cell maturation...
  31. Benson M, Dillon S, Castigli E, Geha R, Xu S, Lam K, et al. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol. 2008;180:3655-9 pubmed
    ..We report herein that long-lived B(MEM) cell survival and function are completely independent of BAFF (B cell-activating factor of the TNF family) or APRIL (a proliferation-inducing ligand)...
  32. Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French D, et al. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 2002;17:515-24 pubmed
    The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52...
  33. Vora K, Wang L, Rao S, Liu Z, Majeau G, Cutler A, et al. Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function. J Immunol. 2003;171:547-51 pubmed
    ..B cell-activating factor belonging to the TNF family (BAFF) is a fundamental B cell survival factor and therefore may influence GC reactions and subsequent Ab responses...
  34. McCarthy D, Chiu S, Gao Y, Summers DeLuca L, Gommerman J. BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT. Cell Immunol. 2006;241:85-94 pubmed
    b>BAFF is a peripheral B cell survival factor and can mediate antibody (Ab) class switching...
  35. Sutherland A, Ng L, Fletcher C, Shum B, Newton R, Grey S, et al. BAFF augments certain Th1-associated inflammatory responses. J Immunol. 2005;174:5537-44 pubmed
    B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the development of autoimmune disorders...
  36. Ng L, Sutherland A, Newton R, Qian F, Cachero T, Scott M, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol. 2004;173:807-17 pubmed
    b>BAFF (B cell-activating factor belonging to the TNF family) is a cell survival and maturation factor for B cells, and overproduction of BAFF is associated with systemic autoimmune disease...
  37. Gardam S, Sierro F, Basten A, Mackay F, Brink R. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity. 2008;28:391-401 pubmed publisher
    ..the absence of this suppressive activity, B cells developed independently of the obligatory B cell survival factor, BAFF (B cell-activating factor of the tumor necrosis factor family)...
  38. Acosta Rodriguez E, Craxton A, Hendricks D, Merino M, Montes C, Clark E, et al. BAFF and LPS cooperate to induce B cells to become susceptible to CD95/Fas-mediated cell death. Eur J Immunol. 2007;37:990-1000 pubmed
    ..PAMP) activate B cells directly by binding to TLR and also indirectly by inducing APC to release cytokines such as BAFF that promote B cell survival...
  39. Huang X, Di Liberto M, Cunningham A, Kang L, Cheng S, Ely S, et al. Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1. Proc Natl Acad Sci U S A. 2004;101:17789-94 pubmed
    ..b>BLyS (BAFF), a cytokine essential for mature B cell development and survival, is thought to act mainly by attenuation of ..
  40. Gavin A, Duong B, Skog P, Ait Azzouzene D, Greaves D, Scott M, et al. deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models. J Immunol. 2005;175:319-28 pubmed
    DeltaBAFF is a novel splicing isoform of the regulator B cell-activating factor (BAFF, BLyS), a TNF family protein with powerful immunoregulatory effects...
  41. Groom J, Fletcher C, Walters S, Grey S, Watt S, Sweet M, et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med. 2007;204:1959-71 pubmed
    ..Transgenic (Tg) mice overexpressing the cytokine B cell-activating factor of the tumor necrosis factor family (BAFF) develop an autoimmune disorder similar to SLE and show impaired B cell tolerance and altered T cell ..
  42. Bossen C, Cachero T, Tardivel A, Ingold K, Willen L, Dobles M, et al. TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood. 2008;111:1004-12 pubmed
    The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared with those of higher-order BAFF oligomers...
  43. Xia X, Treanor J, Senaldi G, Khare S, Boone T, Kelley M, et al. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J Exp Med. 2000;192:137-43 pubmed
    ..The identification and characterization of the receptor for TALL-1 provides useful information for the development of a treatment for B cell-mediated autoimmune diseases such as systemic lupus erythematosus. ..
  44. Scapini P, Hu Y, Chu C, Migone T, DeFranco A, Cassatella M, et al. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010;207:1757-73 pubmed publisher
    ..Autoimmunity is also associated with increased levels of B cell-activating factor of the TNF family (BAFF; also known as B lymphocyte stimulator), a cytokine that promotes survival of self-reactive B cell clones...
  45. Thien M, Phan T, Gardam S, Amesbury M, Basten A, Mackay F, et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity. 2004;20:785-98 pubmed
    The role of BAFF in B cell self tolerance was examined by tracking the fate of anti-HEL self-reactive B cells in BAFF transgenic mice using four different models of self-reactive B cell deletion...
  46. Thompson J, Bixler S, Qian F, Vora K, Scott M, Cachero T, et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science. 2001;293:2108-11 pubmed
    B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family...
  47. Schiemann B, Gommerman J, Vora K, Cachero T, Shulga Morskaya S, Dobles M, et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 2001;293:2111-4 pubmed
    The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R)...
  48. Gross J, Dillon S, Mudri S, Johnston J, Littau A, Roque R, et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity. 2001;15:289-302 pubmed
    b>BLyS and APRIL have similar but distinct biological roles, mediated through two known TNF receptor family members, TACI and BCMA...
  49. Jacob C, Pricop L, Putterman C, Koss M, Liu Y, Kollaros M, et al. Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF. J Immunol. 2006;177:2671-80 pubmed
    Constitutive overexpression of B cell-activating factor belonging to the TNF family (BAFF) promotes development of systemic lupus erythematosus (SLE), and treatment of SLE mice with BAFF antagonists ameliorates disease...
  50. Gorelik L, Cutler A, Thill G, Miklasz S, Shea D, Ambrose C, et al. Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function. J Immunol. 2004;172:762-6 pubmed
    Herein we demonstrate that B cell-activating factor of the TNF family (BAFF), a B cell survival factor, also regulates CD21/35 and CD23 expression...
  51. Stohl W, Xu D, Kim K, Koss M, Jorgensen T, Deocharan B, et al. BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus. Arthritis Rheum. 2005;52:2080-91 pubmed
    To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus-associated end-organ disease in hosts with an underlying autoimmune diathesis...
  52. Patke A, Mecklenbrauker I, Erdjument Bromage H, Tempst P, Tarakhovsky A. BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. J Exp Med. 2006;203:2551-62 pubmed
    B cell life depends critically on the cytokine B cell-activating factor of the tumor necrosis factor family (BAFF). Lack of BAFF signaling leads to B cell death and immunodeficiency...
  53. Claudio E, Brown K, Park S, Wang H, Siebenlist U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat Immunol. 2002;3:958-65 pubmed
    ..We show here that B cell-activating factor (BAFF) activates this second pathway and that this requires the BAFF receptor (BAFF-R), the NF-kappa B-inducing kinase (..
  54. Qian Y, Qin J, Cui G, Naramura M, Snow E, Ware C, et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 2004;21:575-87 pubmed
    ..Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which culminates in lymphadenopathy and splenomegaly, ..
  55. Rahman Z, Rao S, Kalled S, Manser T. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med. 2003;198:1157-69 pubmed
    ..studies have defined a crucial role for the B cell-activating factor belonging to TNF family (BAFF; also called BLyS) in promoting primary B cell survival and development...
  56. Bossen C, Tardivel A, Willen L, Fletcher C, Perroud M, Beermann F, et al. Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. Eur J Immunol. 2011;41:787-97 pubmed publisher
    B-cell-activating factor of the TNF family (BAFF)/BLyS contributes to B-cell homeostasis and function in the periphery...
  57. Hatada E, Do R, Orlofsky A, Liou H, Prystowsky M, MacLennan I, et al. NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells. J Immunol. 2003;171:761-8 pubmed
    B lymphocyte stimulator (BLyS), a TNF family protein essential for peripheral B cell development, functions primarily through attenuation of B cell apoptosis...
  58. Craxton A, Draves K, Gruppi A, Clark E. BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. J Exp Med. 2005;202:1363-74 pubmed
    The B cell activating factor belonging to the tumor necrosis factor family (BAFF) is required for B cell survival and maturation. The mechanisms by which BAFF mediates B cell survival are less understood...
  59. Fairfax K, Tsantikos E, Figgett W, Vincent F, Quah P, LePage M, et al. BAFF-driven autoimmunity requires CD19 expression. J Autoimmun. 2015;62:1-10 pubmed publisher
    b>B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for B cell survival and maturation...
  60. Liu X, Stacey K, Horne Debets J, Cridland J, Fischer K, Narum D, et al. Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival. Eur J Immunol. 2012;42:3291-301 pubmed publisher
    ..that malarial infections result in a decrease in the proportion of DCs that express the B-cell survival factor, BAFF, resulting in a decreased ability of these DCs to support memory B-cell differentiation into antibody secreting ..
  61. Goenka R, Matthews A, Zhang B, O Neill P, Scholz J, Migone T, et al. Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med. 2014;211:45-56 pubmed publisher
    We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the germinal center (GC) reaction and affinity maturation...
  62. Kang S, Keener A, Jones S, Benschop R, Caro Maldonado A, Rathmell J, et al. IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. J Immunol. 2016;196:196-206 pubmed publisher
    ..In this study, we identify a role for IgG-immune complexes (ICs), FcγRs, and BAFF during the formation of memory B cells in mice...